A Microfluidic 3D Endothelium-on-a-Chip Model to Study Transendothelial Migration of T Cells in Health and Disease
de Haan, Luuk, Suijker, Johnny, van Roey, Ruthger, Berges, Nina, Petrova, Elissaveta, Queiroz, Karla, Strijker, Wouter, Olivier, Thomas, Poeschke, Oliver, Garg, Sakshi, van den Broek, Lenie J.
Published in International journal of molecular sciences (01.08.2021)
Published in International journal of molecular sciences (01.08.2021)
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Journal Article
Discovery of Potent, Selective, and Orally Bioavailable Small-Molecule Modulators of the Mediator Complex-Associated Kinases CDK8 and CDK19
Mallinger, Aurélie, Schiemann, Kai, Rink, Christian, Stieber, Frank, Calderini, Michel, Crumpler, Simon, Stubbs, Mark, Adeniji-Popoola, Olajumoke, Poeschke, Oliver, Busch, Michael, Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Ortiz-Ruiz, Maria-Jesus, Schneider, Richard, Thai, Ching, Valenti, Melanie, de Haven Brandon, Alexis, Burke, Rosemary, Workman, Paul, Dale, Trevor, Wienke, Dirk, Clarke, Paul A, Esdar, Christina, Raynaud, Florence I, Eccles, Suzanne A, Rohdich, Felix, Blagg, Julian
Published in Journal of medicinal chemistry (11.02.2016)
Published in Journal of medicinal chemistry (11.02.2016)
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Journal Article
Discovery of Potent, Orally Bioavailable, Small-Molecule Inhibitors of WNT Signaling from a Cell-Based Pathway Screen
Mallinger, Aurélie, Crumpler, Simon, Pichowicz, Mark, Waalboer, Dennis, Stubbs, Mark, Adeniji-Popoola, Olajumoke, Wood, Bozena, Smith, Elizabeth, Thai, Ching, Henley, Alan T, Georgi, Katrin, Court, William, Hobbs, Steve, Box, Gary, Ortiz-Ruiz, Maria-Jesus, Valenti, Melanie, De Haven Brandon, Alexis, TePoele, Robert, Leuthner, Birgitta, Workman, Paul, Aherne, Wynne, Poeschke, Oliver, Dale, Trevor, Wienke, Dirk, Esdar, Christina, Rohdich, Felix, Raynaud, Florence, Clarke, Paul A, Eccles, Suzanne A, Stieber, Frank, Schiemann, Kai, Blagg, Julian
Published in Journal of medicinal chemistry (26.02.2015)
Published in Journal of medicinal chemistry (26.02.2015)
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Journal Article
Discovery of potent and selective CDK8 inhibitors from an HSP90 pharmacophore
Schiemann, Kai, Mallinger, Aurélie, Wienke, Dirk, Esdar, Christina, Poeschke, Oliver, Busch, Michael, Rohdich, Felix, Eccles, Suzanne A., Schneider, Richard, Raynaud, Florence I., Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Urbahns, Klaus, Blagg, Julian
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
Published in Bioorganic & medicinal chemistry letters (01.03.2016)
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Journal Article
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease
Dale, Trevor, Clarke, Paul A, Esdar, Christina, Waalboer, Dennis, Adeniji-Popoola, Olajumoke, Ortiz-Ruiz, Maria-Jesus, Mallinger, Aurélie, Samant, Rahul S, Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Schneider, Klaus, Stubbs, Mark, Ewan, Ken, Fraser, Elizabeth, TePoele, Robert, Court, Will, Box, Gary, Valenti, Melanie, de Haven Brandon, Alexis, Gowan, Sharon, Rohdich, Felix, Raynaud, Florence, Schneider, Richard, Poeschke, Oliver, Blaukat, Andree, Workman, Paul, Schiemann, Kai, Eccles, Suzanne A, Wienke, Dirk, Blagg, Julian
Published in Nature chemical biology (26.10.2015)
Published in Nature chemical biology (26.10.2015)
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Journal Article
A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease
Dale, Trevor, Clarke, Paul A, Esdar, Christina, Waalboer, Dennis, Adeniji-Popoola, Olajumoke, Ortiz-Ruiz, Maria-Jesus, Mallinger, Aurélie, Samant, Rahul S, Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Schneider, Klaus, Stubbs, Mark, Ewan, Ken, Fraser, Elizabeth, TePoele, Robert, Court, Will, Box, Gary, Valenti, Melanie, de Haven Brandon, Alexis, Gowan, Sharon, Rohdich, Felix, Raynaud, Florence, Schneider, Richard, Poeschke, Oliver, Blaukat, Andree, Workman, Paul, Schiemann, Kai, Eccles, Suzanne A, Wienke, Dirk, Blagg, Julian
Published in Nature chemical biology (01.12.2015)
Published in Nature chemical biology (01.12.2015)
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Journal Article
Structure-Based Optimization of Potent, Selective, and Orally Bioavailable CDK8 Inhibitors Discovered by High-Throughput Screening
Czodrowski, Paul, Mallinger, Aurélie, Wienke, Dirk, Esdar, Christina, Pöschke, Oliver, Busch, Michael, Rohdich, Felix, Eccles, Suzanne A, Ortiz-Ruiz, Maria-Jesus, Schneider, Richard, Raynaud, Florence I, Clarke, Paul A, Musil, Djordje, Schwarz, Daniel, Dale, Trevor, Urbahns, Klaus, Blagg, Julian, Schiemann, Kai
Published in Journal of medicinal chemistry (27.10.2016)
Published in Journal of medicinal chemistry (27.10.2016)
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Journal Article
2,8-Disubstituted-1,6-Naphthyridines and 4,6-Disubstituted-Isoquinolines with Potent, Selective Affinity for CDK8/19
Mallinger, Aurélie, Schiemann, Kai, Rink, Christian, Sejberg, Jimmy, Honey, Mark A, Czodrowski, Paul, Stubbs, Mark, Poeschke, Oliver, Busch, Michael, Schneider, Richard, Schwarz, Daniel, Musil, Djordje, Burke, Rosemary, Urbahns, Klaus, Workman, Paul, Wienke, Dirk, Clarke, Paul A, Raynaud, Florence I, Eccles, Suzanne A, Esdar, Christina, Rohdich, Felix, Blagg, Julian
Published in ACS medicinal chemistry letters (09.06.2016)
Published in ACS medicinal chemistry letters (09.06.2016)
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Journal Article
Abstract 3499: M1069 as dual A2A/A2B adenosine receptor antagonist counteracts immune-suppressive mechanisms of adenosine and reduces tumor growth in vivo
Zaynagetdinov, Rinat, Schiemann, Kai, Nallaparaju, Kalyan, Belousova, Natalya, Matevossian, Armine, Chen, Zhouxiang, Kradjian, Giorgio, Pandya, Meghana, Dawra, Nemisha, Krauel, Eva-Maria, Petrova, Elissaveta, Poeschke, Oliver, Fischer, David, Lecomte, Marc, Blaukat, Andree, Huck, Bayard, Moisan, Jacques
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 3025: Discovery of preclinical development candidate inhibitors of the mediator complex-associated kinases CDK8 and CDK19 and evaluation of their therapeutic potential
Clarke, Paul, Esdar, Christina, Mallinger, Aurelie, Schiemann, Kai, Waalboer, Dennis, Crumpler, Simon, Rink, Christian, Stieber, Frank, Calderini, Michel, Adeniji-Popoola, Olajumoke, Ortiz-Ruiz, Maria-Jesus, Samant, Rahul S., Czodrowski, Paul, Musil, Djordje, Schwarz, Daniel, Schneider, Klaus, Busch, Michael, Stubbs, Mark, Burke, Rosemary, TePoele, Robert, Gowan, Sharon, Rohdich, Felix, Raynaud, Florence, Schneider, Richard, Poeschke, Oliver, Blaukat, Andree, Urbahns, Klaus, Workman, Paul, Kaufmann, Wolfgang, Simon, Stephanie, Eccles, Suzanne A., Dale, Trevor, Wienke, Dirk, Blagg, Julian
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER
DORSCH, DIETER, POESCHKE, OLIVER, WEGENER, ANSGAR, CALDERINI, MICHEL, HOELZEMANN, GUENTER
Year of Publication 04.05.2021
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Year of Publication 04.05.2021
Patent
Macrocyclic compounds, their preparation and pharmaceutical compositions containing them
DIETER DORSCH, OLIVER POESCHKE, ANSGAR WEGENER, GUENTER HOLEZEMANN, MICHAEL BUSCH
Year of Publication 30.08.2018
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Year of Publication 30.08.2018
Patent
Macrocycles as kinase inhibitors
Dorsch, Dieter, Poeschke, Oliver, Hoelzemann, Guenter, Busch, Michael, Wegener, Ansgar
Year of Publication 18.01.2018
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Year of Publication 18.01.2018
Patent
Macrocycles as kinase inhibitors
Poeschke Oliver, Busch Michael, Dorsch Dieter, Hoelzemann Guenter, Wegener Ansgar
Year of Publication 09.01.2018
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Year of Publication 09.01.2018
Patent
Triazolo[4,5-d]pyrimidine derivatives
Poeschke Oliver, Dorsch Dieter, Calderini Michel, Hoelzemann Guenter, Wegener Ansgar
Year of Publication 02.01.2018
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Year of Publication 02.01.2018
Patent
BENZYL PIPERIDINE COMPOUNDS AS LYSOPHOSPHATIDIC ACID (LPA) RECEPTOR ANTAGONIST
BUSCH, MICHAEL, SCHIEMANN, KAI, POESCHKE, OLIVER, WIENKE, DIRK, BURGER, CHRISTA, STAEHLE, WOLFGANG
Year of Publication 27.08.2019
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Year of Publication 27.08.2019
Patent
Triazolo(4,5-d)pyrimidine derivatives for the treatment of diseases such as cancer
Dorsch, Dieter, Poeschke, Oliver, Hoelzemann, Guenter, Calderini, Michel, Wegener, Ansgar
Year of Publication 14.09.2017
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Year of Publication 14.09.2017
Patent