Search Results - "POIRIER, Agnès" :: K.UTB vyhledávací portál | TBU Library Retrieval Portal

A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier

A phase 1 healthy male volunteer single escalating dose study of the pharmacokinetics and pharmacodynamics of risdiplam (RG7916, RO7034067), a SMN2 splicing modifier

by Sturm, Stefan, Günther, Andreas, Jaber, Birgit, Jordan, Paul, Al Kotbi, Nada, Parkar, Nikhat, Cleary, Yumi, Frances, Nicolas, Bergauer, Tobias, Heinig, Katja, Kletzl, Heidemarie, Marquet, Anne, Ratni, Hasane, Poirier, Agnès, Müller, Lutz, Czech, Christian, Khwaja, Omar
Published in British journal of clinical pharmacology (01.01.2019)

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Journal Article

Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam

Addressing Today's Absorption, Distribution, Metabolism, and Excretion (ADME) Challenges in the Translation of In Vitro ADME Characteristics to Humans: A Case Study of the SMN2 mRNA Splicing Modifier Risdiplam

by Fowler, Stephen, Brink, Andreas, Cleary, Yumi, Günther, Andreas, Heinig, Katja, Husser, Christophe, Kletzl, Heidemarie, Kratochwil, Nicole, Mueller, Lutz, Savage, Mark, Stillhart, Cordula, Tuerck, Dietrich, Ullah, Mohammed, Umehara, Kenichi, Poirier, Agnès
Published in Drug metabolism and disposition (01.01.2022)

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Journal Article

Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs

Risdiplam distributes and increases SMN protein in both the central nervous system and peripheral organs

by Poirier, Agnès, Weetall, Marla, Heinig, Katja, Bucheli, Franz, Schoenlein, Kerstin, Alsenz, Jochem, Bassett, Simon, Ullah, Mohammed, Senn, Claudia, Ratni, Hasane, Naryshkin, Nikolai, Paushkin, Sergey, Mueller, Lutz
Published in Pharmacology research & perspectives (01.12.2018)

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Calibration of in vitro multidrug resistance protein 1 substrate and inhibition assays as a basis to support the prediction of clinically relevant interactions in vivo

Calibration of in vitro multidrug resistance protein 1 substrate and inhibition assays as a basis to support the prediction of clinically relevant interactions in vivo

by Poirier, Agnès, Cascais, Anne-Christine, Bader, Urs, Portmann, Renée, Brun, Marie-Elise, Walter, Isabelle, Hillebrecht, Alexander, Ullah, Mohammed, Funk, Christoph
Published in Drug metabolism and disposition (01.09.2014)

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Journal Article

Mechanistic Modeling of Hepatic Transport from Cells to Whole Body: Application to Napsagatran and Fexofenadine

Mechanistic Modeling of Hepatic Transport from Cells to Whole Body: Application to Napsagatran and Fexofenadine

by Poirier, Agnès, Funk, Christoph, Scherrmann, Jean-Michel, Lavé, Thierry
Published in Molecular pharmaceutics (07.12.2009)

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Journal Article

Response to "Breast cancer resistance protein substrate and inhibition evaluation: why, when, and how?"

Response to "Breast cancer resistance protein substrate and inhibition evaluation: why, when, and how?"

by Poirier, Agnès, Ullah, Mohammed, Funk, Christoph
Published in Drug metabolism and disposition (01.12.2014)

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Journal Article

The need for human breast cancer resistance protein substrate and inhibition evaluation in drug discovery and development: why, when, and how?

The need for human breast cancer resistance protein substrate and inhibition evaluation in drug discovery and development: why, when, and how?

by Poirier, Agnès, Portmann, Renée, Cascais, Anne-Christine, Bader, Urs, Walter, Isabelle, Ullah, Mohammed, Funk, Christoph
Published in Drug metabolism and disposition (01.09.2014)

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Journal Article

PK/PD assessment in CNS drug discovery: Prediction of CSF concentration in rodents for P-glycoprotein substrates and application to in vivo potency estimation

PK/PD assessment in CNS drug discovery: Prediction of CSF concentration in rodents for P-glycoprotein substrates and application to in vivo potency estimation

by Caruso, Antonello, Alvarez-Sánchez, Ruben, Hillebrecht, Alexander, Poirier, Agnès, Schuler, Franz, Lavé, Thierry, Funk, Christoph, Belli, Sara
Published in Biochemical pharmacology (01.06.2013)

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Journal Article

Prediction of pharmacokinetic profile of valsartan in human based on in vitro uptake transport data

by Poirier, Agnès, Cascais, Anne-Christine, Funk, Christoph, Lavé, Thierry
Published in Journal of pharmacokinetics and pharmacodynamics (01.12.2009)

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Journal Article

Characterization of the Transmembrane Transport and Absolute Bioavailability of the HCV Protease Inhibitor Danoprevir

Characterization of the Transmembrane Transport and Absolute Bioavailability of the HCV Protease Inhibitor Danoprevir

by Brennan, Barbara J., Poirier, Agnès, Moreira, Sebastian, Morcos, Peter N., Goelzer, Petra, Portmann, Renée, Asthappan, Jiney, Funk, Christoph, Smith, Patrick F.
Published in Clinical pharmacokinetics (01.05.2015)

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Journal Article

Design, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro Model

Design, Data Analysis, and Simulation of in Vitro Drug Transport Kinetic Experiments Using a Mechanistic in Vitro Model

by POIRIER, Agnès, LAVE, Thierry, PORTMANN, Renée, BRUN, Marie-Elise, SENNER, Frank, KANSY, Manfred, GRIMM, Hans-Peter, FUNK, Christoph
Published in Drug metabolism and disposition (01.12.2008)

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Journal Article

Discovery of Risdiplam, a Selective Survival of Motor Neuron‑2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

Discovery of Risdiplam, a Selective Survival of Motor Neuron‑2 (SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

by Ratni, Hasane, Ebeling, Martin, Baird, John, Bendels, Stefanie, Bylund, Johan, Chen, Karen S, Denk, Nora, Feng, Zhihua, Green, Luke, Guerard, Melanie, Jablonski, Philippe, Jacobsen, Bjoern, Khwaja, Omar, Kletzl, Heidemarie, Ko, Chien-Ping, Kustermann, Stefan, Marquet, Anne, Metzger, Friedrich, Mueller, Barbara, Naryshkin, Nikolai A, Paushkin, Sergey V, Pinard, Emmanuel, Poirier, Agnès, Reutlinger, Michael, Weetall, Marla, Zeller, Andreas, Zhao, Xin, Mueller, Lutz
Published in Journal of medicinal chemistry (09.08.2018)

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Journal Article

Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies

Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies

by Poirier, Agnès, Belli, Sara, Funk, Christoph, Otteneder, Michael B, Portmann, Renée, Heinig, Katja, Prinssen, Eric, Lazic, Stanley E, Rayner, Craig R, Hoffmann, Gerhard, Singer, Thomas, Smith, David E, Schuler, Franz
Published in Drug metabolism and disposition (01.08.2012)

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Journal Article

Prediction of Pharmacokinetic Profile of Valsartan in Humans Based on in vitro Uptake-Transport Data

by Poirier, Agnès, Cascais, Anne-Christine, Funk, Christoph, Lavé, Thierry
Published in Chemistry & biodiversity (01.11.2009)

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Journal Article

RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models

RG7774 (Vicasinabin), an orally bioavailable cannabinoid receptor 2 (CB2R) agonist, decreases retinal vascular permeability, leukocyte adhesion, and ocular inflammation in animal models

by Grether, Uwe, Foxton, Richard H, Gruener, Sabine, Korn, Claudia, Kimbara, Atsushi, Osterwald, Anja, Zirwes, Elisabeth, Uhles, Sabine, Thoele, Janina, Colé, Nadine, Rogers-Evans, Mark, Röver, Stephan, Nettekoven, Matthias, Martin, Rainer E, Adam, Jean-Michel, Fingerle, Jürgen, Bissantz, Caterina, Guba, Wolfgang, Alker, André, Szczesniak, Anna M, Porter, Ross F, Toguri, Tom J, Revelant, Franco, Poirier, Agnès, Perret, Camille, Winther, Lotte, Caruso, Antonello, Fezza, Filomena, Maccarrone, Mauro, Kelly, Melanie E M, Fauser, Sascha, Ullmer, Christoph
Published in Frontiers in pharmacology (12.07.2024)

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Journal Article

Until now, Strauss-Kahn's libido wasn't a problem for the French

Until now, Strauss-Kahn's libido wasn't a problem for the French

by Poirier, Agnes
Published in New statesman (1996) (23.05.2011)

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Magazine Article

Entente cordiale

Entente cordiale

by Poirier, Agnes
Published in New Statesman (06.07.2009)

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Book Review Magazine Article

The Pope's plot against secularism

The Pope's plot against secularism

by Poirier, Agnes
Published in New statesman (1996) (22.09.2008)

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Magazine Article

Sarkozy needs a lesson in European history

Sarkozy needs a lesson in European history

by Poirier, Agnes
Published in New statesman (1996) (25.08.2008)

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Magazine Article

Parent power confronts Sarkozy

Parent power confronts Sarkozy

by Poirier, Agnes
Published in New statesman (1996) (14.07.2008)

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Magazine Article

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