Virtual Twins: Understanding the Data Required for Model-Informed Precision Dosing
Polasek, Thomas M, Rostami-Hodjegan, Amin
Published in Clinical pharmacology and therapeutics (01.04.2020)
Published in Clinical pharmacology and therapeutics (01.04.2020)
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Journal Article
Contrasting Dynamics in Isoelectronic Anions Formed by Electron Attachment
Nag, P., Ranković, M., Polášek, M., Čurík, R., Slaughter, D. S., Fedor, J.
Published in The journal of physical chemistry letters (01.02.2024)
Published in The journal of physical chemistry letters (01.02.2024)
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The reactivity of methanimine radical cation (H2CNH•+) and its isomer aminomethylene (HCNH2•+) with C2H4
Sundelin, D., Ascenzi, D., Richardson, V., Alcaraz, C., Polášek, M., Romanzin, C., Thissen, R., Tosi, P., Žabka, J., Geppert, W.
Published in Chemical physics letters (16.08.2021)
Published in Chemical physics letters (16.08.2021)
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Journal Article
Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy
Darwich, Adam S, Polasek, Thomas M, Aronson, Jeffrey K, Ogungbenro, Kayode, Wright, Daniel F.B, Achour, Brahim, Reny, Jean-Luc, Daali, Youssef, Eiermann, Birgit, Cook, Jack, Lesko, Lawrence, McLachlan, Andrew J, Rostami-Hodjegan, Amin
Published in Annual review of pharmacology and toxicology (06.01.2021)
Published in Annual review of pharmacology and toxicology (06.01.2021)
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The reactivity of methanimine radical cation (H2CNH+) and its isomer aminomethylene (HCNH2+) with methane
Richardson, V., Alcaraz, C., Geppert, W.D., Polášek, M., Romanzin, C., Sundelin, D., Thissen, R., Tosi, P., Žabka, J., Ascenzi, D.
Published in Chemical physics letters (16.07.2021)
Published in Chemical physics letters (16.07.2021)
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Journal Article
Improving the Efficiency of Clinical Pharmacology Studies
Polasek, Thomas M., Schuck, Virna
Published in Clinical pharmacology in drug development (01.08.2023)
Published in Clinical pharmacology in drug development (01.08.2023)
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Journal Article
Quantifying the Impact of Phenoconversion on Medications With Actionable Pharmacogenomic Guideline Recommendations in an Acute Aged Persons Mental Health Setting
Mostafa, Sam, Polasek, Thomas M., Sheffield, Leslie J., Huppert, David, Kirkpatrick, Carl M. J.
Published in Frontiers in psychiatry (19.08.2021)
Published in Frontiers in psychiatry (19.08.2021)
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A phase I trial of SON-1010, a tumor-targeted, interleukin-12-linked, albumin-binding cytokine, shows favorable pharmacokinetics, pharmacodynamics, and safety in healthy volunteers
Kenney, Richard T, Cini, John K, Dexter, Susan, DaFonseca, Manuel, Bingham, Justus, Kuan, Isabelle, Chawla, Sant P, Polasek, Thomas M, Lickliter, Jason, Ryan, Philip J
Published in Frontiers in immunology (29.02.2024)
Published in Frontiers in immunology (29.02.2024)
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Journal Article
Artificial Intelligence and Machine Learning Applied at the Point of Care
Angehrn, Zuzanna, Haldna, Liina, Zandvliet, Anthe S, Gil Berglund, Eva, Zeeuw, Joost, Amzal, Billy, Cheung, S Y Amy, Polasek, Thomas M, Pfister, Marc, Kerbusch, Thomas, Heckman, Niedre M
Published in Frontiers in pharmacology (18.06.2020)
Published in Frontiers in pharmacology (18.06.2020)
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Journal Article
In Vitro Characterization of the Human Liver Microsomal Kinetics and Reaction Phenotyping of Olanzapine Metabolism
Korprasertthaworn, Porntipa, Polasek, Thomas M, Sorich, Michael J, McLachlan, Andrew J, Miners, John O, Tucker, Geoffrey T, Rowland, Andrew
Published in Drug metabolism and disposition (01.11.2015)
Published in Drug metabolism and disposition (01.11.2015)
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Journal Article
Delineating gene–environment effects using virtual twins of patients treated with clozapine
Mostafa, Sam, Polasek, Thomas M., Bousman, Chad, Rostami‐Hodjegan, Amin, Sheffield, Leslie J., Everall, Ian, Pantelis, Christos, Kirkpatrick, Carl M. J.
Published in CPT: pharmacometrics and systems pharmacology (01.02.2023)
Published in CPT: pharmacometrics and systems pharmacology (01.02.2023)
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Efficacy and safety of pharmacogenomic-guided antidepressant prescribing in patients with depression: an umbrella review and updated meta-analysis
Tesfamicael, Kiflu G, Zhao, Lijun, Fernández-Rodríguez, Rubén, Adelson, David L, Musker, Michael, Polasek, Thomas M, Lewis, Martin David
Published in Frontiers in psychiatry (11.07.2024)
Published in Frontiers in psychiatry (11.07.2024)
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Journal Article
Pharmacogenomics in general practice: 'The time has come'
Polasek, Thomas M, Mina, Kym, Suthers, Graeme
Published in Australian journal of general practice (01.03.2019)
Published in Australian journal of general practice (01.03.2019)
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Journal Article
Virtual twins for model‐informed precision dosing of clozapine in patients with treatment‐resistant schizophrenia
Mostafa, Sam, Rafizadeh, Reza, Polasek, Thomas M., Bousman, Chad A., Rostami‐Hodjegan, Amin, Stowe, Robert, Carrion, Prescilla, Sheffield, Leslie J., Kirkpatrick, Carl M. J.
Published in CPT: pharmacometrics and systems pharmacology (01.03.2024)
Published in CPT: pharmacometrics and systems pharmacology (01.03.2024)
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Journal Article
Combining Therapeutic Drug Monitoring and Pharmacokinetic Modelling Deconvolutes Physiological and Environmental Sources of Variability in Clozapine Exposure
Wills, Kenneth H, Behan, Stephen J, Nance, Michael J, Dawson, Jessica L, Polasek, Thomas M, Hopkins, Ashley M, van Dyk, Madelé, Rowland, Andrew
Published in Pharmaceutics (27.12.2021)
Published in Pharmaceutics (27.12.2021)
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Journal Article
The PRESIDE (PhaRmacogEnomicS In DEpression) Trial: a double-blind randomised controlled trial of pharmacogenomic-informed prescribing of antidepressants on depression outcomes in patients with major depressive disorder in primary care
Saya, Sibel, Chondros, Patty, Abela, Anastasia, Mihalopolous, Cathrine, Chatterton, Mary Lou, Gunn, Jane, Chen, Timothy F, Polasek, Thomas M, Dettmann, Elise, Brooks, Rachel, King, Michelle, Spencer, Luke, Alphonse, Pavithran, Milton, Shakira, Ramsay, Georgia, Siviour, Zoe, Liew, Jamie, Ly, Philip, Thoenig, Matthew, Seychell, Raushaan, La Rocca, Floriana, Hesson, Luke B, Mejias, Nydia, Sivertsen, Terri, Galea, Melanie Anne, Bousman, Chad, Emery, Jon
Published in Current controlled trials in cardiovascular medicine (19.05.2023)
Published in Current controlled trials in cardiovascular medicine (19.05.2023)
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