Discovery and Optimization of an Azetidine Chemical Series As a Free Fatty Acid Receptor 2 (FFA2) Antagonist: From Hit to Clinic
Pizzonero, Mathieu, Dupont, Sonia, Babel, Marielle, Beaumont, Stéphane, Bienvenu, Natacha, Blanqué, Roland, Cherel, Laëtitia, Christophe, Thierry, Crescenzi, Benedetta, De Lemos, Elsa, Delerive, Philippe, Deprez, Pierre, De Vos, Steve, Djata, Fatoumata, Fletcher, Stephen, Kopiejewski, Sabrina, L’Ebraly, Christelle, Lefrançois, Jean-Michel, Lavazais, Stéphanie, Manioc, Murielle, Nelles, Luc, Oste, Line, Polancec, Denis, Quénéhen, Vanessa, Soulas, Florilène, Triballeau, Nicolas, van der Aar, Ellen M, Vandeghinste, Nick, Wakselman, Emanuelle, Brys, Reginald, Saniere, Laurent
Published in Journal of medicinal chemistry (11.12.2014)
Published in Journal of medicinal chemistry (11.12.2014)
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Journal Article
Identification of GLPG/ABBV-2737, a Novel Class of Corrector, Which Exerts Functional Synergy With Other CFTR Modulators
de Wilde, Gert, Gees, Maarten, Musch, Sara, Verdonck, Katleen, Jans, Mia, Wesse, Anne-Sophie, Singh, Ashvani K, Hwang, Tzyh-Chang, Christophe, Thierry, Pizzonero, Mathieu, Van der Plas, Steven, Desroy, Nicolas, Cowart, Marlon, Stouten, Pieter, Nelles, Luc, Conrath, Katja
Published in Frontiers in pharmacology (09.05.2019)
Published in Frontiers in pharmacology (09.05.2019)
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Journal Article
The syntheses of rac-inthomycin A, (+)-inthomycin B and (+)-inthomycin C using a unified synthetic approach
Webb, Michael R., Addie, Matthew S., Crawforth, Catherine M., Dale, James W., Franci, Xavier, Pizzonero, Mathieu, Donald, Craig, Taylor, Richard J.K.
Published in Tetrahedron (19.05.2008)
Published in Tetrahedron (19.05.2008)
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Journal Article
2′-Modified Thymidines with Bioorthogonal Cyclopropene or Sydnone as Building Blocks for Copper-Free Postsynthetic Functionalization of Chemically Synthesized Oligonucleotides
Bristiel, Alexandra, Cadinot, Manon, Pizzonero, Mathieu, Taran, Frédéric, Urban, Dominique, Guignard, Raphaël, Guianvarc’h, Dominique
Published in Bioconjugate chemistry (20.09.2023)
Published in Bioconjugate chemistry (20.09.2023)
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Journal Article
Discovery of GLPG2737, a Potent Type 2 Corrector of CFTR for the Treatment of Cystic Fibrosis in Combination with a Potentiator and a Type 1 Co-corrector
Pizzonero, Mathieu, Akkari, Rhalid, Bock, Xavier, Gosmini, Romain, De Lemos, Elsa, Duthion, Béranger, Newsome, Gregory, Mai, Thi-Thu-Trang, Roques, Virginie, Jary, Hélène, Lefrancois, Jean-Michel, Cherel, Laetitia, Quenehen, Vanessa, Babel, Marielle, Merayo, Nuria, Bienvenu, Natacha, Mammoliti, Oscar, Coti, Ghjuvanni, Palisse, Adeline, Cowart, Marlon, Shrestha, Anurupa, Greszler, Stephen, Van Der Plas, Steven, Jansen, Koen, Claes, Pieter, Jans, Mia, Gees, Maarten, Borgonovi, Monica, De Wilde, Gert, Conrath, Katja
Published in Journal of medicinal chemistry (11.04.2024)
Published in Journal of medicinal chemistry (11.04.2024)
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Journal Article
Mo1234 The FFA2 Antagonist GLPG0974: A Promising Approach to Treat Neutrophil-Driven Inflammation
Vanhoutte, Frédéric P, Namour, Florence S, Dupont, Sonia, Pizzonero, Mathieu, De Vos, Steve, Sanière, Laurent, van der Aa, Annegret, Beetens, Johan, van 't Klooster, Gerben
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2014)
Published in Gastroenterology (New York, N.Y. 1943) (01.05.2014)
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Journal Article
MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE
MING C YEUNG, SYLVAIN COUTY, KARINE FABIENNE MALAGU, PIZZONERO MATHIEU RAFAEL, MERAYO NURIA MERAYO, NICOLAS DESROY, CHRISTOPHER GAETAN HOUSSEMAN, ALTENBACH ROBERT J, GREGORY A GFESSER, PHILIP R KYM, STEVEN EMIEL VAN DER PLAS, THI THU TRANG MAI, LIU BO, OLIVIER LAURENT PICOLET, ANDREW BOGDAN, WANG XUEQING, XENIA B SEARLE
Year of Publication 04.01.2022
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Year of Publication 04.01.2022
Patent
MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN AND METHODS OF USE
MING C YEUNG, SYLVAIN COUTY, KARINE FABIENNE MALAGU, PIZZONERO MATHIEU RAFAEL, MERAYO NURIA MERAYO, NICOLAS DESROY, CHRISTOPHER GAETAN HOUSSEMAN, ALTENBACH ROBERT J, GREGORY A GFESSER, PHILIP R KYM, STEVEN EMIEL VAN DER PLAS, THI THU TRANG MAI, LIU BO, OLIVIER LAURENT PICOLET, ANDREW BOGDAN, WANG XUEQING, XENIA B SEARLE
Year of Publication 04.01.2022
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Year of Publication 04.01.2022
Patent
낭성섬유증 막횡단 전도도 조절자 단백질의 조정자 및 이의 용도
MAI THI THU TRANG, MALAGU KARINE FABIENNE, HOUSSEMAN CHRISTOPHER GAETAN, PIZZONERO MATHIEU RAFAEL, DESROY NICOLAS, COUTY SYLVAIN, PICOLET OLIVIER LAURENT, KYM PHILIP R, ALTENBACH ROBERT J, LIU BO, SEARLE XENIA B, VAN DER PLAS STEVEN EMIEL, WANG XUEQING, GFESSER GREGORY A, YEUNG MING C, BOGDAN ANDREW, MERAYO MERAYO NURIA
Year of Publication 17.07.2020
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Year of Publication 17.07.2020
Patent
Discovery of Pyridones As Oral AMPK Direct Activators
Mirguet, Olivier, Sautet, Stéphane, Clément, Catherine-Anne, Toum, Jérôme, Donche, Frédéric, Marques, Celine, Rondet, Emilie, Pizzonero, Mathieu, Beaufils, Benjamin, Dudit, Yann, Huet, Pascal, Trottet, Lionel, Grondin, Pascal, Brusq, Jean-Marie, Boursier, Eric, Saintillan, Yannick, Nicodeme, Edwige
Published in ACS medicinal chemistry letters (11.07.2013)
Published in ACS medicinal chemistry letters (11.07.2013)
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Journal Article
N-설포닐화 피라졸로[3,4-b]피리딘-6-카복스아미드 및 사용 방법
AKKARI RHALID, BROWN BRIAN S, BOCK XAVIER MARIE, HOUSSEMAN CHRISTOPHER GAETAN, PATEL SACHIN V, JI JIANGUO, DE BLIECK ANN, KYM PHILIP R, SHRESTHA ANURUPA, WANG XUEQING, GFESSER GREGORY A, SWIFT ELIZABETH C, ALVEY LUKE JONATHAN, PALISSE ADELINE MARIE ELISE, NEWSOME GREGORY JOHN ROBERT, PIZZONERO MATHIEU RAFAEL, DESROY NICOLAS, MERAYO NURIA MERAYO, CLAES PIETER ISABELLE ROGER, GOSMINI ROMAIN LUC MARIE, DUTHION BERANGER, MENET CHRISTEL JEANNE MARIE, DE LEMOS ELSA, LEFRANCOIS JEAN MICHEL, MAMMOLITI OSCAR, VAN DER PLAS STEVEN EMIEL, JANSEN KOEN KAREL, COWART MARLON D
Year of Publication 20.07.2018
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Year of Publication 20.07.2018
Patent
AZETIDINE DERIVATIVES USEFUL FOR THE TREATMENT OF METABOLIC AND INFLAMMATORY DISEASES
VANDEGHINSTE NICK ERNEST RENE, BRYS REGINALD CHRISTOPHE XAVIER, TRIBALLEAU NICOLAS, SANIERE LAURENT RAYMOND MAURICE, DE VOS STEVE IRMA JOEL, PIZZONERO MATHIEU RAFAEL, POURBAIX L'EBRALY CHRISTELLE DOMINIQUE
Year of Publication 02.04.2014
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Year of Publication 02.04.2014
Patent
The asymmetric Michael-type alkylation of chiral β-enamino esters: critical role of a benzyl ester group in the racemization of adducts
Pizzonero, Mathieu, Hendra, Frédéric, Delarue-Cochin, Sandrine, Tran Huu-Dau, Marie-Elise, Dumas, Françoise, Cavé, Christian, Nour, Mohammed, d’Angelo, Jean
Published in Tetrahedron: asymmetry (28.11.2005)
Published in Tetrahedron: asymmetry (28.11.2005)
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Journal Article
Crystallographic/Experimental Electron Density Characterizations and Reactions with Nucleophiles of β-Enaminonitriles Possessing a Pyrrolobenzazepine Core
Pizzonero, Mathieu, Keller, Laurent, Dumas, Françoise, Ourevitch, Michèle, Morgant, Georges, Spasojević-de Biré, Anne, Bogdanović, Goran, Ghermani, Nour Eddine, d'Angelo, Jean
Published in Journal of organic chemistry (25.06.2004)
Published in Journal of organic chemistry (25.06.2004)
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Journal Article
Reinvestigation of the fluoride-triggered condensation of allyltrimethylsilane with cinnamonitrile: ‘abnormal Sakurai’ and sequential ‘abnormal Sakurai’–Michael–Thorpe Ziegler side reactions
Keller, Laurent, Dumas, Françoise, Pizzonero, Mathieu, d'Angelo, Jean, Morgant, Georges, Nguyen-Huy, Dung
Published in Tetrahedron letters (22.04.2002)
Published in Tetrahedron letters (22.04.2002)
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Journal Article
ISOQUINOLINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF DISEASES
MAI, Thi Thu Trang, PIZZONERO, Mathieu Rafaël, QUINTON, Evelyne Martine, BARBEAU, Olivier Remi, MODRIC, Marina, JONCOUR, Agnès Marie, STIMSON, Christopher Charles
Year of Publication 13.01.2022
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Year of Publication 13.01.2022
Patent
NOVEL ISOQUINOLINE DERIVATIVES AND PHARMACEUTICAL COPOSITIONS THEREOF FOR THE TREATMENT OF DISEASES
QUINTON, Evelyne, YUEN, Darren Arthur Vee Yip, SOUTHEY, Michelle Wing Van, GILBERT, Richard Ernest, GADOULEAU, Elise Lucienne Paulette, ALBRECHT, Claudia, BARBEAU, Olivier Remi, PIZZONERO, Mathieu, STERNBERGER, Ina, MODRIC, Marina, STIMSON, Christopher Charles, TYE, Heather
Year of Publication 23.06.2022
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Year of Publication 23.06.2022
Patent
N-sulfonylated pyrazolo[3,4-b]pyridin-6-carboxamides and method of use
Alvey, Luke Jonathan, Mammoliti, Oscar, Desroy, Nicolas, Wang, Xueqing, Cowart, Marlon D, Patel, Sachin V, Duthion, Béranger, Merayo, Nuria Merayo, De Lemos, Elsa, Swift, Elizabeth C, Palisse, Adeline Marie Elise, Pizzonero, Mathieu Rafaël, Jansen, Koen Karel, Shrestha, Anurupa, Newsome, Gregory John Robert, De Blieck, Ann, Gfesser, Gregory A, Gosmini, Romain, Claes, Pieter, Bock, Xavier Marie, Menet, Christel Jeanne Marie, Akkari, Rhalid, Brown, Brian S, Housseman, Christopher Gaëtan, Lefrancois, Jean-Michel, Van Der Plas, Steven Emiel, Ji, Jianguo, Kym, Philip R
Year of Publication 31.03.2023
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Year of Publication 31.03.2023
Patent