Therapeutic base editing of human hematopoietic stem cells
Zeng, Jing, Wu, Yuxuan, Ren, Chunyan, Bonanno, Jasmine, Shen, Anne H, Shea, Devlin, Gehrke, Jason M, Clement, Kendell, Luk, Kevin, Yao, Qiuming, Kim, Rachel, Wolfe, Scot A, Manis, John P, Pinello, Luca, Joung, J Keith, Bauer, Daniel E
Published in Nature medicine (01.04.2020)
Published in Nature medicine (01.04.2020)
Get full text
Journal Article
CRISPResso2 provides accurate and rapid genome editing sequence analysis
Clement, Kendell, Rees, Holly, Canver, Matthew C, Gehrke, Jason M, Farouni, Rick, Hsu, Jonathan Y, Cole, Mitchel A, Liu, David R, Joung, J Keith, Bauer, Daniel E, Pinello, Luca
Published in Nature biotechnology (01.03.2019)
Published in Nature biotechnology (01.03.2019)
Get full text
Journal Article
Highly efficient therapeutic gene editing of human hematopoietic stem cells
Wu, Yuxuan, Zeng, Jing, Roscoe, Benjamin P, Liu, Pengpeng, Yao, Qiuming, Lazzarotto, Cicera R, Clement, Kendell, Cole, Mitchel A, Luk, Kevin, Baricordi, Cristina, Shen, Anne H, Ren, Chunyan, Esrick, Erica B, Manis, John P, Dorfman, David M, Williams, David A, Biffi, Alessandra, Brugnara, Carlo, Biasco, Luca, Brendel, Christian, Pinello, Luca, Tsai, Shengdar Q, Wolfe, Scot A, Bauer, Daniel E
Published in Nature medicine (01.05.2019)
Published in Nature medicine (01.05.2019)
Get full text
Journal Article
Single-cell trajectories reconstruction, exploration and mapping of omics data with STREAM
Chen, Huidong, Albergante, Luca, Hsu, Jonathan Y, Lareau, Caleb A, Lo Bosco, Giosuè, Guan, Jihong, Zhou, Shuigeng, Gorban, Alexander N, Bauer, Daniel E, Aryee, Martin J, Langenau, David M, Zinovyev, Andrei, Buenrostro, Jason D, Yuan, Guo-Cheng, Pinello, Luca
Published in Nature communications (23.04.2019)
Published in Nature communications (23.04.2019)
Get full text
Journal Article
PrimeDesign software for rapid and simplified design of prime editing guide RNAs
Hsu, Jonathan Y, Grünewald, Julian, Szalay, Regan, Shih, Justine, Anzalone, Andrew V, Lam, Kin Chung, Shen, Max W, Petri, Karl, Liu, David R, Joung, J Keith, Pinello, Luca
Published in Nature communications (15.02.2021)
Published in Nature communications (15.02.2021)
Get full text
Journal Article
Assessment of computational methods for the analysis of single-cell ATAC-seq data
Chen, Huidong, Lareau, Caleb, Andreani, Tommaso, Vinyard, Michael E, Garcia, Sara P, Clement, Kendell, Andrade-Navarro, Miguel A, Buenrostro, Jason D, Pinello, Luca
Published in Genome Biology (18.11.2019)
Published in Genome Biology (18.11.2019)
Get full text
Journal Article
Dissecting hematopoietic and renal cell heterogeneity in adult zebrafish at single-cell resolution using RNA sequencing
Tang, Qin, Iyer, Sowmya, Lobbardi, Riadh, Moore, John C, Chen, Huidong, Lareau, Caleb, Hebert, Christine, Shaw, McKenzie L, Neftel, Cyril, Suva, Mario L, Ceol, Craig J, Bernards, Andre, Aryee, Martin, Pinello, Luca, Drummond, Iain A, Langenau, David M
Published in The Journal of experimental medicine (02.10.2017)
Published in The Journal of experimental medicine (02.10.2017)
Get full text
Journal Article
Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing
Kleinstiver, Benjamin P, Sousa, Alexander A, Walton, Russell T, Tak, Y Esther, Hsu, Jonathan Y, Clement, Kendell, Welch, Moira M, Horng, Joy E, Malagon-Lopez, Jose, Scarfò, Irene, Maus, Marcela V, Pinello, Luca, Aryee, Martin J, Joung, J Keith
Published in Nature biotechnology (01.03.2019)
Published in Nature biotechnology (01.03.2019)
Get full text
Journal Article
CRISPR prime editing with ribonucleoprotein complexes in zebrafish and primary human cells
Petri, Karl, Zhang, Weiting, Ma, Junyan, Schmidts, Andrea, Lee, Hyunho, Horng, Joy E, Kim, Daniel Y, Kurt, Ibrahim C, Clement, Kendell, Hsu, Jonathan Y, Pinello, Luca, Maus, Marcela V, Joung, J Keith, Yeh, Jing-Ruey Joanna
Published in Nature biotechnology (01.02.2022)
Published in Nature biotechnology (01.02.2022)
Get full text
Journal Article
BCL11A enhancer dissection by Cas9-mediated in situ saturating mutagenesis
Canver, Matthew C, Smith, Elenoe C, Sher, Falak, Pinello, Luca, Sanjana, Neville E, Shalem, Ophir, Chen, Diane D, Schupp, Patrick G, Vinjamur, Divya S, Garcia, Sara P, Luc, Sidinh, Kurita, Ryo, Nakamura, Yukio, Fujiwara, Yuko, Maeda, Takahiro, Yuan, Guo-Cheng, Zhang, Feng, Orkin, Stuart H, Bauer, Daniel E
Published in Nature (London) (12.11.2015)
Published in Nature (London) (12.11.2015)
Get full text
Journal Article
LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing p53 Activity
Wu, Gengze, Cai, Jin, Han, Yu, Chen, Jinghai, Huang, Zhan-Peng, Chen, Caiyu, Cai, Yue, Huang, Hefei, Yang, Yujia, Liu, Yukai, Xu, Zaicheng, He, Duofen, Zhang, Xiaoqun, Hu, Xiaoyun, Pinello, Luca, Zhong, Dan, He, Fengtian, Yuan, Guo-Cheng, Wang, Da-Zhi, Zeng, Chunyu
Published in Circulation (New York, N.Y.) (21.10.2014)
Published in Circulation (New York, N.Y.) (21.10.2014)
Get full text
Journal Article
Predicting chromatin organization using histone marks
Huang, Jialiang, Marco, Eugenio, Pinello, Luca, Yuan, Guo-Cheng
Published in Genome Biology (14.08.2015)
Published in Genome Biology (14.08.2015)
Get full text
Journal Article
BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair
Hatchi, Elodie, Skourti-Stathaki, Konstantina, Ventz, Steffen, Pinello, Luca, Yen, Angela, Kamieniarz-Gdula, Kinga, Dimitrov, Stoil, Pathania, Shailja, McKinney, Kristine M., Eaton, Matthew L., Kellis, Manolis, Hill, Sarah J., Parmigiani, Giovanni, Proudfoot, Nicholas J., Livingston, David M.
Published in Molecular cell (19.02.2015)
Published in Molecular cell (19.02.2015)
Get full text
Journal Article
Three subtypes of lung cancer fibroblasts define distinct therapeutic paradigms
Hu, Haichuan, Piotrowska, Zofia, Hare, Patricia J., Chen, Huidong, Mulvey, Hillary E., Mayfield, Aislinn, Noeen, Sundus, Kattermann, Krystina, Greenberg, Max, Williams, August, Riley, Amanda K., Wilson, Jarad J., Mao, Ying-Qing, Huang, Ruo-Pan, Banwait, Mandeep K., Ho, Jeffrey, Crowther, Giovanna S., Hariri, Lida P., Heist, Rebecca S., Kodack, David P., Pinello, Luca, Shaw, Alice T., Mino-Kenudson, Mari, Hata, Aaron N., Sequist, Lecia V., Benes, Cyril H., Niederst, Matthew J., Engelman, Jeffrey A.
Published in Cancer cell (08.11.2021)
Published in Cancer cell (08.11.2021)
Get full text
Journal Article
GRAFIMO: Variant and haplotype aware motif scanning on pangenome graphs
Tognon, Manuel, Bonnici, Vincenzo, Garrison, Erik, Giugno, Rosalba, Pinello, Luca
Published in PLoS computational biology (01.09.2021)
Published in PLoS computational biology (01.09.2021)
Get full text
Journal Article
Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells
Jadhav, Unmesh, Nalapareddy, Kodandaramireddy, Saxena, Madhurima, O’Neill, Nicholas K., Pinello, Luca, Yuan, Guo-Cheng, Orkin, Stuart H., Shivdasani, Ramesh A.
Published in Cell (02.06.2016)
Published in Cell (02.06.2016)
Get full text
Journal Article
CRISPR-suppressor scanning reveals a nonenzymatic role of LSD1 in AML
Vinyard, Michael E, Su, Cindy, Siegenfeld, Allison P, Waterbury, Amanda L, Freedy, Allyson M, Gosavi, Pallavi M, Park, Yongho, Kwan, Eugene E, Senzer, Benjamin D, Doench, John G, Bauer, Daniel E, Pinello, Luca, Liau, Brian B
Published in Nature chemical biology (01.05.2019)
Published in Nature chemical biology (01.05.2019)
Get full text
Journal Article
Rational targeting of a NuRD subcomplex guided by comprehensive in situ mutagenesis
Sher, Falak, Hossain, Mir, Seruggia, Davide, Schoonenberg, Vivien A C, Yao, Qiuming, Cifani, Paolo, Dassama, Laura M K, Cole, Mitchel A, Ren, Chunyan, Vinjamur, Divya S, Macias-Trevino, Claudio, Luk, Kevin, McGuckin, Connor, Schupp, Patrick G, Canver, Matthew C, Kurita, Ryo, Nakamura, Yukio, Fujiwara, Yuko, Wolfe, Scot A, Pinello, Luca, Maeda, Takahiro, Kentsis, Alex, Orkin, Stuart H, Bauer, Daniel E
Published in Nature genetics (01.07.2019)
Published in Nature genetics (01.07.2019)
Get full text
Journal Article
Developmental Control of Polycomb Subunit Composition by GATA Factors Mediates a Switch to Non-Canonical Functions
Xu, Jian, Shao, Zhen, Li, Dan, Xie, Huafeng, Kim, Woojin, Huang, Jialiang, Taylor, Jordan E., Pinello, Luca, Glass, Kimberly, Jaffe, Jacob D., Yuan, Guo-Cheng, Orkin, Stuart H.
Published in Molecular cell (22.01.2015)
Published in Molecular cell (22.01.2015)
Get full text
Journal Article