Inhibition of RAF Isoforms and Active Dimers by LY3009120 Leads to Anti-tumor Activities in RAS or BRAF Mutant Cancers
Peng, Sheng-Bin, Henry, James R., Kaufman, Michael D., Lu, Wei-Ping, Smith, Bryan D., Vogeti, Subha, Rutkoski, Thomas J., Wise, Scott, Chun, Lawrence, Zhang, Youyan, Van Horn, Robert D., Yin, Tinggui, Zhang, Xiaoyi, Yadav, Vipin, Chen, Shih-Hsun, Gong, Xueqian, Ma, Xiwen, Webster, Yue, Buchanan, Sean, Mochalkin, Igor, Huber, Lysiane, Kays, Lisa, Donoho, Gregory P., Walgren, Jennie, McCann, Denis, Patel, Phenil, Conti, Ilaria, Plowman, Gregory D., Starling, James J., Flynn, Daniel L.
Published in Cancer cell (14.09.2015)
Published in Cancer cell (14.09.2015)
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Targeting the TGFβ pathway with galunisertib, a TGFβRI small molecule inhibitor, promotes anti-tumor immunity leading to durable, complete responses, as monotherapy and in combination with checkpoint blockade
Holmgaard, Rikke B, Schaer, David A, Li, Yanxia, Castaneda, Stephen P, Murphy, Mary Y, Xu, Xiaohong, Inigo, Ivan, Dobkin, Julie, Manro, Jason R, Iversen, Philip W, Surguladze, David, Hall, Gerald E, Novosiadly, Ruslan D, Benhadji, Karim A, Plowman, Gregory D, Kalos, Michael, Driscoll, Kyla E
Published in Journal for immunotherapy of cancer (04.06.2018)
Published in Journal for immunotherapy of cancer (04.06.2018)
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Therapeutic high affinity T cell receptor targeting a KRASG12D cancer neoantigen
Poole, Andrew, Karuppiah, Vijaykumar, Hartt, Annabelle, Haidar, Jaafar N., Moureau, Sylvie, Dobrzycki, Tomasz, Hayes, Conor, Rowley, Christopher, Dias, Jorge, Harper, Stephen, Barnbrook, Keir, Hock, Miriam, Coles, Charlotte, Yang, Wei, Aleksic, Milos, Lin, Aimee Bence, Robinson, Ross, Dukes, Joe D., Liddy, Nathaniel, Van der Kamp, Marc, Plowman, Gregory D., Vuidepot, Annelise, Cole, David K., Whale, Andrew D., Chillakuri, Chandramouli
Published in Nature communications (10.09.2022)
Published in Nature communications (10.09.2022)
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Evolution of protein kinase signaling from yeast to man
Manning, Gerard, Plowman, Gregory D, Hunter, Tony, Sudarsanam, Sucha
Published in Trends in Biochemical Sciences (01.10.2002)
Published in Trends in Biochemical Sciences (01.10.2002)
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Book Review
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Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models
Hamilton, Patricia, Devasthali, Vidusha, Bou Reslan, Hani, Nannini, Michelle A, Cheng, Jason H, Johnson, Leisa, Ho, Calvin C K, Lee, Chingwei V, Fuh, Germaine, Forrest, William F, Molina, Rafael, Clermont, Anne C, Cao, Timothy C, Carano, Richard A D, Yu, Ron X, Koeppen, Hartmut, Plowman, Gregory D, Singh, Mallika, Lima, Anthony, Thompson, Jennifer D
Published in Nature biotechnology (01.06.2010)
Published in Nature biotechnology (01.06.2010)
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Tumor cell expression of vascular endothelial growth factor receptor 2 is an adverse prognostic factor in patients with squamous cell carcinoma of the lung
Holzer, Timothy R, Fulford, Angie D, Nedderman, Drew M, Umberger, Tara S, Hozak, Rebecca R, Joshi, Adarsh, Melemed, Symantha A, Benjamin, Laura E, Plowman, Gregory D, Schade, Andrew E, Ackermann, Bradley L, Konrad, Robert J, Nasir, Aejaz
Published in PloS one (14.11.2013)
Published in PloS one (14.11.2013)
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The Aurora/Ipl1p kinase family: regulators of chromosome segregation and cytokinesis
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The Protein Kinases of Caenorhabditis elegans: A Model for Signal Transduction in Multicellular Organisms
Plowman, Gregory D., Sudarsanam, Sucha, Bingham, Jonathan, Whyte, David, Hunter, Tony
Published in Proceedings of the National Academy of Sciences - PNAS (23.11.1999)
Published in Proceedings of the National Academy of Sciences - PNAS (23.11.1999)
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Aurora A Kinase Inhibition Is Synthetic Lethal with Loss of the RB1 Tumor Suppressor Gene
Gong, Xueqian, Du, Jian, Parsons, Stephen H, Merzoug, Farhana F, Webster, Yue, Iversen, Philip W, Chio, Li-Chun, Van Horn, Robert D, Lin, Xi, Blosser, Wayne, Han, Bomie, Jin, Shaoling, Yao, Sufang, Bian, Huimin, Ficklin, Chris, Fan, Li, Kapoor, Avnish, Antonysamy, Stephen, Mc Nulty, Ann M, Froning, Karen, Manglicmot, Danalyn, Pustilnik, Anna, Weichert, Kenneth, Wasserman, Stephen R, Dowless, Michele, Marugán, Carlos, Baquero, Carmen, Lallena, María José, Eastman, Scott W, Hui, Yu-Hua, Dieter, Matthew Z, Doman, Thompson, Chu, Shaoyou, Qian, Hui-Rong, Ye, Xiang S, Barda, David A, Plowman, Gregory D, Reinhard, Christoph, Campbell, Robert M, Henry, James R, Buchanan, Sean G
Published in Cancer discovery (01.02.2019)
Published in Cancer discovery (01.02.2019)
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Oncogenic BRAF Deletions That Function as Homodimers and Are Sensitive to Inhibition by RAF Dimer Inhibitor LY3009120
Chen, Shih-Hsun, Zhang, Youyan, Van Horn, Robert D, Yin, Tinggui, Buchanan, Sean, Yadav, Vipin, Mochalkin, Igor, Wong, Swee Seong, Yue, Yong Gang, Huber, Lysiane, Conti, Ilaria, Henry, James R, Starling, James J, Plowman, Gregory D, Peng, Sheng-Bin
Published in Cancer discovery (01.03.2016)
Published in Cancer discovery (01.03.2016)
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ERK Inhibitor LY3214996 Targets ERK Pathway-Driven Cancers: A Therapeutic Approach Toward Precision Medicine
Bhagwat, Shripad V, McMillen, William T, Cai, Shufen, Zhao, Baohui, Whitesell, Matthew, Shen, Weihua, Kindler, Lisa, Flack, Robert S, Wu, Wenjuan, Anderson, Bryan, Zhai, Yan, Yuan, Xiu-Juan, Pogue, Meghann, Van Horn, Robert D, Rao, Xi, McCann, Denis, Dropsey, Andrew J, Manro, Jason, Walgren, Jennie, Yuen, Eunice, Rodriguez, Michael J, Plowman, Gregory D, Tiu, Ramon V, Joseph, Sajan, Peng, Sheng-Bin
Published in Molecular cancer therapeutics (01.02.2020)
Published in Molecular cancer therapeutics (01.02.2020)
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Aurora A-Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy
Du, Jian, Yan, Lei, Torres, Raquel, Gong, Xueqian, Bian, Huimin, Marugán, Carlos, Boehnke, Karsten, Baquero, Carmen, Hui, Yu-Hua, Chapman, Sonya C, Yang, Yanzhu, Zeng, Yi, Bogner, Sarah M, Foreman, Robert T, Capen, Andrew, Donoho, Gregory P, Van Horn, Robert D, Barnard, Darlene S, Dempsey, Jack A, Beckmann, Richard P, Marshall, Mark S, Chio, Li-Chun, Qian, Yuewei, Webster, Yue W, Aggarwal, Amit, Chu, Shaoyou, Bhattachar, Shobha, Stancato, Louis F, Dowless, Michele S, Iversen, Phillip W, Manro, Jason R, Walgren, Jennie L, Halstead, Bartley W, Dieter, Matthew Z, Martinez, Ricardo, Bhagwat, Shripad V, Kreklau, Emiko L, Lallena, Maria Jose, Ye, Xiang S, Patel, Bharvin K R, Reinhard, Christoph, Plowman, Gregory D, Barda, David A, Henry, James R, Buchanan, Sean G, Campbell, Robert M
Published in Molecular cancer therapeutics (01.12.2019)
Published in Molecular cancer therapeutics (01.12.2019)
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Mouse PDX Trial Suggests Synergy of Concurrent Inhibition of RAF and EGFR in Colorectal Cancer with BRAF or KRAS Mutations
Yao, Yung-Mae M, Donoho, Gregory P, Iversen, Philip W, Zhang, Youyan, Van Horn, Robert D, Forest, Amelie, Novosiadly, Ruslan D, Webster, Yue Wang, Ebert, Philip, Bray, Steven, Ting, Jason C, Aggarwal, Amit, Henry, James R, Tiu, Ramon V, Plowman, Gregory D, Peng, Sheng-Bin
Published in Clinical cancer research (15.09.2017)
Published in Clinical cancer research (15.09.2017)
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Characterization of 7A5: A Human CD137 (4-1BB) Receptor Binding Monoclonal Antibody with Differential Agonist Properties That Promotes Antitumor Immunity
Kotanides, Helen, Sattler, Rose Marie, Lebron, Maria B, Carpenito, Carmine, Shen, Juqun, Li, Jingxing, Surguladze, David, Haidar, Jaafar N, Burns, Colleen, Shen, Leyi, Inigo, Ivan, Pennello, Anthony L, Forest, Amelie, Chen, Xinlei, Chin, Darin, Sonyi, Andreas, Topper, Michael, Boucher, Lauren, Sharma, Prachi, Zhang, Yiwei, Burtrum, Douglas, Novosiadly, Ruslan D, Ludwig, Dale L, Plowman, Gregory D, Kalos, Michael
Published in Molecular cancer therapeutics (01.04.2020)
Published in Molecular cancer therapeutics (01.04.2020)
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Bispecific Targeting of PD-1 and PD-L1 Enhances T-cell Activation and Antitumor Immunity
Kotanides, Helen, Li, Yiwen, Malabunga, Maria, Carpenito, Carmine, Eastman, Scott W, Shen, Yang, Wang, George, Inigo, Ivan, Surguladze, David, Pennello, Anthony L, Persaud, Krishnadatt, Hindi, Sagit, Topper, Michael, Chen, Xinlei, Zhang, Yiwei, Bulaon, Danielle K, Bailey, Tim, Lao, Yanbin, Han, Bing, Torgerson, Stacy, Chin, Darin, Sonyi, Andreas, Haidar, Jaafar N, Novosiadly, Ruslan D, Moxham, Christopher M, Plowman, Gregory D, Ludwig, Dale L, Kalos, Michael
Published in Cancer immunology research (01.10.2020)
Published in Cancer immunology research (01.10.2020)
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Systematic generation of high-resolution deletion coverage of the Drosophila melanogaster genome
Friedman, Lori, Deal, Jennifer E, Howie, Elizabeth, Tan, Lory R, Edgar, Kyle A, Plowman, Gregory D, Marcinko, Marie, Winter, Christopher G, Milash, Brett, Winner, Millicent A, Cook, Kevin R, Parks, Annette L, Belvin, Marcia, Fawcett, Robert, Andrade, Rachel S, Kopczynski, Casey, Killpack, Keith, Duyk, Geoffrey, Grant, Deanna, Shaw, Kenneth J, Huppert, Kari, Miyazaki, Wesley Y, Margolis, Jonathan, Tabios, Mariano, Thao, Doua, Vysotskaia, Valentina, Kaufman, Thomas C, Zhao, Lora, Francis-Lang, Helen L, Robertson, Stephanie, Dompe, Nicholas A, Curtis, Daniel, Whittaker, Kellie, Deal-Herr, Megan E, Norton, Amanda, Bogart, Kevin P, Singer, Matthew A
Published in Nature genetics (01.03.2004)
Published in Nature genetics (01.03.2004)
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Structure and Function of Human Amphiregulin: A Member of the Epidermal Growth Factor Family
Shoyab, Mohammed, Plowman, Gregory D., McDonald, Vicki L., Bradley, J. Garrett, Todaro, George J.
Published in Science (American Association for the Advancement of Science) (24.02.1989)
Published in Science (American Association for the Advancement of Science) (24.02.1989)
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Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions
Peles, Elior, Nativ, Moshe, Lustig, Marc, Grumet, Martin, Schilling, James, Martinez, Ricardo, Plowman, Gregory D., Schlessinger, Joseph
Published in The EMBO journal (03.03.1997)
Published in The EMBO journal (03.03.1997)
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The carbonic anhydrase domain of receptor tyrosine phosphatase β is a functional ligand for the axonal cell recognition molecule contactin
Peles, Elior, Nativ, Moshe, Campbell, Phillip L, Sakurai, Takeshi, Martinez, Ricardo, Levt, Sima, Clary, Douglas O, Schilling, James, Barnea, Gilad, Plowman, Gregory D, Grumet, Martin, Schlessinger, Joseph
Published in Cell (28.07.1995)
Published in Cell (28.07.1995)
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