Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist
Hong, Qingmei, Bakshi, Raman K., Palucki, Brenda L., Park, Min K., Ye, Zhixiong, He, Shuwen, Pollard, Patrick G., Sebhat, Iyassu K., Liu, Jian, Guo, Liangqin, Cashen, Doreen E., Martin, William J., Weinberg, David H., MacNeil, Tanya, Tang, Rui, Tamvakopoulos, Constantin, Peng, Qianping, Miller, Randy R., Stearns, Ralph A., Chen, Howard Y., Chen, Airu S., Strack, Alison M., Fong, Tung M., MacIntyre, D. Euan, Wyvratt, Matthew J., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
Published in Bioorganic & medicinal chemistry letters (15.04.2011)
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Discovery of (2 S)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist
Palucki, Brenda L., Park, Min K., Nargund, Ravi P., Ye, Zhixiong, Sebhat, Iyassu K., Pollard, Patrick G., Kalyani, Rubana N., Tang, Rui, MacNeil, Tanya, Weinberg, David H., Vongs, Aurawan, Rosenblum, Charles I., Doss, George A., Miller, Randall R., Stearns, Ralph A., Peng, Qianping, Tamvakopoulos, Constantin, McGowan, Erin, Martin, William J., Metzger, Joseph M., Shepherd, Cherrie A., Strack, Alison M., MacIntyre, D. Euan, Van der Ploeg, Lex H.T., Patchett, Arthur A.
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
Published in Bioorganic & medicinal chemistry letters (03.01.2005)
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Discovery and activity of (1 R,4 S,6 R)- N-[(1 R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subtype-4 receptor agonist
Ye, Zhixiong, Guo, Liangqin, Barakat, Khaled J., Pollard, Patrick G., Palucki, Brenda L., Sebhat, Iyassu K., Bakshi, Raman K., Tang, Rui, Kalyani, Rubana N., Vongs, Aurawan, Chen, Airu S., Chen, Howard Y., Rosenblum, Charles I., MacNeil, Tanya, Weinberg, David H., Peng, Qianping, Tamvakopoulos, Constantin, Miller, Randy R., Stearns, Ralph A., Cashen, Doreen E., Martin, William J., Metzger, Joseph M., Strack, Alison M., MacIntyre, D. Euan, Van der Ploeg, Lex H.T., Patchett, Arthur A., Wyvratt, Matthew J., Nargund, Ravi P.
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
Published in Bioorganic & medicinal chemistry letters (01.08.2005)
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Journal Article
Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)-amino]carbonyl]-1-piperidin yl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide (MB243), a potent and selective melanocortin subtype-4 receptor agonist
PALUCKI, Brenda L, PARK, Min K, VONGS, Aurawan, ROSENBLUM, Charles I, DOSS, George A, MILLER, Randall R, STEARNS, Ralph A, QIANPING PENG, TAMVAKOPOULOS, Constantin, MCGOWAN, Erin, MARTIN, William J, METZGER, Joseph M, NARGUND, Ravi P, SHEPHERD, Cherrie A, STRACK, Alison M, MACINTYRE, D. Euan, VAN DER PLOEG, Lex H. T, PATCHETT, Arthur A, ZHIXIONG YE, SEBHAT, Iyassu K, POLLARD, Patrick G, KALYANI, Rubana N, RUI TANG, MACNEIL, Tanya, WEINBERG, David H
Published in Bioorganic & medicinal chemistry letters (2005)
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Published in Bioorganic & medicinal chemistry letters (2005)
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SUBSTITUTED PIPERIDINES AS MELANOCORTIN RECEPTOR AGONISTS
PARK, MIN K, PALUCKI, BRENDA L, LAI, YINGJIE, YE, ZHIXIONG, POLLARD, PATRICK G, SEBHAT, IYASSU K, GUO, LIANGQIN, NARGUND, RAVI P, BARAKAT, KHALED J
Year of Publication 26.01.2010
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Year of Publication 26.01.2010
Patent
Acylated piperazine derivatives as melanocortin-4 receptor agonists
Bakshi, Raman K, Guo, Liangqin, Hong, Qingmei, Nargund, Ravi P, Pollard, Patrick G, Sebhat, Iyassu K, Ujjainwalla, Feroze, Ye, Zhixiong
Year of Publication 09.01.2007
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Year of Publication 09.01.2007
Patent
Acylated piperazine derivatives as melanocortin-4 receptor agonists
UJJAINWALLA FEROZE, BAKSHI RAMAN K, GUO LIANGQIN, HONG QINGMEI, SEBHAT IYASSU K, YE ZHIXIONG, NARGUND RAVI P, POLLARD PATRICK G
Year of Publication 09.01.2007
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Year of Publication 09.01.2007
Patent
ACYLATED PIPERAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS
BAKSHI, RAMAN, K, HONG, QINGMEI, SEBHAT, IYASSU, K, YE, ZHIXIONG, NARGUND, RAVI, P, POLLARD, PATRICK, G, UJJAINWALLA, FEROZE
Year of Publication 16.09.2004
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Year of Publication 16.09.2004
Patent
Substituted piperidines as melanocortin receptor agonists
RAVI P. NARGUND, MIN K. PARK, KHALED J BARAKAT, IYASSU K. SEBHAT, ZHIXIONG YE, LIANGQIN GUO, BRENDA L. PALUCKI, YINGJIE LAI, PATRICK G. POLLARD
Year of Publication 24.03.2005
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Year of Publication 24.03.2005
Patent
Acylated piperazine derivatives as melanocortin-4 receptor agonists
UJJAINWALLA FEROZE, BAKSHI RAMAN K, GUO LIANGQIN, HONG QINGMEI, SEBHAT IYASSU K, YE ZHIXIONG, NARGUND RAVI P, POLLARD PATRICK G
Year of Publication 14.10.2004
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Year of Publication 14.10.2004
Patent
ACYLATED PIPERAZINE DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS
BAKSHI, RAMAN, K, HONG, QINGMEI, SEBHAT, IYASSU, K, YE, ZHIXIONG, NARGUND, RAVI, P, POLLARD, PATRICK, G, GUO, LIANGQIN, UJJAINWALLA, FEROZE
Year of Publication 16.09.2004
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Year of Publication 16.09.2004
Patent
SUBSTITUTED PIPERIDINES AS MELANOCORTIN RECEPTOR AGONISTS
LAI, YINGJIE, SEBHAT, IYASSU, K, YE, ZHIXIONG, PARK, MIN, K, NARGUND, RAVI, P, PALUCKI, BRENDA, L, POLLARD, PATRICK, G, BARAKAT, KHALED, J, GUO, LIANGQIN
Year of Publication 15.09.2004
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Year of Publication 15.09.2004
Patent
SUBSTITUTED PIPERIDINES AS MELANOCORTIN RECEPTOR AGONISTS
LAI, YINGJIE, SEBHAT, IYASSU, K, YE, ZHIXIONG, PARK, MIN, K, NARGUND, RAVI, P, PALUCKI, BRENDA, L, POLLARD, PATRICK, G, BARAKAT, KHALED, J, GUO, LIANGQIN
Year of Publication 02.01.2003
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Year of Publication 02.01.2003
Patent
Substituted piperidines as melanocortin receptor agonists
Palucki, Brenda L, Barakat, Khaled J, Guo, Liangqin, Lai, Yingjie, Nargund, Ravi P, Park, Min K, Pollard, Patrick G, Sebhat, Iyassu K, Ye, Zhixiong
Year of Publication 01.10.2002
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Year of Publication 01.10.2002
Patent
Substituted piperidines as melanocortin receptor agonists
LAI YINGJIE, GUO LIANGQIN, SEBHAT IYASSU K, YE ZHIXIONG, PALUCKI BRENDA L, PARK MIN K, BARAKAT KHALED J, NARGUND RAVI P, POLLARD PATRICK G
Year of Publication 01.10.2002
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Year of Publication 01.10.2002
Patent
Substituted piperidines as melanocortin receptor agonists
LAI YINGJIE, GUO LIANGQIN, SEBHAT IYASSU K, YE ZHIXIONG, PALUCKI BRENDA L, PARK MIN K, BARAKAT KHALED J, NARGUND RAVI P, POLLARD PATRICK G
Year of Publication 14.02.2002
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Year of Publication 14.02.2002
Patent
Substituted piperidines as melanocortin receptor agonists
RAVI P. NARGUND, MIN K. PARK, KHALED J BARAKAT, IYASSU K. SEBHAT, ZHIXIONG YE, BRENDA L. PALUCKI, LIANGQIN GUO, YINGJIE LAI, PATRICK G. POLLARD
Year of Publication 03.10.2001
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Year of Publication 03.10.2001
Patent
SUBSTITUTED PIPERIDINES AS MELANOCORTIN RECEPTOR AGONISTS
PARK, MIN K, PALUCKI, BRENDA L, LAI, YINGJIE, YE, ZHIXIONG, POLLARD, PATRICK G, SEBHAT, IYASSU K, NARGUND, RAVI P, GUO, LIANGQIN, BARAKAT, KHALED J
Year of Publication 27.09.2001
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Year of Publication 27.09.2001
Patent
SUBSTITUTED PIPERIDINES AS MELANOCORTIN RECEPTOR AGONISTS
LAI, YINGJIE, SEBHAT, IYASSU, K, YE, ZHIXIONG, PARK, MIN, K, NARGUND, RAVI, P, PALUCKI, BRENDA, L, POLLARD, PATRICK, G, BARAKAT, KHALED, J, GUO, LIANGQIN
Year of Publication 27.09.2001
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Year of Publication 27.09.2001
Patent
DERIVADOS DE PIPERAZINA ACILADOS COMO AGONISTAS DEL RECEPTOR DE MELANOCORTINA-4
UJJAINWALLA FEROZE, BAKSHI RAMAN K, HONG QINGMEI, SEBHAT IYASSU K, YE ZHIXIONG, NARGUND RAVI P, POLLARD PATRICK G
Year of Publication 14.12.2004
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Year of Publication 14.12.2004
Patent