Inhibition of tissue‐nonspecific alkaline phosphatase protects against medial arterial calcification and improves survival probability in the CKD‐MBD mouse model
Tani, Takashi, Fujiwara, Megumi, Orimo, Hideo, Shimizu, Akira, Narisawa, Sonoko, Pinkerton, Anthony B, Millán, José Luis, Tsuruoka, Shuichi
Published in The Journal of pathology (01.01.2020)
Published in The Journal of pathology (01.01.2020)
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Aberrant Lipid Metabolism in Anaplastic Thyroid Carcinoma Reveals Stearoyl CoA Desaturase 1 as a Novel Therapeutic Target
von Roemeling, Christina A, Marlow, Laura A, Pinkerton, Anthony B, Crist, Angela, Miller, James, Tun, Han W, Smallridge, Robert C, Copland, John A
Published in The journal of clinical endocrinology and metabolism (01.05.2015)
Published in The journal of clinical endocrinology and metabolism (01.05.2015)
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Boosting NAD+ with a small molecule that activates NAMPT
Gardell, Stephen J., Hopf, Meghan, Khan, Asima, Dispagna, Mauro, Hampton Sessions, E., Falter, Rebecca, Kapoor, Nidhi, Brooks, Jeanne, Culver, Jeffrey, Petucci, Chris, Ma, Chen-Ting, Cohen, Steven E., Tanaka, Jun, Burgos, Emmanuel S., Hirschi, Jennifer S., Smith, Steven R., Sergienko, Eduard, Pinkerton, Anthony B.
Published in Nature communications (19.07.2019)
Published in Nature communications (19.07.2019)
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Pathophysiological Role of Vascular Smooth Muscle Alkaline Phosphatase in Medial Artery Calcification
Sheen, Campbell R, Kuss, Pia, Narisawa, Sonoko, Yadav, Manisha C, Nigro, Jessica, Wang, Wei, Chhea, T Nicole, Sergienko, Eduard A, Kapoor, Kapil, Jackson, Michael R, Hoylaerts, Marc F, Pinkerton, Anthony B, O'Neill, W Charles, Millán, José Luis
Published in Journal of bone and mineral research (01.05.2015)
Published in Journal of bone and mineral research (01.05.2015)
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Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists
Shiryaev, Sergey A., Farhy, Chen, Pinto, Antonella, Huang, Chun-Teng, Simonetti, Nicole, Ngono, Annie Elong, Dewing, Antimone, Shresta, Sujan, Pinkerton, Anthony B., Cieplak, Piotr, Strongin, Alex Y., Terskikh, Alexey V.
Published in Antiviral research (01.07.2017)
Published in Antiviral research (01.07.2017)
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β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors
Slosky, Lauren M., Bai, Yushi, Toth, Krisztian, Ray, Caroline, Rochelle, Lauren K., Badea, Alexandra, Chandrasekhar, Rahul, Pogorelov, Vladimir M., Abraham, Dennis M., Atluri, Namratha, Peddibhotla, Satyamaheshwar, Hedrick, Michael P., Hershberger, Paul, Maloney, Patrick, Yuan, Hong, Li, Zibo, Wetsel, William C., Pinkerton, Anthony B., Barak, Lawrence S., Caron, Marc G.
Published in Cell (11.06.2020)
Published in Cell (11.06.2020)
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Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11
Li, Jing, Yakushi, Tanya, Parlati, Francesco, Mackinnon, Andrew L, Perez, Christian, Ma, Yuyong, Carter, Kyle P, Colayco, Sharon, Magnuson, Gavin, Brown, Brock, Nguyen, Kevin, Vasile, Stefan, Suyama, Eigo, Smith, Layton H, Sergienko, Eduard, Pinkerton, Anthony B, Chung, Thomas D Y, Palmer, Amy E, Pass, Ian, Hess, Sonja, Cohen, Seth M, Deshaies, Raymond J
Published in Nature chemical biology (01.05.2017)
Published in Nature chemical biology (01.05.2017)
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Discovery of DS68702229 as a Potent, Orally Available NAMPT (Nicotinamide Phosphoribosyltransferase) Activator
Akiu, Mayuko, Tsuji, Takashi, Iida, Kouki, Sogawa, Yoshitaka, Terayama, Koji, Yokoyama, Mika, Tanaka, Jun, Asano, Daigo, Honda, Tomohiro, Sakurai, Ken, Pinkerton, Anthony B., Nakamura, Tsuyoshi
Published in Chemical & pharmaceutical bulletin (01.11.2021)
Published in Chemical & pharmaceutical bulletin (01.11.2021)
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Journal Article
Pharmacological TNAP inhibition efficiently inhibits arterial media calcification in a warfarin rat model but deserves careful consideration of potential physiological bone formation/mineralization impairment
Opdebeeck, Britt, Neven, Ellen, Millán, José Luis, Pinkerton, Anthony B., D'Haese, Patrick C., Verhulst, Anja
Published in Bone (New York, N.Y.) (01.08.2020)
Published in Bone (New York, N.Y.) (01.08.2020)
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Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia
Romanelli, Filippo, Corbo, AnthonyMarco, Salehi, Maryam, Yadav, Manisha C, Salman, Soha, Petrosian, David, Rashidbaigi, Omid J, Chait, Jesse, Kuruvilla, Jes, Plummer, Maria, Radichev, Ilian, Margulies, Kenneth B, Gerdes, A Martin, Pinkerton, Anthony B, Millán, José Luis, Savinov, Alexei Y, Savinova, Olga V
Published in PloS one (12.10.2017)
Published in PloS one (12.10.2017)
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Journal Article
Inhibition of Tissue-Nonspecific Alkaline Phosphatase Attenuates Ectopic Mineralization in the Abcc6–/– Mouse Model of PXE but Not in the Enpp1 Mutant Mouse Models of GACI
Li, Qiaoli, Huang, Jianhe, Pinkerton, Anthony B., Millan, Jose Luis, van Zelst, Bertrand D., Levine, Michael A., Sundberg, John P., Uitto, Jouni
Published in Journal of investigative dermatology (01.02.2019)
Published in Journal of investigative dermatology (01.02.2019)
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Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase
Ziegler, Shira G, Ferreira, Carlos R, MacFarlane, Elena Gallo, Riddle, Ryan C, Tomlinson, Ryan E, Chew, Emily Y, Martin, Ludovic, Ma, Chen-Ting, Sergienko, Eduard, Pinkerton, Anthony B, Millán, José Luis, Gahl, William A, Dietz, Harry C
Published in Science translational medicine (07.06.2017)
Published in Science translational medicine (07.06.2017)
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Targeting tumor phenotypic plasticity and metabolic remodeling in adaptive cross-drug tolerance
Goldman, Aaron, Khiste, Sachin, Freinkman, Elizaveta, Dhawan, Andrew, Majumder, Biswanath, Mondal, Jayanta, Pinkerton, Anthony B, Eton, Elliot, Medhi, Ragini, Chandrasekar, Vineethkrishna, Rahman, M Mamunur, Ichimura, Takaharu, Gopinath, Kodaganur S, Majumder, Pradip, Kohandel, Mohammad, Sengupta, Shiladitya
Published in Science signaling (20.08.2019)
Published in Science signaling (20.08.2019)
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Neurotensin receptor 1-biased ligand attenuates neurotensin-mediated excitation of ventral tegmental area dopamine neurons and dopamine release in the nucleus accumbens
Singhal, Sarthak M., Zell, Vivien, Faget, Lauren, Slosky, Lauren M., Barak, Lawrence S., Caron, Marc G., Pinkerton, Anthony B., Hnasko, Thomas S.
Published in Neuropharmacology (15.08.2023)
Published in Neuropharmacology (15.08.2023)
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Neurotensin Receptor Allosterism Revealed in Complex with a Biased Allosteric Modulator
Krumm, Brian E., DiBerto, Jeffrey F., Olsen, Reid H. J., Kang, Hye Jin, Slocum, Samuel T., Zhang, Shicheng, Strachan, Ryan T., Huang, Xi-Ping, Slosky, Lauren M., Pinkerton, Anthony B., Barak, Lawrence S., Caron, Marc G., Kenakin, Terry, Fay, Jonathan F., Roth, Bryan L.
Published in Biochemistry (Easton) (04.04.2023)
Published in Biochemistry (Easton) (04.04.2023)
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Discovery of 1-[2-(1-methyl-1H-pyrazol-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-6-yl]-3-(pyridin-4-ylmethyl)urea as a potent NAMPT (nicotinamide phosphoribosyltransferase) activator with attenuated CYP inhibition
Akiu, Mayuko, Tsuji, Takashi, Sogawa, Yoshitaka, Terayama, Koji, Yokoyama, Mika, Tanaka, Jun, Asano, Daigo, Sakurai, Ken, Sergienko, Eduard, Sessions, E. Hampton, Gardell, Stephen J., Pinkerton, Anthony B., Nakamura, Tsuyoshi
Published in Bioorganic & medicinal chemistry letters (01.07.2021)
Published in Bioorganic & medicinal chemistry letters (01.07.2021)
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Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor
Pinkerton, Anthony B., Sergienko, Eduard, Bravo, Yalda, Dahl, Russell, Ma, Chen-Ting, Sun, Qing, Jackson, Michael R., Cosford, Nicholas D.P., Millán, José Luis
Published in Bioorganic & medicinal chemistry letters (01.01.2018)
Published in Bioorganic & medicinal chemistry letters (01.01.2018)
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Journal Article
Optimization of a urea-containing series of nicotinamide phosphoribosyltransferase (NAMPT) activators
Pinkerton, Anthony B., Sessions, E. Hampton, Hershberger, Paul, Maloney, Patrick R., Peddibhotla, Satyamaheshwar, Hopf, Meghan, Sergienko, Eduard, Ma, Chen-Ting, Smith, Layton H., Jackson, Michael R., Tanaka, Jun, Tsuji, Takashi, Akiu, Mayuko, Cohen, Steven E., Nakamura, Tsuyoshi, Gardell, Stephen J.
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
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Repurposing antimalarial aminoquinolines and related compounds for treatment of retinal neovascularization
McAnally, Danielle, Siddiquee, Khandaker, Gomaa, Ahmed, Szabo, Andras, Vasile, Stefan, Maloney, Patrick R, Divlianska, Daniela B, Peddibhotla, Satyamaheshwar, Morfa, Camilo J, Hershberger, Paul, Falter, Rebecca, Williamson, Robert, Terry, David B, Farjo, Rafal, Pinkerton, Anthony B, Qi, Xiaping, Quigley, Judith, Boulton, Michael E, Grant, Maria B, Smith, Layton H
Published in PloS one (12.09.2018)
Published in PloS one (12.09.2018)
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The Compound SBI-0090799 Inhibits Zika Virus Infection by Blocking De Novo Formation of the Membranous Replication Compartment
Riva, Laura, Goellner, Sarah, Biering, Scott B, Huang, Chun-Teng, Rubanov, Andrey N, Haselmann, Uta, Warnes, Colin M, De Jesus, Paul D, Martin-Sancho, Laura, Terskikh, Alexey V, Harris, Eva, Pinkerton, Anthony B, Bartenschlager, Ralf, Chanda, Sumit K
Published in Journal of virology (27.10.2021)
Published in Journal of virology (27.10.2021)
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