Discovery of cyclic guanidine-linked sulfonamides as inhibitors of LMTK3 kinase
Ortiz, Maria A., Michaels, Heather, Molina, Brandon, Toenjes, Sean, Davis, Jennifer, Marconi, Guya Diletta, Hecht, David, Gustafson, Jeffrey L., Piedrafita, F. Javier, Nefzi, Adel
Published in Bioorganic & medicinal chemistry letters (01.05.2020)
Published in Bioorganic & medicinal chemistry letters (01.05.2020)
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Journal Article
Synthesis and pharmacological evaluations of novel 2H-benzo[b][1,4]oxazin-3(4H)-one derivatives as a new class of anti-cancer agents
Rajitha, Chittipaka, Dubey, P. K., Sunku, Venkataiah, Piedrafita, F. Javier, Veeramaneni, Venugopal Rao, Pal, Manojit
Published in European journal of medicinal chemistry (01.10.2011)
Published in European journal of medicinal chemistry (01.10.2011)
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Journal Article
Necrotic Concentrations of Cisplatin Activate the Apoptotic Machinery but Inhibit Effector Caspases and Interfere with the Execution of Apoptosis
Sancho-Martínez, Sandra M., Piedrafita, F. Javier, Cannata-Andía, Jorge B., López-Novoa, José M., López-Hernández, Francisco J.
Published in Toxicological sciences (01.07.2011)
Published in Toxicological sciences (01.07.2011)
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Journal Article
Leveraging Atropisomerism to Obtain a Selective Inhibitor of RET Kinase with Secondary Activities toward EGFR Mutants
Toenjes, Sean T, Garcia, Valeria, Maddox, Sean M, Dawson, Gregory A, Ortiz, Maria A, Piedrafita, F. Javier, Gustafson, Jeffrey L
Published in ACS chemical biology (20.09.2019)
Published in ACS chemical biology (20.09.2019)
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Journal Article
Controlling Ibrutinib’s Conformations about Its Heterobiaryl Axis to Increase BTK Selectivity
Toenjes, Sean T., Heydari, Bahar S., Albright, Samuel T., Hazin, Ramsey, Ortiz, Maria A., Piedrafita, F. Javier, Gustafson, Jeffrey L.
Published in ACS medicinal chemistry letters (09.03.2023)
Published in ACS medicinal chemistry letters (09.03.2023)
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Journal Article
Diversity oriented synthesis and IKK inhibition of aminobenzimidazole tethered quinazoline-2,4-diones, thioxoquinazolin-4-ones, benzodiazepine-2,3,5-triones, isoxazoles and isoxazolines
Dadiboyena, Sureshbabu, Arfaoui, Aïcha, Amri, Hassen, Piedrafita, F. Javier, Nefzi, Adel
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
Published in Bioorganic & medicinal chemistry letters (01.02.2015)
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Journal Article
Synthesis of dihydroimidazole tethered imidazolinethiones and their activity as novel antagonists of the nuclear retinoic acid receptor-related orphan receptors (RORs)
Nefzi, Adel, Marconi, Guya D., Ortiz, Maria A., Davis, Jennifer C., Piedrafita, F. Javier
Published in Bioorganic & medicinal chemistry letters (01.04.2017)
Published in Bioorganic & medicinal chemistry letters (01.04.2017)
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Journal Article
Tetrahydrobenzothiophene carboxamides: Beyond the kinase domain and into the fatty acid realm
Llona-Minguez, Sabin, Fayezi, Shabnam, Alihemmati, Alireza, Juárez-Jiménez, Jordi, Piedrafita, F. Javier, Helleday, Thomas
Published in Bioorganic & medicinal chemistry letters (15.09.2017)
Published in Bioorganic & medicinal chemistry letters (15.09.2017)
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Journal Article
Peroxisome Proliferator-activated Receptor γ Ligands Regulate Myeloperoxidase Expression in Macrophages by an Estrogen-dependent Mechanism Involving the -463GA Promoter Polymorphism
Kumar, Alan P., Piedrafita, F. Javier, Reynolds, Wanda F.
Published in The Journal of biological chemistry (27.02.2004)
Published in The Journal of biological chemistry (27.02.2004)
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Journal Article
Adamantyl Arotinoids That Inhibit IκB Kinase α and IκB Kinase β
Lorenzo, Paula, Ortiz, María A., Álvarez, Rosana, Piedrafita, F. Javier, de Lera, Ángel R.
Published in ChemMedChem (01.07.2013)
Published in ChemMedChem (01.07.2013)
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Journal Article
Highly twisted adamantyl arotinoids: Synthesis, antiproliferative effects and RXR transactivation profiles
Pérez-Rodríguez, Santiago, Ortiz, Maria A., Pereira, Raquel, Rodríguez-Barrios, Fátima, de Lera, Ángel R., Piedrafita, F. Javier
Published in European journal of medicinal chemistry (01.06.2009)
Published in European journal of medicinal chemistry (01.06.2009)
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Journal Article
Inhibition of IκB Kinase by a New Class of Retinoid-Related Anticancer Agents That Induce Apoptosis
Bayon, Yolanda, Ortiz, Maria A., Lopez-Hernandez, Francisco J., Gao, Feng, Karin, Michael, Pfahl, Magnus, Piedrafita, F. Javier
Published in Molecular and Cellular Biology (01.02.2003)
Published in Molecular and Cellular Biology (01.02.2003)
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Journal Article
Z-FA-fmk inhibits effector caspases but not initiator caspases 8 and 10, and demonstrates that novel anticancer retinoid-related molecules induce apoptosis via the intrinsic pathway
Lopez-Hernandez, Francisco J, Ortiz, Maria A, Bayon, Yolanda, Piedrafita, F Javier
Published in Molecular cancer therapeutics (01.03.2003)
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Published in Molecular cancer therapeutics (01.03.2003)
Journal Article
The human myeloperoxidase gene is regulated by LXR and PPARalpha ligands
Reynolds, Wanda F, Kumar, Alan P, Piedrafita, F Javier
Published in Biochemical and biophysical research communications (20.10.2006)
Published in Biochemical and biophysical research communications (20.10.2006)
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Journal Article