Structural basis for RNA replication by the hepatitis C virus polymerase
Appleby, Todd C., Perry, Jason K., Murakami, Eisuke, Barauskas, Ona, Feng, Joy, Cho, Aesop, Fox, David, Wetmore, Diana R., McGrath, Mary E., Ray, Adrian S., Sofia, Michael J., Swaminathan, S., Edwards, Thomas E.
Published in Science (American Association for the Advancement of Science) (13.02.2015)
Published in Science (American Association for the Advancement of Science) (13.02.2015)
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Structural basis for substrate selection by the SARS-CoV-2 replicase
Malone, Brandon F, Perry, Jason K, Olinares, Paul Dominic B, Lee, Hery W, Chen, James, Appleby, Todd C, Feng, Joy Y, Bilello, John P, Ng, Honkit, Sotiris, Johanna, Ebrahim, Mark, Chua, Eugene Y D, Mendez, Joshua H, Eng, Ed T, Landick, Robert, Götte, Matthias, Chait, Brian T, Campbell, Elizabeth A, Darst, Seth A
Published in Nature (London) (23.02.2023)
Published in Nature (London) (23.02.2023)
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Role of Mitochondrial RNA Polymerase in the Toxicity of Nucleotide Inhibitors of Hepatitis C Virus
Feng, Joy Y, Xu, Yili, Barauskas, Ona, Perry, Jason K, Ahmadyar, Shekeba, Stepan, George, Yu, Helen, Babusis, Darius, Park, Yeojin, McCutcheon, Krista, Perron, Michel, Schultz, Brian E, Sakowicz, Roman, Ray, Adrian S
Published in Antimicrobial agents and chemotherapy (01.02.2016)
Published in Antimicrobial agents and chemotherapy (01.02.2016)
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Glide: A New Approach for Rapid, Accurate Docking and Scoring. 1. Method and Assessment of Docking Accuracy
Friesner, Richard A, Banks, Jay L, Murphy, Robert B, Halgren, Thomas A, Klicic, Jasna J, Mainz, Daniel T, Repasky, Matthew P, Knoll, Eric H, Shelley, Mee, Perry, Jason K, Shaw, David E, Francis, Perry, Shenkin, Peter S
Published in Journal of medicinal chemistry (25.03.2004)
Published in Journal of medicinal chemistry (25.03.2004)
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The Nucleoside/Nucleotide Analogs Tenofovir and Emtricitabine Are Inactive against SARS-CoV-2
Feng, Joy Y., Du Pont, Venice, Babusis, Darius, Gordon, Calvin J., Tchesnokov, Egor P., Perry, Jason K., Duong, Vincent, Vijjapurapu, Arya, Zhao, Xiaofeng, Chan, Julie, Cohen, Cal, Juneja, Kavita, Cihlar, Tomas, Götte, Matthias, Bilello, John P.
Published in Molecules (Basel, Switzerland) (30.06.2022)
Published in Molecules (Basel, Switzerland) (30.06.2022)
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Discovery of velpatasvir (GS-5816): A potent pan-genotypic HCV NS5A inhibitor in the single-tablet regimens Vosevi® and Epclusa
Link, John O., Taylor, James G., Trejo-Martin, Alejandra, Kato, Darryl, Katana, Ashley A., Krygowski, Evan S., Yang, Zheng-Yu, Zipfel, Sheila, Cottell, Jeromy J., Bacon, Elizabeth M., Tran, Chinh V., Yang, Cheng Y., Wang, Yujin, Wang, Kelly W., Zhao, Guangyu, Cheng, Guofeng, Tian, Yang, Gong, Ruoyu, Lee, Yu-Jen, Yu, Mei, Gorman, Eric, Mogalian, Erik, Perry, Jason K.
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
Published in Bioorganic & medicinal chemistry letters (15.08.2019)
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Structural and Binding Analysis of Pyrimidinol Carboxylic Acid and N-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors
LANSDON, Eric B, QI LIU, KIRSCHBERG, Thorsten A, LEAVITT, Stephanie A, BALAKRISHNAN, Mini, PERRY, Jason K, LANCASTER-MOYER, Candra, KUTTY, Nilima, XIAOHONG LIU, SQUIRES, Neil H, WATKINS, William J
Published in Antimicrobial Agents and Chemotherapy (01.06.2011)
Published in Antimicrobial Agents and Chemotherapy (01.06.2011)
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No Remdesivir Resistance Observed in the Phase 3 Severe and Moderate COVID-19 SIMPLE Trials
Hedskog, Charlotte, Spinner, Christoph D, Protzer, Ulrike, Hoffmann, Dieter, Ko, Chunkyu, Gottlieb, Robert L, Askar, Medhat, Roestenberg, Meta, de Vries, Jutte J C, Carbo, Ellen C, Martin, Ross, Li, Jiani, Han, Dong, Rodriguez, Lauren, Parvangada, Aiyappa, Perry, Jason K, Ferrer, Ricard, Antón, Andrés, Andrés, Cristina, Casares, Vanessa, Günthard, Huldrych F, Huber, Michael, McComsey, Grace A, Sadri, Navid, Aberg, Judith A, van Bakel, Harm, Porter, Danielle P
Published in Viruses (01.04.2024)
Published in Viruses (01.04.2024)
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RNase H Active Site Inhibitors of Human Immunodeficiency Virus Type 1 Reverse Transcriptase: Design, Biochemical Activity, and Structural Information
Kirschberg, Thorsten A, Balakrishnan, Mini, Squires, Neil H, Barnes, Tiffany, Brendza, Katherine M, Chen, Xiaowu, Eisenberg, Eugene J, Jin, Weili, Kutty, Nilima, Leavitt, Stephanie, Liclican, Albert, Liu, Qi, Liu, Xiaohong, Mak, John, Perry, Jason K, Wang, Michael, Watkins, William J, Lansdon, Eric B
Published in Journal of medicinal chemistry (08.10.2009)
Published in Journal of medicinal chemistry (08.10.2009)
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Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency
Gordon, Calvin J., Tchesnokov, Egor P., Woolner, Emma, Perry, Jason K., Feng, Joy Y., Porter, Danielle P., Götte, Matthias
Published in The Journal of biological chemistry (15.05.2020)
Published in The Journal of biological chemistry (15.05.2020)
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Template-dependent inhibition of coronavirus RNA-dependent RNA polymerase by remdesivir reveals a second mechanism of action
Tchesnokov, Egor P., Gordon, Calvin J., Woolner, Emma, Kocinkova, Dana, Perry, Jason K., Feng, Joy Y., Porter, Danielle P., Götte, Matthias
Published in The Journal of biological chemistry (20.11.2020)
Published in The Journal of biological chemistry (20.11.2020)
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Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice
Pruijssers, Andrea J., George, Amelia S., Schäfer, Alexandra, Leist, Sarah R., Gralinksi, Lisa E., Dinnon, Kenneth H., Yount, Boyd L., Agostini, Maria L., Stevens, Laura J., Chappell, James D., Lu, Xiaotao, Hughes, Tia M., Gully, Kendra, Martinez, David R., Brown, Ariane J., Graham, Rachel L., Perry, Jason K., Du Pont, Venice, Pitts, Jared, Ma, Bin, Babusis, Darius, Murakami, Eisuke, Feng, Joy Y., Bilello, John P., Porter, Danielle P., Cihlar, Tomas, Baric, Ralph S., Denison, Mark R., Sheahan, Timothy P.
Published in Cell Reports (21.07.2020)
Published in Cell Reports (21.07.2020)
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Mutations in the SARS-CoV-2 RNA-dependent RNA polymerase confer resistance to remdesivir by distinct mechanisms
Stevens, Laura J, Pruijssers, Andrea J, Lee, Hery W, Gordon, Calvin J, Tchesnokov, Egor P, Gribble, Jennifer, George, Amelia S, Hughes, Tia M, Lu, Xiaotao, Li, Jiani, Perry, Jason K, Porter, Danielle P, Cihlar, Tomas, Sheahan, Timothy P, Baric, Ralph S, Götte, Matthias, Denison, Mark R
Published in Science translational medicine (03.08.2022)
Published in Science translational medicine (03.08.2022)
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An atomistic model of the coronavirus replication-transcription complex as a hexamer assembled around nsp15
Perry, Jason K., Appleby, Todd C., Bilello, John P., Feng, Joy Y., Schmitz, Uli, Campbell, Elizabeth A.
Published in The Journal of biological chemistry (01.10.2021)
Published in The Journal of biological chemistry (01.10.2021)
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Remdesivir and GS-441524 Retain Antiviral Activity against Delta, Omicron, and Other Emergent SARS-CoV-2 Variants
Pitts, Jared, Li, Jiani, Perry, Jason K, Du Pont, Venice, Riola, Nicholas, Rodriguez, Lauren, Lu, Xianghan, Kurhade, Chaitanya, Xie, Xuping, Camus, Gregory, Manhas, Savrina, Martin, Ross, Shi, Pei-Yong, Cihlar, Tomas, Porter, Danielle P, Mo, Hongmei, Maiorova, Evguenia, Bilello, John P
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Published in Antimicrobial agents and chemotherapy (21.06.2022)
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Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B
Mackman, Richard L, Mish, Michael, Chin, Gregory, Perry, Jason K, Appleby, Todd, Aktoudianakis, Vangelis, Metobo, Sammy, Pyun, Peter, Niu, Congrong, Daffis, Stephane, Yu, Helen, Zheng, Jim, Villasenor, Armando G, Zablocki, Jeff, Chamberlain, Jason, Jin, Haolun, Lee, Gary, Suekawa-Pirrone, Kimberley, Santos, Rex, Delaney, William E, Fletcher, Simon P
Published in Journal of medicinal chemistry (24.09.2020)
Published in Journal of medicinal chemistry (24.09.2020)
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Ensemble cryo-EM reveals conformational states of the nsp13 helicase in the SARS-CoV-2 helicase replication-transcription complex
Chen, James, Wang, Qi, Malone, Brandon, Llewellyn, Eliza, Pechersky, Yakov, Maruthi, Kashyap, Eng, Ed T, Perry, Jason K, Campbell, Elizabeth A, Shaw, David E, Darst, Seth A
Published in Nature structural & molecular biology (01.03.2022)
Published in Nature structural & molecular biology (01.03.2022)
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Remdesivir targets a structurally analogous region of the Ebola virus and SARS-CoV-2 polymerases
Lo, Michael K., Albariño, César G., Perry, Jason K., Chang, Silvia, Tchesnokov, Egor P., Guerrero, Lisa, Chakrabarti, Ayan, Shrivastava-Ranjan, Punya, Chatterjee, Payel, McMullan, Laura K., Martin, Ross, Jordan, Robert, Götte, Matthias, Montgomery, Joel M., Nichol, Stuart T., Flint, Mike, Porter, Danielle, Spiropoulou, Christina F.
Published in Proceedings of the National Academy of Sciences - PNAS (27.10.2020)
Published in Proceedings of the National Academy of Sciences - PNAS (27.10.2020)
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Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir
Gordon, Calvin J., Lee, Hery W., Tchesnokov, Egor P., Perry, Jason K., Feng, Joy Y., Bilello, John P., Porter, Danielle P., Götte, Matthias
Published in The Journal of biological chemistry (01.02.2022)
Published in The Journal of biological chemistry (01.02.2022)
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In Vitro Selection of Remdesivir-Resistant SARS-CoV-2 Demonstrates High Barrier to Resistance
Checkmahomed, Liva, Carbonneau, Julie, Du Pont, Venice, Riola, Nicholas C, Perry, Jason K, Li, Jiani, Paré, Bastien, Simpson, Shawn M, Smith, Martin A, Porter, Danielle P, Boivin, Guy
Published in Antimicrobial agents and chemotherapy (19.07.2022)
Published in Antimicrobial agents and chemotherapy (19.07.2022)
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