SLAM-seq defines direct gene-regulatory functions of the BRD4-MYC axis
Muhar, Matthias, Ebert, Anja, Neumann, Tobias, Umkehrer, Christian, Jude, Julian, Wieshofer, Corinna, Rescheneder, Philipp, Lipp, Jesse J, Herzog, Veronika A, Reichholf, Brian, Cisneros, David A, Hoffmann, Thomas, Schlapansky, Moritz F, Bhat, Pooja, von Haeseler, Arndt, Köcher, Thomas, Obenauf, Anna C, Popow, Johannes, Ameres, Stefan L, Zuber, Johannes
Published in Science (American Association for the Advancement of Science) (18.05.2018)
Published in Science (American Association for the Advancement of Science) (18.05.2018)
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Journal Article
Analysis of orthologous groups reveals archease and DDX1 as tRNA splicing factors
Popow, Johannes, Jurkin, Jennifer, Schleiffer, Alexander, Martinez, Javier
Published in Nature (London) (03.07.2014)
Published in Nature (London) (03.07.2014)
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Journal Article
The mammalian tRNA ligase complex mediates splicing of XBP1 mRNA and controls antibody secretion in plasma cells
Jurkin, Jennifer, Henkel, Theresa, Nielsen, Anne Færch, Minnich, Martina, Popow, Johannes, Kaufmann, Therese, Heindl, Katrin, Hoffmann, Thomas, Busslinger, Meinrad, Martinez, Javier
Published in The EMBO journal (17.12.2014)
Published in The EMBO journal (17.12.2014)
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Journal Article
HSPC117 Is the Essential Subunit of a Human tRNA Splicing Ligase Complex
Popow, Johannes, Englert, Markus, Weitzer, Stefan, Schleiffer, Alexander, Mierzwa, Beata, Mechtler, Karl, Trowitzsch, Simon, Will, Cindy L, Lührmann, Reinhard, Söll, Dieter, Martinez, Javier
Published in Science (American Association for the Advancement of Science) (11.02.2011)
Published in Science (American Association for the Advancement of Science) (11.02.2011)
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Journal Article
A transcription factor–based mechanism for mouse heterochromatin formation
Bulut-Karslioglu, Aydan, Perrera, Valentina, Scaranaro, Manuela, de la Rosa-Velazquez, Inti Alberto, van de Nobelen, Suzanne, Shukeir, Nicholas, Popow, Johannes, Gerle, Borbala, Opravil, Susanne, Pagani, Michaela, Meidhof, Simone, Brabletz, Thomas, Manke, Thomas, Lachner, Monika, Jenuwein, Thomas
Published in Nature structural & molecular biology (01.10.2012)
Published in Nature structural & molecular biology (01.10.2012)
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Journal Article
Diversity and roles of (t)RNA ligases
Popow, Johannes, Schleiffer, Alexander, Martinez, Javier
Published in Cellular and molecular life sciences : CMLS (01.08.2012)
Published in Cellular and molecular life sciences : CMLS (01.08.2012)
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Journal Article
Pan-KRAS inhibitor disables oncogenic signalling and tumour growth
Kim, Dongsung, Herdeis, Lorenz, Rudolph, Dorothea, Zhao, Yulei, Böttcher, Jark, Vides, Alberto, Ayala-Santos, Carlos I., Pourfarjam, Yasin, Cuevas-Navarro, Antonio, Xue, Jenny Y., Mantoulidis, Andreas, Bröker, Joachim, Wunberg, Tobias, Schaaf, Otmar, Popow, Johannes, Wolkerstorfer, Bernhard, Kropatsch, Katrin Gabriele, Qu, Rui, de Stanchina, Elisa, Sang, Ben, Li, Chuanchuan, McConnell, Darryl B., Kraut, Norbert, Lito, Piro
Published in Nature (London) (06.07.2023)
Published in Nature (London) (06.07.2023)
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Journal Article
FASTKD2 is an RNA-binding protein required for mitochondrial RNA processing and translation
Popow, Johannes, Alleaume, Anne-Marie, Curk, Tomaz, Schwarzl, Thomas, Sauer, Sven, Hentze, Matthias W
Published in RNA (Cambridge) (01.11.2015)
Published in RNA (Cambridge) (01.11.2015)
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Journal Article
Highly Selective PTK2 Proteolysis Targeting Chimeras to Probe Focal Adhesion Kinase Scaffolding Functions
Popow, Johannes, Arnhof, Heribert, Bader, Gerd, Berger, Helmut, Ciulli, Alessio, Covini, David, Dank, Christian, Gmaschitz, Teresa, Greb, Peter, Karolyi-Özguer, Jale, Koegl, Manfred, McConnell, Darryl B, Pearson, Mark, Rieger, Maria, Rinnenthal, Joerg, Roessler, Vanessa, Schrenk, Andreas, Spina, Markus, Steurer, Steffen, Trainor, Nicole, Traxler, Elisabeth, Wieshofer, Corinna, Zoephel, Andreas, Ettmayer, Peter
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Journal Article
The novel BET bromodomain inhibitor BI 894999 represses super-enhancer-associated transcription and synergizes with CDK9 inhibition in AML
Gerlach, Daniel, Tontsch-Grunt, Ulrike, Baum, Anke, Popow, Johannes, Scharn, Dirk, Hofmann, Marco H., Engelhardt, Harald, Kaya, Onur, Beck, Janina, Schweifer, Norbert, Gerstberger, Thomas, Zuber, Johannes, Savarese, Fabio, Kraut, Norbert
Published in Oncogene (01.05.2018)
Published in Oncogene (01.05.2018)
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Journal Article
Interrogation of cancer gene dependencies reveals paralog interactions of autosome and sex chromosome-encoded genes
Köferle, Anna, Schlattl, Andreas, Hörmann, Alexandra, Thatikonda, Venu, Popa, Alexandra, Spreitzer, Fiona, Ravichandran, Madhwesh C., Supper, Verena, Oberndorfer, Sarah, Puchner, Teresa, Wieshofer, Corinna, Corcokovic, Maja, Reiser, Christoph, Wöhrle, Simon, Popow, Johannes, Pearson, Mark, Martinez, Javier, Weitzer, Stefan, Mair, Barbara, Neumüller, Ralph A.
Published in Cell reports (Cambridge) (12.04.2022)
Published in Cell reports (Cambridge) (12.04.2022)
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Journal Article
Targeting cancer with small-molecule pan-KRAS degraders
Popow, Johannes, Farnaby, William, Gollner, Andreas, Kofink, Christiane, Fischer, Gerhard, Wurm, Melanie, Zollman, David, Wijaya, Andre, Mischerikow, Nikolai, Hasenoehrl, Carina, Prokofeva, Polina, Arnhof, Heribert, Arce-Solano, Silvia, Bell, Sammy, Boeck, Georg, Diers, Emelyne, Frost, Aileen B, Goodwin-Tindall, Jake, Karolyi-Oezguer, Jale, Khan, Shakil, Klawatsch, Theresa, Koegl, Manfred, Kousek, Roland, Kratochvil, Barbara, Kropatsch, Katrin, Lauber, Arnel A, McLennan, Ross, Olt, Sabine, Peter, Daniel, Petermann, Oliver, Roessler, Vanessa, Stolt-Bergner, Peggy, Strack, Patrick, Strauss, Eva, Trainor, Nicole, Vetma, Vesna, Whitworth, Claire, Zhong, Siying, Quant, Jens, Weinstabl, Harald, Kuster, Bernhard, Ettmayer, Peter, Ciulli, Alessio
Published in Science (American Association for the Advancement of Science) (20.09.2024)
Published in Science (American Association for the Advancement of Science) (20.09.2024)
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Journal Article
Abstract 4449: Synthetic lethality between CSTF2 and CSTF2T in lung adenocarcinoma and melanoma cell lines
Popow, Johannes, Wieshofer, Corinna, Schlattl, Andreas, Woehrle, Simon, Neumüller, Ralph, Petronczki, Mark P., Boettcher, Jark, Koegl, Manfred, Pearson, Mark
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Zongertinib (BI 1810631), an irreversible HER2 TKI, spares EGFR signaling and improves therapeutic response in preclinical models and patients with HER2-driven cancers
Wilding, Birgit, Woelflingseder, Lydia, Baum, Anke, Chylinski, Krzysztof, Vainorius, Gintautas, Gibson, Neil, Waizenegger, Irene C, Gerlach, Daniel, Augsten, Martin, Spreitzer, Fiona, Shirai, Yukina, Ikegami, Masachika, Tilandyova, Sylvia, Scharn, Dirk, Pearson, Mark A, Popow, Johannes, Obenauf, Anna C, Yamamoto, Noboru, Kondo, Shunsuke, Opdam, Frans L, Bruining, Annemarie, Kohsaka, Shinji, Kraut, Norbert, Heymach, John V, Solca, Flavio, Neumuller, Ralph A
Published in Cancer discovery (09.09.2024)
Published in Cancer discovery (09.09.2024)
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Journal Article
Abstract 1271: In vitro and in vivo characterization of BI 1823911 - a novel KRASG12C selective small molecule inhibitor
Savarese, Fabio, Gollner, Andreas, Rudolph, Dorothea, Lipp, Jesse, Popow, Johannes, Hofmann, Marco H., Arnhof, Heribert, Rinnenthal, Jörg, Trapani, Francesca, Gmachl, Michael, Gerlach, Daniel, Broeker, Joachim, Ettmayer, Peter, Mantoulidis, Andreas, Phan, Jason, Smethurst, Christian A., Treu, Matthias, Waterson, Alex G., Lu, Hengyu, Machado, Annette, Daniele, Joseph, Fesik, Stephan W., Vellano, Christopher P., Heffernan, Timothy P., Marszalek, Joseph R., McConnell, Darryl B., Petronczki, Mark, Kraut, Norbert, Waizenegger, Irene C.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Intron excision from precursor tRNA molecules in mammalian cells requires ATP hydrolysis and phosphorylation of tRNA-splicing endonuclease components
Mair, Barbara, Popow, Johannes, Mechtler, Karl, Weitzer, Stefan, Martinez, Javier
Published in Biochemical Society transactions (01.08.2013)
Published in Biochemical Society transactions (01.08.2013)
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Journal Article
Abstract 6506: SOS1 inhibition in combination with HER2 inhibition in models of HER2-driven cancer
Schenk, Robyn L., Kostyrko, Kaja, Popow, Johannes, Gewinner, Christina, Baum, Anke, Albrecht, Christoph, Hinkel, Melanie, Jacob, Robin, Madensky, Tom, Ruzicka, Regina, Strauss, Eva, Lyu, Hengyu, Lopez, Anastasia M., Feng, Ningping, Vellano, Christopher P., Marszalek, Joseph R., Heffernan, Timothy P., Pearson, Mark, Hofmann, Marco H.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Abstract B103: Development and characterisation of KRASmulti inhibitors for the treatment of KRAS mutant pancreatic ductal adenocarcinoma
Tedeschi, Antonio, Schaaf, Otmar, Gmachl, Michael, Herdeis, Lorenz, Rocchetti, Francesca, Popow, Johannes, Schischlik, Fiorella, Gerlach, Daniel, Lipp, Jesse, Bröker, Joachim, Mantoulidis, Andreas, Smethurst, Chris, Kessler, Dirk, Boettcher, Jark, Wunberg, Tobias, Santoro, Valeria, Waterson, Alex, Phan, Jason, Little, Andrew, Abbott, Jason, Sun, Qi, Fesik, Stephen, Mcconnell, Darryl, Pearson, Mark A., Kraut, Norbert, Rudolph, Dorothea
Published in Cancer research (Chicago, Ill.) (16.01.2024)
Published in Cancer research (Chicago, Ill.) (16.01.2024)
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