Correlating preclinical animal studies and human clinical trials of a multifunctional, polymeric nanoparticle
Eliasof, Scott, Lazarus, Douglas, Peters, Christian G., Case, Roy I., Cole, Roderic O., Hwang, Jungyeon, Schluep, Thomas, Chao, Joseph, Lin, James, Yen, Yun, Han, Han, Wiley, Devin T., Zuckerman, Jonathan E., Davis, Mark E.
Published in Proceedings of the National Academy of Sciences - PNAS (10.09.2013)
Published in Proceedings of the National Academy of Sciences - PNAS (10.09.2013)
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Journal Article
Megakaryocytes package contents into separate α-granules that are differentially distributed in platelets
Battinelli, Elisabeth M., Thon, Jonathan N., Okazaki, Ross, Peters, Christian G., Vijey, Prakrith, Wilkie, Adrian R., Noetzli, Leila J., Flaumenhaft, Robert, Italiano, Joseph E.
Published in Blood advances (22.10.2019)
Published in Blood advances (22.10.2019)
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Journal Article
The unfolded protein response links ER stress to cancer-associated thrombosis
Muse, Oluwatoyosi, Patell, Rushad, Peters, Christian G, Yang, Moua, El-Darzi, Emale, Schulman, Sol, Falanga, Anna, Marchetti, Marina, Russo, Laura, Zwicker, Jeffrey I, Flaumenhaft, Robert
Published in JCI insight (31.08.2023)
Published in JCI insight (31.08.2023)
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Journal Article
PAR1 agonists stimulate APC-like endothelial cytoprotection and confer resistance to thromboinflammatory injury
De Ceunynck, Karen, Peters, Christian G., Jain, Abhishek, Higgins, Sarah J., Aisiku, Omozuanvbo, Fitch-Tewfik, Jennifer L., Chaudhry, Sharjeel A., Dockendorff, Chris, Parikh, Samir M., Ingber, Donald E., Flaumenhaft, Robert
Published in Proceedings of the National Academy of Sciences - PNAS (30.01.2018)
Published in Proceedings of the National Academy of Sciences - PNAS (30.01.2018)
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Journal Article
CRLX101, a Nanoparticle-Drug Conjugate Containing Camptothecin, Improves Rectal Cancer Chemoradiotherapy by Inhibiting DNA Repair and HIF1α
Tian, Xi, Nguyen, Minh, Foote, Henry P, Caster, Joseph M, Roche, Kyle C, Peters, Christian G, Wu, Pauline, Jayaraman, Lata, Garmey, Edward G, Tepper, Joel E, Eliasof, Scott, Wang, Andrew Z
Published in Cancer research (Chicago, Ill.) (01.01.2017)
Published in Cancer research (Chicago, Ill.) (01.01.2017)
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Journal Article
Parmodulins inhibit thrombus formation without inducing endothelial injury caused by vorapaxar
Aisiku, Omozuanvbo, Peters, Christian G., De Ceunynck, Karen, Ghosh, Chandra C., Dilks, James R., Fustolo-Gunnink, Susanna F., Huang, Mingdong, Dockendorff, Chris, Parikh, Samir M., Flaumenhaft, Robert
Published in Blood (19.03.2015)
Published in Blood (19.03.2015)
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Journal Article
Preclinical Efficacy of Bevacizumab with CRLX101, an Investigational Nanoparticle-Drug Conjugate, in Treatment of Metastatic Triple-Negative Breast Cancer
Pham, Elizabeth, Yin, Melissa, Peters, Christian G, Lee, Christina R, Brown, Donna, Xu, Ping, Man, Shan, Jayaraman, Lata, Rohde, Ellen, Chow, Annabelle, Lazarus, Douglas, Eliasof, Scott, Foster, F Stuart, Kerbel, Robert S
Published in Cancer research (Chicago, Ill.) (01.08.2016)
Published in Cancer research (Chicago, Ill.) (01.08.2016)
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Journal Article
Translational impact of nanoparticle-drug conjugate CRLX101 with or without bevacizumab in advanced ovarian cancer
Pham, Elizabeth, Birrer, Michael J, Eliasof, Scott, Garmey, Edward G, Lazarus, Douglas, Lee, Christina R, Man, Shan, Matulonis, Ursula A, Peters, Christian G, Xu, Ping, Krasner, Carolyn, Kerbel, Robert S
Published in Clinical cancer research (15.02.2015)
Published in Clinical cancer research (15.02.2015)
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Journal Article
The secreted tyrosine kinase VLK is essential for normal platelet activation and thrombus formation
Revollo, Leila, Merrill-Skoloff, Glenn, De Ceunynck, Karen, Dilks, James R., Guo, Shihui, Bordoli, Mattia R., Peters, Christian G., Noetzli, Leila, Ionescu, Andreia, Rosen, Vicki, Italiano, Joseph E., Whitman, Malcolm, Flaumenhaft, Robert
Published in Blood (06.01.2022)
Published in Blood (06.01.2022)
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Journal Article
CRLX101, an investigational camptothecin-containing nanoparticle-drug conjugate, targets cancer stem cells and impedes resistance to antiangiogenic therapy in mouse models of breast cancer
Conley, Sarah J., Baker, Trenton L., Burnett, Joseph P., Theisen, Rebecca L., Lazarus, Douglas, Peters, Christian G., Clouthier, Shawn G., Eliasof, Scott, Wicha, Max S.
Published in Breast cancer research and treatment (01.04.2015)
Published in Breast cancer research and treatment (01.04.2015)
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Journal Article
The Platelet Actin Cytoskeleton Associates with SNAREs and Participates in α-Granule Secretion
Woronowicz, Kamil, Dilks, James R, Rozenvayn, Nataliya, Dowal, Louisa, Blair, Price S, Peters, Christian G, Woronowicz, Lucyna, Flaumenhaft, Robert
Published in Biochemistry (Easton) (01.06.2010)
Published in Biochemistry (Easton) (01.06.2010)
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Journal Article
Dynamin-Related Protein-1 Controls Fusion Pore Dynamics During Platelet Granule Exocytosis
Koseoglu, Secil, Dilks, James R, Peters, Christian G, Fitch-Tewfik, Jennifer L, Fadel, Nathalie A, Jasuja, Reema, Italiano, Joseph E, Haynes, Christy L, Flaumenhaft, Robert
Published in Arteriosclerosis, thrombosis, and vascular biology (01.03.2013)
Published in Arteriosclerosis, thrombosis, and vascular biology (01.03.2013)
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Journal Article
Visualizing form and function in organotypic slices of the adult mouse parotid gland
Warner, Jennifer D, Peters, Christian G, Saunders, Rudel, Won, Jong Hak, Betzenhauser, Matthew J, Gunning, 3rd, William T, Yule, David I, Giovannucci, David R
Published in American journal of physiology: Gastrointestinal and liver physiology (01.09.2008)
Published in American journal of physiology: Gastrointestinal and liver physiology (01.09.2008)
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Journal Article
Abstract 1345: Tumor selective localization of CRLX101, an investigational nanoparticle-drug conjugate of camptothecin
Peters, Christian G., Lazarus, Douglas, Brown, Donna, Zhang, Ningning, Stockmann, Adam P., Case, Roy, Rohde, Ellen, Eliasof, Scott, Jayaraman, Lata
Published in Cancer research (Chicago, Ill.) (15.07.2016)
Published in Cancer research (Chicago, Ill.) (15.07.2016)
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Journal Article
Abstract B37: Selective tumor localization of CRLX101, a novel nanoparticle-drug conjugate
Peters, Christian G., Lazarus, Douglas, Brown, Donna, Zhang, Ningning, Case, Roy, Rohde, Ellen, Eliasof, Scott, Jayaraman, Lata
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Journal Article
Effects Of Biased PAR1 Ligands On Platelets and Endothelial Cells
Aisiku, Omozuanvbo R., Peters, Christian G., Gunnink, Suzanne, Dilks, James R., Dockendorff, Chris, Flaumenhaft, Robert
Published in Blood (15.11.2013)
Published in Blood (15.11.2013)
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Journal Article