Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer
Wong, Marie, Mayoh, Chelsea, Lau, Loretta M. S., Khuong-Quang, Dong-Anh, Pinese, Mark, Kumar, Amit, Barahona, Paulette, Wilkie, Emilie E., Sullivan, Patricia, Bowen-James, Rachel, Syed, Mustafa, Martincorena, Iñigo, Abascal, Federico, Sherstyuk, Alexandra, Bolanos, Noemi A., Baber, Jonathan, Priestley, Peter, Dolman, M. Emmy M., Fleuren, Emmy D. G., Gauthier, Marie-Emilie, Mould, Emily V. A., Gayevskiy, Velimir, Gifford, Andrew J., Grebert-Wade, Dylan, Strong, Patrick A., Manouvrier, Elodie, Warby, Meera, Thomas, David M., Kirk, Judy, Tucker, Katherine, O’Brien, Tracey, Alvaro, Frank, McCowage, Geoffry B., Dalla-Pozza, Luciano, Gottardo, Nicholas G., Tapp, Heather, Wood, Paul, Khaw, Seong-Lin, Hansford, Jordan R., Moore, Andrew S., Norris, Murray D., Trahair, Toby N., Lock, Richard B., Tyrrell, Vanessa, Haber, Michelle, Marshall, Glenn M., Ziegler, David S., Ekert, Paul G., Cowley, Mark J.
Published in Nature medicine (01.11.2020)
Published in Nature medicine (01.11.2020)
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Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis
Vennin, Claire, Chin, Venessa T, Warren, Sean C, Lucas, Morghan C, Herrmann, David, Magenau, Astrid, Melenec, Pauline, Walters, Stacey N, Del Monte-Nieto, Gonzalo, Conway, James R W, Nobis, Max, Allam, Amr H, McCloy, Rachael A, Currey, Nicola, Pinese, Mark, Boulghourjian, Alice, Zaratzian, Anaiis, Adam, Arne A S, Heu, Celine, Nagrial, Adnan M, Chou, Angela, Steinmann, Angela, Drury, Alison, Froio, Danielle, Giry-Laterriere, Marc, Harris, Nathanial L E, Phan, Tri, Jain, Rohit, Weninger, Wolfgang, McGhee, Ewan J, Whan, Renee, Johns, Amber L, Samra, Jaswinder S, Chantrill, Lorraine, Gill, Anthony J, Kohonen-Corish, Maija, Harvey, Richard P, Biankin, Andrew V, Evans, T R Jeffry, Anderson, Kurt I, Grey, Shane T, Ormandy, Christopher J, Gallego-Ortega, David, Wang, Yingxiao, Samuel, Michael S, Sansom, Owen J, Burgess, Andrew, Cox, Thomas R, Morton, Jennifer P, Pajic, Marina, Timpson, Paul
Published in Science translational medicine (05.04.2017)
Published in Science translational medicine (05.04.2017)
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Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma
Ziegler, David S., Wong, Marie, Mayoh, Chelsea, Kumar, Amit, Tsoli, Maria, Mould, Emily, Tyrrell, Vanessa, Khuong-Quang, Dong-Anh, Pinese, Mark, Gayevskiy, Velimir, Cohn, Richard J., Lau, Loretta M. S., Reynolds, Mark, Cox, Michael C., Gifford, Andrew, Rodriguez, Michael, Cowley, Mark J., Ekert, Paul G., Marshall, Glenn M., Haber, Michelle
Published in British journal of cancer (11.09.2018)
Published in British journal of cancer (11.09.2018)
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Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer
Chou, Angela, Froio, Danielle, Nagrial, Adnan M, Parkin, Ashleigh, Murphy, Kendelle J, Chin, Venessa T, Wohl, Dalia, Steinmann, Angela, Stark, Rhys, Drury, Alison, Walters, Stacey N, Vennin, Claire, Burgess, Andrew, Pinese, Mark, Chantrill, Lorraine A, Cowley, Mark J, Molloy, Timothy J, Waddell, Nicola, Johns, Amber, Grimmond, Sean M, Chang, David K, Biankin, Andrew V, Sansom, Owen J, Morton, Jennifer P, Grey, Shane T, Cox, Thomas R, Turchini, John, Samra, Jaswinder, Clarke, Stephen J, Timpson, Paul, Gill, Anthony J, Pajic, Marina
Published in Gut (01.12.2018)
Published in Gut (01.12.2018)
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Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy
Miller, Bryan W, Morton, Jennifer P, Pinese, Mark, Saturno, Grazia, Jamieson, Nigel B, McGhee, Ewan, Timpson, Paul, Leach, Joshua, McGarry, Lynn, Shanks, Emma, Bailey, Peter, Chang, David, Oien, Karin, Karim, Saadia, Au, Amy, Steele, Colin, Carter, Christopher Ross, McKay, Colin, Anderson, Kurt, Evans, Thomas R Jeffry, Marais, Richard, Springer, Caroline, Biankin, Andrew, Erler, Janine T, Sansom, Owen J
Published in EMBO molecular medicine (01.08.2015)
Published in EMBO molecular medicine (01.08.2015)
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Genome‐wide DNA methylation patterns in pancreatic ductal adenocarcinoma reveal epigenetic deregulation of SLIT‐ROBO, ITGA2 and MET signaling
Nones, Katia, Waddell, Nic, Song, Sarah, Patch, Ann‐Marie, Miller, David, Johns, Amber, Wu, Jianmin, Kassahn, Karin S., Wood, David, Bailey, Peter, Fink, Lynn, Manning, Suzanne, Christ, Angelika N., Nourse, Craig, Kazakoff, Stephen, Taylor, Darrin, Leonard, Conrad, Chang, David K., Jones, Marc D., Thomas, Michelle, Watson, Clare, Pinese, Mark, Cowley, Mark, Rooman, Ilse, Pajic, Marina, Butturini, Giovanni, Malpaga, Anna, Corbo, Vincenzo, Crippa, Stefano, Falconi, Massimo, Zamboni, Giuseppe, Castelli, Paola, Lawlor, Rita T., Gill, Anthony J., Scarpa, Aldo, Pearson, John V., Biankin, Andrew V., Grimmond, Sean M.
Published in International journal of cancer (01.09.2014)
Published in International journal of cancer (01.09.2014)
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ClinSV: clinical grade structural and copy number variant detection from whole genome sequencing data
Minoche, Andre E, Lundie, Ben, Peters, Greg B, Ohnesorg, Thomas, Pinese, Mark, Thomas, David M, Zankl, Andreas, Roscioli, Tony, Schonrock, Nicole, Kummerfeld, Sarah, Burnett, Leslie, Dinger, Marcel E, Cowley, Mark J
Published in Genome medicine (25.02.2021)
Published in Genome medicine (25.02.2021)
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The Medical Genome Reference Bank contains whole genome and phenotype data of 2570 healthy elderly
Pinese, Mark, Lacaze, Paul, Rath, Emma M., Stone, Andrew, Brion, Marie-Jo, Ameur, Adam, Nagpal, Sini, Puttick, Clare, Husson, Shane, Degrave, Dmitry, Cristina, Tina Navin, Kahl, Vivian F. S., Statham, Aaron L., Woods, Robyn L., McNeil, John J., Riaz, Moeen, Barr, Margo, Nelson, Mark R., Reid, Christopher M., Murray, Anne M., Shah, Raj C., Wolfe, Rory, Atkins, Joshua R., Fitzsimmons, Chantel, Cairns, Heath M., Green, Melissa J., Carr, Vaughan J., Cowley, Mark J., Pickett, Hilda A., James, Paul A., Powell, Joseph E., Kaplan, Warren, Gibson, Greg, Gyllensten, Ulf, Cairns, Murray J., McNamara, Martin, Dinger, Marcel E., Thomas, David M.
Published in Nature communications (23.01.2020)
Published in Nature communications (23.01.2020)
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Introme accurately predicts the impact of coding and noncoding variants on gene splicing, with clinical applications
Sullivan, Patricia J, Gayevskiy, Velimir, Davis, Ryan L, Wong, Marie, Mayoh, Chelsea, Mallawaarachchi, Amali, Hort, Yvonne, McCabe, Mark J, Beecroft, Sarah, Jackson, Matilda R, Arts, Peer, Dubowsky, Andrew, Laing, Nigel, Dinger, Marcel E, Scott, Hamish S, Oates, Emily, Pinese, Mark, Cowley, Mark J
Published in Genome Biology (17.05.2023)
Published in Genome Biology (17.05.2023)
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Histomolecular Phenotypes and Outcome in Adenocarcinoma of the Ampulla of Vater
CHANG, David K, JAMIESON, Nigel B, NAGRIAL, Adnan M, CHANTRILL, Lorraine A, CHIN, Venessa T, PINHO, Andreia V, ROOMAN, Ilse, COWLEY, Mark J, JIANMIN WU, MEAD, R. Scott, COLVIN, Emily K, SAMRA, Jaswinder S, JOHNS, Amber L, CORBO, Vincenzo, BASSI, Claudio, FALCONI, Massimo, LAWLOR, Rita T, CRIPPA, Stefano, SPERANDIO, Nicola, BERSANI, Samantha, DICKSON, Euan J, MOHAMED, Mohamed A. A, OIEN, Karin A, SCARLETT, Christopher J, FOULIS, Alan K, MUSGROVE, Elizabeth A, SUTHERLAND, Robert L, KENCH, James G, CARTER, C. Ross, GILL, Anthony J, SCARPA, Aldo, MCKAY, Colin J, BIANKIN, Andrew V, PAJIC, Marina, CHOU, Angela, PINESE, Mark, HUMPHRIS, Jeremy L, JONES, Marc D, TOON, Christopher
Published in Journal of clinical oncology (01.04.2013)
Published in Journal of clinical oncology (01.04.2013)
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Intravital Imaging to Monitor Therapeutic Response in Moving Hypoxic Regions Resistant to PI3K Pathway Targeting in Pancreatic Cancer
Conway, James R.W., Warren, Sean C., Herrmann, David, Murphy, Kendelle J., Cazet, Aurélie S., Vennin, Claire, Shearer, Robert F., Killen, Monica J., Magenau, Astrid, Mélénec, Pauline, Pinese, Mark, Nobis, Max, Zaratzian, Anaiis, Boulghourjian, Alice, Da Silva, Andrew M., del Monte-Nieto, Gonzalo, Adam, Arne S.A., Harvey, Richard P., Haigh, Jody J., Wang, Yingxiao, Croucher, David R., Sansom, Owen J., Pajic, Marina, Caldon, C. Elizabeth, Morton, Jennifer P., Timpson, Paul
Published in Cell reports (Cambridge) (12.06.2018)
Published in Cell reports (Cambridge) (12.06.2018)
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Adar3 Is Involved in Learning and Memory in Mice
Mladenova, Dessislava, Barry, Guy, Konen, Lyndsey M, Pineda, Sandy S, Guennewig, Boris, Avesson, Lotta, Zinn, Raphael, Schonrock, Nicole, Bitar, Maina, Jonkhout, Nicky, Crumlish, Lauren, Kaczorowski, Dominik C, Gong, Andrew, Pinese, Mark, Franco, Gloria R, Walkley, Carl R, Vissel, Bryce, Mattick, John S
Published in Frontiers in neuroscience (13.04.2018)
Published in Frontiers in neuroscience (13.04.2018)
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Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells
HOCHGRÄFE, Falko, LUXI ZHANG, SHEARER, Robert, NAIR, Radhika, SWARBRICK, Alexander, FARATIAN, Dana, MULLEN, Peter, HARRISON, David J, BIANKIN, Andrew V, SUTHERLAND, Robert L, RAFTERY, Mark J, DALY, Roger J, O'TOOLE, Sandra A, BROWNE, Brigid C, PINESE, Mark, PORTA CUBAS, Ana, LEHRBACH, Gillian M, CROUCHER, David R, RICKWOOD, Danny, BOULGHOURJIAN, Alice
Published in Cancer research (Chicago, Ill.) (15.11.2010)
Published in Cancer research (Chicago, Ill.) (15.11.2010)
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The pseudokinase SgK223 promotes invasion of pancreatic ductal epithelial cells through JAK1/Stat3 signaling
Tactacan, Carole M, Phua, Yu Wei, Liu, Ling, Zhang, Luxi, Humphrey, Emily S, Cowley, Mark, Pinese, Mark, Biankin, Andrew V, Daly, Roger J
Published in Molecular cancer (29.07.2015)
Published in Molecular cancer (29.07.2015)
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qpure: A tool to estimate tumor cellularity from genome-wide single-nucleotide polymorphism profiles
Song, Sarah, Nones, Katia, Miller, David, Harliwong, Ivon, Kassahn, Karin S, Pinese, Mark, Pajic, Marina, Gill, Anthony J, Johns, Amber L, Anderson, Matthew, Holmes, Oliver, Leonard, Conrad, Taylor, Darrin, Wood, Scott, Xu, Qinying, Newell, Felicity, Cowley, Mark J, Wu, Jianmin, Wilson, Peter, Fink, Lynn, Biankin, Andrew V, Waddell, Nic, Grimmond, Sean M, Pearson, John V
Published in PloS one (25.09.2012)
Published in PloS one (25.09.2012)
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In vitro and in vivo drug screens of tumor cells identify novel therapies for high‐risk child cancer
Lau, Loretta M S, Mayoh, Chelsea, Xie, Jinhan, Barahona, Paulette, MacKenzie, Karen L, Wong, Marie, Kamili, Alvin, Tsoli, Maria, Failes, Tim W, Kumar, Amit, Mould, Emily V A, Gifford, Andrew, Chow, Shu‐Oi, Pinese, Mark, Fletcher, Jamie I, Arndt, Greg M, Khuong‐Quang, Dong‐Anh, Wadham, Carol, Batey, Daniel, Eden, Georgina, Trebilcock, Peter, Joshi, Swapna, Alfred, Stephanie, Gopalakrishnan, Anjana, Khan, Aaminah, Grebert Wade, Dylan, Strong, Patrick A, Manouvrier, Elodie, Morgan, Lisa T, Span, Miriam, Lim, Jin Yi, Cadiz, Roxanne, Ung, Caitlin, Thomas, David M, Tucker, Katherine M, Warby, Meera, McCowage, Geoffrey B, Dalla‐Pozza, Luciano, Byrne, Jennifer A, Saletta, Federica, Fellowes, Andrew, Fox, Stephen B, Norris, Murray D, Tyrrell, Vanessa, Trahair, Toby N, Lock, Richard B, Cowley, Mark J, Ekert, Paul G, Haber, Michelle, Ziegler, David S, Marshall, Glenn M
Published in EMBO molecular medicine (07.04.2022)
Published in EMBO molecular medicine (07.04.2022)
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Clinical and Pathologic Features of Familial Pancreatic Cancer
HUMPHRIS, Jeremy L, JOHNS, Amber L, SCOTT MEAD, R, GILL, Anthony J, SAMRA, Jaswinder S, KENCH, James G, MUSGROVE, Elizabeth A, TUCKER, Katherine M, SPIGELMAN, Allan D, WADDELL, Nic, GRIMMOND, Sean M, BIANKIN, Andrew V, SIMPSON, Skye H, COWLEY, Mark J, PAJIC, Marina, CHANG, David K, NAGRIAL, Adnan M, CHIN, Venessa T, CHANTRILL, Lorraine A, PINESE, Mark
Published in Cancer (01.12.2014)
Published in Cancer (01.12.2014)
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Somatic point mutation calling in low cellularity tumors
Kassahn, Karin S, Holmes, Oliver, Nones, Katia, Patch, Ann-Marie, Miller, David K, Christ, Angelika N, Harliwong, Ivon, Bruxner, Timothy J, Xu, Qinying, Anderson, Matthew, Wood, Scott, Leonard, Conrad, Taylor, Darrin, Newell, Felicity, Song, Sarah, Idrisoglu, Senel, Nourse, Craig, Nourbakhsh, Ehsan, Manning, Suzanne, Wani, Shivangi, Steptoe, Anita, Pajic, Marina, Cowley, Mark J, Pinese, Mark, Chang, David K, Gill, Anthony J, Johns, Amber L, Wu, Jianmin, Wilson, Peter J, Fink, Lynn, Biankin, Andrew V, Waddell, Nicola, Grimmond, Sean M, Pearson, John V
Published in PloS one (08.11.2013)
Published in PloS one (08.11.2013)
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Protocol for a comprehensive prospective cohort study of trio-based whole-genome sequencing for underlying cancer predisposition in paediatric and adolescent patients newly diagnosed with cancer: the PREDICT study
Fuentes Bolanos, Noemi Auxiliadora, Padhye, Bhavna, Daley, Macabe, Hunter, Jacqueline, Hetherington, Kate, Warby, Meera, Courtney, Eliza, Kirk, Judy, Josephi-Taylor, Sarah, Chen, Yuyan, Alvaro, Frank, Barlow-Stewart, Kristine, Wong-Erasmus, Marie, Barahona, Paulette, Ajuyah, Pamela, Altekoester, Ann-Kristin, Tyrrell, Vanessa J, Lau, Loretta M S, Wakefield, Claire, Sylvester, Dianne, Tucker, Katherine, Pinese, Mark, Dalla Pozza, Luciano, O’Brien, Tracey A
Published in BMJ open (30.05.2023)
Published in BMJ open (30.05.2023)
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10. Precision Oncology in Surgery: Patient Selection Biomarkers for Operable Pancreatic Cancer
Dreyer, Stephan, Pinese, Mark, Jamieson, Nigel, Upstill-Goddard, Rosanna, Duthie, Fraser, McKay, Colin, Biankin, Andrew, Chang, David
Published in European journal of surgical oncology (01.11.2018)
Published in European journal of surgical oncology (01.11.2018)
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