Target-Based Identification and Optimization of 5‑Indazol-5-yl Pyridones as Toll-like Receptor 7 and 8 Antagonists Using a Biochemical TLR8 Antagonist Competition Assay
Knoepfel, Thomas, Nimsgern, Pierre, Jacquier, Sébastien, Bourrel, Marjorie, Vangrevelinghe, Eric, Glatthar, Ralf, Behnke, Dirk, Alper, Phil B, Michellys, Pierre-Yves, Deane, Jonathan, Junt, Tobias, Zipfel, Géraldine, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric, Boulay, Thomas, Loetscher, Pius, Faller, Michael, Blank, Jutta, Feifel, Roland, Betschart, Claudia
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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An Amphiphilic Polymer-Supported Strategy Enables Chemical Transformations under Anhydrous Conditions for DNA-Encoded Library Synthesis
Ruff, Yves, Martinez, Roberto, Pellé, Xavier, Nimsgern, Pierre, Fille, Pascale, Ratnikov, Maxim, Berst, Frédéric
Published in ACS combinatorial science (09.03.2020)
Published in ACS combinatorial science (09.03.2020)
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Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4
Fairhurst, Robin A, Knoepfel, Thomas, Buschmann, Nicole, Leblanc, Catherine, Mah, Robert, Todorov, Milen, Nimsgern, Pierre, Ripoche, Sebastien, Niklaus, Michel, Warin, Nicolas, Luu, Van Huy, Madoerin, Mario, Wirth, Jasmin, Graus-Porta, Diana, Weiss, Andreas, Kiffe, Michael, Wartmann, Markus, Kinyamu-Akunda, Jacqueline, Sterker, Dario, Stamm, Christelle, Adler, Flavia, Buhles, Alexandra, Schadt, Heiko, Couttet, Philippe, Blank, Jutta, Galuba, Inga, Trappe, Jörg, Voshol, Johannes, Ostermann, Nils, Zou, Chao, Berghausen, Jörg, Del Rio Espinola, Alberto, Jahnke, Wolfgang, Furet, Pascal
Published in Journal of medicinal chemistry (12.11.2020)
Published in Journal of medicinal chemistry (12.11.2020)
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Discovery and In Vivo Exploration of 1,3,4-Oxadiazole and α-Fluoroacrylate Containing IL-17 Inhibitors
Velcicky, Juraj, Bauer, Matthias R., Schlapbach, Achim, Lapointe, Guillaume, Meyer, Arndt, Vögtle, Markus, Blum, Ernst, Ngo, Estelle, Rolando, Catherine, Nimsgern, Pierre, Teixeira-Fouchard, Sylvie, Lehmann, Hansjoerg, Furet, Pascal, Berst, Frédéric, Schümann, Jens, Stringer, Rowan, Larger, Patrice, Schmid, Cindy, Prendergast, Catriona T., Riek, Simone, Schmutz, Patrick, Lehmann, Sylvie, Berghausen, Jörg, Scheufler, Clemens, Rondeau, Jean-Michel, Burkhart, Christoph, Knoepfel, Thomas, Gommermann, Nina
Published in Journal of medicinal chemistry (14.09.2024)
Published in Journal of medicinal chemistry (14.09.2024)
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Structure-Based Optimization of a Fragment-like TLR8 Binding Screening Hit to an In Vivo Efficacious TLR7/8 Antagonist
Betschart, Claudia, Faller, Michael, Zink, Florence, Hemmig, René, Blank, Jutta, Vangrevelinghe, Eric, Bourrel, Marjorie, Glatthar, Ralf, Behnke, Dirk, Barker, Kerstin, Heizmann, Andreas, Angst, Daniela, Nimsgern, Pierre, Jacquier, Sébastien, Junt, Tobias, Zipfel, Géraldine, Ruzzante, Giulia, Loetscher, Pius, Limonta, Sarah, Hawtin, Stuart, Andre, Cedric Bernard, Boulay, Thomas, Feifel, Roland, Knoepfel, Thomas
Published in ACS medicinal chemistry letters (14.04.2022)
Published in ACS medicinal chemistry letters (14.04.2022)
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CONDENSED BICYCLIC PYRIDYL DERIVATIVE AS FGFR4 INHIBITOR
PIERRE NIMSGERN, XIONG JING, ROBIN ALEC FAIRHURST, LIAO LV, THOMAS KNOEPFEL, WANG CAN, ZHAO XIANGLIN, MAH ROBERT, CATHERINE LEBLANC, SEBASTIEN RIPOCHE, PASCAL FURET, HAN BO, NICOLE BUSCHMANN
Year of Publication 28.02.2019
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Year of Publication 28.02.2019
Patent
USE OF RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS
ANDREAS WEISS, LV LIAO, PIERRE NIMSGERN, XIONG JING, ROBIN ALEC FAIRHURST, THOMAS KNOEPFEL, WANG CAN, ZHAO XIANGLIN, MAH ROBERT, WANG YOUZHEN, DALE PORTER, CATHERINE LEBLANC, SEBASTIEN RIPOCHE, PASCAL FURET, HAN BO, PORTA DIANA GRAUS, CAROLINA HAEFLIGER, MICHAEL PALMER, NICOLE BUSCHMANN, MURAKAMI MASAHITO
Year of Publication 26.12.2019
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Year of Publication 26.12.2019
Patent
FUSED BICYCLIC PYRIDYL DERIVATIVE AS FGFR4 INHIBITOR
PIERRE NIMSGERN, XIONG JING, ROBIN ALEC FAIRHURST, LIAO LV, THOMAS KNOEPFEL, WANG CAN, ZHAO XIANGLIN, MAH ROBERT, CATHERINE LEBLANC, SEBASTIEN RIPOCHE, PASCAL FURET, HAN BO, NICOLE BUSCHMANN
Year of Publication 07.12.2017
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Year of Publication 07.12.2017
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GLUE DEGRADERS AND METHODS OF USE THEREOF
NIMSGERN, Pierre, LACHAL, Julie, CERNIJENKO, Artiom, HORNAK, Viktor, DEWHURST, Janetta, HOLDER, Lauren, KERRIGAN, John Ryan, MANNING, James R, JAIN, Rama, IMASE, Hidetomo, MOREAU, Robert Joseph, MCKAY, Daniel, BECKWITH, Rohan Eric John, HESSE, Matthew James, ZHAO, Junping, YAMADA, Ken, O'BRIEN, Gary, MA, Fupeng, VULPETTI, Anna, JIN, Xianming, BONAZZI, Simone, BUSCHMANN, Nicole, AXFORD, Jake, FAZAL, Aleem, MALIK, Hasnain Ahmed
Year of Publication 17.11.2022
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Year of Publication 17.11.2022
Patent
RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS
BUSCHMANN, NICOLE, MAH, ROBERT, FAIRHURST, ROBIN ALEC, NIMSGERN, PIERRE, RIPOCHE, SEBASTIEN, LEBLANC, CATHERINE, LIAO, LV, KNOPFEL, THOMAS, HAN, BO, ZHAO, XIANGLIN, XIONG, JING, FURET, PASCAL, WANG, CAN
Year of Publication 28.09.2021
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Year of Publication 28.09.2021
Patent
GLUE DEGRADERS AND METHODS OF USE THEREOF
NIMSGERN, Pierre, LACHAL, Julie, CERNIJENKO, Artiom, HORNAK, Viktor, DEWHURST, Janetta, HOLDER, Lauren, KERRIGAN, John Ryan, MANNING, James R, JAIN, Rama, IMASE, Hidetomo, MOREAU, Robert Joseph, MCKAY, Daniel, BECKWITH, Rohan Eric John, HESSE, Matthew James, ZHAO, Junping, YAMADA, Ken, O'BRIEN, Gary, MA, Fupeng, VULPETTI, Anna, JIN, Xianming, BONAZZI, Simone, BUSCHMANN, Nicole, AXFORD, Jake, FAZAL, Aleem, MALIK, Hasnain Ahmed
Year of Publication 27.07.2022
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Year of Publication 27.07.2022
Patent
GLUE DEGRADERS AND METHODS OF USE THEREOF
NIMSGERN, Pierre, LACHAL, Julie, CERNIJENKO, Artiom, HORNAK, Viktor, DEWHURST, Janetta, HOLDER, Lauren, KERRIGAN, John Ryan, MANNING, James R, JAIN, Rama, IMASE, Hidetomo, MOREAU, Robert Joseph, MCKAY, Daniel, BECKWITH, Rohan Eric John, HESSE, Matthew James, ZHAO, Junping, YAMADA, Ken, O'BRIEN, Gary, MA, Fupeng, VULPETTI, Anna, JIN, Xianming, BONAZZI, Simone, BUSCHMANN, Nicole, AXFORD, Jake, FAZAL, Aleem, MALIK, Hasnain Ahmed
Year of Publication 25.03.2021
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Year of Publication 25.03.2021
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USE OF RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS
FURET, Pascal, NIMSGERN, Pierre, KNÖPFEL, Thomas, XIONG, Jing, WANG, Can, FAIRHURST, Robin Alec, HAN, Bo, ZHAO, Xianglin, LIAO, Lv, MAH, Robert, BUSCHMANN, Nicole, RIPOCHE, Sebastien, LEBLANC, Catherine
Year of Publication 14.03.2019
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Year of Publication 14.03.2019
Patent
RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS
FURET, Pascal, NIMSGERN, Pierre, KNÖPFEL, Thomas, XIONG, Jing, WANG, Can, FAIRHURST, Robin Alec, HAN, Bo, ZHAO, Xianglin, MAH, Robert, LIAO, Lv, BUSCHMANN, Nicole, RIPOCHE, Sebastien, LEBLANC, Catherine
Year of Publication 02.05.2018
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Year of Publication 02.05.2018
Patent
USE OF RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS
HAEFLIGER, CAROLINA, KNÖPFEL, THOMAS, BUSCHMANN, NICOLE, MAH, ROBERT, FAIRHURST, ROBIN ALEC, NIMSGERN, PIERRE, RIPOCHE, SEBASTIEN, LEBLANC, CATHERINE, LIAO, LV, PORTER, DALE, MURAKAMI, MASATO, HAN, BO, ZHAO, XIANGLIN, WANG, YOUZHEN, PALMER, MICHAEL, WEISS, ANDREAS, XIONG, JING, FURET, PASCAL, WANG, CAN, GRAUS PORTA, DIANA
Year of Publication 31.03.2020
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Year of Publication 31.03.2020
Patent
Ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors
Wang Can, Furet Pascal, Han Bo, Fairhurst Robin Alec, Nimsgern Pierre, Liao Lv, Ripoche Sebastien, Zhao Xianglin, Leblanc Catherine, Mah Robert, Xiong Jing, Buschmann Nicole, Knöpfel Thomas
Year of Publication 20.02.2018
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Year of Publication 20.02.2018
Patent
Use of ring-fused bicyclic pyridyl derivatives as FGFR4 inhibitors
Furet, Pascal, Graus Porta, Diana, Leblanc, Catherine, Palmer, Michael, Porter, Dale, Han, Bo, Knöpfel, Thomas, Nimsgern, Pierre, Wang, Can, Fairhurst, Robin Alec, Xiong, Jing, Mah, Robert, Murakami, Masato, Ripoche, Sebastien, Weiss, Andreas, Zhao, Xianglin, Liao, Lv, Wang, Youzhen, Haefliger, Carolina, Buschmann, Nicole
Year of Publication 17.12.2019
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Year of Publication 17.12.2019
Patent
RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS
BUSCHMANN, NICOLE, KNÖPFEL, THOMAS, MAH, ROBERT, FAIRHURST, ROBIN ALEC, NIMSGERN, PIERRE, RIPOCHE, SEBASTIEN, LEBLANC, CATHERINE, LIAO, LV, HAN, BO, ZHAO, XIANGLIN, XIONG, JING, FURET, PASCAL, WANG, CAN
Year of Publication 31.10.2018
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Year of Publication 31.10.2018
Patent
USE OF RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS
FURET, Pascal, NIMSGERN, Pierre, GRAUS PORTA, Diana, MURAKAMI, Masato, PALMER, Michael, KNÖPFEL, Thomas, XIONG, Jing, WANG, Can, HAN, Bo, ZHAO, Xianglin, LIAO, Lv, MAH, Robert, WANG, Youzhen, FAIRHURST, Robin, Alec, PORTER, Dale, BUSCHMANN, Nicole, RIPOCHE, Sebastien, HAEFLIGER, Carolina, WEISS, Andreas, LEBLANC, Catherine
Year of Publication 28.08.2019
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Year of Publication 28.08.2019
Patent
USE OF RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS
FURET, Pascal, NIMSGERN, Pierre, GRAUS PORTA, Diana, MURAKAMI, Masato, KNOPFEL, Thomas, PALMER, Michael, XIONG, Jing, WANG, Can, FAIRHURST, Robin Alec, HAN, Bo, ZHAO, Xianglin, LIAO, Lv, MAH, Robert, WANG, Youzhen, BUSCHMANN, Nicole, PORTER, Dale, RIPOCHE, Sebastien, HAEFLIGER, Carolina, WEISS, Andreas, LEBLANC, Catherine
Year of Publication 01.08.2019
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Year of Publication 01.08.2019
Patent