Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
El-Osta, Assam, Brasacchio, Daniella, Yao, Dachun, Pocai, Alessandro, Jones, Peter L, Roeder, Robert G, Cooper, Mark E, Brownlee, Michael
Published in The Journal of experimental medicine (29.09.2008)
Published in The Journal of experimental medicine (29.09.2008)
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Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes
Marselli, Lorella, Piron, Anthony, Suleiman, Mara, Colli, Maikel L., Yi, Xiaoyan, Khamis, Amna, Carrat, Gaelle R., Rutter, Guy A., Bugliani, Marco, Giusti, Laura, Ronci, Maurizio, Ibberson, Mark, Turatsinze, Jean-Valery, Boggi, Ugo, De Simone, Paolo, De Tata, Vincenzo, Lopes, Miguel, Nasteska, Daniela, De Luca, Carmela, Tesi, Marta, Bosi, Emanuele, Singh, Pratibha, Campani, Daniela, Schulte, Anke M., Solimena, Michele, Hecht, Peter, Rady, Brian, Bakaj, Ivona, Pocai, Alessandro, Norquay, Lisa, Thorens, Bernard, Canouil, Mickaël, Froguel, Philippe, Eizirik, Decio L., Cnop, Miriam, Marchetti, Piero
Published in Cell reports (Cambridge) (01.12.2020)
Published in Cell reports (Cambridge) (01.12.2020)
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Journal Article
Glucagon-Like Peptide 1/Glucagon Receptor Dual Agonism Reverses Obesity in Mice
POCAI, Alessandro, CARRINGTON, Paul E, LIU, Franklin, MILLER, Corey, TOTA, Laurie M, GAOCHAO ZHOU, XIAOPING ZHANG, SOUNTIS, Michael M, SANTOPRETE, Alessia, CAPITO', Elena, CHICCHI, Gary G, THORNBERRY, Nancy, ADAMS, Jennifer R, BIANCHI, Elisabetta, PESSI, Antonello, MARSH, Donald J, SINHAROY, Ranabir, WRIGHT, Michael, EIERMANN, George, LAN ZHU, XIAOBING DU, PETROV, Aleksandr, LASSMAN, Michael E, GUOQIANG JIANG
Published in Diabetes (New York, N.Y.) (01.10.2009)
Published in Diabetes (New York, N.Y.) (01.10.2009)
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Journal Article
PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells
Rady, Brian, Nishio, Takahiro, Dhar, Debanjan, Liu, Xiao, Erion, Mark, Kisseleva, Tatiana, Brenner, David A, Pocai, Alessandro
Published in PloS one (08.12.2021)
Published in PloS one (08.12.2021)
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Journal Article
Hypothalamic KATP channels control hepatic glucose production
POCAL, Alessandro, LAM, Tony K. T, GUTIERREZ-JUAREZ, Roger, OBICI, Silvana, SCHWARTZ, Gary J, BRYAN, Joseph, AGULLAR-BRYAN, Lydia, ROSSETTI, Luciano
Published in Nature (London) (21.04.2005)
Published in Nature (London) (21.04.2005)
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Journal Article
Activation of hypothalamic S6 kinase mediates diet-induced hepatic insulin resistance in rats
Ono, Hiraku, Pocai, Alessandro, Wang, Yuhua, Sakoda, Hideyuki, Asano, Tomoichiro, Backer, Jonathan M, Schwartz, Gary J, Rossetti, Luciano
Published in The Journal of clinical investigation (01.08.2008)
Published in The Journal of clinical investigation (01.08.2008)
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Journal Article
The mitochondrial fission protein Drp1 in liver is required to mitigate NASH and prevents the activation of the mitochondrial ISR
Steffen, Janos, Ngo, Jennifer, Wang, Sheng-Ping, Williams, Kevin, Kramer, Henning F., Ho, George, Rodriguez, Carlos, Yekkala, Krishna, Amuzie, Chidozie, Bialecki, Russell, Norquay, Lisa, Nawrocki, Andrea R., Erion, Mark, Pocai, Alessandro, Shirihai, Orian S., Liesa, Marc
Published in Molecular metabolism (Germany) (01.10.2022)
Published in Molecular metabolism (Germany) (01.10.2022)
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Journal Article
The Irs1 Branch of the Insulin Signaling Cascade Plays a Dominant Role in Hepatic Nutrient Homeostasis
Guo, Shaodong, Copps, Kyle D., Dong, Xiaocheng, Park, Sunmin, Cheng, Zhiyong, Pocai, Alessandro, Rossetti, Luciano, Sajan, Mini, Farese, Robert V., White, Morris F.
Published in Molecular and Cellular Biology (01.09.2009)
Published in Molecular and Cellular Biology (01.09.2009)
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Journal Article
Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
Rossetti, Luciano, Lam, Tony K T, Pocai, Alessandro, Gutierrez-Juarez, Roger, Obici, Silvana, Bryan, Joseph, Aguilar-Bryan, Lydia, Schwartz, Gary J
Published in Nature medicine (01.03.2005)
Published in Nature medicine (01.03.2005)
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A FFAR1 full agonist restores islet function in models of impaired glucose-stimulated insulin secretion and diabetic non-human primates
Rady, Brian, Liu, Jianying, Huang, Hui, Bakaj, Ivona, Qi, Jenson, Lee, S P, Martin, Tonya, Norquay, Lisa, Player, Mark, Pocai, Alessandro
Published in Frontiers in endocrinology (Lausanne) (22.11.2022)
Published in Frontiers in endocrinology (Lausanne) (22.11.2022)
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Glucagon like receptor 1/ glucagon dual agonist acutely enhanced hepatic lipid clearance and suppressed de novo lipogenesis in mice
More, Vijay R, Lao, Julie, McLaren, David G, Cumiskey, Anne-Marie, Murphy, Beth Ann, Chen, Ying, Previs, Stephen, Stout, Steven, Patel, Rajesh, Satapati, Santhosh, Li, Wenyu, Kowalik, Edward, Szeto, Daphne, Nawrocki, Andrea, Pocai, Alessandro, Wang, Liangsu, Carrington, Paul
Published in PloS one (24.10.2017)
Published in PloS one (24.10.2017)
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Development of a Liver-Targeted Stearoyl-CoA Desaturase (SCD) Inhibitor (MK-8245) to Establish a Therapeutic Window for the Treatment of Diabetes and Dyslipidemia
Oballa, Renata M, Belair, Liette, Black, W. Cameron, Bleasby, Kelly, Chan, Chi Chung, Desroches, Carole, Du, Xiaobing, Gordon, Robert, Guay, Jocelyne, Guiral, Sebastien, Hafey, Michael J, Hamelin, Emelie, Huang, Zheng, Kennedy, Brian, Lachance, Nicolas, Landry, France, Li, Chun Sing, Mancini, Joseph, Normandin, Denis, Pocai, Alessandro, Powell, David A, Ramtohul, Yeeman K, Skorey, Kathryn, Sørensen, Dan, Sturkenboom, Wayne, Styhler, Angela, Waddleton, Deena M, Wang, Hao, Wong, Simon, Xu, Lijing, Zhang, Lei
Published in Journal of medicinal chemistry (28.07.2011)
Published in Journal of medicinal chemistry (28.07.2011)
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Journal Article
Regulation of Fasted Blood Glucose by Resistin
Banerjee, Ronadip R., Rangwala, Shamina M., Shapiro, Jennifer S., Rich, A. Sophie, Rhoades, Ben, Qi, Yong, Wang, Juan, Rajala, Michael W., Pocai, Alessandro, Scherer, Phillipp E., Steppan, Claire M., Ahima, Rexford S., Obici, Silvana, Rossetti, Luciano, Lazar, Mitchell A.
Published in Science (American Association for the Advancement of Science) (20.02.2004)
Published in Science (American Association for the Advancement of Science) (20.02.2004)
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VEPTP inhibition with an extracellular domain targeting antibody did not restore albuminuria in a mouse model of diabetic kidney disease
Rana, Rajashree, Natoli, Thomas A., Khandelwal, Puneet, Pissios, Pavlos, Muhammad, Abdul Bari, Chipashvili, Vaja, Farrington, Krista P., Zhou, Wen, Zheng, Gang, Bukanov, Nikolay O., Pocai, Alessandro, Magnone, Maria Chiara
Published in Physiological reports (01.09.2024)
Published in Physiological reports (01.09.2024)
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