Multiplex Genome-Edited T-cell Manufacturing Platform for "Off-the-Shelf" Adoptive T-cell Immunotherapies
Poirot, Laurent, Philip, Brian, Schiffer-Mannioui, Cécile, Le Clerre, Diane, Chion-Sotinel, Isabelle, Derniame, Sophie, Potrel, Pierrick, Bas, Cécile, Lemaire, Laetitia, Galetto, Roman, Lebuhotel, Céline, Eyquem, Justin, Cheung, Gordon Weng-Kit, Duclert, Aymeric, Gouble, Agnès, Arnould, Sylvain, Peggs, Karl, Pule, Martin, Scharenberg, Andrew M, Smith, Julianne
Published in Cancer research (Chicago, Ill.) (15.09.2015)
Published in Cancer research (Chicago, Ill.) (15.09.2015)
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Journal Article
Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy
Das, Shipra, Valton, Julien, Duchateau, Philippe, Poirot, Laurent
Published in Frontiers in immunology (12.05.2023)
Published in Frontiers in immunology (12.05.2023)
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Journal Article
Endowing universal CAR T-cell with immune-evasive properties using TALEN-gene editing
Jo, Sumin, Das, Shipra, Williams, Alan, Chretien, Anne-Sophie, Pagliardini, Thomas, Le Roy, Aude, Fernandez, Jorge Postigo, Le Clerre, Diane, Jahangiri, Billal, Chion-Sotinel, Isabelle, Rozlan, Sandra, Dessez, Emilie, Gouble, Agnes, Dusséaux, Mathilde, Galetto, Roman, Duclert, Aymeric, Marcenaro, Emanuela, Devillier, Raynier, Olive, Daniel, Duchateau, Philippe, Poirot, Laurent, Valton, Julien
Published in Nature communications (30.06.2022)
Published in Nature communications (30.06.2022)
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Journal Article
Modulation of chimeric antigen receptor surface expression by a small molecule switch
Juillerat, Alexandre, Tkach, Diane, Busser, Brian W, Temburni, Sonal, Valton, Julien, Duclert, Aymeric, Poirot, Laurent, Depil, Stéphane, Duchateau, Philippe
Published in BMC biotechnology (03.07.2019)
Published in BMC biotechnology (03.07.2019)
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Journal Article
Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy
Silva, George, Poirot, Laurent, Galetto, Roman, Smith, Julianne, Montoya, Guillermo, Duchateau, Philippe, Pâques, Frédéric
Published in Current gene therapy (01.02.2011)
Published in Current gene therapy (01.02.2011)
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Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality
Sachdeva, Mohit, Busser, Brian W., Temburni, Sonal, Jahangiri, Billal, Gautron, Anne-Sophie, Maréchal, Alan, Juillerat, Alexandre, Williams, Alan, Depil, Stéphane, Duchateau, Philippe, Poirot, Laurent, Valton, Julien
Published in Nature communications (13.11.2019)
Published in Nature communications (13.11.2019)
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Journal Article
Gene editing of PKLR gene in human hematopoietic progenitors through 5' and 3' UTR modified TALEN mRNA
Quintana-Bustamante, Oscar, Fañanas-Baquero, Sara, Orman, Israel, Torres, Raul, Duchateau, Philippe, Poirot, Laurent, Gouble, Agnès, Bueren, Juan A, Segovia, Jose C
Published in PloS one (16.10.2019)
Published in PloS one (16.10.2019)
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Optimized two‐step electroporation process to achieve efficient nonviral‐mediated gene insertion into primary T cells
Yang, Ming, Tkach, Diane, Boyne, Alex, Kazancioglu, Selena, Duclert, Aymeric, Poirot, Laurent, Duchateau, Philippe, Juillerat, Alexandre
Published in FEBS open bio (01.01.2022)
Published in FEBS open bio (01.01.2022)
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Journal Article
254 TGF-beta blockade combined with activation-induced IL12 secretion synergize to optimize potency of MUC1-CAR T-cells in preclinical targeting of triple-negative breast cancer
Erler, Piril, Cho, Hana, Skinner, Jordan, Poirot, Laurent, Aranda-Orgilles, Beatriz
Published in Journal for immunotherapy of cancer (01.11.2023)
Published in Journal for immunotherapy of cancer (01.11.2023)
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Journal Article
The intramembrane protease Sppl2a is required for B cell and DC development and survival via cleavage of the invariant chain
Beisner, Daniel R, Langerak, Petra, Parker, Albert E, Dahlberg, Carol, Otero, Francella J, Sutton, Sue E, Poirot, Laurent, Barnes, Whitney, Young, Michael A, Niessen, Sherry, Wiltshire, Tim, Bodendorf, Ursula, Martoglio, Bruno, Cravatt, Benjamin, Cooke, Michael P
Published in The Journal of experimental medicine (14.01.2013)
Published in The Journal of experimental medicine (14.01.2013)
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Author Correction: Repurposing endogenous immune pathways to tailor and control chimeric antigen receptor T cell functionality
Sachdeva, Mohit, Busser, Brian W., Temburni, Sonal, Jahangiri, Billal, Gautron, Anne-Sophie, Maréchal, Alan, Juillerat, Alexandre, Williams, Alan, Depil, Stéphane, Duchateau, Philippe, Poirot, Laurent, Valton, Julien
Published in Nature communications (07.05.2020)
Published in Nature communications (07.05.2020)
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Journal Article
Fine and Predictable Tuning of TALEN Gene Editing Targeting for Improved T Cell Adoptive Immunotherapy
Gautron, Anne-Sophie, Juillerat, Alexandre, Guyot, Valérie, Filhol, Jean-Marie, Dessez, Emilie, Duclert, Aymeric, Duchateau, Philippe, Poirot, Laurent
Published in Molecular therapy. Nucleic acids (15.12.2017)
Published in Molecular therapy. Nucleic acids (15.12.2017)
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Journal Article
Optimized tuning of TALEN specificity using non-conventional RVDs
Juillerat, Alexandre, Pessereau, Coline, Dubois, Gwendoline, Guyot, Valérie, Maréchal, Alan, Valton, Julien, Daboussi, Fayza, Poirot, Laurent, Duclert, Aymeric, Duchateau, Philippe
Published in Scientific reports (30.01.2015)
Published in Scientific reports (30.01.2015)
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Journal Article
Chromosomal context and epigenetic mechanisms control the efficacy of genome editing by rare-cutting designer endonucleases
Daboussi, Fayza, Zaslavskiy, Mikhail, Poirot, Laurent, Loperfido, Mariana, Gouble, Agnès, Guyot, Valerie, Leduc, Sophie, Galetto, Roman, Grizot, Sylvestre, Oficjalska, Danusia, Perez, Christophe, Delacôte, Fabien, Dupuy, Aurélie, Chion-Sotinel, Isabelle, Le Clerre, Diane, Lebuhotel, Céline, Danos, Olivier, Lemaire, Frédéric, Oussedik, Kahina, Cédrone, Frédéric, Epinat, Jean-Charles, Smith, Julianne, Yáñez-Muñoz, Rafael J, Dickson, George, Popplewell, Linda, Koo, Taeyoung, VandenDriessche, Thierry, Chuah, Marinee K, Duclert, Aymeric, Duchateau, Philippe, Pâques, Frédéric
Published in Nucleic acids research (01.07.2012)
Published in Nucleic acids research (01.07.2012)
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Journal Article
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells
Garate, Zita, Quintana-Bustamante, Oscar, Crane, Ana M., Olivier, Emmanuel, Poirot, Laurent, Galetto, Roman, Kosinski, Penelope, Hill, Collin, Kung, Charles, Agirre, Xabi, Orman, Israel, Cerrato, Laura, Alberquilla, Omaira, Rodriguez-Fornes, Fatima, Fusaki, Noemi, Garcia-Sanchez, Felix, Maia, Tabita M., Ribeiro, Maria L., Sevilla, Julian, Prosper, Felipe, Jin, Shengfang, Mountford, Joanne, Guenechea, Guillermo, Gouble, Agnes, Bueren, Juan A., Davis, Brian R., Segovia, Jose C.
Published in Stem cell reports (08.12.2015)
Published in Stem cell reports (08.12.2015)
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Journal Article
Pre-TCRα supports CD3-dependent reactivation and expansion of TCRα-deficient primary human T-cells
Galetto, Román, Lebuhotel, Celine, Poirot, Laurent, Gouble, Agnès, Toribio, Maria L, Smith, Julianne, Scharenberg, Andrew
Published in Molecular therapy. Methods & clinical development (01.01.2014)
Published in Molecular therapy. Methods & clinical development (01.01.2014)
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Journal Article
Granulocyte–macrophage colony-stimulating factor inactivation in CAR T-cells prevents monocyte-dependent release of key cytokine release syndrome mediators
Sachdeva, Mohit, Duchateau, Philippe, Depil, Stéphane, Poirot, Laurent, Valton, Julien
Published in The Journal of biological chemistry (05.04.2019)
Published in The Journal of biological chemistry (05.04.2019)
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Journal Article
An oxygen sensitive self-decision making engineered CAR T-cell
Juillerat, Alexandre, Marechal, Alan, Filhol, Jean Marie, Valogne, Yannick, Valton, Julien, Duclert, Aymeric, Duchateau, Philippe, Poirot, Laurent
Published in Scientific reports (20.01.2017)
Published in Scientific reports (20.01.2017)
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