Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability
Clark, Charles G., Rossi, Karen A., Corte, James R., Fang, Tianan, Smallheer, Joanne M., De Lucca, Indawati, Nirschl, David S., Orwat, Michael J., Pinto, Donald J.P., Hu, Zilun, Wang, Yufeng, Yang, Wu, Jeon, Yoon, Ewing, William R., Myers, Joseph E., Sheriff, Steven, Lou, Zhen, Bozarth, Jeffrey M., Wu, Yiming, Rendina, Alan, Harper, Timothy, Zheng, Joanna, Xin, Baomin, Xiang, Qian, Luettgen, Joseph M., Seiffert, Dietmar A., Wexler, Ruth R., Lam, Patrick Y.S.
Published in Bioorganic & medicinal chemistry letters (01.10.2019)
Published in Bioorganic & medicinal chemistry letters (01.10.2019)
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Journal Article
DIHYDROPYRIDONE AS FACTOR XIA INHIBITORS
YANG, Wu, WANG, Yufeng, GILLIGAN, Paul J, CORTE, James R, PINTO, Donald J.P. Pinto, EWING, William R
Year of Publication 28.07.2017
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Year of Publication 28.07.2017
Patent
DIHYDROPYRIDONE AS FACTOR XIA INHIBITORS
GILLIGAN, PAUL J, CORTE, JAMES R, EWING, WILLIAM R, YANG, WU, WANG, YUFENG, PINTO, DONALD J.P. PINTO
Year of Publication 30.06.2017
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Year of Publication 30.06.2017
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DIHYDROPYRIDONE AS FACTOR XIA INHIBITORS
WANG YUFENG, PINTO DONALD J.P. PINTO, EWING WILLIAM R, YANG WU, CORTE JAMES R, GILLIGAN PAUL J
Year of Publication 31.05.2017
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Year of Publication 31.05.2017
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DIHYDROPYRIDONE AS FACTOR XIA INHIBITORS
WANG Yufeng, YANG Wu, GILLIGAN Paul J, PINTO Donald J.P. Pinto, CORTE James R, EWING William R
Year of Publication 31.01.2017
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Year of Publication 31.01.2017
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DIHYDROPYRIDON SOM FAKTOR-XIA-HÆMMERE
YANG, Wu, WANG, Yufeng, GILLIGAN, Paul J, CORTE, James R, PINTO, Donald J.P. Pinto, EWING, William R
Year of Publication 30.01.2017
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Year of Publication 30.01.2017
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DIHYDROPYRIDONE AS FACTOR XIa INHIBITORS
YANG, Wu, WANG, Yufeng, GILLIGAN, Paul J, CORTE, James R, PINTO, Donald J.P. Pinto, EWING, William R
Year of Publication 12.12.2016
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Year of Publication 12.12.2016
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DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
Ewing, William R, Wang, Yufeng, Pinto, Donald J.P. Pinto, Gilligan, Paul J, Corte, James R, Yang, Wu
Year of Publication 02.12.2016
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Year of Publication 02.12.2016
Patent
DIHYDROPYRIDONE AS FACTOR XIA INHIBITORS
GILLIGAN, PAUL J, CORTE, JAMES R, EWING, WILLIAM R, YANG, WU, WANG, YUFENG, PINTO, DONALD J.P. PINTO
Year of Publication 12.10.2016
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Year of Publication 12.10.2016
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Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group
Corte, James R., Fang, Tianan, Pinto, Donald J.P., Orwat, Michael J., Rendina, Alan R., Luettgen, Joseph M., Rossi, Karen A., Wei, Anzhi, Ramamurthy, Vidhyashankar, Myers, Joseph E., Sheriff, Steven, Narayanan, Rangaraj, Harper, Timothy W., Zheng, Joanna J., Li, Yi-Xin, Seiffert, Dietmar A., Wexler, Ruth R., Quan, Mimi L.
Published in Bioorganic & medicinal chemistry (15.05.2016)
Published in Bioorganic & medicinal chemistry (15.05.2016)
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Journal Article
Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties
Pinto, Donald J.P., Smallheer, Joanne M., Corte, James R., Austin, Erin J.D., Wang, Cailan, Fang, Tianan, Smith, Leon M., Rossi, Karen A., Rendina, Alan R., Bozarth, Jeffrey M., Zhang, Ge, Wei, Anzhi, Ramamurthy, Vidhyashankar, Sheriff, Steven, Myers, Joseph E., Morin, Paul E., Luettgen, Joseph M., Seiffert, Dietmar A., Quan, Mimi L., Wexler, Ruth R.
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
Published in Bioorganic & medicinal chemistry letters (01.04.2015)
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DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
Ewing, William R, Dilger, Andrew K, Pabbisetty, Kumar B, Wang, Yufeng, Smith, Leon M, Fang, Tianan, Pinto, Donald J.P. Pinto, Gilligan, Paul J, Corte, James R, Yang, Wu
Year of Publication 02.06.2017
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Year of Publication 02.06.2017
Patent
Novel phenylalanine derived diamides as Factor XIa inhibitors
Smith, Leon M., Orwat, Michael J., Hu, Zilun, Han, Wei, Wang, Cailan, Rossi, Karen A., Gilligan, Paul J., Pabbisetty, Kumar B., Osuna, Honey, Corte, James R., Rendina, Alan R., Luettgen, Joseph M., Wong, Pancras C., Narayanan, Ranga, Harper, Timothy W., Bozarth, Jeffrey M., Crain, Earl J., Wei, Anzhi, Ramamurthy, Vidhyashankar, Morin, Paul E., Xin, Baomin, Zheng, Joanna, Seiffert, Dietmar A., Quan, Mimi L., Lam, Patrick Y.S., Wexler, Ruth R., Pinto, Donald J.P.
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
Published in Bioorganic & medicinal chemistry letters (15.01.2016)
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Journal Article
DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
GILLIGAN, Paul, J, PINTO, Donald, J.P., Pinto, YANG, Wu, CORTE, James, R, SMITH II, Leon, M, PABBISETTY, Kumar, B, EWING, William, R, WANG, Yufeng, FANG, Tianan, DILGER, Andrew, K
Year of Publication 30.10.2017
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Year of Publication 30.10.2017
Patent
DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
FANG, TIANAN, PINTO, DONALD, J.P., PINTO, EWING, WILLIAM, R, SMITH II, LEON, M, CORTE, JAMES, R, PABBISETTY, KUMAR, B, DILGER, ANDREW, K, GILLIGAN, PAUL, J, YANG, WU, WANG, YUFENG
Year of Publication 29.09.2017
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Year of Publication 29.09.2017
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DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
PABBISETTY KUMAR B, SMITH II LEON M, WANG YUFENG, FANG TIANAN, PINTO DONALD J.P. PINTO, DILGER ANDREW K, EWING WILLIAM R, YANG WU, CORTE JAMES R, GILLIGAN PAUL J
Year of Publication 31.08.2017
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Year of Publication 31.08.2017
Patent
DIHYDROPYRIDONE AS FACTOR XIA INHIBITORS
GILLIGAN, PAUL J, CORTE, JAMES R, EWING, WILLIAM R, YANG, WU, WANG, YUFENG, PINTO, DONALD J.P. PINTO
Year of Publication 17.06.2015
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Year of Publication 17.06.2015
Patent
DIHYDROPYRIDON-P1 SOM FAKTOR XIA-HÆMMERE
GILLIGAN, Paul, J, PINTO, Donald, J.P., Pinto, YANG, Wu, CORTE, James, R, SMITH II, Leon, M, PABBISETTY, Kumar, B, EWING, William, R, WANG, Yufeng, FANG, Tianan, DILGER, Andrew, K
Year of Publication 06.06.2017
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Year of Publication 06.06.2017
Patent
DIHYDROPYRIDONE P1 AS FACTOR XIA INHIBITORS
GILLIGAN, PAUL J, CORTE, JAMES R, EWING, WILLIAM R, YANG, WU, WANG, YUFENG, PINTO, DONALD J.P. PINTO
Year of Publication 30.03.2015
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Year of Publication 30.03.2015
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Dihydropyridone P1 as factor XIa inhibitors
GILLIGAN, PAUL J, CORTE, JAMES R, EWING, WILLIAM R, YANG, WU, WANG, YUFENG, PINTO, DONALD J.P. PINTO
Year of Publication 19.03.2015
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Year of Publication 19.03.2015
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