Discovery of Novel Thiophene-Based, Thumb Pocket 2 Allosteric Inhibitors of the Hepatitis C NS5B Polymerase with Improved Potency and Physicochemical Profiles
Court, John J, Poisson, Carl, Ardzinski, Andrzej, Bilimoria, Darius, Chan, Laval, Chandupatla, Kishan, Chauret, Nathalie, Collier, Philip N, Das, Sanjoy Kumar, Denis, Francois, Dorsch, Warren, Iyer, Ganesh, Lauffer, David, L’Heureux, Lucille, Li, Pan, Luisi, Brian S, Mani, Nagraj, Nanthakumar, Suganthi, Nicolas, Olivier, Rao, B. Govinda, Ronkin, Steven, Selliah, Subajini, Shawgo, Rebecca S, Tang, Qing, Waal, Nathan D, Yannopoulos, Constantin G, Green, Jeremy
Published in Journal of medicinal chemistry (14.07.2016)
Published in Journal of medicinal chemistry (14.07.2016)
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Journal Article
Synthesis and evaluation of NS5A inhibitors containing diverse heteroaromatic cores
Henderson, James A., Bilimoria, Darius, Bubenik, Monica, Cadilhac, Caroline, Cottrell, Kevin M., Denis, Francois, Dietrich, Evelyne, Ewing, Nigel, Falardeau, Guy, Giroux, Simon, L’Heureux, Lucille, Liu, Bingcan, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Pereira, Oswy Z., Poisson, Carl, Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Vaillancourt, Louis, Wang, Jian, Xu, Jinwang, Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., Maxwell, John P.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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Benzimidazole-containing HCV NS5A inhibitors: Effect of 4-substituted pyrrolidines in balancing genotype 1a and 1b potency
Henderson, James A., Bilimoria, Darius, Bubenik, Monica, Cadilhac, Caroline, Cottrell, Kevin M., Dietrich, Evelyne, Denis, Francois, Ewing, Nigel, Falardeau, Guy, Giroux, Simon, Grey, Ronald, L’Heureux, Lucille, Liu, Bingcan, Mani, Nagraj, Morris, Mark, Nicolas, Olivier, Pereira, Oswy Z., Poisson, Carl, Govinda Rao, B., Reddy, T. Jagadeeswar, Selliah, Subajini, Shawgo, Rebecca S., Vaillancourt, Louis, Wang, Jian, Yannopoulos, Constantin G., Chauret, Nathalie, Berlioz-Seux, Francoise, Chan, Laval C., Das, Sanjoy K., Grillot, Anne-Laure, Bennani, Youssef L., Maxwell, John P.
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
Published in Bioorganic & medicinal chemistry letters (15.02.2015)
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Journal Article
Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 2: Tertiary amides
Chan, Laval, Pereira, Oswy, Reddy, T.Jagadeeswar, Das, Sanjoy K., Poisson, Carl, Courchesne, Marc, Proulx, Mélanie, Siddiqui, Arshad, Yannopoulos, Constantin G., Nguyen-Ba, Nghe, Roy, Caroline, Nasturica, Daniel, Moinet, Christophe, Bethell, Richard, Hamel, Martine, L'Heureux, Lucille, David, Maud, Nicolas, Olivier, Courtemanche-Asselin, Philippe, Brunette, Stéphanie, Bilimoria, Darius, Bédard, Jean
Published in Bioorganic & medicinal chemistry letters (09.02.2004)
Published in Bioorganic & medicinal chemistry letters (09.02.2004)
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Discovery of thiophene-2-carboxylic acids as potent inhibitors of HCV NS5B polymerase and HCV subgenomic RNA replication. Part 1: Sulfonamides
Chan, Laval, Das, Sanjoy K., Reddy, T.Jagadeeswar, Poisson, Carl, Proulx, Mélanie, Pereira, Oswy, Courchesne, Marc, Roy, Caroline, Wang, Wuyi, Siddiqui, Arshad, Yannopoulos, Constantin G., Nguyen-Ba, Nghe, Labrecque, Denis, Bethell, Richard, Hamel, Martine, Courtemanche-Asselin, Philippe, L'Heureux, Lucille, David, Maud, Nicolas, Olivier, Brunette, Stéphanie, Bilimoria, Darius, Bédard, Jean
Published in Bioorganic & medicinal chemistry letters (09.02.2004)
Published in Bioorganic & medicinal chemistry letters (09.02.2004)
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Journal Article
Preparation of 2-alkenylperhydro-1,3-benzoxazines and application for 2-isoxazolines synthesis
Poisson, Carl, Lacoste, Jean-Éric, Rochon, Fernande D., Breau, Livain
Published in Tetrahedron: asymmetry (04.11.2009)
Published in Tetrahedron: asymmetry (04.11.2009)
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Journal Article
Identification of N,N-Disubstituted Phenylalanines as a Novel Class of Inhibitors of Hepatitis C NS5B Polymerase
Chan, Laval, Reddy, T. Jagadeeswar, Proulx, Mélanie, Das, Sanjoy K, Pereira, Oswy, Wang, Wuyi, Siddiqui, Arshad, Yannopoulos, Constantin G, Poisson, Carl, Turcotte, Nathalie, Drouin, Alexandre, Alaoui-Ismaili, M. Hicham, Bethell, Richard, Hamel, Martine, L'Heureux, Lucille, Bilimoria, Darius, Nguyen-Ba, Nghe
Published in Journal of medicinal chemistry (10.04.2003)
Published in Journal of medicinal chemistry (10.04.2003)
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MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS
LEVESQUE JEAN FRANCOIS, DIETRICH EVELYNE, VALLEE FREDERIC, GALLANT MICHEL, REDDY THUMKUNTA JAGADEESWAR, POISSON CARL, RAMTOHUL YEEMAN, LESSARD STEPHANIE, MARTEL JULIEN, DAS SANJOY KUMAR, LIU BINGCAN
Year of Publication 12.11.2015
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Year of Publication 12.11.2015
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MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS
DIETRICH EVELYNE, RAMTOHUL YEEMAN K, VALLEE FREDERIC, REDDY THUMKUNTA JAGADEESWAR, GALLANT MICHEL, POISSON CARL, VAILLANCOURT LOUIS, MARTEL JULIEN, DAS SANJOY KUMAR, CADILHAC CAROLINE, LIU BINGCAN
Year of Publication 26.08.2015
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Year of Publication 26.08.2015
Patent
Further SAR studies on novel small molecule inhibitors of the hepatitis C (HCV) NS5B polymerase
Reddy, T.Jagadeeswar, Chan, Laval, Turcotte, Nathalie, Proulx, Melanie, Pereira, Oswy Z., Das, Sanjoy K., Siddiqui, Arshad, Wang, Wuyi, Poisson, Carl, Yannopoulos, Constantin G., Bilimoria, Darius, L'Heureux, Lucille, Alaoui, Hicham M.A., Nguyen-Ba, Nghe
Published in Bioorganic & medicinal chemistry letters (06.10.2003)
Published in Bioorganic & medicinal chemistry letters (06.10.2003)
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Journal Article
HCV NS5B polymerase-bound conformation of a soluble sulfonamide inhibitor by 2D transferred NOESY
YANNOPOULOS, Constantin G, PING XU, PROULX, Melanie, HALAB, Lilianne, WUYI WANG, BEDARD, Jean, MORIN, Nicolas, HAMEL, Martine, NICOLAS, Olivier, BILIMORIA, Darius, L'HEUREUX, Lucille, BETHELL, Richard, FENG NI, DIONNE, Gervais, CHAN, Laval, PEREIRA, Oswy Z, JAGADEESWAR REDDY, T, DAS, Sanjoy K, POISSON, Carl, NGUYEN-BA, Nghe, TURCOTTE, Nathalie
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
Published in Bioorganic & medicinal chemistry letters (01.11.2004)
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Mannose derivatives for treating bacterial infections
Gallant, Michel, Ramtohul, Yeeman K, Vallee, Frederic, Dietrich, Evelyne, Vaillancourt, Louis, Cadilhac, Caroline, Liu, Bingcan, Poisson, Carl, Das, Sanjoy Kumar, Reddy, Thumkunta Jagadeeswar, Martel, Julien
Year of Publication 25.04.2023
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Year of Publication 25.04.2023
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Mannose Derivatives for Treating Bacterial Infections
Gallant, Michel, Ramtohul, Yeeman K, Vallee, Frederic, Dietrich, Evelyne, Vaillancourt, Louis, Cadilhac, Caroline, Liu, Bingcan, Poisson, Carl, Das, Sanjoy Kumar, Reddy, Thumkunta Jagadeeswar, Martel, Julien
Year of Publication 05.05.2022
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Year of Publication 05.05.2022
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MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS
MARTEL, JULIEN, VALLEE, FREDERIC, GALLANT, MICHEL, RAMTOHUL, YEEMAN, DIETRICH, EVELYNE, LEVESQUE, JEAN-FRANCOIS, LESSARD, STEPHANIE, REDDY, THUMKUNTA JAGADEESWAR, LIU, BINGCAN, DAS, SANJOY KUMAR, POISSON, CARL
Year of Publication 06.07.2021
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Year of Publication 06.07.2021
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2,7-dibromospiro[fluorene-9,4′-piperidine] compounds
Gallant, Michel, Ramtohul, Yeeman K, Vallee, Frederic, Dietrich, Evelyne, Vaillancourt, Louis, Cadilhac, Caroline, Liu, Bingcan, Poisson, Carl, Das, Sanjoy Kumar, Reddy, Thumkunta Jagadeeswar, Martel, Julien
Year of Publication 09.02.2021
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Year of Publication 09.02.2021
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Mannose derivatives for treating bacterial infections
Gallant, Michel, Vallee, Frederic, Dietrich, Evelyne, Liu, Bingcan, Ramtohul, Yeeman, Das, Sanjoy, Poisson, Carl, Lessard, Stephanie, Reddy, Thumkunta, Levesque, Jean-Francois, Martel, Julien
Year of Publication 18.12.2020
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Year of Publication 18.12.2020
Patent
331 Thiophene-2-carboxylic acids: a series of novel HCV polymerase inhibitors
Zhang, Ming-Qiang, Chan, Laval, Das, Sanjoy K., Reddy, Thumkunta J., Pereira, Oswy Z., Poisson, Carl, Proulx, Mélanie, Halab, Liliane, Roy, Caroline, Yannopoulos, Constantin G., Nguyen-Ba, Nghe, Bethell, Richard, David, Maud, Bédard, Jean, Hamel, Martine, Bilimoria, Darius, Nicolas, Olivier, Morin, Nicolas, Courtemanche-Asselin, Philippe, Hamelin, Bettina, Dong, Kelly, Rioux, Nathalie, Richard, Annie
Published in Hepatology (Baltimore, Md.) (2003)
Published in Hepatology (Baltimore, Md.) (2003)
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Journal Article
Mannose Derivatives for Treating Bacterial Infections
Gallant, Michel, Ramtohul, Yeeman K, Vallee, Frederic, Dietrich, Evelyne, Vaillancourt, Louis, Cadilhac, Caroline, Liu, Bingcan, Poisson, Carl, Das, Sanjoy Kumar, Reddy, Thumkunta Jagadeeswar, Martel, Julien
Year of Publication 27.08.2020
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Year of Publication 27.08.2020
Patent
MANNOSE DERIVATIVES FOR TREATING BACTERIAL INFECTIONS
MARTEL, JULIEN, CADILHAC, CAROLINE, VALLEE, FREDERIC, GALLANT, MICHEL, DIETRICH, EVELYNE, VAILLANCOURT, LOUIS, REDDY, THUMKUNTA JAGADEESWAR, DAS, SANJOY KUMAR, LIU, BINGCAN, RAMTOHUL, YEEMAN K, POISSON, CARL
Year of Publication 28.07.2020
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Year of Publication 28.07.2020
Patent
Mannose derivatives for treating bacterial infections
Gallant, Michel, Ramtohul, Yeeman K, Vallee, Frederic, Dietrich, Evelyne, Vaillancourt, Louis, Cadilhac, Caroline, Liu, Bingcan, Poisson, Carl, Das, Sanjoy Kumar, Reddy, Thumkunta Jagadeeswar, Martel, Julien
Year of Publication 02.06.2020
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Year of Publication 02.06.2020
Patent