Design, Synthesis, and Evaluation of Novel and Selective G‑protein Coupled Receptor 120 (GPR120) Spirocyclic Agonists
Cox, Jason M, Chu, Hong D, Chelliah, Mariappan V, Debenham, John S, Eagen, Keith, Lan, Ping, Lombardo, Matthew, London, Clare, Plotkin, Michael A, Shah, Unmesh, Sun, Zhongxiang, Vaccaro, Henry M, Venkatraman, Srikanth, Suzuki, Takao, Wang, Nengxue, Ashley, Eric R, Crespo, Alejandro, Madeira, Maria, Leung, Dennis H, Alleyne, Candice, Ogawa, Aimie M, Souza, Sarah, Thomas-Fowlkes, Brande, Di Salvo, Jerry, Weinglass, Adam, Kirkland, Melissa, Pachanski, Michele, Powles, Mary Ann, Tozzo, Effie, Akiyama, Taro E, Ujjainwalla, Feroze, Tata, James R, Sinz, Christopher J
Published in ACS medicinal chemistry letters (12.01.2017)
Published in ACS medicinal chemistry letters (12.01.2017)
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Selective small-molecule inhibition of an RNA structural element
Howe, John A., Wang, Hao, Fischmann, Thierry O., Balibar, Carl J., Xiao, Li, Galgoci, Andrew M., Malinverni, Juliana C., Mayhood, Todd, Villafania, Artjohn, Nahvi, Ali, Murgolo, Nicholas, Barbieri, Christopher M., Mann, Paul A., Carr, Donna, Xia, Ellen, Zuck, Paul, Riley, Dan, Painter, Ronald E., Walker, Scott S., Sherborne, Brad, de Jesus, Reynalda, Pan, Weidong, Plotkin, Michael A., Wu, Jin, Rindgen, Diane, Cummings, John, Garlisi, Charles G., Zhang, Rumin, Sheth, Payal R., Gill, Charles J., Tang, Haifeng, Roemer, Terry
Published in Nature (London) (29.10.2015)
Published in Nature (London) (29.10.2015)
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Plotkin, Michael A., Labroli, Marc, Schubert, Jeffrey, Shaw, Anthony, Schlegel, Kelly-Ann S., Berger, Richard, Cooke, Andrew J., Hayes, Robert P., Armacost, Kira A., Kinek, Keith, Krosky, Paula, Burlein, Christine, Meng, Shi, DiNunzio, Edward, Murray, Edward M., Agrawal, Sony, Madeira, Maria, Flattery, Amy, Yao, Huifang, Leithead, Andrew, Rose, William A, Cox, Christopher, Tellers, David M., McKenna, Philip M., Raheem, Izzat
Published in ACS medicinal chemistry letters (08.08.2024)
Published in ACS medicinal chemistry letters (08.08.2024)
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Redefining the Histone Deacetylase Inhibitor Pharmacophore: High Potency with No Zinc Cofactor Interaction
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Published in ACS medicinal chemistry letters (08.04.2021)
Published in ACS medicinal chemistry letters (08.04.2021)
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Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects
Lombardo, Matthew, Bender, Kate, London, Clare, Plotkin, Michael A., Kirkland, Melissa, Mane, Joel, Pachanski, Michele, Geissler, Wayne, Cummings, John, Habulihaz, Bahanu, Akiyama, Taro E., Di Salvo, Jerry, Madeira, Maria, Pols, Joanna, Powles, Mary Ann, Finley, Michael F., Johnson, Eric, Roussel, Thomas, Uebele, Victor N., Crespo, Alejandro, Leung, Dennis, Alleyne, Candice, Trusca, Dorina, Lei, Ying, Howard, Andrew D., Ujjainwalla, Feroze, Tata, James R., Sinz, Christopher J.
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
Published in Bioorganic & medicinal chemistry letters (01.12.2016)
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Optimization of Preclinical Metabolism for Somatostatin Receptor Subtype 5‑Selective Antagonists
Liu, Weiguo, Hussain, Zahid, Zang, Yi, Sweis, Ramzi F, Romero, F. Anthony, Finke, Paul E, Moningka, Remond, Bao, Jianming, Plotkin, Michael A, Shang, Jin, Dingley, Karen H, Salituro, Gino, Murphy, Beth Ann, Howard, Andrew D, Ujjainwalla, Feroze, Wood, Harold B, Duffy, Joseph L
Published in ACS medicinal chemistry letters (08.11.2018)
Published in ACS medicinal chemistry letters (08.11.2018)
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2‑Aryl-3-methyloctahydrophenanthrene-2,3,7-triols as Potent Dissociated Glucocorticoid Receptor Agonists
Chantigny, Yves A, Murray, John C, Kleinman, Edward F, Robinson, Ralph P, Plotkin, Michael A, Reese, Matthew R, Buckbinder, Leonard, McNiff, Patricia A, Millham, Michele L, Schaefer, Jean F, Abramov, Yuriy A, Bordner, Jon
Published in Journal of medicinal chemistry (26.03.2015)
Published in Journal of medicinal chemistry (26.03.2015)
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Corrigendum to “Discovery of benzofuran propanoic acid GPR120 agonists: From uHTS hit to mechanism-based pharmacodynamic effects” [Bioorg. Med. Chem. Lett. 26 (2016) 5724–5728]
Lombardo, Matthew, Bender, Kate, London, Clare, Plotkin, Michael A., Kirkland, Melissa, Mane, Joel, Pachanski, Michele, Geissler, Wayne, Cummings, John, Habulihaz, Bahanu, Akiyama, Taro E., Di Salvo, Jerry, Madeira, Maria, Pols, Joanna, Powles, Mary Ann, Finley, Michael F., Johnson, Eric, Roussel, Thomas, Uebele, Victor N., Crespo, Alejandro, Leung, Dennis, Alleyne, Candice, Trusca, Dorina, Lei, Ying, Howard, Andrew D., Ujjainwalla, Feroze, Tata, James R., Sinz, Christopher J.
Published in Bioorganic & medicinal chemistry letters (01.03.2017)
Published in Bioorganic & medicinal chemistry letters (01.03.2017)
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Free Radical-Mediated Aryl Amination and Its Use in a Convergent [3 + 2] Strategy for Enantioselective Indoline α-Amino Acid Synthesis
Viswanathan, Rajesh, Prabhakaran, Erode N, Plotkin, Michael A, Johnston, Jeffrey N
Published in Journal of the American Chemical Society (08.01.2003)
Published in Journal of the American Chemical Society (08.01.2003)
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Year of Publication 03.04.2023
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Year of Publication 03.04.2023
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SUBSTITUTED SPIROPIPERIDINYL COMPOUNDS USEFUL AS GPR120 AGONISTS
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Year of Publication 17.06.2015
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Year of Publication 17.06.2015
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Year of Publication 23.10.2024
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Year of Publication 23.10.2024
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Year of Publication 28.08.2024
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Year of Publication 28.08.2024
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Year of Publication 07.06.2023
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Year of Publication 02.03.2023
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Year of Publication 02.03.2023
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Year of Publication 03.02.2022
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Year of Publication 03.02.2022
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POLYCYCLIC CAP-DEPENDENT ENDONUCLEASE INHIBITORS FOR TREATING OR PREVENTING INFLUENZA
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Year of Publication 03.02.2022
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