Function-Oriented Synthesis, Step Economy, and Drug Design
Wender, Paul A, Verma, Vishal A, Paxton, Thomas J, Pillow, Thomas H
Published in Accounts of chemical research (01.01.2008)
Published in Accounts of chemical research (01.01.2008)
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Antibody-Drug Conjugates for the Treatment of Cancer
Flygare, John A., Pillow, Thomas H., Aristoff, Paul
Published in Chemical biology & drug design (01.01.2013)
Published in Chemical biology & drug design (01.01.2013)
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LRRC15 + myofibroblasts dictate the stromal setpoint to suppress tumour immunity
Krishnamurty, Akshay T, Shyer, Justin A, Thai, Minh, Gandham, Vineela, Buechler, Matthew B, Yang, Yeqing Angela, Pradhan, Rachana N, Wang, Amber W, Sanchez, Patricia L, Qu, Yan, Breart, Beatrice, Chalouni, Cécile, Dunlap, Debra, Ziai, James, Elstrott, Justin, Zacharias, Neelie, Mao, Weiguang, Rowntree, Rebecca K, Sadowsky, Jack, Lewis, Gail D, Pillow, Thomas H, Nabet, Barzin Y, Banchereau, Romain, Tam, Lucinda, Caothien, Roger, Bacarro, Natasha, Roose-Girma, Merone, Modrusan, Zora, Mariathasan, Sanjeev, Müller, Sören, Turley, Shannon J
Published in Nature (London) (03.11.2022)
Published in Nature (London) (03.11.2022)
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High-Throughput Cysteine Scanning To Identify Stable Antibody Conjugation Sites for Maleimide- and Disulfide-Based Linkers
Ohri, Rachana, Bhakta, Sunil, Fourie-O’Donohue, Aimee, dela Cruz-Chuh, Josefa, Tsai, Siao Ping, Cook, Ryan, Wei, Binqing, Ng, Carl, Wong, Athena W, Bos, Aaron B, Farahi, Farzam, Bhakta, Jiten, Pillow, Thomas H, Raab, Helga, Vandlen, Richard, Polakis, Paul, Liu, Yichin, Erickson, Hans, Junutula, Jagath R, Kozak, Katherine R
Published in Bioconjugate chemistry (21.02.2018)
Published in Bioconjugate chemistry (21.02.2018)
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Cathepsin B Is Dispensable for Cellular Processing of Cathepsin B-Cleavable Antibody-Drug Conjugates
Caculitan, Niña G, Dela Cruz Chuh, Josefa, Ma, Yong, Zhang, Donglu, Kozak, Katherine R, Liu, Yichin, Pillow, Thomas H, Sadowsky, Jack, Cheung, Tommy K, Phung, Qui, Haley, Benjamin, Lee, Byoung-Chul, Akita, Robert W, Sliwkowski, Mark X, Polson, Andrew G
Published in Cancer research (Chicago, Ill.) (15.12.2017)
Published in Cancer research (Chicago, Ill.) (15.12.2017)
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Targeted drug delivery through the traceless release of tertiary and heteroaryl amines from antibody-drug conjugates
Staben, Leanna R., Koenig, Stefan G., Lehar, SophieM, Vandlen, Richard, Zhang, Donglu, Chuh, Josefa, Yu, Shang-Fan, Ng, Carl, Guo, Jun, Liu, Yanzhou, Fourie-O'Donohue, Aimee, Go, MaryAnn, Xin Linghu, Segraves, Nathaniel L., Wang, Tao, Chen, Jinhua, Wei, BinQing, Phillips, Gail D. Lewis, Xu, Keyang, Kozak, Katherine R., Mariathasan, Sanjeev, Flygare, John A., Pillow, Thomas H.
Published in Nature chemistry (01.12.2016)
Published in Nature chemistry (01.12.2016)
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Journal Article
The design of guanidinium-rich transporters and their internalization mechanisms
Wender, Paul A., Galliher, Wesley C., Goun, Elena A., Jones, Lisa R., Pillow, Thomas H.
Published in Advanced drug delivery reviews (01.03.2008)
Published in Advanced drug delivery reviews (01.03.2008)
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Antibody Conjugation of a Chimeric BET Degrader Enables in vivo Activity
Pillow, Thomas H., Adhikari, Pragya, Blake, Robert A., Chen, Jinhua, Del Rosario, Geoffrey, Deshmukh, Gauri, Figueroa, Isabel, Gascoigne, Karen E., Kamath, Amrita V., Kaufman, Susan, Kleinheinz, Tracy, Kozak, Katherine R., Latifi, Brandon, Leipold, Douglas D., Sing Li, Chun, Li, Ruina, Mulvihill, Melinda M., O'Donohue, Aimee, Rowntree, Rebecca K., Sadowsky, Jack D., Wai, John, Wang, Xinxin, Wu, Cong, Xu, Zijin, Yao, Hui, Yu, Shang‐Fan, Zhang, Donglu, Zang, Richard, Zhang, Hongyan, Zhou, Hao, Zhu, Xiaoyu, Dragovich, Peter S.
Published in ChemMedChem (07.01.2020)
Published in ChemMedChem (07.01.2020)
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Journal Article
Overcoming multidrug resistance of small-molecule therapeutics through conjugation with releasable octaarginine transporters
Dubikovskaya, Elena A, Thorne, Steve H, Pillow, Thomas H, Contag, Christopher H, Wender, Paul A
Published in Proceedings of the National Academy of Sciences - PNAS (26.08.2008)
Published in Proceedings of the National Academy of Sciences - PNAS (26.08.2008)
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Decoupling stability and release in disulfide bonds with antibody-small molecule conjugates
Pillow, Thomas H., Sadowsky, Jack D., Zhang, Donglu, Yu, Shang-Fan, Del Rosario, Geoffrey, Xu, Keyang, He, Jintang, Bhakta, Sunil, Ohri, Rachana, Kozak, Katherine R., Ha, Edward, Junutula, Jagath R., Flygare, John A.
Published in Chemical science (Cambridge) (01.01.2017)
Published in Chemical science (Cambridge) (01.01.2017)
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High-Resolution Accurate-Mass Mass Spectrometry Enabling In-Depth Characterization of in Vivo Biotransformations for Intact Antibody-Drug Conjugates
He, Jintang, Su, Dian, Ng, Carl, Liu, Luna, Yu, Shang-Fan, Pillow, Thomas H, Del Rosario, Geoffrey, Darwish, Martine, Lee, Byoung-Chul, Ohri, Rachana, Zhou, Hongxiang, Wang, Xueji, Lu, Jiawei, Kaur, Surinder, Xu, Keyang
Published in Analytical chemistry (Washington) (16.05.2017)
Published in Analytical chemistry (Washington) (16.05.2017)
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Reactive-site-centric chemoproteomics identifies a distinct class of deubiquitinase enzymes
Hewings, David S, Heideker, Johanna, Ma, Taylur P, AhYoung, Andrew P, El Oualid, Farid, Amore, Alessia, Costakes, Gregory T, Kirchhofer, Daniel, Brasher, Bradley, Pillow, Thomas, Popovych, Nataliya, Maurer, Till, Schwerdtfeger, Carsten, Forrest, William F, Yu, Kebing, Flygare, John, Bogyo, Matthew, Wertz, Ingrid E
Published in Nature communications (21.03.2018)
Published in Nature communications (21.03.2018)
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An Anti-CLL-1 Antibody-Drug Conjugate for the Treatment of Acute Myeloid Leukemia
Zheng, Bing, Yu, Shang-Fan, Del Rosario, Geoffrey, Leong, Steven R, Lee, Genee Y, Vij, Rajesh, Chiu, Cecilia, Liang, Wei-Ching, Wu, Yan, Chalouni, Cecile, Sadowsky, Jack, Clark, Vanessa, Hendricks, Angela, Poon, Kirsten Achilles, Chu, Wayne, Pillow, Thomas, Schutten, Melissa M, Flygare, John, Polson, Andrew G
Published in Clinical cancer research (15.02.2019)
Published in Clinical cancer research (15.02.2019)
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On Demand Bioorthogonal Switching of an Antibody-Conjugated SPECT Probe to a Cytotoxic Payload: from Imaging to Therapy
Adhikari, Pragya, Li, Guangmin, Go, MaryAnn, Mandikian, Danielle, Rafidi, Hanine, Ng, Carl, Anifa, Sagana, Johnson, Kevin, Bao, Linda, Hernandez Barry, Hilda, Rowntree, Rebecca, Agard, Nicholas, Wu, Cong, Chou, Kang-Jye, Zhang, Donglu, Kozak, Katherine R., Pillow, Thomas H., Lewis, Gail D., Yu, Shang-Fan, Boswell, C. Andrew, Sadowsky, Jack D.
Published in Journal of the American Chemical Society (17.07.2024)
Published in Journal of the American Chemical Society (17.07.2024)
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Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity
Barreira da Silva, Rosa, Leitao, Ricardo M, Pechuan-Jorge, Ximo, Werneke, Scott, Oeh, Jason, Javinal, Vincent, Wang, Yingyun, Phung, Wilson, Everett, Christine, Nonomiya, Jim, Arnott, David, Lu, Cheng, Hsiao, Yi-Chun, Koerber, James T, Hötzel, Isidro, Ziai, James, Modrusan, Zora, Pillow, Thomas H, Roose-Girma, Merone, Schartner, Jill M, Merchant, Mark, Rutz, Sascha, Eidenschenk, Céline, Mellman, Ira, Albert, Matthew L
Published in Nature immunology (01.04.2022)
Published in Nature immunology (01.04.2022)
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Modulating Antibody–Drug Conjugate Payload Metabolism by Conjugation Site and Linker Modification
Su, Dian, Kozak, Katherine R, Sadowsky, Jack, Yu, Shang-Fan, Fourie-O’Donohue, Aimee, Nelson, Christopher, Vandlen, Richard, Ohri, Rachana, Liu, Luna, Ng, Carl, He, Jintang, Davis, Helen, Lau, Jeff, Del Rosario, Geoffrey, Cosino, Ely, Cruz-Chuh, Josefa dela, Ma, Yong, Zhang, Donglu, Darwish, Martine, Cai, Wenwen, Chen, Chunjiao, Zhou, Hongxiang, Lu, Jiawei, Liu, Yichin, Kaur, Surinder, Xu, Keyang, Pillow, Thomas H
Published in Bioconjugate chemistry (18.04.2018)
Published in Bioconjugate chemistry (18.04.2018)
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Journal Article
Catalytic Cleavage of Disulfide Bonds in Small Molecules and Linkers of Antibody-Drug Conjugates
Zhang, Donglu, Fourie-O'Donohue, Aimee, Dragovich, Peter S, Pillow, Thomas H, Sadowsky, Jack D, Kozak, Katherine R, Cass, Robert T, Liu, Liling, Deng, Yuzhong, Liu, Yichin, Hop, Cornelis E C A, Khojasteh, S Cyrus
Published in Drug metabolism and disposition (01.10.2019)
Published in Drug metabolism and disposition (01.10.2019)
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Journal Article
Systematic Variation of Pyrrolobenzodiazepine (PBD)-Dimer Payload Physicochemical Properties Impacts Efficacy and Tolerability of the Corresponding Antibody–Drug Conjugates
Staben, Leanna R, Chen, Jinhua, Cruz-Chuh, Josefa dela, del Rosario, Geoff, Go, Mary Ann, Guo, Jun, Khojasteh, S. Cyrus, Kozak, Katherine R, Li, Guangmin, Ng, Carl, Lewis Phillips, Gail D, Pillow, Thomas H, Rowntree, Rebecca K, Wai, John, Wei, BinQing, Xu, Keyang, Xu, Zijin, Yu, Shang-Fan, Zhang, Donglu, Dragovich, Peter S
Published in Journal of medicinal chemistry (10.09.2020)
Published in Journal of medicinal chemistry (10.09.2020)
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Journal Article
Exposure-Efficacy Analysis of Antibody-Drug Conjugates Delivering an Excessive Level of Payload to Tissues
Zhang, Donglu, Dragovich, Peter S, Yu, Shang-Fan, Ma, Yong, Pillow, Thomas H, Sadowsky, Jack D, Su, Dian, Wang, Wei, Polson, Andrew, Khojasteh, S Cyrus, Hop, Cornelis E C A
Published in Drug metabolism and disposition (01.10.2019)
Published in Drug metabolism and disposition (01.10.2019)
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