Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late INai) of the cardiac Nav1.5 channel with improved efficacy and potency relative to ranolazine
Koltun, Dmitry O., Parkhill, Eric Q., Elzein, Elfatih, Kobayashi, Tetsuya, Jiang, Robert H., Li, Xiaofen, Perry, Thao D., Avila, Belem, Wang, Wei-Qun, Hirakawa, Ryoko, Smith-Maxwell, Catherine, Wu, Lin, Dhalla, Arvinder K., Rajamani, Sridharan, Mollova, Nevena, Stafford, Brian, Tang, Jennifer, Belardinelli, Luiz, Zablocki, Jeff A.
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Get full text
Journal Article
Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late INai) of the cardiac NaV 1.5 channel with improved efficacy and potency relative to ranolazine
Koltun, Dmitry O., Parkhill, Eric Q., Elzein, Elfatih, Kobayashi, Tetsuya, Notte, Gregory T., Kalla, Rao, Jiang, Robert H., Li, Xiaofen, Perry, Thao D., Avila, Belem, Wang, Wei-Qun, Smith-Maxwell, Catherine, Dhalla, Arvinder K., Rajamani, Sridharan, Stafford, Brian, Tang, Jennifer, Mollova, Nevena, Belardinelli, Luiz, Zablocki, Jeff A.
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Get full text
Journal Article
Discovery of potent and selective inhibitors of calmodulin-dependent kinase II (CaMKII)
Koltun, Dmitry O., Parkhill, Eric Q., Kalla, Rao, Perry, Thao D., Elzein, Elfatih, Li, Xiaofen, Simonovich, Scott P., Ziebenhaus, Christopher, Hansen, Timothy R., Marchand, Bruno, Hung, WaiLok K., Lagpacan, Leanna, Hung, Magdeleine, Aoyama, Ron G., Murray, Bernard P., Perry, Jason K., Somoza, John R., Villaseñor, Armando G., Pagratis, Nikos, Zablocki, Jeff A.
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Published in Bioorganic & medicinal chemistry letters (01.02.2018)
Get full text
Journal Article
1'-시아노 뉴클레오시드 유사체 및 이의 용도
KOLTUN DMITRY, SIMONOVICH SCOTT P, JANSA PETR, MACKMAN RICHARD L, SIEGEL DUSTIN S, CLARKE MICHAEL O, PERRY THAO D, CHUN BYOUNG KWON, KALLA RAO V, BYUN DANIEL H
Year of Publication 28.02.2023
Get full text
Year of Publication 28.02.2023
Patent
HPK1 억제제로서의 치환된 6-아자벤즈이미다졸 화합물
ZABLOCKI JEFF, KIM MUSONG, CHANDRASEKHAR JAYARAMAN, LEE SEUNG H, SWAMINATHAN SUNDARAMOORTHI, MITCHELL SCOTT A, BALAN GAYATRI, LOYER DREW JENNIFER A, COSMAN JENNIFER L, LO JENNIFER R, SALVO PATRICK J, KASUN ZACHARY A, CONWAY JOHN H, VAN VELDHUIZEN JOSHUA J, PHILLIPS GARY B, PERRY THAO D, YEUNG SUET C, BARTLETT MARK J, KALLA RAO V, CODELLI JULIAN A
Year of Publication 08.07.2021
Get full text
Year of Publication 08.07.2021
Patent
HPK1 억제 활성을 갖는 치환된 6-아자벤즈이미다졸 화합물
ZABLOCKI JEFF, KIM MUSONG, CHANDRASEKHAR JAYARAMAN, LEE SEUNG H, MITCHELL SCOTT A, BALAN GAYATRI, LOYER DREW JENNIFER A, COSMAN JENNIFER L, LO JENNIFER R, SALVO PATRICK J, CONWAY JOHN H, VAN VELDHUIZEN JOSHUA J, PHILLIPS GARY B, PERRY THAO D, YEUNG SUET C, BARTLETT MARK J, KALLA RAO V, CODELLI JULIAN A
Year of Publication 07.07.2021
Get full text
Year of Publication 07.07.2021
Patent
Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late I(Na)i) of the cardiac Na-V 1.5 channel with improved efficacy and potency relative to ranolazine
Koltun, Dmitry O., Parkhill, Eric Q., Elzein, Elfatih, Kobayashi, Tetsuya, Notte, Gregory T., Kalla, Rao, Jiang, Robert H., Li, Xiaofen, Perry, Thao D., Avila, Belem, Wang, Wei-Qun, Smith-Maxwell, Catherine, Dhalla, Arvinder K., Rajamani, Sridharan, Stafford, Brian, Tang, Jennifer, Mollova, Nevena, Belardinelli, Luiz, Zablocki, Jeff A.
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Get full text
Journal Article
Discovery of triazolopyridinone GS-462808, a late sodium current inhibitor (Late I Na i) of the cardiac Na v 1.5 channel with improved efficacy and potency relative to ranolazine
Koltun, Dmitry O., Parkhill, Eric Q., Elzein, Elfatih, Kobayashi, Tetsuya, Jiang, Robert H., Li, Xiaofen, Perry, Thao D., Avila, Belem, Wang, Wei-Qun, Hirakawa, Ryoko, Smith-Maxwell, Catherine, Wu, Lin, Dhalla, Arvinder K., Rajamani, Sridharan, Mollova, Nevena, Stafford, Brian, Tang, Jennifer, Belardinelli, Luiz, Zablocki, Jeff A.
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Get full text
Journal Article
Discovery of triazolopyridine GS-458967, a late sodium current inhibitor (Late I Na i) of the cardiac Na V 1.5 channel with improved efficacy and potency relative to ranolazine
Koltun, Dmitry O., Parkhill, Eric Q., Elzein, Elfatih, Kobayashi, Tetsuya, Notte, Gregory T., Kalla, Rao, Jiang, Robert H., Li, Xiaofen, Perry, Thao D., Avila, Belem, Wang, Wei-Qun, Smith-Maxwell, Catherine, Dhalla, Arvinder K., Rajamani, Sridharan, Stafford, Brian, Tang, Jennifer, Mollova, Nevena, Belardinelli, Luiz, Zablocki, Jeff A.
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Published in Bioorganic & medicinal chemistry letters (01.07.2016)
Get full text
Journal Article
1'-CYANO NUCLEOSIDE ANALOGS AND USES THEREOF
Mackman, Richard L, Byun, Daniel H, Clarke, Michael O, Kalla, Rao V, Siegel, Dustin S, Perry, Thao D, Jansa, Petr, Koltun, Dmitry, Simonovich, Scott P, Chun, Byoung-Kwon
Year of Publication 29.08.2024
Get full text
Year of Publication 29.08.2024
Patent
1′-cyano nucleoside analogs and uses thereof
Mackman, Richard L, Byun, Daniel H, Clarke, Michael O, Kalla, Rao V, Siegel, Dustin S, Perry, Thao D, Jansa, Petr, Koltun, Dmitry, Simonovich, Scott P, Chun, Byoung-Kwon
Year of Publication 26.03.2024
Get full text
Year of Publication 26.03.2024
Patent
Substituted eneoxindoles and uses thereof
Elbel, Kristyna M, Chandrasekhar, Jayaraman, Mitchell, Scott A, Kalla, Rao V, Metobo, Samuel E, Codelli, Julian A, Perry, Thao D, Aktoudianakis, Evangelos, Conway, John H, Simonovich, Scott P, Ziebenhaus, Christopher A
Year of Publication 16.07.2024
Get full text
Year of Publication 16.07.2024
Patent
1'-CYANO NUCLEOSIDE ANALOGS AND USES THEREOF
SIEGEL, Dustin S, KOLTUN, Dmitry, BYUN, Daniel H, JANSA, Petr, MACKMAN, Richard L, PERRY, Thao D, CHUN, Byoung-Kwon, CLARKE, Michael O, KALLA, Rao V, SIMONOVICH, Scott P
Year of Publication 03.05.2023
Get full text
Year of Publication 03.05.2023
Patent
1'-cyano nucleoside analogs and uses thereof
SIEGEL, Dustin S, KOLTUN, Dmitry, BYUN, Daniel H, JANSA, Petr, MACKMAN, Richard L, PERRY, Thao D, CHUN, Byoung-Kwon, CLARKE, Michael O, KALLA, Rao V, SIMONOVICH, Scott P
Year of Publication 16.02.2023
Get full text
Year of Publication 16.02.2023
Patent
1'-CYANO NUCLEOSIDE ANALOGS AND USES THEREOF
Mackman, Richard L, Byun, Daniel H, Clarke, Michael O, Kalla, Rao V, Siegel, Dustin S, Perry, Thao D, Jansa, Petr, Koltun, Dmitry, Simonovich, Scott P, Chun, Byoung-Kwon
Year of Publication 09.02.2023
Get full text
Year of Publication 09.02.2023
Patent
SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS
Lo, Jennifer R, Chandrasekhar, Jayaraman, Kim, Musong, Salvo, Patrick J, Codelli, Julian A, Perry, Thao D, Loyer-Drew, Jennifer A, Bartlett, Mark J, Kasun, Zachary A, Zablocki, Jeff, Mitchell, Scott A, Lee, Seung H, Balan, Gayatri, Van Veldhuizen, Joshua J, Cosman Ellis, Jennifer L, Kalla, Rao V, Yeung, Suet C, Phillips, Gary B, Conway, John H, Swaminathan, Sundaramoorthi
Year of Publication 29.08.2024
Get full text
Year of Publication 29.08.2024
Patent
SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS
Lo, Jennifer R, Chandrasekhar, Jayaraman, Kim, Musong, Salvo, Patrick J, Codelli, Julian A, Perry, Thao D, Cosman, Jennifer L, Loyer-Drew, Jennifer A, Bartlett, Mark J, Kasun, Zachary A, Zablocki, Jeff, Mitchell, Scott A, Lee, Seung H, Balan, Gayatri, Van Veldhuizen, Joshua J, Kalla, Rao V, Yeung, Suet C, Phillips, Gary B, Conway, John H, Swaminathan, Sundaramoorthi
Year of Publication 05.07.2024
Get full text
Year of Publication 05.07.2024
Patent
SUBSTITUTED 6-AZABENZIMIDAZOLE COMPOUNDS AS HPK1 INHIBITORS
LO Jennifer R, COSMAN Jennifer L, BALAN Gayatri, BARTLETT Mark J, LOYER-DREW Jennifer A, MITCHELL Scott A, SWAMINATHAN Sundaramoorthi, CONWAY John H, PHILLIPS Gary B, PERRY Thao D, YEUNG Suet C, VAN VELDHUIZEN Joshua J, CHANDRASEKHAR Jayaraman, SALVO Patrick J, LEE Seung H, CODELLI Julian A, KASUN Zachary A, ZABLOCKI Jeff, KALLA Rao V, KIM Musong
Year of Publication 28.06.2024
Get full text
Year of Publication 28.06.2024
Patent
Substituted 6-azabenzimidazole compounds as HPK1 inhibitors
CODELLIA, Julian A, SALVO, Patrick J, SWAMINATHAN, Sundaramoorthi, PHILLIPS, Gary B, VAN VELDHUIZEN, Joshua J, LEE, Seung H, PERRY, Thao D, LO, Jennifer R, ZABLOCKI, Jeff, CONWAY, John H, KIM, Musong, COSMAN, Jennifer L, KASUN, Zachary A, YEUNG, Suet C, BALAN, Gayatri, MITCHELL, Scott A, CHANDRASEKHAR, Jayaraman, LOYER-DREW, Jennifer A, KALLA, Rao V, BARTLETT, Mark J
Year of Publication 20.06.2024
Get full text
Year of Publication 20.06.2024
Patent
Substituted 6-azabenzimidazole compounds as HPK1 inhibitors
Lo, Jennifer R, Chandrasekhar, Jayaraman, Salvo, Patrick J, Kim, Musong, Codelli, Julian A, Perry, Thao D, Cosman, Jennifer L, Loyer-Drew, Jennifer A, Bartlett, Mark J, Kasun, Zachary A, Zablocki, Jeff, Mitchell, Scott A, Lee, Seung H, Balan, Gayatri, Kalla, Rao V, Yeung, Suet C, Phillips, Gary B, Conway, John H, van Veldhuizen, Joshua J, Swaminathan, Sundaramoorthi
Year of Publication 13.06.2024
Get full text
Year of Publication 13.06.2024
Patent