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Effective “activated PI3Kδ syndrome”–targeted therapy with the PI3Kδ inhibitor leniolisib
Rao, V. Koneti, Webster, Sharon, Dalm, Virgil A.S.H., Šedivá, Anna, van Hagen, P. Martin, Holland, Steven, Rosenzweig, Sergio D., Christ, Andreas D., Sloth, Birgitte, Cabanski, Maciej, Joshi, Aniket D., de Buck, Stefan, Doucet, Julie, Guerini, Danilo, Kalis, Christoph, Pylvaenaeinen, Ilona, Soldermann, Nicolas, Kashyap, Anuj, Uzel, Gulbu, Lenardo, Michael J., Patel, Dhavalkumar D., Lucas, Carrie L., Burkhart, Christoph
Published in Blood (23.11.2017)
Published in Blood (23.11.2017)
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Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE−/− mice
Wang, Zhu, Guo, Jingjing, Han, Xinqiang, Xue, Ming, Wang, Wenming, Mi, Lei, Sheng, Yuguo, Ma, Chao, Wu, Jian, Wu, Xuejun
Published in Cell & bioscience (27.08.2019)
Published in Cell & bioscience (27.08.2019)
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Mass balance, metabolic disposition, and pharmacokinetics of a novel selective inhibitor of PI3Kδ [14C] SHC014748M in healthy Chinese subjects following oral administration
Guo, Fei, Liu, Bingyan, Li, Xiaoli, Wang, Haidong, Zhu, Xingyu, Su, Yue, He, Cuixia, Zhu, Minhui, Ding, Jiaxiang, Xu, Yuanyuan, Zhao, Xiangdi, Wang, Ying, Shan, Rongfang, Zhu, Juan, Xie, Jing, Ge, Qin, Fan, Ling, Ding, Yuzhou, Xie, Yunqiu, Zhang, Chaoyang, Li, Hongtao, Wang, Hongju, Zhou, Huan
Published in Cancer chemotherapy and pharmacology (01.02.2023)
Published in Cancer chemotherapy and pharmacology (01.02.2023)
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Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4+ T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals
Mauro, Claudio, Smith, Joanne, Cucchi, Danilo, Coe, David, Fu, Hongmei, Bonacina, Fabrizia, Baragetti, Andrea, Cermenati, Gaia, Caruso, Donatella, Mitro, Nico, Catapano, Alberico L., Ammirati, Enrico, Longhi, Maria P., Okkenhaug, Klaus, Norata, Giuseppe D., Marelli-Berg, Federica M.
Published in Cell metabolism (07.03.2017)
Published in Cell metabolism (07.03.2017)
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Airway Microbiota Is Associated with Upregulation of the PI3K Pathway in Lung Cancer
Tsay, Jun-Chieh J., Wu, Benjamin G., Badri, Michelle H., Clemente, Jose C., Shen, Nan, Meyn, Peter, Li, Yonghua, Yie, Ting-An, Lhakhang, Tenzin, Olsen, Evan, Murthy, Vivek, Michaud, Gaetane, Sulaiman, Imran, Tsirigos, Aristotelis, Heguy, Adriana, Pass, Harvey, Weiden, Michael D., Rom, William N., Sterman, Daniel H., Bonneau, Richard, Blaser, Martin J., Segal, Leopoldo N.
Published in American journal of respiratory and critical care medicine (01.11.2018)
Published in American journal of respiratory and critical care medicine (01.11.2018)
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Insulin–PI3K signalling: an evolutionarily insulated metabolic driver of cancer
Hopkins, Benjamin D., Goncalves, Marcus D., Cantley, Lewis C.
Published in Nature reviews. Endocrinology (01.05.2020)
Published in Nature reviews. Endocrinology (01.05.2020)
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Intermittent High-Dose Scheduling of AZD8835, a Novel Selective Inhibitor of PI3Kα and PI3Kδ, Demonstrates Treatment Strategies for PIK3CA -Dependent Breast Cancers
Hudson, Kevin, Hancox, Urs J., Trigwell, Cath, McEwen, Robert, Polanska, Urszula M., Nikolaou, Myria, Morentin Gutierrez, Pablo, Avivar-Valderas, Alvaro, Delpuech, Oona, Dudley, Phillippa, Hanson, Lyndsey, Ellston, Rebecca, Jones, Alys, Cumberbatch, Marie, Cosulich, Sabina C., Ward, Lara, Cruzalegui, Francisco, Green, Stephen
Published in Molecular cancer therapeutics (01.05.2016)
Published in Molecular cancer therapeutics (01.05.2016)
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PI3K inhibitors in inflammation, autoimmunity and cancer
Stark, Anne-Katrien, Sriskantharajah, Srividya, Hessel, Edith M, Okkenhaug, Klaus
Published in Current opinion in pharmacology (01.08.2015)
Published in Current opinion in pharmacology (01.08.2015)
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Targeting the PI3K/Akt/mTOR Pathway in Hepatocellular Carcinoma
Sun, Eun Jin, Wankell, Miriam, Palamuthusingam, Pranavan, McFarlane, Craig, Hebbard, Lionel
Published in Biomedicines (08.11.2021)
Published in Biomedicines (08.11.2021)
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Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component
Thibault, Benoit, Ramos‐Delgado, Fernanda, Pons‐Tostivint, Elvire, Therville, Nicole, Cintas, Celia, Arcucci, Silvia, Cassant‐Sourdy, Stephanie, Reyes‐Castellanos, Gabriela, Tosolini, Marie, Villard, Amelie V, Cayron, Coralie, Baer, Romain, Bertrand‐Michel, Justine, Pagan, Delphine, Ferreira Da Mota, Dina, Yan, Hongkai, Falcomatà, Chiara, Muscari, Fabrice, Bournet, Barbara, Delord, Jean‐Pierre, Aksoy, Ezra, Carrier, Alice, Cordelier, Pierre, Saur, Dieter, Basset, Celine, Guillermet‐Guibert, Julie
Published in EMBO molecular medicine (07.07.2021)
Published in EMBO molecular medicine (07.07.2021)
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A randomised, placebo-controlled study of omipalisib (PI3K/mTOR) in idiopathic pulmonary fibrosis
Lukey, Pauline T., Harrison, Stephen A., Yang, Shuying, Man, Yim, Holman, Beverley F., Rashidnasab, Alaleh, Azzopardi, Gabrielle, Grayer, Michael, Simpson, Juliet K., Bareille, Philippe, Paul, Lyn, Woodcock, Hannah V., Toshner, Richard, Saunders, Peter, Molyneaux, Philip L., Thielemans, Kris, Wilson, Frederick J., Mercer, Paul F., Chambers, Rachel C., Groves, Ashley M., Fahy, William A., Marshall, Richard P., Maher, Toby M.
Published in The European respiratory journal (01.03.2019)
Published in The European respiratory journal (01.03.2019)
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Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers
Fedele, Clare G., Ooms, Lisa M., Ho, Miriel, Vieusseux, Jessica, O'Toole, Sandra A., Millar, Ewan K., Lopez-Knowles, Elena, Sriratana, Absorn, Gurung, Rajendra, Baglietto, Laura, Giles, Graham G., Bailey, Charles G., Rasko, John E. J., Shields, Benjamin J., Price, John T., Majerus, Philip W., Sutherland, Robert L., Tiganis, Tony, McLean, Catriona A., Mitchell, Christina A.
Published in Proceedings of the National Academy of Sciences - PNAS (21.12.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (21.12.2010)
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Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer
Kavitha, K., Kowshik, J., Kishore, T. Kranthi Kiran, Baba, Abdul Basit, Nagini, S.
Published in Biochimica et biophysica acta (01.10.2013)
Published in Biochimica et biophysica acta (01.10.2013)
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PI3K/AKT/PTEN pathway as a target for Crohn's disease therapy (Review)
TOKUHIRA, NANA, KITAGISHI, YASUKO, SUZUKI, MIHO, MINAMI, AKARI, NAKANISHI, ATSUKO, ONO, YUNA, KOBAYASHI, KEIKO, MATSUDA, SATORU, OGURA, YASUNORI
Published in International journal of molecular medicine (01.01.2015)
Published in International journal of molecular medicine (01.01.2015)
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Population pharmacokinetic modeling of idelalisib, a novel PI3Kδ inhibitor, in healthy subjects and patients with hematologic malignancies
Jin, Feng, Gao, Yuying, Zhou, Huafeng, Fang, Lorna, Li, Xiaoming, Ramanathan, Srini
Published in Cancer chemotherapy and pharmacology (01.01.2016)
Published in Cancer chemotherapy and pharmacology (01.01.2016)
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Combination of Diosmetin With Chrysin Against Hepatocellular Carcinoma Through Inhibiting PI3K/AKT/mTOR/NF‐кB Signaling Pathway: TCGA Analysis, Molecular Docking, Molecular Dynamics, In Vitro Experiment
Yu, Xiang, Zhang, Di, Hu, Chengming, Yu, Zejun, Li, Yang, Fang, Cheng, Qiu, Yinsheng, Mei, Zhinan, Xu, Lingyun
Published in Chemical biology & drug design (01.10.2024)
Published in Chemical biology & drug design (01.10.2024)
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Discovery of a Selective Phosphoinositide-3-Kinase (PI3K)‑γ Inhibitor (IPI-549) as an Immuno-Oncology Clinical Candidate
Evans, Catherine A, Liu, Tao, Lescarbeau, André, Nair, Somarajan J, Grenier, Louis, Pradeilles, Johan A, Glenadel, Quentin, Tibbitts, Thomas, Rowley, Ann M, DiNitto, Jonathan P, Brophy, Erin E, O’Hearn, Erin L, Ali, Janid A, Winkler, David G, Goldstein, Stanley I, O’Hearn, Patrick, Martin, Christian M, Hoyt, Jennifer G, Soglia, John R, Cheung, Culver, Pink, Melissa M, Proctor, Jennifer L, Palombella, Vito J, Tremblay, Martin R, Castro, Alfredo C
Published in ACS medicinal chemistry letters (08.09.2016)
Published in ACS medicinal chemistry letters (08.09.2016)
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A high-avidity biosensor reveals plasma membrane PI(3,4)P 2 is predominantly a class I PI3K signaling product
Goulden, Brady D, Pacheco, Jonathan, Dull, Allyson, Zewe, James P, Deiters, Alexander, Hammond, Gerald R V
Published in The Journal of cell biology (04.03.2019)
Published in The Journal of cell biology (04.03.2019)
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Heterozygous splice mutation in PIK3R1 causes human immunodeficiency with lymphoproliferation due to dominant activation of PI3K
Lucas, Carrie L., Zhang, Yu, Venida, Anthony, Wang, Ying, Hughes, Jason, McElwee, Joshua, Butrick, Morgan, Matthews, Helen, Price, Susan, Biancalana, Matthew, Wang, Xiaochuan, Richards, Michael, Pozos, Tamara, Barlan, Isil, Ozen, Ahmet, Rao, V. Koneti, Su, Helen C., Lenardo, Michael J.
Published in The Journal of experimental medicine (15.12.2014)
Published in The Journal of experimental medicine (15.12.2014)
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Soluble T-cadherin secretion from endothelial cells is regulated via insulin/PI3K/Akt signalling
Okita, Tomonori, Kita, Shunbun, Fukuda, Shiro, Kondo, Yuta, Sakaue, Taka-aki, Iioka, Masahito, Fukuoka, Keita, Kawada, Keitaro, Nagao, Hirofumi, Obata, Yoshinari, Fujishima, Yuya, Ebihara, Takeshi, Matsumoto, Hisatake, Nakagawa, Satoshi, Kimura, Tadashi, Nishizawa, Hitoshi, Shimomura, Iichiro
Published in Biochemical and biophysical research communications (05.11.2024)
Published in Biochemical and biophysical research communications (05.11.2024)
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