A Randomized, Double-Masked, Multicenter Trial of Topical Acrizanib (LHA510), a Tyrosine Kinase VEGF-Receptor Inhibitor, in Treatment-Experienced Subjects With Neovascular Age-Related Macular Degeneration
Poor, Stephen H., Weissgerber, Georges, Adams, Christopher M., Bhatt, Harit, Browning, David J., Chastain, James, Ciulla, Thomas A., Ferriere, Michael, Gedif, Kinfemichael, Glazer, Louis C., Joondeph, Brian C., Normand, Guillaume, Sheth, Veeral, Watters, Christie, Grosskreutz, Cynthia L.
Published in American journal of ophthalmology (01.07.2022)
Published in American journal of ophthalmology (01.07.2022)
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A proteogenomic signature of age-related macular degeneration in blood
Emilsson, Valur, Gudmundsson, Elias F., Jonmundsson, Thorarinn, Jonsson, Brynjolfur G., Twarog, Michael, Gudmundsdottir, Valborg, Li, Zhiguang, Finkel, Nancy, Poor, Stephen, Liu, Xin, Esterberg, Robert, Zhang, Yiyun, Jose, Sandra, Huang, Chia-Ling, Liao, Sha-Mei, Loureiro, Joseph, Zhang, Qin, Grosskreutz, Cynthia L., Nguyen, Andrew A., Huang, Qian, Leehy, Barrett, Pitts, Rebecca, Aspelund, Thor, Lamb, John R., Jonasson, Fridbert, Launer, Lenore J., Cotch, Mary Frances, Jennings, Lori L., Gudnason, Vilmundur, Walshe, Tony E.
Published in Nature communications (13.06.2022)
Published in Nature communications (13.06.2022)
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Journal Article
Reliability of the mouse model of choroidal neovascularization induced by laser photocoagulation
Poor, Stephen H, Qiu, Yubin, Fassbender, Elizabeth S, Shen, Siyuan, Woolfenden, Amber, Delpero, Andrea, Kim, Yong, Buchanan, Natasha, Gebuhr, Thomas C, Hanks, Shawn M, Meredith, Erik L, Jaffee, Bruce D, Dryja, Thaddeus P
Published in Investigative ophthalmology & visual science (09.09.2014)
Published in Investigative ophthalmology & visual science (09.09.2014)
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Journal Article
Long-acting protein drugs for the treatment of ocular diseases
Ghosh, Joy G., Nguyen, Andrew A., Bigelow, Chad E., Poor, Stephen, Qiu, Yubin, Rangaswamy, Nalini, Ornberg, Richard, Jackson, Brittany, Mak, Howard, Ezell, Tucker, Kenanova, Vania, de la Cruz, Elisa, Carrion, Ana, Etemad-Gilbertson, Bijan, Caro, Roxana Garcia, Zhu, Kan, George, Vinney, Bai, Jirong, Sharma-Nahar, Radhika, Shen, Siyuan, Wang, Yiqin, Subramanian, Kulandayan K., Fassbender, Elizabeth, Maker, Michael, Hanks, Shawn, Vrouvlianis, Joanna, Leehy, Barrett, Long, Debby, Prentiss, Melissa, Kansara, Viral, Jaffee, Bruce, Dryja, Thaddeus P., Roguska, Michael
Published in Nature communications (23.03.2017)
Published in Nature communications (23.03.2017)
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Journal Article
Amount of Mononuclear Phagocyte Infiltrate Does Not Predict Area of Experimental Choroidal Neovascularization (CNV)
Will-Orrego, Adrian, Qiu, Yubin, Fassbender, Elizabeth S, Shen, Siyuan, Aranda, Jorge, Kotagiri, Namrata, Maker, Michael, Liao, Sha-Mei, Jaffee, Bruce D, Poor, Stephen H
Published in Journal of ocular pharmacology and therapeutics (01.09.2018)
Published in Journal of ocular pharmacology and therapeutics (01.09.2018)
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Journal Article
Characteristics and Spatial Distribution of Structural Features in Age-Related Macular Degeneration: A MACUSTAR Study Report
Saßmannshausen, Marlene, Behning, Charlotte, Weinz, Jonas, Goerdt, Lukas, Terheyden, Jan H, Chang, Petrus, Schmid, Matthias, Poor, Stephen H, Zakaria, Nadia, Finger, Robert P, Holz, Frank G, Pfau, Maximilian, Schmitz-Valckenberg, Steffen, Thiele, Sarah
Published in Ophthalmology retina (01.05.2023)
Published in Ophthalmology retina (01.05.2023)
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Journal Article
Lack of involvement of CEP adducts in TLR activation and in angiogenesis
Gounarides, John, Cobb, Jennifer S, Zhou, Jing, Cook, Frank, Yang, Xuemei, Yin, Hong, Meredith, Erik, Rao, Chang, Huang, Qian, Xu, YongYao, Anderson, Karen, De Erkenez, Andrea, Liao, Sha-Mei, Crowley, Maura, Buchanan, Natasha, Poor, Stephen, Qiu, Yubin, Fassbender, Elizabeth, Shen, Siyuan, Woolfenden, Amber, Jensen, Amy, Cepeda, Rosemarie, Etemad-Gilbertson, Bijan, Giza, Shelby, Mogi, Muneto, Jaffee, Bruce, Azarian, Sassan
Published in PloS one (24.10.2014)
Published in PloS one (24.10.2014)
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Journal Article
Forms of nostalgia in the rhetorical history of Jack Daniel’s
Seifried, Chad S., Novicevic, Milorad M., Poor, Stephen
Published in Journal of management history (2006) (06.06.2024)
Published in Journal of management history (2006) (06.06.2024)
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Journal Article
Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration
Demirs, John T, Yang, Junzheng, Crowley, Maura A, Twarog, Michael, Delgado, Omar, Qiu, Yubin, Poor, Stephen, Rice, Dennis S, Dryja, Thaddeus P, Anderson, Karen, Liao, Sha-Mei
Published in Investigative ophthalmology & visual science (01.06.2021)
Published in Investigative ophthalmology & visual science (01.06.2021)
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Journal Article
Disease-specific assessment of Vision Impairment in Low Luminance in age-related macular degeneration - a MACUSTAR study report
Terheyden, Jan Henrik, Pondorfer, Susanne G, Behning, Charlotte, Berger, Moritz, Carlton, Jill, Rowen, Donna, Bouchet, Christine, Poor, Stephen, Luhmann, Ulrich F O, Leal, Sergio, Holz, Frank G, Butt, Thomas, Brazier, John E, Finger, Robert P
Published in British journal of ophthalmology (01.08.2023)
Published in British journal of ophthalmology (01.08.2023)
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Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration
Crowley, Maura A, Garland, Donita L, Sellner, Holger, Banks, Angela, Fan, Lin, Rejtar, Tomas, Buchanan, Natasha, Delgado, Omar, Xu, Yong Yao, Jose, Sandra, Adams, Christopher M, Mogi, Muneto, Wang, Karen, Bigelow, Chad E, Poor, Stephen, Anderson, Karen, Jaffee, Bruce D, Prasanna, Ganesh, Grosskreutz, Cynthia, Fernandez-Godino, Rosario, Pierce, Eric A, Dryja, Thaddeus P, Liao, Sha-Mei
Published in Human molecular genetics (06.01.2023)
Published in Human molecular genetics (06.01.2023)
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Journal Article
Screening Medications for Association with Progression to Wet Age-Related Macular Degeneration
Wang, Shirley V., Kulldorff, Martin, Poor, Stephen, Rice, Dennis S., Banks, Angela, Li, Ning, Lii, Joyce, Gagne, Joshua J.
Published in Ophthalmology (Rochester, Minn.) (01.02.2021)
Published in Ophthalmology (Rochester, Minn.) (01.02.2021)
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The Discovery of N‑(1-Methyl-5-(trifluoromethyl)‑1H‑pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)‑1H‑indole-1-carboxamide (Acrizanib), a VEGFR‑2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration
Adams, Christopher M, Anderson, Karen, Artman, Gerald, Bizec, Jean-Claude, Cepeda, Rosemarie, Elliott, Jason, Fassbender, Elizabeth, Ghosh, Malay, Hanks, Shawn, Hardegger, Leo A, Hosagrahara, Vinayak P, Jaffee, Bruce, Jendza, Keith, Ji, Nan, Johnson, Leland, Lee, Wendy, Liu, Donglei, Liu, Fang, Long, Debby, Ma, Fupeng, Mainolfi, Nello, Meredith, Erik L, Miranda, Karl, Peng, Yao, Poor, Stephen, Powers, James, Qiu, Yubin, Rao, Chang, Shen, Siyuan, Sivak, Jeremy M, Solovay, Catherine, Tarsa, Peter, Woolfenden, Amber, Zhang, Chun, Zhang, Yiqin
Published in Journal of medicinal chemistry (22.02.2018)
Published in Journal of medicinal chemistry (22.02.2018)
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Artificial intelligence-based strategies to identify patient populations and advance analysis in age-related macular degeneration clinical trials
Yaghy, Antonio, Lee, Aaron Y., Keane, Pearse A., Keenan, Tiarnan D.L., Mendonca, Luisa S.M., Lee, Cecilia S., Cairns, Anne Marie, Carroll, Joseph, Chen, Hao, Clark, Julie, Cukras, Catherine A., de Sisternes, Luis, Domalpally, Amitha, Durbin, Mary K., Goetz, Kerry E., Grassmann, Felix, Haines, Jonathan L., Honda, Naoto, Hu, Zhihong Jewel, Mody, Christopher, Orozco, Luz D., Owsley, Cynthia, Poor, Stephen, Reisman, Charles, Ribeiro, Ramiro, Sadda, Srinivas R., Sivaprasad, Sobha, Staurenghi, Giovanni, Ting, Daniel SW, Tumminia, Santa J., Zalunardo, Luca, Waheed, Nadia K.
Published in Experimental eye research (01.07.2022)
Published in Experimental eye research (01.07.2022)
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Journal Article
Discovery of Oral VEGFR‑2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration
Meredith, Erik L, Mainolfi, Nello, Poor, Stephen, Qiu, Yubin, Miranda, Karl, Powers, James, Liu, Donglei, Ma, Fupeng, Solovay, Catherine, Rao, Chang, Johnson, Leland, Ji, Nan, Artman, Gerald, Hardegger, Leo, Hanks, Shawn, Shen, Siyuan, Woolfenden, Amber, Fassbender, Elizabeth, Sivak, Jeremy M, Zhang, Yiqin, Long, Debby, Cepeda, Rosemarie, Liu, Fang, Hosagrahara, Vinayak P, Lee, Wendy, Tarsa, Peter, Anderson, Karen, Elliott, Jason, Jaffee, Bruce
Published in Journal of medicinal chemistry (10.12.2015)
Published in Journal of medicinal chemistry (10.12.2015)
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Journal Article
Core Replacements in a Potent Series of VEGFR‑2 Inhibitors and Their Impact on Potency, Solubility, and hERG
Mainolfi, Nello, Powers, James, Meredith, Erik, Elliott, Jason, Gunderson, Karl G, Poor, Stephen, Liu, Fang, Anderson, Karen
Published in ACS medicinal chemistry letters (14.04.2016)
Published in ACS medicinal chemistry letters (14.04.2016)
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Journal Article
The Discovery of N -(1-Methyl-5-(trifluoromethyl)-1 H -pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1 H -indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration
Adams, Christopher M., Anderson, Karen, Artman, Gerald, Bizec, Jean-Claude, Cepeda, Rosemarie, Elliott, Jason, Fassbender, Elizabeth, Ghosh, Malay, Hanks, Shawn, Hardegger, Leo A., Hosagrahara, Vinayak P., Jaffee, Bruce, Jendza, Keith, Ji, Nan, Johnson, Leland, Lee, Wendy, Liu, Donglei, Liu, Fang, Long, Debby, Ma, Fupeng, Mainolfi, Nello, Meredith, Erik L., Miranda, Karl, Peng, Yao, Poor, Stephen, Powers, James, Qiu, Yubin, Rao, Chang, Shen, Siyuan, Sivak, Jeremy M., Solovay, Catherine, Tarsa, Peter, Woolfenden, Amber, Zhang, Chun, Zhang, Yiqin
Published in Journal of medicinal chemistry (22.02.2018)
Published in Journal of medicinal chemistry (22.02.2018)
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Journal Article
Test-Retest Variability and Discriminatory Power of Measurements From Microperimetry and Dark Adaptation Assessment in People With Intermediate Age-Related Macular Degeneration - A MACUSTAR Study Report
Higgins, Bethany E, Montesano, Giovanni, Dunbar, Hannah M P, Binns, Alison M, Taylor, Deanna J, Behning, Charlotte, Abdirahman, Amina, Schmid, Matthias C, Terheyden, Jan H, Zakaria, Nadia, Poor, Stephen, Finger, Robert P, Leal, Sergio, Holz, Frank G, Rubin, Gary S, Luhmann, Ulrich F O, Crabb, David P
Published in Translational vision science & technology (21.07.2023)
Published in Translational vision science & technology (21.07.2023)
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