Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange
Burns, Michael C., Qi Sun, Daniels, R. Nathan, Camper, DeMarco, Kennedy, J. Phillip, Phan, Jason, Olejniczak, Edward T., Lee, Taekyu, Waterson, Alex G., Rossanese, Olivia W., Fesik, Stephen W.
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Published in Proceedings of the National Academy of Sciences - PNAS (04.03.2014)
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Structure-based Design of High Affinity Peptides Inhibiting the Interaction of p53 with MDM2 and MDMX
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Published in The Journal of biological chemistry (15.01.2010)
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Displacement of WDR5 from Chromatin by a WIN Site Inhibitor with Picomolar Affinity
Aho, Erin R., Wang, Jing, Gogliotti, Rocco D., Howard, Gregory C., Phan, Jason, Acharya, Pankaj, Macdonald, Jonathan D., Cheng, Ken, Lorey, Shelly L., Lu, Bin, Wenzel, Sabine, Foshage, Audra M., Alvarado, Joseph, Wang, Feng, Shaw, J. Grace, Zhao, Bin, Weissmiller, April M., Thomas, Lance R., Vakoc, Christopher R., Hall, Matthew D., Hiebert, Scott W., Liu, Qi, Stauffer, Shaun R., Fesik, Stephen W., Tansey, William P.
Published in Cell reports (Cambridge) (12.03.2019)
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Discovery and Structure-Based Optimization of Benzimidazole-Derived Activators of SOS1-Mediated Nucleotide Exchange on RAS
Hodges, Timothy R, Abbott, Jason R, Little, Andrew J, Sarkar, Dhruba, Salovich, James M, Howes, Jennifer E, Akan, Denis T, Sai, Jiqing, Arnold, Allison L, Browning, Carrie, Burns, Michael C, Sobolik, Tammy, Sun, Qi, Beesetty, Yugandhar, Coker, Jesse A, Scharn, Dirk, Stadtmueller, Heinz, Rossanese, Olivia W, Phan, Jason, Waterson, Alex G, McConnell, Darryl B, Fesik, Stephen W
Published in Journal of medicinal chemistry (11.10.2018)
Published in Journal of medicinal chemistry (11.10.2018)
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Structural Basis for the Substrate Specificity of Tobacco Etch Virus Protease
Phan, Jason, Zdanov, Alexander, Evdokimov, Artem G., Tropea, Joseph E., Peters, Howard K., Kapust, Rachel B., Li, Mi, Wlodawer, Alexander, Waugh, David S.
Published in The Journal of biological chemistry (27.12.2002)
Published in The Journal of biological chemistry (27.12.2002)
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Erosion of embolization coils into the renal collecting system mimicking stone
Phan, Jason, Lall, Chandana, Moskowitz, Ross, Clayman, Ralph, Landman, Jaime
Published in The western journal of emergency medicine (01.02.2012)
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Structure of Human Thymidylate Synthase Suggests Advantages of Chemotherapy with Noncompetitive Inhibitors
Phan, J, Steadman, D J, Koli, S, Ding, W C, Minor, W, Dunlap, R B, Berger, S H, Lebioda, L
Published in The Journal of biological chemistry (27.04.2001)
Published in The Journal of biological chemistry (27.04.2001)
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Synthesis of tripeptides as potent Yersinia protein tyrosine phosphatase inhibitors
Lee, Kyeong, Boovanahalli, Shanthaveerappa K., Nam, Ky-Youb, Kang, Sang-Uk, Lee, Mijeoung, Phan, Jason, Wu, Li, Waugh, David S., Zhang, Zhong-Yin, No, Kyoung Tai, Lee, Jung Jun, Burke, Terrence R.
Published in Bioorganic & medicinal chemistry letters (15.09.2005)
Published in Bioorganic & medicinal chemistry letters (15.09.2005)
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Kesslera, Dirk, Gmachla, Michael, Mantoulidisa, Andreas, Martin, Laetitia J., Zoephel, Andreas, Mayer, Moriz, Gollner, Andreas, Covini, David, Fischer, Silke, Gerstberger, Thomas, Gmaschitz, Teresa, Goodwin, Craig, Greb, Peter, Häring, Daniela, Hela, Wolfgang, Hoffmann, Johann, Karolyi-Oezguer, Jale, Knesl, Petr, Kornigg, Stefan, Koegl, Manfred, Kousek, Roland, Lamarre, Lyne, Moser, Franziska, Munico-Martinez, Silvia, Peinsipp, Christoph, Phan, Jason, Rinnenthal, Jörg, Sai, Jiqing, Salamon, Christian, Scherbantin, Yvonne, Schipany, Katharina, Schnitzer, Renate, Schrenk, Andreas, Sharps, Bernadette, Siszler, Gabriella, Sun, Qi, Waterson, Alex, Wolkerstorfer, Bernhard, Zeeb, Markus, Pearson, Mark, Fesik, Stephen W., McConnell, Darryl B.
Published in Proceedings of the National Academy of Sciences - PNAS (06.08.2019)
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Fragment-Based Screening of the Bromodomain of ATAD2
Harner, Mary J, Chauder, Brian A, Phan, Jason, Fesik, Stephen W
Published in Journal of medicinal chemistry (26.11.2014)
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Discovery of Small Molecules that Bind to K-Ras and Inhibit Sos-Mediated Activation
Sun, Qi, Burke, Jason P., Phan, Jason, Burns, Michael C., Olejniczak, Edward T., Waterson, Alex G., Lee, Taekyu, Rossanese, Olivia W., Fesik, Stephen W.
Published in Angewandte Chemie International Edition (18.06.2012)
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Interaction with WDR5 Promotes Target Gene Recognition and Tumorigenesis by MYC
Thomas, Lance R., Wang, Qingguo, Grieb, Brian C., Phan, Jason, Foshage, Audra M., Sun, Qi, Olejniczak, Edward T., Clark, Travis, Dey, Soumyadeep, Lorey, Shelly, Alicie, Bethany, Howard, Gregory C., Cawthon, Bryan, Ess, Kevin C., Eischen, Christine M., Zhao, Zhongming, Fesik, Stephen W., Tansey, William P.
Published in Molecular cell (07.05.2015)
Published in Molecular cell (07.05.2015)
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Heterologous desensitization of cardiac β-adrenergic signal via hormone-induced βAR/arrestin/PDE4 complexes
Shi, Qian, Li, Minghui, Mika, Delphine, Fu, Qin, Kim, Sungjin, Phan, Jason, Shen, Ao, Vandecasteele, Gregoire, Xiang, Yang K
Published in Cardiovascular research (01.05.2017)
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Discovery of WD Repeat-Containing Protein 5 (WDR5)–MYC Inhibitors Using Fragment-Based Methods and Structure-Based Design
Chacón Simon, Selena, Wang, Feng, Thomas, Lance R, Phan, Jason, Zhao, Bin, Olejniczak, Edward T, Macdonald, Jonathan D, Shaw, J. Grace, Schlund, Caden, Payne, William, Creighton, Joy, Stauffer, Shaun R, Waterson, Alex G, Tansey, William P, Fesik, Stephen W
Published in Journal of medicinal chemistry (23.04.2020)
Published in Journal of medicinal chemistry (23.04.2020)
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Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods
Sarkar, Dhruba, Olejniczak, Edward T, Phan, Jason, Coker, Jesse A, Sai, Jiqing, Arnold, Allison, Beesetty, Yugandhar, Waterson, Alex G, Fesik, Stephen W
Published in Journal of medicinal chemistry (13.08.2020)
Published in Journal of medicinal chemistry (13.08.2020)
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Discovery of Potent 2-Aryl-6,7-dihydro-5 H-pyrrolo[1,2- a]imidazoles as WDR5-WIN-Site Inhibitors Using Fragment-Based Methods and Structure-Based Design
Wang, Feng, Jeon, Kyu Ok, Salovich, James M, Macdonald, Jonathan D, Alvarado, Joseph, Gogliotti, Rocco D, Phan, Jason, Olejniczak, Edward T, Sun, Qi, Wang, Shidong, Camper, DeMarco, Yuh, Joannes P, Shaw, J Grace, Sai, Jiqing, Rossanese, Olivia W, Tansey, William P, Stauffer, Shaun R, Fesik, Stephen W
Published in Journal of medicinal chemistry (12.07.2018)
Published in Journal of medicinal chemistry (12.07.2018)
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