Rethinking drug design in the artificial intelligence era
Schneider, Petra, Walters, W Patrick, Plowright, Alleyn T, Sieroka, Norman, Listgarten, Jennifer, Goodnow, Jr, Robert A, Fisher, Jasmin, Jansen, Johanna M, Duca, José S, Rush, Thomas S, Zentgraf, Matthias, Hill, John Edward, Krutoholow, Elizabeth, Kohler, Matthias, Blaney, Jeff, Funatsu, Kimito, Luebkemann, Chris, Schneider, Gisbert
Published in Nature reviews. Drug discovery (01.05.2020)
Published in Nature reviews. Drug discovery (01.05.2020)
Get full text
Journal Article
New Modalities for Challenging Targets in Drug Discovery
Valeur, Eric, Guéret, Stéphanie M., Adihou, Hélène, Gopalakrishnan, Ranganath, Lemurell, Malin, Waldmann, Herbert, Grossmann, Tom N., Plowright, Alleyn T.
Published in Angewandte Chemie International Edition (21.08.2017)
Published in Angewandte Chemie International Edition (21.08.2017)
Get full text
Journal Article
Oxadiazoles in Medicinal Chemistry
Boström, Jonas, Hogner, Anders, Llinàs, Antonio, Wellner, Eric, Plowright, Alleyn T
Published in Journal of medicinal chemistry (08.03.2012)
Published in Journal of medicinal chemistry (08.03.2012)
Get full text
Journal Article
Directing evolution: the next revolution in drug discovery?
Davis, Andrew M, Plowright, Alleyn T, Valeur, Eric
Published in Nature reviews. Drug discovery (01.10.2017)
Published in Nature reviews. Drug discovery (01.10.2017)
Get full text
Journal Article
Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway
Mills, Richard J., Parker, Benjamin L., Quaife-Ryan, Gregory A., Voges, Holly K., Needham, Elise J., Bornot, Aurelie, Ding, Mei, Andersson, Henrik, Polla, Magnus, Elliott, David A., Drowley, Lauren, Clausen, Maryam, Plowright, Alleyn T., Barrett, Ian P., Wang, Qing-Dong, James, David E., Porrello, Enzo R., Hudson, James E.
Published in Cell stem cell (06.06.2019)
Published in Cell stem cell (06.06.2019)
Get full text
Journal Article
Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest
Mills, Richard J., Titmarsh, Drew M., Koenig, Xaver, Parker, Benjamin L., Ryall, James G., Quaife-Ryan, Gregory A., Voges, Holly K., Hodson, Mark P., Ferguson, Charles, Drowley, Lauren, Plowright, Alleyn T., Needham, Elise J., Wang, Qing-Dong, Gregorevic, Paul, Xin, Mei, Thomas, Walter G., Parton, Robert G., Nielsen, Lars K., Launikonis, Bradley S., James, David E., Elliott, David A., Porrello, Enzo R., Hudson, James E.
Published in Proceedings of the National Academy of Sciences - PNAS (03.10.2017)
Published in Proceedings of the National Academy of Sciences - PNAS (03.10.2017)
Get full text
Journal Article
Phenotypic screen identifies FOXO inhibitor to counteract maturation and promote expansion of human iPS cell-derived cardiomyocytes
Schade, Dennis, Drowley, Lauren, Wang, Qing-Dong, Plowright, Alleyn T., Greber, Boris
Published in Bioorganic & medicinal chemistry (01.07.2022)
Published in Bioorganic & medicinal chemistry (01.07.2022)
Get full text
Journal Article
Aligned nanofiber scaffolds improve functionality of cardiomyocytes differentiated from human induced pluripotent stem cell-derived cardiac progenitor cells
Ding, Mei, Andersson, Henrik, Martinsson, Sofia, Sabirsh, Alan, Jonebring, Anna, Wang, Qing-Dong, Plowright, Alleyn T, Drowley, Lauren
Published in Scientific reports (11.08.2020)
Published in Scientific reports (11.08.2020)
Get full text
Journal Article
C−H Functionalization—Prediction of Selectivity in Iridium(I)‐Catalyzed Hydrogen Isotope Exchange Competition Reactions
Valero, Mégane, Kruissink, Thomas, Blass, Jennifer, Weck, Remo, Güssregen, Stefan, Plowright, Alleyn T., Derdau, Volker
Published in Angewandte Chemie International Edition (27.03.2020)
Published in Angewandte Chemie International Edition (27.03.2020)
Get full text
Journal Article
A protein tertiary structure mimetic modulator of the Hippo signalling pathway
Adihou, Hélène, Gopalakrishnan, Ranganath, Förster, Tim, Guéret, Stéphanie M., Gasper, Raphael, Geschwindner, Stefan, Carrillo García, Carmen, Karatas, Hacer, Pobbati, Ajaybabu V., Vazquez‐Chantada, Mercedes, Davey, Paul, Wassvik, Carola M., Pang, Jeremy Kah Sheng, Soh, Boon Seng, Hong, Wanjin, Chiarparin, Elisabetta, Schade, Dennis, Plowright, Alleyn T., Valeur, Eric, Lemurell, Malin, Grossmann, Tom N., Waldmann, Herbert
Published in Nature communications (27.10.2020)
Published in Nature communications (27.10.2020)
Get full text
Journal Article
Joining Forces: The Chemical Biology–Medicinal Chemistry Continuum
Plowright, Alleyn T., Ottmann, Christian, Arkin, Michelle, Auberson, Yves P., Timmerman, Henk, Waldmann, Herbert
Published in Cell chemical biology (21.09.2017)
Published in Cell chemical biology (21.09.2017)
Get full text
Journal Article
Emerging modes-of-action in drug discovery
Valeur, Eric, Narjes, Frank, Ottmann, Christian, Plowright, Alleyn T
Published in MedChemComm (01.09.2019)
Published in MedChemComm (01.09.2019)
Get full text
Journal Article
Macrocyclic Modalities Combining Peptide Epitopes and Natural Product Fragments
Guéret, Stéphanie M, Thavam, Sasikala, Carbajo, Rodrigo J, Potowski, Marco, Larsson, Niklas, Dahl, Göran, Dellsén, Anita, Grossmann, Tom N, Plowright, Alleyn T, Valeur, Eric, Lemurell, Malin, Waldmann, Herbert
Published in Journal of the American Chemical Society (11.03.2020)
Published in Journal of the American Chemical Society (11.03.2020)
Get full text
Journal Article
Discovery and Early Clinical Development of an Inhibitor of 5‑Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease
Pettersen, Daniel, Broddefalk, Johan, Emtenäs, Hans, Hayes, Martin A, Lemurell, Malin, Swanson, Marianne, Ulander, Johan, Whatling, Carl, Amilon, Carl, Ericsson, Hans, Westin Eriksson, Annika, Granberg, Kenneth, Plowright, Alleyn T, Shamovsky, Igor, Dellsèn, Anita, Sundqvist, Monica, Någård, Mats, Lindstedt, Eva-Lotte
Published in Journal of medicinal chemistry (09.05.2019)
Published in Journal of medicinal chemistry (09.05.2019)
Get full text
Journal Article
Melanocortin 1 Receptor Agonists Based on a Bivalent, Bicyclic Peptide Framework
Durek, Thomas, Kaas, Quentin, White, Andrew M, Weidmann, Joachim, Fuaad, Abdullah Ahmad, Cheneval, Olivier, Schroeder, Christina I, de Veer, Simon J, Dellsén, Anita, Österlund, Torben, Larsson, Niklas, Knerr, Laurent, Bauer, Udo, Plowright, Alleyn T, Craik, David J
Published in Journal of medicinal chemistry (22.07.2021)
Published in Journal of medicinal chemistry (22.07.2021)
Get full text
Journal Article
Long-term self-renewing human epicardial cells generated from pluripotent stem cells under defined xeno-free conditions
Bao, Xiaoping, Lian, Xiaojun, Hacker, Timothy A, Schmuck, Eric G, Qian, Tongcheng, Bhute, Vijesh J, Han, Tianxiao, Shi, Mengxuan, Drowley, Lauren, Plowright, Alleyn, Wang, Qing-Dong, Goumans, Marie-Jose, Palecek, Sean P
Published in Nature biomedical engineering (01.01.2016)
Published in Nature biomedical engineering (01.01.2016)
Get full text
Journal Article