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Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Thibault, Benoit, Ramos‐Delgado, Fernanda, Pons‐Tostivint, Elvire, Therville, Nicole, Cintas, Celia, Arcucci, Silvia, Cassant‐Sourdy, Stephanie, Reyes‐Castellanos, Gabriela, Tosolini, Marie, Villard, Amelie V, Cayron, Coralie, Baer, Romain, Bertrand‐Michel, Justine, Pagan, Delphine, Ferreira Da Mota, Dina, Yan, Hongkai, Falcomatà, Chiara, Muscari, Fabrice, Bournet, Barbara, Delord, Jean‐Pierre, Aksoy, Ezra, Carrier, Alice, Cordelier, Pierre, Saur, Dieter, Basset, Celine, Guillermet‐Guibert, Julie
Published in EMBO molecular medicine (07.07.2021)
Published in EMBO molecular medicine (07.07.2021)
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Journal Article
Web Resource
Phosphatidylinositol 3-Kinase Isoform-Specific Effects in Airway Mesenchymal Cell Function
Moir, Lyn M., Trian, Thomas, Ge, Qi, Shepherd, Peter R., Burgess, Janette K., Oliver, Brian G.G., Black, Judith L.
Published in The Journal of pharmacology and experimental therapeutics (01.05.2011)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2011)
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Journal Article
Abstract CT085: Phase III randomized, double-blind, controlled studies of the PI3K inhibitor copanlisib in combination with rituximab or rituximab-based chemotherapy in subjects with relapsed indolent B-cell non-Hodgkin's lymphoma (iNHL): CHRONOS-3 and CHRONOS-4
Gerecitano, John F., Zinzani, Pier L., Zheng, HongXia, Ito, Rodrigo, Tanaka, Paula Y., Mueller, Katharina, Yuan, Jason, Childs, Barrett H.
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Compounds that inhibit pi3k isoform alpha and methods for treating cancer
Year of Publication 01.04.2024
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Patent
Abstract 1752: A phase I/IIa, first time in human, open-label dose-escalation study of GSK2636771 in subjects with advanced solid tumors with PTEN deficiency
Blackman, Samuel C., Gainer, Shelby D., Suttle, Benjamin B., Skordos, Konstantine W., Greshock, Joel D., Motwani, Monica, Roadcap, Lori T., Hardwicke, Mary Ann A., Wooster, Richard F.
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Journal Article
Abstract 4851: Second generation 2,3-dihydroimidazo[1,2-c]quinazoline PI3K inhibitors: development of BAY 1082439, a novel balanced PI3Ká / PI3Kâ inhibitor
Scott, William J., Liu, Ningshu, Hägebarth, Andreas, Möwes, Manfred, Mönning, Ursula, Bömer, Ulf, Mumberg, Dominik, von Nussbaum, Franz, Brands, Michael, Lafranc, Julien
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract 213: VS-5584 a dual mTORC1/2 and PI3K inhibitor has anti-tumor activity in multiple in vivo xenograft tumor models and enhanced efficacy in combination with cisplatin or docetaxel
Trombino, Anthony F., Kolev, Vihren N., Wright, Quentin G., Xu, Qunli, Padval, Mahesh V.
Published in Cancer research (Chicago, Ill.) (01.10.2014)
Published in Cancer research (Chicago, Ill.) (01.10.2014)
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Journal Article
Update On The Safety and Efficacy Of The Pan Class I PI3K Inhibitor SAR245408 (XL147) In Chronic Lymphocytic Leukemia and Non-Hodgkin's Lymphoma Patients
Brown, Jennifer R., Davids, Matthew S., Rodon, Jordi, Abrisqueta, Pau, Egile, Coumaran, Ruiz-Soto, Rodrigo, Awan, Farrukh
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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Journal Article
PI3K-Alpha Plays A Major Role In Multiple Myeloma and Its Inhibition With BYL917 Decreases Proliferation, Synergizes With Other Therapies and Overcomes Stroma-Induced Resistance
Azab, Feda, Vali, Shireen, Potter, Nicholas, Abraham, Joseph, Muz, Barbara, De La Puente, Pilar, Abbasi, Taher, Vij, Ravi, Azab, Abdel Kareem
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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Journal Article
Isoform-selective phosphoinositide 3-kinase inhibition ameliorates a broad range of fragile X syndrome-associated deficits in a mouse model
Gross, Christina, Banerjee, Anwesha, Tiwari, Durgesh, Longo, Francesco, White, Angela R., Allen, A. G., Schroeder-Carter, Lindsay M., Krzeski, Joseph C., Elsayed, Nada A., Puckett, Rosemary, Klann, Eric, Rivero, Ralph A., Gourley, Shannon L., Bassell, Gary J.
Published in Neuropsychopharmacology (New York, N.Y.) (01.01.2019)
Published in Neuropsychopharmacology (New York, N.Y.) (01.01.2019)
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Journal Article