A bifunctional nociceptin and mu opioid receptor agonist is analgesic without opioid side effects in nonhuman primates
Ding, Huiping, Kiguchi, Norikazu, Yasuda, Dennis, Daga, Pankaj R, Polgar, Willma E, Lu, James J, Czoty, Paul W, Kishioka, Shiroh, Zaveri, Nurulain T, Ko, Mei-Chuan
Published in Science translational medicine (29.08.2018)
Published in Science translational medicine (29.08.2018)
Get more information
Journal Article
Attenuated G protein signaling and minimal receptor phosphorylation as a biochemical signature of low side-effect opioid analgesics
Dasgupta, Pooja, Mann, Anika, Polgar, Willma E., Reinscheid, Rainer K., Zaveri, Nurulain T., Schulz, Stefan
Published in Scientific reports (03.05.2022)
Published in Scientific reports (03.05.2022)
Get full text
Journal Article
The first universal opioid ligand, (2S)-2-[(5R,6R,7R,14S)-N-cyclopropylmethyl-4,5-epoxy-6,14-ethano-3-hydroxy-6-methoxymorphinan-7-yl]-3,3-dimethylpentan-2-ol (BU08028): characterization of the in vitro profile and in vivo behavioral effects in mouse models of acute pain and cocaine-induced reward
Khroyan, Taline V, Polgar, Willma E, Cami-Kobeci, Gerta, Husbands, Stephen M, Zaveri, Nurulain T, Toll, Lawrence
Published in The Journal of pharmacology and experimental therapeutics (01.03.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.03.2011)
Get full text
Journal Article
Synthesis, Biological Evaluation, and SAR Studies of 14β-phenylacetyl Substituted 17-cyclopropylmethyl-7, 8-dihydronoroxymorphinones Derivatives: Ligands With Mixed NOP and Opioid Receptor Profile
Kumar, Vinod, Polgar, Willma E, Cami-Kobeci, Gerta, Thomas, Mark P, Khroyan, Taline V, Toll, Lawrence, Husbands, Stephen M
Published in Frontiers in psychiatry (19.09.2018)
Published in Frontiers in psychiatry (19.09.2018)
Get full text
Journal Article
Discovery and structure-activity relationships (SAR) of a novel class of 2-substituted N-piperidinyl indole-based nociceptin opioid receptor ligands
Meyer, Michael E., Doshi, Arpit, Polgar, Willma E., Zaveri, Nurulain T.
Published in Bioorganic & medicinal chemistry (07.09.2023)
Published in Bioorganic & medicinal chemistry (07.09.2023)
Get full text
Journal Article
Differential In vitro Pharmacological Profiles of Structurally Diverse Nociceptin Receptor Agonists in Activating G-protein and Beta-arrestin Signaling at the Human Nociceptin Opioid Receptor
Lu, James J, Polgar, Willma E, Mann, Anika, Dasgupta, Pooja, Schulz, Stefan, Zaveri, Nurulain T
Published in Molecular pharmacology (01.07.2021)
Published in Molecular pharmacology (01.07.2021)
Get full text
Journal Article
Discovery and Structure–Activity Relationships of Nociceptin Receptor Partial Agonists That Afford Symptom Ablation in Parkinson’s Disease Models
Kamakolanu, Uma Gayathri, Meyer, Michael E, Yasuda, Dennis, Polgar, Willma E, Marti, Matteo, Mercatelli, Daniela, Pisanò, Clarissa Anna, Brugnoli, Alberto, Morari, Michele, Zaveri, Nurulain T
Published in Journal of medicinal chemistry (12.03.2020)
Published in Journal of medicinal chemistry (12.03.2020)
Get full text
Journal Article
High affinity α3β4 nicotinic acetylcholine receptor ligands AT-1001 and AT-1012 attenuate cocaine-induced conditioned place preference and behavioral sensitization in mice
Khroyan, Taline V., Yasuda, Dennis, Toll, Lawrence, Polgar, Willma E., Zaveri, Nurulain T.
Published in Biochemical pharmacology (15.10.2015)
Published in Biochemical pharmacology (15.10.2015)
Get full text
Journal Article
Differential effects of nociceptin/orphanin FQ (NOP) receptor agonists in acute versus chronic pain: studies with bifunctional NOP/μ receptor agonists in the sciatic nerve ligation chronic pain model in mice
Khroyan, Taline V, Polgar, Willma E, Orduna, Juan, Montenegro, Jose, Jiang, Faming, Zaveri, Nurulain T, Toll, Lawrence
Published in The Journal of pharmacology and experimental therapeutics (01.11.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.11.2011)
Get full text
Journal Article
Nociceptin/orphanin FQ receptor activation attenuates antinociception induced by mixed nociceptin/orphanin FQ/mu-opioid receptor agonists
Khroyan, Taline V, Polgar, Willma E, Jiang, Faming, Zaveri, Nurulain T, Toll, Lawrence
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
Published in The Journal of pharmacology and experimental therapeutics (01.12.2009)
Get full text
Journal Article
A Novel and Selective Nociceptin Receptor (NOP) Agonist (1‐(1‐((cis)‐4‐isopropylcyclohexyl)piperidin‐4‐yl)‐1H‐indol‐2‐yl)methanol (AT‐312) Decreases Acquisition of Ethanol‐Induced Conditioned Place Preference in Mice
Zaveri, Nurulain T., Marquez, Paul V., Meyer, Michael E., Polgar, Willma E., Hamid, Abdul, Lutfy, Kabirullah
Published in Alcoholism, clinical and experimental research (01.02.2018)
Published in Alcoholism, clinical and experimental research (01.02.2018)
Get full text
Journal Article
AT-1001: A High Affinity and Selective alpha 3 beta 4 Nicotinic Acetylcholine Receptor Antagonist Blocks Nicotine Self-Administration in Rats
Toll, Lawrence, Zaveri, Nurulain T, Polgar, Willma E, Jiang, Faming, Khroyan, Taline V, Zhou, Wei, Xie, Xinmin, Stauber, Gregory B, Costello, Matthew R, Leslie, Frances M
Published in Neuropsychopharmacology (New York, N.Y.) (01.05.2012)
Published in Neuropsychopharmacology (New York, N.Y.) (01.05.2012)
Get full text
Journal Article
AT- 1001: A High Affinity and Selective α3β4 Nicotinic Acetylcholine Receptor Antagonist Blocks Nicotine Self-Administration in Rats
TOLL, Lawrence, ZAVERI, Nurulain T, POLGAR, Willma E, FAMING JIANG, KHROYAN, Taline V, WEI ZHOU, XIE, Xinmin (simon), STAUBER, Gregory B, COSTELLO, Matthew R, LESLIE, Frances M
Published in Neuropsychopharmacology (New York, N.Y.) (01.05.2012)
Published in Neuropsychopharmacology (New York, N.Y.) (01.05.2012)
Get full text
Journal Article
Anti-nociceptive and anti-allodynic effects of a high affinity NOP hexapeptide [Ac-RY(3-Cl)YRWR-NH 2] (Syn 1020) in rodents
Khroyan, Taline V., Polgar, Willma E., Orduna, Juan, Zaveri, Naunihal T., Judd, Amrit K., Tuttle, David J., Sanchez, Agustin, Toll, Lawrence
Published in European journal of pharmacology (29.03.2007)
Published in European journal of pharmacology (29.03.2007)
Get full text
Journal Article
Anti‐Parkinsonian and anti‐dyskinetic profiles of two novel potent and selective nociceptin/orphanin FQ receptor agonists
Arcuri, Ludovico, Novello, Salvatore, Frassineti, Martina, Mercatelli, Daniela, Pisanò, Clarissa Anna, Morella, Ilaria, Fasano, Stefania, Journigan, Blair V, Meyer, Michael E, Polgar, Willma E, Brambilla, Riccardo, Zaveri, Nurulain T, Morari, Michele
Published in British journal of pharmacology (01.03.2018)
Published in British journal of pharmacology (01.03.2018)
Get full text
Journal Article
In vitro functional characterization of novel nociceptin/orphanin FQ receptor agonists in recombinant and native preparations
Ferrari, Federica, Cerlesi, Maria Camilla, Malfacini, Davide, Asth, Laila, Gavioli, Elaine C., Journigan, Blair V., Kamakolanu, Uma Gayathri, Meyer, Michael E., Yasuda, Dennis, Polgar, Willma E., Rizzi, Anna, Guerrini, Remo, Ruzza, Chiara, Zaveri, Nurulain T., Calo, Girolamo
Published in European journal of pharmacology (15.12.2016)
Published in European journal of pharmacology (15.12.2016)
Get full text
Journal Article