Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis
Lunde, Christopher S., Stebbins, Erin E., Jumani, Rajiv S., Hasan, Md Mahmudul, Miller, Peter, Barlow, John, Freund, Yvonne R., Berry, Pamela, Stefanakis, Rianna, Gut, Jiri, Rosenthal, Philip J., Love, Melissa S., McNamara, Case W., Easom, Eric, Plattner, Jacob J., Jacobs, Robert T., Huston, Christopher D.
Published in Nature communications (27.06.2019)
Published in Nature communications (27.06.2019)
Get full text
Journal Article
Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate
Zhang, Yong-Kang, Plattner, Jacob J, Easom, Eric E, Jacobs, Robert T, Guo, Denghui, Freund, Yvonne R, Berry, Pamela, Ciaravino, Vic, Erve, John C. L, Rosenthal, Philip J, Campo, Brice, Gamo, Francisco-Javier, Sanz, Laura M, Cao, Jianxin
Published in Journal of medicinal chemistry (13.07.2017)
Published in Journal of medicinal chemistry (13.07.2017)
Get full text
Journal Article
Antifungal Agent Inhibits an Aminoacyl-tRNA Synthetase by Trapping tRNA in the Editing Site
Rock, Fernando L, Mao, Weimin, Yaremchuk, Anya, Tukalo, Mikhail, Crépin, Thibaut, Zhou, Huchen, Zhang, Yong-Kang, Hernandez, Vincent, Akama, Tsutomu, Baker, Stephen J, Plattner, Jacob J, Shapiro, Lucy, Martinis, Susan A, Benkovic, Stephen J, Cusack, Stephen, Alley, M.R.K
Published in Science (American Association for the Advancement of Science) (22.06.2007)
Published in Science (American Association for the Advancement of Science) (22.06.2007)
Get full text
Journal Article
Discovery and structure–activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis
Akama, Tsutomu, Baker, Stephen J., Zhang, Yong-Kang, Hernandez, Vincent, Zhou, Huchen, Sanders, Virginia, Freund, Yvonne, Kimura, Richard, Maples, Kirk R., Plattner, Jacob J.
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Published in Bioorganic & medicinal chemistry letters (15.04.2009)
Get full text
Journal Article
Discovery of a New Boron-Containing Antifungal Agent, 5-Fluoro-1,3-dihydro-1-hydroxy-2,1- benzoxaborole (AN2690), for the Potential Treatment of Onychomycosis
Baker, Stephen J, Zhang, Yong-Kang, Akama, Tsutomu, Lau, Agnes, Zhou, Huchen, Hernandez, Vincent, Mao, Weimin, Alley, M. R. K, Sanders, Virginia, Plattner, Jacob J
Published in Journal of medicinal chemistry (27.07.2006)
Published in Journal of medicinal chemistry (27.07.2006)
Get full text
Journal Article
Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation
Sindhe, Kirthana M V, Wu, Wesley, Legac, Jenny, Zhang, Yong-Kang, Easom, Eric E, Cooper, Roland A, Plattner, Jacob J, Freund, Yvonne R, DeRisi, Joseph L, Rosenthal, Philip J
Published in mBio (28.01.2020)
Published in mBio (28.01.2020)
Get full text
Journal Article
Crystal Structures of the Human and Fungal Cytosolic Leucyl-tRNA Synthetase Editing Domains: A Structural Basis for the Rational Design of Antifungal Benzoxaboroles
Seiradake, Elena, Mao, Weimin, Hernandez, Vincent, Baker, Stephen J., Plattner, Jacob J., Alley, M.R.K., Cusack, Stephen
Published in Journal of molecular biology (10.07.2009)
Published in Journal of molecular biology (10.07.2009)
Get full text
Journal Article
Discovery of an orally bioavailable isoxazoline benzoxaborole (AN8030) as a long acting animal ectoparasiticide
Zhang, Yong-Kang, Plattner, Jacob J., Easom, Eric E., Zhou, Yasheen, Akama, Tsutomu, Bu, Wei, White, W. Hunter, Defauw, Jean M., Winkle, Joseph R., Balko, Terry W., Guo, Shenghai, Xue, Jian, Cao, Jianxin, Zou, Wuxin
Published in Bioorganic & medicinal chemistry letters (01.12.2015)
Published in Bioorganic & medicinal chemistry letters (01.12.2015)
Get full text
Journal Article
In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis
Ehrens, Alexandra, Lunde, Christopher S, Jacobs, Robert T, Struever, Dominique, Koschel, Marianne, Frohberger, Stefan J, Lenz, Franziska, Fendler, Martina, Turner, Joseph D, Ward, Stephen A, Taylor, Mark J, Freund, Yvonne R, Stefanakis, Rianna, Easom, Eric, Li, Xianfeng, Plattner, Jacob J, Hoerauf, Achim, Hübner, Marc P
Published in PLoS neglected tropical diseases (01.01.2020)
Published in PLoS neglected tropical diseases (01.01.2020)
Get full text
Journal Article
Discovery and structure–activity relationships of 6-(benzoylamino)benzoxaboroles as orally active anti-inflammatory agents
Akama, Tsutomu, Dong, Chen, Virtucio, Charlotte, Freund, Yvonne R., Chen, Daitao, Orr, Matthew D., Jacobs, Robert T., Zhang, Yong-Kang, Hernandez, Vincent, Liu, Yang, Wu, Anne, Bu, Wei, Liu, Liang, Jarnagin, Kurt, Plattner, Jacob J.
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Published in Bioorganic & medicinal chemistry letters (01.11.2013)
Get full text
Journal Article
Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)‑3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)‑ol (GSK656)
Li, Xianfeng, Hernandez, Vincent, Rock, Fernando L, Choi, Wai, Mak, Yvonne S. L, Mohan, Manisha, Mao, Weimin, Zhou, Yasheen, Easom, Eric E, Plattner, Jacob J, Zou, Wuxin, Pérez-Herrán, Esther, Giordano, Ilaria, Mendoza-Losana, Alfonso, Alemparte, Carlos, Rullas, Joaquín, Angulo-Barturen, Iñigo, Crouch, Sabrinia, Ortega, Fátima, Barros, David, Alley, M. R. K
Published in Journal of medicinal chemistry (12.10.2017)
Published in Journal of medicinal chemistry (12.10.2017)
Get full text
Journal Article
Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase
Palencia, Andrés, Li, Xianfeng, Bu, Wei, Choi, Wai, Ding, Charles Z, Easom, Eric E, Feng, Lisa, Hernandez, Vincent, Houston, Paul, Liu, Liang, Meewan, Maliwan, Mohan, Manisha, Rock, Fernando L, Sexton, Holly, Zhang, Suoming, Zhou, Yasheen, Wan, Baojie, Wang, Yuehong, Franzblau, Scott G, Woolhiser, Lisa, Gruppo, Veronica, Lenaerts, Anne J, O'Malley, Theresa, Parish, Tanya, Cooper, Christopher B, Waters, M Gerard, Ma, Zhenkun, Ioerger, Thomas R, Sacchettini, James C, Rullas, Joaquín, Angulo-Barturen, Iñigo, Pérez-Herrán, Esther, Mendoza, Alfonso, Barros, David, Cusack, Stephen, Plattner, Jacob J, Alley, M R K
Published in Antimicrobial agents and chemotherapy (01.10.2016)
Published in Antimicrobial agents and chemotherapy (01.10.2016)
Get full text
Journal Article
Identification of a 4-fluorobenzyl l-valinate amide benzoxaborole (AN11736) as a potential development candidate for the treatment of Animal African Trypanosomiasis (AAT)
Akama, Tsutomu, Zhang, Yong-Kang, Freund, Yvonne R., Berry, Pamela, Lee, Joanne, Easom, Eric E., Jacobs, Robert T., Plattner, Jacob J., Witty, Michael J., Peter, Rosemary, Rowan, Tim G., Gillingwater, Kirsten, Brun, Reto, Nare, Bakela, Mercer, Luke, Xu, Musheng, Wang, Jiangong, Liang, Hao
Published in Bioorganic & medicinal chemistry letters (01.01.2018)
Published in Bioorganic & medicinal chemistry letters (01.01.2018)
Get full text
Journal Article
Topical Treatment for Cutaneous Leishmaniasis: Dermato-Pharmacokinetic Lead Optimization of Benzoxaboroles
Van Bocxlaer, Katrien, Gaukel, Eric, Hauser, Deirdre, Park, Seong Hee, Schock, Sara, Yardley, Vanessa, Randolph, Ryan, Plattner, Jacob J, Merchant, Tejal, Croft, Simon L, Jacobs, Robert T, Wring, Stephen A
Published in Antimicrobial agents and chemotherapy (01.05.2018)
Published in Antimicrobial agents and chemotherapy (01.05.2018)
Get full text
Journal Article
Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center
Freund, Yvonne R., Akama, Tsutomu, Alley, M.R.K., Antunes, Joana, Dong, Chen, Jarnagin, Kurt, Kimura, Richard, Nieman, James A., Maples, Kirk R., Plattner, Jacob J., Rock, Fernando, Sharma, Rashmi, Singh, Rajeshwar, Sanders, Virginia, Zhou, Yasheen
Published in FEBS letters (21.09.2012)
Published in FEBS letters (21.09.2012)
Get full text
Journal Article
Boron-based drugs as antiprotozoals
Jacobs, Robert T, Plattner, Jacob J, Keenan, Martine
Published in Current opinion in infectious diseases (01.12.2011)
Published in Current opinion in infectious diseases (01.12.2011)
Get more information
Journal Article
Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria
HERNANDEZ, Vincent, CREPIN, Thibaut, MEEWAN, Maliwan, MOHAN, Manisha, WEIMIN MAO, ROCK, Fernando L, SEXTON, Holly, SHEORAN, Anita, YANCHEN ZHANG, ZHANG, Yong-Kang, ZHOU, Yasheen, NIEMAN, James A, PALENCIA, Andrés, MAHIPAL REDDY ANUGULA, EL MEHDI KERAMANE, SAVARIRAJ, Kingsley, SHEKHAR REDDY, D, SHARMA, Rashmi, SUBEDI, Rajendra, SINGH, Rajeshwar, O'LEARY, Ann, SIMON, Nerissa L, DE MARSH, Peter L, CUSACK, Stephen, MUSHTAQ, Shazad, WARNER, Marina, LIVERMORE, David M, ALLEY, M. R. K, PLATTNER, Jacob J, AKAMA, Tsutomu, BAKER, Stephen J, WEI BU, LISA FENG, FREUND, Yvonne R, LIANG LIU
Published in Antimicrobial Agents and Chemotherapy (01.03.2013)
Published in Antimicrobial Agents and Chemotherapy (01.03.2013)
Get full text
Journal Article
Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis
Jacobs, Robert T, Lunde, Christopher S, Freund, Yvonne R, Hernandez, Vincent, Li, Xianfeng, Xia, Yi, Carter, David S, Berry, Pamela W, Halladay, Jason, Rock, Fernando, Stefanakis, Rianna, Easom, Eric, Plattner, Jacob J, Ford, Louise, Johnston, Kelly L, Cook, Darren A. N, Clare, Rachel, Cassidy, Andrew, Myhill, Laura, Tyrer, Hayley, Gamble, Joanne, Guimaraes, Ana F, Steven, Andrew, Lenz, Franziska, Ehrens, Alexandra, Frohberger, Stefan J, Koschel, Marianne, Hoerauf, Achim, Hübner, Marc P, McNamara, Case W, Bakowski, Malina A, Turner, Joseph D, Taylor, Mark J, Ward, Stephen A
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
Get full text
Journal Article
SCYX-7158, an orally-active benzoxaborole for the treatment of stage 2 human African trypanosomiasis
Jacobs, Robert T, Nare, Bakela, Wring, Stephen A, Orr, Matthew D, Chen, Daitao, Sligar, Jessica M, Jenks, Matthew X, Noe, Robert A, Bowling, Tana S, Mercer, Luke T, Rewerts, Cindy, Gaukel, Eric, Owens, Jennifer, Parham, Robin, Randolph, Ryan, Beaudet, Beth, Bacchi, Cyrus J, Yarlett, Nigel, Plattner, Jacob J, Freund, Yvonne, Ding, Charles, Akama, Tsutomu, Zhang, Y-K, Brun, Reto, Kaiser, Marcel, Scandale, Ivan, Don, Robert
Published in PLoS neglected tropical diseases (01.06.2011)
Published in PLoS neglected tropical diseases (01.06.2011)
Get full text
Journal Article
Benzoxaborole Antimalarial Agents. Part 4. Discovery of Potent 6‑(2-(Alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles
Zhang, Yong-Kang, Plattner, Jacob J, Easom, Eric E, Jacobs, Robert T, Guo, Denghui, Sanders, Virginia, Freund, Yvonne R, Campo, Brice, Rosenthal, Philip J, Bu, Wei, Gamo, Francisco-Javier, Sanz, Laura M, Ge, Min, Li, Liang, Ding, Jie, Yang, Yin
Published in Journal of medicinal chemistry (09.07.2015)
Published in Journal of medicinal chemistry (09.07.2015)
Get full text
Journal Article