Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL
Piggott, Luke, Omidvar, Nader, Martí Pérez, Salvador, French, Rhiannon, Eberl, Matthias, Clarkson, Richard W E
Published in Breast cancer research : BCR (14.09.2011)
Published in Breast cancer research : BCR (14.09.2011)
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Journal Article
Efficient Intravenous Tumor Targeting Using the αvβ6 Integrin-Selective Precision Virotherapy Ad5NULL-A20
Davies, James A., Marlow, Gareth, Uusi-Kerttula, Hanni K., Seaton, Gillian, Piggott, Luke, Badder, Luned M., Clarkson, Richard W. E., Chester, John D., Parker, Alan L.
Published in Viruses (08.05.2021)
Published in Viruses (08.05.2021)
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Journal Article
Antibody drug conjugates against the receptor for advanced glycation end products (RAGE), a novel therapeutic target in endometrial cancer
Healey, Gareth D., Pan-Castillo, Belen, Garcia-Parra, Jezabel, Davies, Julia, Roberts, Shaun, Jones, Eilir, Dhar, Kalyan, Nandanan, Sarika, Tofazzal, Nasima, Piggott, Luke, Clarkson, Richard, Seaton, Gillian, Frostell, Asa, Fagge, Tim, McKee, Colin, Margarit, Lavinia, Conlan, R. Steven, Gonzalez, Deyarina
Published in Journal for immunotherapy of cancer (29.10.2019)
Published in Journal for immunotherapy of cancer (29.10.2019)
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Journal Article
Debio 0123-101: A phase 1 trial of Debio 0123 in combination with carboplatin in advanced solid tumors—Safety, pharmacokinetic, and preliminary antitumor activity data
Gelderblom, Hans, Jalving, Mathilde, Desar, Ingrid, Saavedra, Omar, Gietema, Jourik A., van Ravensteijn, Stefan, Ajmone Marsan, Nina, Bellon, Anne, Micallef, Sandrine, Luong, Noemie, Piggott, Luke, Frederiksen Franzen, Rikke, Rodrigo Imedio, Esteban
Published in Journal of clinical oncology (01.06.2023)
Published in Journal of clinical oncology (01.06.2023)
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Journal Article
RTID-03. A PHASE 1/2 STUDY OF THE WEE1 INHIBITOR DEBIO 0123 IN COMBINATION WITH TEMOZOLOMIDE +- RADIOTHERAPY IN ADULTS WITH RECURRENT OR NEWLY DIAGNOSED GLIOBLASTOMA
Roth, Patrick, Papadopoulos, Kyriakos P, Vieito, Maria, Yang, Jonathan, Majd, Nazanin, Sepúlveda, Juan, Schaff, Lauren, Moreno, Victor, Pérez -Larraya, Jaime Gállego, Micallef, Sandrine, Bellon, Anne, Omar, Mokhtar, Imedio, Esteban Rodrigo, Piggott, Luke, Rodriguez-Freixinos, Victor, Rodon, Jordi
Published in Neuro-oncology (Charlottesville, Va.) (10.11.2023)
Published in Neuro-oncology (Charlottesville, Va.) (10.11.2023)
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Abstract 702: Development of a radioresistant PDX prostate cancer model to evaluate potential radiosensitizing compounds
Alfsen, Maria Zeiler, Thaysen, Maria, Nielsen, Nikoline, Wick, Michael, Piggott, Luke, Gnosa, Sebastian, Nielsen, Carsten Haagen
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Abstract 6507: Simulation driven identification of combinations for the WEE1 inhibitor Debio 0123 results in synergistic effect with cabozantinib validated in vivo
Elek, Boldizsar, Chessex, Anne V., Piggott, Luke, Papp, Orsolya, Fekete, Ivan, Veres, Daniel
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
Acquired Resistance of ER-Positive Breast Cancer to Endocrine Treatment Confers an Adaptive Sensitivity to TRAIL through Posttranslational Downregulation of c-FLIP
Piggott, Luke, Silva, Andreia, Robinson, Timothy, Santiago-Gómez, Angelica, Simões, Bruno M, Becker, Michael, Fichtner, Iduna, Andera, Ladislav, Young, Philippa, Morris, Christine, Barrett-Lee, Peter, Alchami, Fouad, Piva, Marco, Vivanco, Maria dM, Clarke, Robert B, Gee, Julia, Clarkson, Richard
Published in Clinical cancer research (15.05.2018)
Published in Clinical cancer research (15.05.2018)
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Journal Article
The Discovery of a Novel Antimetastatic Bcl3 Inhibitor
Soukupová, Jitka, Bordoni, Cinzia, Turnham, Daniel J, Yang, William W, Seaton, Gillian, Gruca, Aleksandra, French, Rhiannon, Lee, Kok Yung, Varnava, Athina, Piggott, Luke, Clarkson, Richard W E, Westwell, Andrew D, Brancale, Andrea
Published in Molecular cancer therapeutics (01.05.2021)
Published in Molecular cancer therapeutics (01.05.2021)
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Journal Article
Abstract 6185: Debio 0123 is a selective WEE1 inhibitor that effectively penetrates the brain and demonstrates anti-tumor activity in preclinical models of glioblastoma
Piggott, Luke, Luong, Noemie, Massiere, Frederic, Kunze, Annett, Chardonnens, Christophe, Vaslin, Anne
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Journal Article
Synergistic targeting of breast cancer stem‐like cells by human γδ T cells and CD8+ T cells
Chen, Hung‐Chang, Joalland, Noémie, Bridgeman, John S, Alchami, Fouad S, Jarry, Ulrich, Khan, Mohd Wajid A, Piggott, Luke, Shanneik, Yasmin, Li, Jianqiang, Herold, Marco J, Herrmann, Thomas, Price, David A, Gallimore, Awen M, Clarkson, Richard W, Scotet, Emmanuel, Moser, Bernhard, Eberl, Matthias
Published in Immunology and cell biology (01.08.2017)
Published in Immunology and cell biology (01.08.2017)
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Journal Article
Abstract 3443: The IAP antagonist xevinapant, in combination with high-dose cisplatin chemoradiotherapy, induces NF-kB and apoptotic pathway biomarkers in patients with high-risk locally advanced squamous cell carcinoma of the head and neck
Piggott, Luke, Gavillet, Bruno, Brichory, Franck, Gollmer, Kathrin, Bouisset, Florilene, Vuagniaux, Gregoire
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract 2303: The WEE1 inhibitor Debio 0123 enhances the efficacy of standard of care DNA damaging agents in lung cancer models
Piggott, Luke, Vaslin-Chessex, Anne, Luong, Noemie, Tschumi, Benjamin, Vuagniaux, Gregoire
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Abstract CT202: Xevinapant plus avelumab in patients (pts) with advanced or metastatic non-small cell lung cancer (NSCLC): Phase 1b dose-expansion results and exploratory biomarker analyses
Chu, Quincy, Ciuleanu, Tudor, Ramlau, Rodryg, Renouf, Daniel, Juergens, Rosalyn, Kalinka, Ewa, Sawrycki, Piotr, Bramson, Jonathan, Nelson, Brad, Crabbé, Rafael, Sahlender, Daniela A., Crompton, Philippa, Rouits, Elisabeth, Spaggiari, Dany, Brichory, Franck, Piggott, Luke, Schenker, Mike, Goss, Glenwood
Published in Cancer research (Chicago, Ill.) (14.04.2023)
Published in Cancer research (Chicago, Ill.) (14.04.2023)
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Journal Article
Erratum to: Suppression of apoptosis inhibitor c-FLIP selectively eliminates breast cancer stem cell activity in response to the anti-cancer agent, TRAIL
Piggott, Luke, Omidvar, Nader, Martí Pérez, Salvador, French, Rhiannon, Eberl, Matthias, Clarkson, Richard We
Published in Breast cancer research : BCR (16.07.2015)
Published in Breast cancer research : BCR (16.07.2015)
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Journal Article
Efficient Intravenous Tumor Targeting Using the αvβ6 Integrin-Selective Precision Virotherapy Ad5 NULL -A20
Davies, James A, Marlow, Gareth, Uusi-Kerttula, Hanni K, Seaton, Gillian, Piggott, Luke, Badder, Luned M, Clarkson, Richard W E, Chester, John D, Parker, Alan L
Published in Viruses (08.05.2021)
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Published in Viruses (08.05.2021)
Journal Article
Synergistic targeting of breast cancer stem-like cells by human [gamma][delta] T cells and CD8+ T cells
Chen, Hung-chang, Joalland, Noémie, Bridgeman, John S, Alchami, Fouad S, Jarry, Ulrich, Khan, Mohd Wajid A, Piggott, Luke, Shanneik, Yasmin, Li, Jianqiang, Herold, Marco J, Herrmann, Thomas, Price, David A, Gallimore, Awen M, Clarkson, Richard W, Scotet, Emmanuel, Moser, Bernhard, Eberl, Matthias
Published in Immunology and cell biology (01.08.2017)
Published in Immunology and cell biology (01.08.2017)
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Journal Article