Phase 1 randomized trial of a plant-derived virus-like particle vaccine for COVID-19
Ward, Brian J., Gobeil, Philipe, Séguin, Annie, Atkins, Judith, Boulay, Iohann, Charbonneau, Pierre-Yves, Couture, Manon, D’Aoust, Marc-André, Dhaliwall, Jiwanjeet, Finkle, Carolyn, Hager, Karen, Mahmood, Asif, Makarkov, Alexander, Cheng, Matthew P., Pillet, Stéphane, Schimke, Patricia, St-Martin, Sylvie, Trépanier, Sonia, Landry, Nathalie
Published in Nature medicine (01.06.2021)
Published in Nature medicine (01.06.2021)
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Efficacy and Safety of a Recombinant Plant-Based Adjuvanted Covid-19 Vaccine
Hager, Karen J., Pérez Marc, Gonzalo, Gobeil, Philipe, Diaz, Ricardo S., Heizer, Gretchen, Llapur, Conrado, Makarkov, Alexander I., Vasconcellos, Eduardo, Pillet, Stéphane, Riera, Fernando, Saxena, Pooja, Geller Wolff, Priscila, Bhutada, Kapil, Wallace, Garry, Aazami, Hessam, Jones, Christine E., Polack, Fernando P., Ferrara, Luciana, Atkins, Judith, Boulay, Iohann, Dhaliwall, Jiwanjeet, Charland, Nathalie, Couture, Manon M.J., Jiang-Wright, Julia, Landry, Nathalie, Lapointe, Sophie, Lorin, Aurélien, Mahmood, Asif, Moulton, Lawrence H., Pahmer, Emmy, Parent, Julie, Séguin, Annie, Tran, Luan, Breuer, Thomas, Ceregido, Maria-Angeles, Koutsoukos, Marguerite, Roman, François, Namba, Junya, D’Aoust, Marc-André, Trepanier, Sonia, Kimura, Yosuke, Ward, Brian J.
Published in New England Journal of Medicine (02.06.2022)
Published in New England Journal of Medicine (02.06.2022)
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Safety, immunogenicity, and protection provided by unadjuvanted and adjuvanted formulations of a recombinant plant-derived virus-like particle vaccine candidate for COVID-19 in nonhuman primates
Pillet, Stéphane, Arunachalam, Prabhu S., Andreani, Guadalupe, Golden, Nadia, Fontenot, Jane, Aye, Pyone Pyone, Röltgen, Katharina, Lehmicke, Gabrielle, Gobeil, Philipe, Dubé, Charlotte, Trépanier, Sonia, Charland, Nathalie, D’Aoust, Marc-André, Russell-Lodrigue, Kasi, Monjure, Christopher, Blair, Robert V., Boyd, Scott D., Bohm, Rudolf P., Rappaport, Jay, Villinger, François, Landry, Nathalie, Pulendran, Bali, Ward, Brian J.
Published in Cellular & molecular immunology (01.02.2022)
Published in Cellular & molecular immunology (01.02.2022)
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Safety and immunogenicity of an AS03-adjuvanted plant-based SARS-CoV-2 vaccine in Adults with and without Comorbidities
Charland, Nathalie, Gobeil, Philipe, Pillet, Stéphane, Boulay, Iohann, Séguin, Annie, Makarkov, Alexander, Heizer, Gretchen, Bhutada, Kapil, Mahmood, Asif, Trépanier, Sonia, Hager, Karen, Jiang-Wright, Julia, Atkins, Judith, Saxena, Pooja, Cheng, Matthew P., Vinh, Donald C., Boutet, Philippe, Roman, François, Van Der Most, Robbert, Ceregido, Maria Angeles, Dionne, Marc, Tellier, Guy, Gauthier, Jean-Sébastien, Essink, Brandon, Libman, Michael, Haffizulla, Jason, Fréchette, André, D’Aoust, Marc-André, Landry, Nathalie, Ward, Brian J.
Published in npj vaccines (09.11.2022)
Published in npj vaccines (09.11.2022)
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Immunogenicity and safety of a quadrivalent plant-derived virus like particle influenza vaccine candidate-Two randomized Phase II clinical trials in 18 to 49 and ≥50 years old adults
Pillet, Stéphane, Couillard, Julie, Trépanier, Sonia, Poulin, Jean-François, Yassine-Diab, Bader, Guy, Bruno, Ward, Brian J, Landry, Nathalie
Published in PloS one (05.06.2019)
Published in PloS one (05.06.2019)
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Efficacy, immunogenicity, and safety of a plant-derived, quadrivalent, virus-like particle influenza vaccine in adults (18–64 years) and older adults (≥65 years): two multicentre, randomised phase 3 trials
Ward, Brian J, Makarkov, Alexander, Séguin, Annie, Pillet, Stéphane, Trépanier, Sonia, Dhaliwall, Jiwanjeet, Libman, Michael D, Vesikari, Timo, Landry, Nathalie
Published in The Lancet (British edition) (07.11.2020)
Published in The Lancet (British edition) (07.11.2020)
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A plant-derived VLP influenza vaccine elicits a balanced immune response even in very old mice with co-morbidities
Hodgins, Breanna, Pillet, Stephane, Landry, Nathalie, Ward, Brian James
Published in PloS one (10.01.2019)
Published in PloS one (10.01.2019)
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Durability and cross-reactivity of immune responses induced by a plant-based virus-like particle vaccine for COVID-19
Gobeil, Philipe, Pillet, Stéphane, Boulay, Iohann, Charland, Nathalie, Lorin, Aurélien, Cheng, Matthew P., Vinh, Donald C., Boutet, Philippe, Van Der Most, Robbert, Roman, François, Ceregido, Maria Angeles, Landry, Nathalie, D’Aoust, Marc-André, Ward, Brian J.
Published in Nature communications (12.11.2022)
Published in Nature communications (12.11.2022)
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A plant-derived quadrivalent virus like particle influenza vaccine induces cross-reactive antibody and T cell response in healthy adults
Pillet, Stéphane, Aubin, Éric, Trépanier, Sonia, Bussière, Diane, Dargis, Michèle, Poulin, Jean-François, Yassine-Diab, Bader, Ward, Brian J, Landry, Nathalie
Published in Clinical immunology (Orlando, Fla.) (01.07.2016)
Published in Clinical immunology (Orlando, Fla.) (01.07.2016)
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Sustained protection against Ebola virus infection following treatment of infected nonhuman primates with ZMAb
Qiu, Xiangguo, Audet, Jonathan, Wong, Gary, Fernando, Lisa, Bello, Alexander, Pillet, Stéphane, Alimonti, Judie B., Kobinger, Gary P.
Published in Scientific reports (28.11.2013)
Published in Scientific reports (28.11.2013)
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Humoral and cell-mediated immune responses to H5N1 plant-made virus-like particle vaccine are differentially impacted by alum and GLA-SE adjuvants in a Phase 2 clinical trial
Pillet, Stéphane, Aubin, Éric, Trépanier, Sonia, Poulin, Jean-François, Yassine-Diab, Bader, ter Meulen, Jan, Ward, Brian J., Landry, Nathalie
Published in npj vaccines (23.01.2018)
Published in npj vaccines (23.01.2018)
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Influenza virus-like particle vaccines made in Nicotiana benthamiana elicit durable, poly-functional and cross-reactive T cell responses to influenza HA antigens
Landry, Nathalie, Pillet, Stéphane, Favre, David, Poulin, Jean-François, Trépanier, Sonia, Yassine-Diab, Bader, Ward, Brian J
Published in Clinical immunology (Orlando, Fla.) (01.10.2014)
Published in Clinical immunology (Orlando, Fla.) (01.10.2014)
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Immune parameters correlate with protection against ebola virus infection in rodents and nonhuman primates
Wong, Gary, Richardson, Jason S, Pillet, Stéphane, Patel, Ami, Qiu, Xiangguo, Alimonti, Judie, Hogan, Jeff, Zhang, Yi, Takada, Ayato, Feldmann, Heinz, Kobinger, Gary P
Published in Science translational medicine (31.10.2012)
Published in Science translational medicine (31.10.2012)
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Cellular Immunity Is Critical for Assessing COVID-19 Vaccine Effectiveness in Immunocompromised Individuals
Paramithiotis, Eustache, Sugden, Scott, Papp, Eszter, Bonhomme, Marie, Chermak, Todd, Crawford, Stephanie Y, Demetriades, Stefanie Z, Galdos, Gerson, Lambert, Bruce L, Mattison, John, McDade, Thomas, Pillet, Stephane, Murphy, Robert
Published in Frontiers in immunology (26.05.2022)
Published in Frontiers in immunology (26.05.2022)
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Plant-made virus-like particles bearing influenza hemagglutinin (HA) recapitulate early interactions of native influenza virions with human monocytes/macrophages
Makarkov, Alexander I., Chierzi, Sabrina, Pillet, Stéphane, Murai, Keith K., Landry, Nathalie, Ward, Brian J.
Published in Vaccine (16.08.2017)
Published in Vaccine (16.08.2017)
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Elimination of receptor binding by influenza hemagglutinin improves vaccine-induced immunity
Hendin, Hilary E., Lavoie, Pierre-Olivier, Gravett, Jason M., Pillet, Stéphane, Saxena, Pooja, Landry, Nathalie, D’Aoust, Marc-André, Ward, Brian J.
Published in npj vaccines (11.04.2022)
Published in npj vaccines (11.04.2022)
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Plant-made virus-like particle vaccines bearing the hemagglutinin of either seasonal (H1) or avian (H5) influenza have distinct patterns of interaction with human immune cells in vitro
Hendin, Hilary E, Pillet, Stéphane, Lara, Amanda N, Wu, Cheng-Ying, Charland, Nathalie, Landry, Nathalie, Ward, Brian J
Published in Vaccine (02.05.2017)
Published in Vaccine (02.05.2017)
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