proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates
Chan, Joyce C.Y, Piper, Derek E, Cao, Qiong, Liu, Dongming, King, Chadwick, Wang, Wei, Tang, Jie, Liu, Qiang, Higbee, Jared, Xia, Zhen, Di, Yongmei, Shetterly, Susan, Arimura, Ziva, Salomonis, Heather, Romanow, William G, Thibault, Stephen T, Zhang, Richard, Cao, Ping, Yang, Xiao-Ping, Yu, Timothy, Lu, Mei, Retter, Marc W, Kwon, Gayle, Henne, Kirk, Pan, Oscar, Tsai, Mei-Mei, Fuchslocher, Bryna, Yang, Evelyn, Zhou, Lei, Lee, Ki Jeong, Daris, Mark, Sheng, Jackie, Wang, Yan, Shen, Wenyan D, Yeh, Wen-Chen, Emery, Maurice, Walker, Nigel P.C, Shan, Bei, Schwarz, Margrit, Jackson, Simon M
Published in Proceedings of the National Academy of Sciences - PNAS (16.06.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (16.06.2009)
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Journal Article
The Crystal Structure of PCSK9: A Regulator of Plasma LDL-Cholesterol
Piper, Derek E., Jackson, Simon, Liu, Qiang, Romanow, William G., Shetterly, Susan, Thibault, Stephen T., Shan, Bei, Walker, Nigel P.C.
Published in Structure (London) (01.05.2007)
Published in Structure (London) (01.05.2007)
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Journal Article
Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers
Herter, Sylvia, Piper, Derek E, Aaron, Wade, Gabriele, Timothy, Cutler, Gene, Cao, Ping, Bhatt, Ami S, Choe, Youngchool, Craik, Charles S, Walker, Nigel, Meininger, David, Hoey, Timothy, Austin, Richard J
Published in Biochemical journal (15.08.2005)
Published in Biochemical journal (15.08.2005)
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Journal Article
The high-resolution crystal structure of human LCAT
Piper, Derek E, Romanow, William G, Gunawardane, Ruwanthi N, Fordstrom, Preston, Masterman, Stephanie, Pan, Oscar, Thibault, Stephen T, Zhang, Richard, Meininger, David, Schwarz, Margrit, Wang, Zhulun, King, Chadwick, Zhou, Mingyue, Walker, Nigel P C
Published in Journal of lipid research (01.09.2015)
Published in Journal of lipid research (01.09.2015)
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Journal Article
Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement
Henne, Kirk R, Ason, Brandon, Howard, Monique, Wang, Wei, Sun, Jeonghoon, Higbee, Jared, Tang, Jie, Matsuda, Katherine C, Xu, Ren, Zhou, Lei, Chan, Joyce C Y, King, Chadwick, Piper, Derek E, Ketchem, Randal R, Michaels, Mark Leo, Jackson, Simon M, Retter, Marc W
Published in The Journal of pharmacology and experimental therapeutics (01.04.2015)
Published in The Journal of pharmacology and experimental therapeutics (01.04.2015)
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Journal Article
Discovery and optimization of a series of liver X receptor antagonists
Jiao, XianYun, Kopecky, David J., Fisher, Ben, Piper, Derek E., Labelle, Marc, McKendry, Sharon, Harrison, Martin, Jones, Stuart, Jaen, Juan, Shiau, Andrew K., Escaron, Patrick, Danao, Jean, Chai, Anne, Coward, Peter, Kayser, Frank
Published in Bioorganic & medicinal chemistry letters (15.09.2012)
Published in Bioorganic & medicinal chemistry letters (15.09.2012)
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Journal Article
Discovery of a new binding mode for a series of liver X receptor agonists
Kopecky, David J., Jiao, Xian Yun, Fisher, Ben, McKendry, Sharon, Labelle, Marc, Piper, Derek E., Coward, Peter, Shiau, Andrew K., Escaron, Patrick, Danao, Jean, Chai, Anne, Jaen, Juan, Kayser, Frank
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
Published in Bioorganic & medicinal chemistry letters (01.04.2012)
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Journal Article
Molecular basis of PCSK9 function
Lambert, Gilles, Charlton, Francesca, Rye, Kerry-Anne, Piper, Derek E
Published in Atherosclerosis (01.03.2009)
Published in Atherosclerosis (01.03.2009)
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Journal Article
Discovery of Selective Pituitary Adenylate Cyclase 1 Receptor (PAC1R) Antagonist Peptides Potent in a Maxadilan/PACAP38-Induced Increase in Blood Flow Pharmacodynamic Model
Hu, Essa, Hong, Fang-Tsao, Aral, Jennifer, Long, Jason, Piper, Derek E, Poppe, Leszek, Andrews, Kristin L, Hager, Todd, Davis, Carl, Li, Hongyan, Wong, Philip, Gavva, Narender, Shi, Licheng, Zhu, Dawn X. D, Lehto, Sonya G, Xu, Cen, Miranda, Les P
Published in Journal of medicinal chemistry (25.03.2021)
Published in Journal of medicinal chemistry (25.03.2021)
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Journal Article
Agonistic Human Antibodies Binding to Lecithin-Cholesterol Acyltransferase Modulate High Density Lipoprotein Metabolism
Gunawardane, Ruwanthi N., Fordstrom, Preston, Piper, Derek E., Masterman, Stephanie, Siu, Sophia, Liu, Dongming, Brown, Mike, Lu, Mei, Tang, Jie, Zhang, Richard, Cheng, Janet, Gates, Andrew, Meininger, David, Chan, Joyce, Carlson, Tim, Walker, Nigel, Schwarz, Margrit, Delaney, John, Zhou, Mingyue
Published in The Journal of biological chemistry (05.02.2016)
Published in The Journal of biological chemistry (05.02.2016)
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Journal Article
The high-resolution crystal structure of human LCAT1
Piper, Derek E., Romanow, William G., Gunawardane, Ruwanthi N., Fordstrom, Preston, Masterman, Stephanie, Pan, Oscar, Thibault, Stephen T., Zhang, Richard, Meininger, David, Schwarz, Margrit, Wang, Zhulun, King, Chadwick, Zhou, Mingyue, Walker, NigelP.C.
Published in Journal of lipid research (01.09.2015)
Published in Journal of lipid research (01.09.2015)
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Journal Article
Discovery of AMG 925, a FLT3 and CDK4 Dual Kinase Inhibitor with Preferential Affinity for the Activated State of FLT3
Li, Zhihong, Wang, Xianghong, Eksterowicz, John, Gribble, Michael W, Alba, Grace Q, Ayres, Merrill, Carlson, Timothy J, Chen, Ada, Chen, Xiaoqi, Cho, Robert, Connors, Richard V, DeGraffenreid, Michael, Deignan, Jeffrey T, Duquette, Jason, Fan, Pingchen, Fisher, Benjamin, Fu, Jiasheng, Huard, Justin N, Kaizerman, Jacob, Keegan, Kathleen S, Li, Cong, Li, Kexue, Li, Yunxiao, Liang, Lingming, Liu, Wen, Lively, Sarah E, Lo, Mei-Chu, Ma, Ji, McMinn, Dustin L, Mihalic, Jeffrey T, Modi, Kriti, Ngo, Rachel, Pattabiraman, Kanaka, Piper, Derek E, Queva, Christophe, Ragains, Mark L, Suchomel, Julia, Thibault, Steve, Walker, Nigel, Wang, Xiaodong, Wang, Zhulun, Wanska, Malgorzata, Wehn, Paul M, Weidner, Margaret F, Zhang, Alex J, Zhao, Xiaoning, Kamb, Alexander, Wickramasinghe, Dineli, Dai, Kang, McGee, Lawrence R, Medina, Julio C
Published in Journal of medicinal chemistry (24.04.2014)
Published in Journal of medicinal chemistry (24.04.2014)
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Journal Article
SAR and Mode of Action of Novel Non-Nucleoside Inhibitors of Hepatitis C NS5b RNA Polymerase
Powers, Jay P, Piper, Derek E, Li, Yang, Mayorga, Veronica, Anzola, John, Chen, James M, Jaen, Juan C, Lee, Gary, Liu, Jinqian, Peterson, M. Greg, Tonn, George R, Ye, Qiuping, Walker, Nigel P. C, Wang, Zhulun
Published in Journal of medicinal chemistry (09.02.2006)
Published in Journal of medicinal chemistry (09.02.2006)
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Journal Article
BacMam production of active recombinant lecithin–cholesterol acyltransferase: Expression, purification and characterization
Romanow, William G., Piper, Derek E., Fordstrom, Preston, Thibault, Stephen, Zhou, Mingyue, Walker, Nigel P.C.
Published in Protein expression and purification (01.09.2016)
Published in Protein expression and purification (01.09.2016)
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Journal Article
Novel Inhibitors of Hepatitis C Virus RNA-dependent RNA Polymerases
Lee, Gary, Piper, Derek E., Wang, Zhulun, Anzola, John, Powers, Jay, Walker, Nigel, Li, Yang
Published in Journal of molecular biology (07.04.2006)
Published in Journal of molecular biology (07.04.2006)
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Journal Article
Structure of a HoxB1–Pbx1 Heterodimer Bound to DNA
Piper, Derek E., Batchelor, Adrian H., Chang, Ching-Pin, Cleary, Michael L., Wolberger, Cynthia
Published in Cell (01.02.1999)
Published in Cell (01.02.1999)
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Journal Article
The Structure of GABPα/β: An ETS Domain-Ankyrin Repeat Heterodimer Bound to DNA
Batchelor, Adrian H., Piper, Derek E., de la Brousse, Fabienne Charles, McKnight, Steven L., Wolberger, Cynthia
Published in Science (American Association for the Advancement of Science) (13.02.1998)
Published in Science (American Association for the Advancement of Science) (13.02.1998)
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Journal Article
ASGR INHIBITORS FOR REDUZING CHOLESTEROL LEVELS
ZHANG, Jun, NIOI, Paul, MURAWSKY, Christopher, GARCES, Fernando, LI, Yang, CHAN, Brian, Mingtung, PIPER, Derek, E, COWARD, Peter
Year of Publication 25.09.2024
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Year of Publication 25.09.2024
Patent
ASGR inhibitors
Li, Yang, Piper, Derek E, Chan, Brian Mingtung, Nioi, Paul, Murawsky, Christopher, Zhang, Jun, Coward, Peter, Garces, Fernando
Year of Publication 04.07.2024
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Year of Publication 04.07.2024
Patent