The Glucagon Receptor Is Involved in Mediating the Body Weight‐Lowering Effects of Oxyntomodulin
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Published in Obesity (Silver Spring, Md.) (01.08.2012)
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Optimization of co-agonism at GLP-1 and glucagon receptors to safely maximize weight reduction in DIO-rodents
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Published in Biopolymers (2012)
Published in Biopolymers (2012)
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A PEGylated analog of the gut hormone oxyntomodulin with long-lasting antihyperglycemic, insulinotropic and anorexigenic activity
Bianchi, Elisabetta, Carrington, Paul E., Ingallinella, Paolo, Finotto, Marco, Santoprete, Alessia, Petrov, Aleksandr, Eiermann, George, Kosinski, Jennifer, Marsh, Donald J., Pocai, Alessandro, SinhaRoy, Ranabir, Pessi, Antonello
Published in Bioorganic & medicinal chemistry (15.11.2013)
Published in Bioorganic & medicinal chemistry (15.11.2013)
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Differential effects of oxyntomodulin and GLP-1 on glucose metabolism
Du, Xiaobing, Kosinski, Jennifer R, Lao, Julie, Shen, Xiaolan, Petrov, Aleksandr, Chicchi, Gary G, Eiermann, George J, Pocai, Alessandro
Published in American journal of physiology: endocrinology and metabolism (15.07.2012)
Published in American journal of physiology: endocrinology and metabolism (15.07.2012)
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Discovery of novel benzo[b]thiophene tetrazoles as non-carboxylate GPR40 agonists
Huang, Hui, Winters, Michael P., Meegalla, Sanath K., Arnoult, Eric, Paul Lee, S., Zhao, Shuyuan, Martin, Tonya, Rady, Brian, Liu, Jianying, Towers, Meghan, Otieno, Monicah, Xu, Fran, Lim, Heng Keang, Silva, Jose, Pocai, Alessandro, Player, Mark R.
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
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Restoration of hypothalamic lipid sensing normalizes energy and glucose homeostasis in overfed rats
Pocai, Alessandro, Lam, Tony K T, Obici, Silvana, Gutierrez-Juarez, Roger, Muse, Evan D, Arduini, Arduino, Rossetti, Luciano
Published in The Journal of clinical investigation (01.04.2006)
Published in The Journal of clinical investigation (01.04.2006)
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Quantification of Intact and Truncated Stromal Cell-Derived Factor-1α in Circulation by Immunoaffinity Enrichment and Tandem Mass Spectrometry
Wang, Weixun, Choi, Bernard K., Li, Wenyu, Lao, Zhege, Lee, Anita Y. H., Souza, Sandra C., Yates, Nathan A., Kowalski, Timothy, Pocai, Alessandro, Cohen, Lucinda H.
Published in Journal of the American Society for Mass Spectrometry (01.04.2014)
Published in Journal of the American Society for Mass Spectrometry (01.04.2014)
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Discovery of a novel potent GPR40 full agonist
Meegalla, Sanath K., Huang, Hui, Martin, Tonya, Xu, June, Zhao, Shuyuan, Liu, Jianying, Hall, Meghan, Gunnet, Joe, Wang, Yuanping, Rady, Brian, Silva, Jose, Otieno, Monicah, Arnoult, Eric, Paul Lee, S., Pocai, Alessandro, Player, Mark R.
Published in Bioorganic & medicinal chemistry letters (15.02.2018)
Published in Bioorganic & medicinal chemistry letters (15.02.2018)
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A comparative study of the binding properties, dipeptidyl peptidase‐4 (DPP‐4) inhibitory activity and glucose‐lowering efficacy of the DPP‐4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice
Berger, Joel P., SinhaRoy, Ranabir, Pocai, Alessandro, Kelly, Theresa M., Scapin, Giovanna, Gao, Ying‐Duo, Pryor, Kelly Ann D., Wu, Joseph K., Eiermann, George J., Xu, Shiyao S., Zhang, Xiaoping, Tatosian, Daniel A., Weber, Ann E., Thornberry, Nancy A., Carr, Richard D.
Published in Endocrinology, diabetes & metabolism (01.01.2018)
Published in Endocrinology, diabetes & metabolism (01.01.2018)
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FFAR1 Agonism Restores Insulin Secretion in Rodents, Human Islets, and Diabetic Monkeys
Liu, Jianying, Lee, Seunghun P, Martin, Tonya, Rady, Brian, Meegalla, Sanath, Huang, Hui, Winters, Michael P, Norquay, Lisa D, Qi, Jenson, Du, Fuyong, Nawrocki, Andrea R, Player, Mark, Pocai, Alessandro
Published in Diabetes (New York, N.Y.) (01.07.2018)
Published in Diabetes (New York, N.Y.) (01.07.2018)
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PNPLA3 downregulation exacerbates the fibrotic response in human hepatic stellate cells
Brian Rady, Takahiro Nishio, Debanjan Dhar, Xiao Liu, Mark Erion, Tatiana Kisseleva, David A. Brenner, Alessandro Pocai
Published in PloS one (01.01.2021)
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Published in PloS one (01.01.2021)
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Discovery of a GPR40 Superagonist: The Impact of Aryl Propionic Acid α‑Fluorination
Huang, Hui, Meegalla, Sanath K, Lanter, James C, Winters, Michael P, Zhao, Shuyuan, Littrell, James, Qi, Jenson, Rady, Brian, Lee, Paul S, Liu, Jianying, Martin, Tonya, Lam, Wing W, Xu, Fran, Lim, Heng Keang, Wilde, Thomas, Silva, Jose, Otieno, Monicah, Pocai, Alessandro, Player, Mark R
Published in ACS medicinal chemistry letters (10.01.2019)
Published in ACS medicinal chemistry letters (10.01.2019)
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Regulation of hypothalamic endocannabinoid levels by neuropeptides and hormones involved in food intake and metabolism: Insulin and melanocortins
Matias, Isabel, Vergoni, Anna Valeria, Petrosino, Stefania, Ottani, Alessandra, Pocai, Alessandro, Bertolini, Alfio, Di Marzo, Vincenzo
Published in Neuropharmacology (01.01.2008)
Published in Neuropharmacology (01.01.2008)
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Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo
Qi, Jenson, Lang, Wensheng, Connelly, Margery A, Du, Fuyong, Liang, Yin, Caldwell, Gary W, Martin, Tonya, Hansen, Michael K, Kuo, Gee-Hong, Gaul, Michael D, Pocai, Alessandro, Lee, Seunghun
Published in Analytical biochemistry (01.05.2017)
Published in Analytical biochemistry (01.05.2017)
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DPP-IV-resistant, long-acting oxyntomodulin derivatives
Santoprete, Alessia, Capitò, Elena, Carrington, Paul E., Pocai, Alessandro, Finotto, Marco, Langella, Annunziata, Ingallinella, Paolo, Zytko, Karolina, Bufali, Simone, Cianetti, Simona, Veneziano, Maria, Bonelli, Fabio, Zhu, Lan, Monteagudo, Edith, Marsh, Donald J., SinhaRoy, Ranabir, Bianchi, Elisabetta, Pessi, Antonello
Published in Journal of peptide science (01.04.2011)
Published in Journal of peptide science (01.04.2011)
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Development of a neuromedin U-human serum albumin conjugate as a long-acting candidate for the treatment of obesity and diabetes. Comparison with the PEGylated peptide
Neuner, Philippe, Peier, Andrea M., Talamo, Fabio, Ingallinella, Paolo, Lahm, Armin, Barbato, Gaetano, Di Marco, Annalise, Desai, Kunal, Zytko, Karolina, Qian, Ying, Du, Xiaobing, Ricci, Davide, Monteagudo, Edith, Laufer, Ralph, Pocai, Alessandro, Bianchi, Elisabetta, Marsh, Donald J., Pessi, Antonello
Published in Journal of peptide science (01.01.2014)
Published in Journal of peptide science (01.01.2014)
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Differential effects of oxyntomodulin and GLP-1 on glucose metabolism
XIAOBING DU, KOSINSKI, Jennifer R, JULIE LAO, XIAOLAN SHEN, PETROV, Aleksandr, CHICCHI, Gary G, EIERMANN, George J, POCAI, Alessandro
Published in American journal of physiology: endocrinology and metabolism (2012)
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Published in American journal of physiology: endocrinology and metabolism (2012)
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Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia
El-Osta, Assam, Brasacchio, Daniella, Yao, Dachun, Pocai, Alessandro, Jones, Peter L., Roeder, Robert G., Cooper, Mark E., Brownlee, Michael
Published in The Journal of experimental medicine (27.10.2008)
Published in The Journal of experimental medicine (27.10.2008)
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