Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition
Bedard, Gabriel T., Gilaj, Nord, Peregrina, Karina, Brew, Isabella, Tosti, Elena, Shaffer, Karl, Tyler, Peter C., Edelmann, Winfried, Augenlicht, Leonard H., Schramm, Vern L.
Published in The Journal of biological chemistry (01.01.2024)
Published in The Journal of biological chemistry (01.01.2024)
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Journal Article
Shotgun ion mobility mass spectrometry sequencing of heparan sulfate saccharides
Miller, Rebecca L., Guimond, Scott E., Schwörer, Ralf, Zubkova, Olga V., Tyler, Peter C., Xu, Yongmei, Liu, Jian, Chopra, Pradeep, Boons, Geert-Jan, Grabarics, Márkó, Manz, Christian, Hofmann, Johanna, Karlsson, Niclas G., Turnbull, Jeremy E., Struwe, Weston B., Pagel, Kevin
Published in Nature communications (20.03.2020)
Published in Nature communications (20.03.2020)
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Synthesis of a Targeted Library of Heparan Sulfate Hexa- to Dodecasaccharides as Inhibitors of β-Secretase: Potential Therapeutics for Alzheimer's Disease
Schwörer, Ralf, Zubkova, Olga V., Turnbull, Jeremy E., Tyler, Peter C.
Published in Chemistry : a European journal (17.05.2013)
Published in Chemistry : a European journal (17.05.2013)
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Journal Article
Expedient synthesis of imino-C-nucleoside fleximers featuring a one-pot procedure to prepare aryl triazoles
Wong, C. H. Andy, Hubert, Jonathan G, Sparrow, Kevin J, Harris, Lawrence D, Tyler, Peter C, Brimble, Margaret A
Published in Organic & biomolecular chemistry (02.08.2023)
Published in Organic & biomolecular chemistry (02.08.2023)
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Journal Article
Using automated glycan assembly (AGA) for the practical synthesis of heparan sulfate oligosaccharide precursors
Budhadev, Darshita, Saxby, Karinna, Walton, Julia, Davies, Gideon, Tyler, Peter C, Schwörer, Ralf, Fascione, Martin A
Published in Organic & biomolecular chemistry (13.02.2019)
Published in Organic & biomolecular chemistry (13.02.2019)
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Journal Article
Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine–Guanine Phosphoribosyltransferases
Glockzin, Kayla, Kostomiris, Demetrios, Minnow, Yacoba V. T., Suthagar, Kajitha, Clinch, Keith, Gai, Sinan, Buckler, Joshua N., Schramm, Vern L., Tyler, Peter C., Meek, Thomas D., Katzfuss, Ardala
Published in Biochemistry (Easton) (04.10.2022)
Published in Biochemistry (Easton) (04.10.2022)
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Journal Article
Rational synthesis of a heparan sulfate saccharide that promotes the activity of BMP2
Shaffer, Karl J., Smith, Raymond A.A., Daines, Alison M., Luo, Xiaoman, Lu, Xiaohua, Tan, Tuan Chun, Le, Bach Q., Schwörer, Ralf, Hinkley, Simon F.R., Tyler, Peter C., Nurcombe, Victor, Cool, Simon M.
Published in Carbohydrate polymers (01.06.2024)
Published in Carbohydrate polymers (01.06.2024)
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Journal Article
Kinetic and Structural Characterization of Trypanosoma cruzi Hypoxanthine–Guanine–Xanthine Phosphoribosyltransferases and Repurposing of Transition-State Analogue Inhibitors
Glockzin, Kayla, Meneely, Kathleen M., Hughes, Ryan, Maatouk, Sean W., Piña, Grace E., Suthagar, Kajitha, Clinch, Keith, Buckler, Joshua N., Lamb, Audrey L., Tyler, Peter C., Meek, Thomas D., Katzfuss, Ardala
Published in Biochemistry (Easton) (18.07.2023)
Published in Biochemistry (Easton) (18.07.2023)
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Journal Article
The Immucillins: Design, Synthesis and Application of Transition- State Analogues
Evans, Gary B, Schramm, Vern L, Tyler, Peter C
Published in Current medicinal chemistry (01.01.2015)
Published in Current medicinal chemistry (01.01.2015)
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Journal Article
Infrastructure as a Complex Adaptive System
Hall, Jim W., Tyler, Peter, Usher, Will, Oughton, Edward J.
Published in Complexity (New York, N.Y.) (01.01.2018)
Published in Complexity (New York, N.Y.) (01.01.2018)
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Journal Article
'Levelling up' the UK: reinforcing the policy agenda
Martin, Ron, Pike, Andy, Sunley, Peter, Tyler, Peter, Gardiner, Ben
Published in Regional studies, regional science (31.12.2022)
Published in Regional studies, regional science (31.12.2022)
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Journal Article
Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1
Lamiable-Oulaidi, Farah, Harijan, Rajesh K, Shaffer, Karl J, Crump, Douglas R, Sun, Yan, Du, Quan, Gulab, Shivali A, Khan, Ashna A, Luxenburger, Andreas, Woolhouse, Anthony D, Sidoli, Simone, Tyler, Peter C, Schramm, Vern L
Published in Journal of medicinal chemistry (14.04.2022)
Published in Journal of medicinal chemistry (14.04.2022)
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Journal Article
Single-Entity Heparan Sulfate Glycomimetic Clusters for Therapeutic Applications
Tyler, Peter C., Guimond, Scott E., Turnbull, Jeremy E., Zubkova, Olga V.
Published in Angewandte Chemie (International ed.) (23.02.2015)
Published in Angewandte Chemie (International ed.) (23.02.2015)
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Journal Article
New Antibiotic Candidates against Helicobacter pylori
Wang, Shanzhi, Cameron, Scott A, Clinch, Keith, Evans, Gary B, Wu, Zhimeng, Schramm, Vern L, Tyler, Peter C
Published in Journal of the American Chemical Society (18.11.2015)
Published in Journal of the American Chemical Society (18.11.2015)
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