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Published in The Journal of clinical investigation (15.03.2023)
Published in The Journal of clinical investigation (15.03.2023)
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Discovery of Narlaprevir (SCH 900518): A Potent, Second Generation HCV NS3 Serine Protease Inhibitor
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Published in ACS medicinal chemistry letters (13.05.2010)
Published in ACS medicinal chemistry letters (13.05.2010)
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Asymmetric Synthesis of 4,4-Disubstituted-2-Imidazoli-dinones: Potent NK1 Antagonists
Reichard, Gregory A, Stengone, Carmine, Paliwal, Sunil, Mergelsberg, Ingrid, Majmundar, Sapna, Wang, Cheng, Tiberi, Robert, McPhail, Andrew T, Piwinski, John J, Shih, Neng-Yang
Published in Organic letters (13.11.2003)
Published in Organic letters (13.11.2003)
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Identification of a dual histamine H1/H3 receptor ligand based on the H1 antagonist chlorpheniramine
ASLANIAN, Robert, MUTAHI, Mwangi Wa, SHIH, Neng-Yang, PIWINSKI, John J, WEST, Robert, WILLIAMS, Shirley M, SHE, Susan, WU, Ren-Long, HEY, John A
Published in Bioorganic & medicinal chemistry letters (16.06.2003)
Published in Bioorganic & medicinal chemistry letters (16.06.2003)
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Cyclic urea derivatives as potent NK1 selective antagonists. Part II: Effects of fluoro and benzylic methyl substitutions
Shue, Ho-Jane, Chen, Xiao, Schwerdt, John H, Paliwal, Sunil, Blythin, David J, Lin, Ling, Gu, Danlin, Wang, Cheng, Reichard, Gregory A, Wang, Hongwu, Piwinski, John J, Duffy, Ruth A, Lachowicz, Jean E, Coffin, Vicki L, Nomeir, Amin A, Morgan, Cynthia A, Varty, Geoffrey B, Shih, Neng-Yang
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
Published in Bioorganic & medicinal chemistry letters (15.02.2006)
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A Useful Pd-Catalyzed Negishi Coupling Approach to Benzylic Sulfonamide Derivatives
Zhou, Gang, Ting, Pauline, Aslanian, Robert, Piwinski, John J
Published in Organic letters (19.06.2008)
Published in Organic letters (19.06.2008)
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Structural characterization of in vitro rat liver microsomal metabolites of antihistamine desloratadine using LTQ-Orbitrap hybrid mass spectrometer in combination with online hydrogen/deuterium exchange HR-LC/MS
Chen, Guodong, Daaro, Ibrahim, Pramanik, Birendra N, Piwinski, John J
Published in Journal of mass spectrometry. (01.02.2009)
Published in Journal of mass spectrometry. (01.02.2009)
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Discovery and SAR of hydantoin TACE inhibitors
Yu, Wensheng, Guo, Zhuyan, Orth, Peter, Madison, Vincent, Chen, Lei, Dai, Chaoyang, Feltz, Robert J., Girijavallabhan, Vinay M., Kim, Seong Heon, Kozlowski, Joseph A., Lavey, Brian J., Li, Dansu, Lundell, Daniel, Niu, Xiaoda, Piwinski, John J., Popovici-Muller, Janeta, Rizvi, Razia, Rosner, Kristin E., Shankar, Bandarpalle B., Shih, Neng-Yang, Arshad Siddiqui, M., Sun, Jing, Tong, Ling, Umland, Shelby, Wong, Michael K.C., Yang, De-yi, Zhou, Guowei
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
Published in Bioorganic & medicinal chemistry letters (15.03.2010)
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Discovery of oxazole-based PDE4 inhibitors with picomolar potency
Kuang, Rongze, Shue, Ho-Jane, Xiao, Li, Blythin, David J., Shih, Neng-Yang, Chen, Xiao, Gu, Danlin, Schwerdt, John, Lin, Ling, Ting, Pauline C., Cao, Jianhua, Aslanian, Robert, Piwinski, John J., Prelusky, Daniel, Wu, Ping, Zhang, Ji, Zhang, Xiang, Celly, Chander S., Billah, Motasim, Wang, Peng
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
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Synthesis and NK1/NK2 binding activities of a series of diacyl-substituted 2-arylpiperazines
BLYTHIN, David J, XIAO CHEN, PIWINSKI, John J, SHIH, Neng-Yang, SHUE, Ho-Jane, ANTHES, John C, MCPHAIL, Andrew T
Published in Bioorganic & medicinal chemistry letters (04.11.2002)
Published in Bioorganic & medicinal chemistry letters (04.11.2002)
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Synthesis and profile of SCH351591, a novel PDE4 inhibitor
Billah, Motasim, Cooper, Nicola, Cuss, Francis, Davenport, Richard J., Dyke, Hazel J., Egan, Robert, Ganguly, Ashit, Gowers, Lewis, Hannah, Duncan R., Haughan, Alan F., Kendall, Hannah J., Lowe, Christopher, Minnicozzi, Michael, Montana, John G., Naylor, Robert, Oxford, Janet, Peake, Joanna C., Piwinski, John J., Runcie, Karen A., Sabin, Verity, Sharpe, Andrew, Shih, Neng-Yang, Warneck, Julie B.H.
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
Published in Bioorganic & medicinal chemistry letters (17.06.2002)
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2-(2-Aminothiazol-4-yl)pyrrolidine-based tartrate diamides as potent, selective and orally bioavailable TACE inhibitors
Dai, Chaoyang, Li, Dansu, Popovici-Muller, Janeta, Zhao, Lianyun, Girijavallabhan, Vinay M., Rosner, Kristin E., Lavey, Brian J., Rizvi, Razia, Shankar, Bandarpalle B., Wong, Michael K.C., Guo, Zhuyan, Orth, Peter, Strickland, Corey O., Sun, Jing, Niu, Xiaoda, Chen, Shiying, Kozlowski, Joseph A., Lundell, Daniel J., Piwinski, John J., Shih, Neng-Yang, Siddiqui, M. Arshad
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
Published in Bioorganic & medicinal chemistry letters (15.05.2011)
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5-Benzothiazole substituted pyrimidine derivatives as HCV replication (replicase) inhibitors
Arasappan, Ashok, Bennett, Frank, Girijavallabhan, Vinay, Huang, Yuhua, Huelgas, Regina, Alvarez, Carmen, Chen, Lei, Gavalas, Stephen, Kim, Seong-Heon, Kosinski, Aneta, Pinto, Patrick, Rizvi, Razia, Rossman, Randall, Shankar, Bandarpalle, Tong, Ling, Velazquez, Francisco, Venkatraman, Srikanth, Verma, Vishal A., Kozlowski, Joseph, Shih, Neng-Yang, Piwinski, John J., MacCoss, Malcolm, Kwong, Cecil D., Clark, Jeremy L., Fowler, Anita T., Geng, Feng, Kezar, Hollis S., Roychowdhury, Abhijit, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Li, Cheng, Chase, Robert, Curry, Stephanie, Huang, Hsueh-Cheng, Tong, Xiao, Njoroge, F. George
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
Published in Bioorganic & medicinal chemistry letters (01.05.2012)
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Biaryl substituted hydantoin compounds as TACE inhibitors
Yu, Wensheng, Tong, Ling, Kim, Seong Heon, Wong, Michael K.C., Chen, Lei, Yang, De-Yi, Shankar, Bandarpalle B., Lavey, Brian J., Zhou, Guowei, Kosinski, Aneta, Rizvi, Razia, Li, Dansu, Feltz, Robert J., Piwinski, John J., Rosner, Kristin E., Shih, Neng-Yang, Siddiqui, M. Arshad, Guo, Zhuyan, Orth, Peter, Shah, Himanshu, Sun, Jing, Umland, Shelby, Lundell, Daniel J., Niu, Xiaoda, Kozlowski, Joseph A.
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
Published in Bioorganic & medicinal chemistry letters (01.09.2010)
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Novel substituted pyrimidines as HCV replication (replicase) inhibitors
Kwong, Cecil D., Clark, Jeremy L., Fowler, Anita T., Geng, Feng, Kezar, Hollis S., Roychowdhury, Abhijit, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Shih, Neng-Yang, Piwinski, John J., Li, Cheng, Feld, Boris, Huang, Hsueh-Cheng, Tong, Xiao, George Njoroge, F., Arasappan, Ashok
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
Published in Bioorganic & medicinal chemistry letters (15.01.2012)
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Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors
Girijavallabhan, Vinay M., Alvarez, Carmen, Bennett, Frank, Chen, Lei, Gavalas, Stephen, Huang, Yuhua, Kim, Seong-Heon, Kosinski, Aneta, Pinto, Patrick, Rizvi, Razia, Rossman, Randall, Shankar, Bandarpalle, Tong, Ling, Velazquez, Francisco, Venkatraman, Srikanth, Verma, Vishal A., Kozlowski, Joseph, Shih, Neng-Yang, Piwinski, John J., MacCoss, Malcolm, Kwong, Cecil D., Bansal, Namita, Clark, Jeremy L., Fowler, Anita T., Kezar, Hollis S., Valiyaveettil, Jacob, Reynolds, Robert C., Maddry, Joseph A., Ananthan, Subramaniam, Secrist, John A., Li, Cheng, Chase, Robert, Curry, Stephanie, Huang, Hsueh-Cheng, Tong, Xiao, Njoroge, F. George, Arasappan, Ashok
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
Published in Bioorganic & medicinal chemistry letters (01.09.2012)
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The discovery of novel tartrate-based TNF-α converting enzyme (TACE) inhibitors
Rosner, Kristin E., Guo, Zhuyan, Orth, Peter, Shipps, Gerald W., Belanger, David B., Chan, Tin Yau, Curran, Patrick J., Dai, Chaoyang, Deng, Yongqi, Girijavallabhan, Vinay M., Hong, Liwu, Lavey, Brian J., Lee, Joe F., Li, Dansu, Liu, Zhidan, Popovici-Muller, Janeta, Ting, Pauline C., Vaccaro, Henry, Wang, Li, Wang, Tong, Yu, Wensheng, Zhou, Guowei, Niu, Xiaoda, Sun, Jing, Kozlowski, Joseph A., Lundell, Daniel J., Madison, Vincent, McKittrick, Brian, Piwinski, John J., Shih, Neng -Yang, Arshad Siddiqui, M., Strickland, Corey O.
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
Published in Bioorganic & medicinal chemistry letters (01.02.2010)
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Journal Article
Novel TNF-α converting enzyme (TACE) inhibitors as potential treatment for inflammatory diseases
Girijavallabhan, Vinay M., Chen, Lei, Dai, Chaoyang, Feltz, Robert J., Firmansjah, Luke, Li, Dansu, Kim, Seong Heon, Kozlowski, Joseph A., Lavey, Brian J., Kosinski, Aneta, Piwinski, John J., Popovici-Muller, Janeta, Rizvi, Razia, Rosner, Kristin E., Shankar, Banderpalle B., Shih, Neng-Yang, Siddiqui, M. Arshad, Tong, Ling, Wong, Michael K.C., Yang, De-yi, Yang, Liping, Yu, Wensheng, Zhou, Guowei, Guo, Zhuyan, Orth, Peter, Madison, Vincent, Bian, Hong, Lundell, Daniel, Niu, Xiaoda, Shah, Himanshu, Sun, Jing, Umland, Shelby
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
Published in Bioorganic & medicinal chemistry letters (15.12.2010)
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