Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid
Pippione, Agnese Chiara, Carnovale, Irene Maria, Bonanni, Davide, Sini, Marcella, Goyal, Parveen, Marini, Elisabetta, Pors, Klaus, Adinolfi, Salvatore, Zonari, Daniele, Festuccia, Claudio, Wahlgren, Weixiao Yuan, Friemann, Rosmarie, Bagnati, Renzo, Boschi, Donatella, Oliaro-Bosso, Simonetta, Lolli, Marco Lucio
Published in European journal of medicinal chemistry (25.04.2018)
Published in European journal of medicinal chemistry (25.04.2018)
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Journal Article
Polysialic acid sustains cancer cell survival and migratory capacity in a hypoxic environment
Elkashef, Sara M., Allison, Simon J., Sadiq, Maria, Basheer, Haneen A., Ribeiro Morais, Goreti, Loadman, Paul M., Pors, Klaus, Falconer, Robert A.
Published in Scientific reports (09.09.2016)
Published in Scientific reports (09.09.2016)
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Journal Article
Design, Synthesis, Biological Evaluation and In Silico Study of Benzyloxybenzaldehyde Derivatives as Selective ALDH1A3 Inhibitors
Ibrahim, Ali I. M., Ikhmais, Balqis, Batlle, Elisabet, AbuHarb, Waed K., Jha, Vibhu, Jaradat, Khaled T., Jiménez, Rafael, Pequerul, Raquel, Parés, Xavier, Farrés, Jaume, Pors, Klaus
Published in Molecules (Basel, Switzerland) (23.09.2021)
Published in Molecules (Basel, Switzerland) (23.09.2021)
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Journal Article
The Chemerin-CMKLR1 Axis is Functionally important for Central Regulation of Energy Homeostasis
Yun, Haesung, Dumbell, Rebecca, Hanna, Katie, Bowen, Junior, McLean, Samantha L., Kantamneni, Sriharsha, Pors, Klaus, Wu, Qing-Feng, Helfer, Gisela
Published in Frontiers in physiology (30.05.2022)
Published in Frontiers in physiology (30.05.2022)
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Journal Article
Cytochrome P450 isoforms 1A1, 1B1 AND 2W1 as targets for therapeutic intervention in head and neck cancer
Presa, Daniela, Khurram, Syed A., Zubir, Amir Z. A., Smarakan, Sneha, Cooper, Patricia A., Morais, Goreti R., Sadiq, Maria, Sutherland, Mark, Loadman, Paul M., McCaul, James, Shnyder, Steven D., Patterson, Laurence H., Pors, Klaus
Published in Scientific reports (23.09.2021)
Published in Scientific reports (23.09.2021)
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Journal Article
Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies
Sneha, Smarakan, Baker, Simon C, Green, Andrew, Storr, Sarah, Aiyappa, Radhika, Martin, Stewart, Pors, Klaus
Published in Biomedicines (12.03.2021)
Published in Biomedicines (12.03.2021)
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Journal Article
Encapsulation and Delivery of Mitoxantrone Using Zirconium-Based Metal–Organic Frameworks (MOFs) and Their Cytotoxic Potential in Breast Cancer Cells
Singhal, Mitali, Riches-Suman, Kirsten, Pors, Klaus, Addicoat, Matthew A, Ruiz, Amalia, Nayak, Sanjit, Elies, Jacobo
Published in Applied sciences (01.02.2024)
Published in Applied sciences (01.02.2024)
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Journal Article
Quantitative analysis of cytochrome P450 isoforms in human liver microsomes by the combination of proteomics and chemical probe-based assay
Liu, Xidong, Hu, Lianghai, Ge, Guangbo, Yang, Bo, Ning, Jing, Sun, Shixin, Yang, Ling, Pors, Klaus, Gu, Jingkai
Published in Proteomics (Weinheim) (01.08.2014)
Published in Proteomics (Weinheim) (01.08.2014)
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Journal Article
Aldehyde Dehydrogenases and Prostate Cancer: Shedding Light on Isoform Distribution to Reveal Druggable Target
Quattrini, Luca, Sadiq, Maria, Petrarolo, Giovanni, Maitland, Norman J, Frame, Fiona M, Pors, Klaus, La Motta, Concettina
Published in Biomedicines (04.12.2020)
Published in Biomedicines (04.12.2020)
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Journal Article
Current challenges and opportunities in treating hypoxic prostate tumors
McKenna, Declan J., Errington, Rachel, Pors, Klaus
Published in Journal of cancer metastasis and treatment (01.03.2018)
Published in Journal of cancer metastasis and treatment (01.03.2018)
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Journal Article
Androgen-AR axis in primary and metastatic prostate cancer: chasing steroidogenic enzymes for therapeutic intervention
Pippione, Agnese C., Boschi, Donatella, Pors, Klaus, Oliaro-Bosso, Simonetta, Lolli, Marco L.
Published in Journal of cancer metastasis and treatment (12.12.2017)
Published in Journal of cancer metastasis and treatment (12.12.2017)
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Journal Article
Alchemix: A Novel Alkylating Anthraquinone with Potent Activity against Anthracycline- and Cisplatin-resistant Ovarian Cancer
Pors, Klaus, Paniwnyk, Zennia, Teesdale-Spittle, Paul, Plumb, Jane A, Willmore, Elaine, Austin, Caroline A, Patterson, Laurence H
Published in Molecular cancer therapeutics (01.07.2003)
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Published in Molecular cancer therapeutics (01.07.2003)
Journal Article
How can the potential of the duocarmycins be unlocked for cancer therapy?
Jukes, Zoë, Morais, Goreti Ribeiro, Loadman, Paul M., Pors, Klaus
Published in Drug discovery today (01.02.2021)
Published in Drug discovery today (01.02.2021)
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Journal Article
Cytochrome P450 Binding and Bioactivation of Tumor-Targeted Duocarmycin Agents
Bart, Aaron G., Morais, Goreti, Vangala, Venu R., Loadman, Paul M., Pors, Klaus, Scott, Emily E.
Published in Drug metabolism and disposition (04.10.2021)
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Published in Drug metabolism and disposition (04.10.2021)
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