Chronic myeloid leukemia: mechanisms of blastic transformation
Perrotti, Danilo, Jamieson, Catriona, Goldman, John, Skorski, Tomasz
Published in The Journal of clinical investigation (01.07.2010)
Published in The Journal of clinical investigation (01.07.2010)
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Journal Article
MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
Fabbri, Muller, Paone, Alessio, Calore, Federica, Galli, Roberta, Gaudio, Eugenio, Santhanam, Ramasamy, Lovat, Francesca, Fadda, Paolo, Mao, Charlene, Nuovo, Gerard J, Zanesi, Nicola, Crawford, Melissa, Ozer, Gulcin H, Wernicke, Dorothee, Alder, Hansjuerg, Caligiuri, Michael A, Nana-Sinkam, Patrick, Perrotti, Danilo, Croce, Carlo M
Published in Proceedings of the National Academy of Sciences - PNAS (31.07.2012)
Published in Proceedings of the National Academy of Sciences - PNAS (31.07.2012)
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Journal Article
Bone marrow niche trafficking of miR-126 controls the self-renewal of leukemia stem cells in chronic myelogenous leukemia
Zhang, Bin, Nguyen, Le Xuan Truong, Li, Ling, Zhao, Dandan, Kumar, Bijender, Wu, Herman, Lin, Allen, Pellicano, Francesca, Hopcroft, Lisa, Su, Yu-Lin, Copland, Mhairi, Holyoake, Tessa L, Kuo, Calvin J, Bhatia, Ravi, Snyder, David S, Ali, Haris, Stein, Anthony S, Brewer, Casey, Wang, Huafeng, McDonald, Tinisha, Swiderski, Piotr, Troadec, Estelle, Chen, Ching-Cheng, Dorrance, Adrienne, Pullarkat, Vinod, Yuan, Yate-Ching, Perrotti, Danilo, Carlesso, Nadia, Forman, Stephen J, Kortylewski, Marcin, Kuo, Ya-Huei, Marcucci, Guido
Published in Nature medicine (01.04.2018)
Published in Nature medicine (01.04.2018)
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MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1
Garzon, Ramiro, Liu, Shujun, Fabbri, Muller, Liu, Zhongfa, Heaphy, Catherine E.A., Callegari, Elisa, Schwind, Sebastian, Pang, Jiuxia, Yu, Jianhua, Muthusamy, Natarajan, Havelange, Violaine, Volinia, Stefano, Blum, William, Rush, Laura J., Perrotti, Danilo, Andreeff, Michael, Bloomfield, Clara D., Byrd, John C., Chan, Kenneth, Wu, Lai-Chu, Croce, Carlo M., Marcucci, Guido
Published in Blood (18.06.2009)
Published in Blood (18.06.2009)
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Targeted Delivery of microRNA-29b by Transferrin-Conjugated Anionic Lipopolyplex Nanoparticles: A Novel Therapeutic Strategy in Acute Myeloid Leukemia
XIAOMENG HUANG, SCHWIND, Sebastian, BLUM, William, PERROTTI, Danilo, BYRD, John C, BLOOMFIELD, Clara D, CALIGIURI, Michael A, LEE, Robert J, GARZON, Ramiro, MUTHUSAMY, Natarajan, LEE, Ly James, MARCUCCI, Guido, BO YU, SANTHANAM, Ramasamy, HONGYAN WANG, HOELLERBAUER, Pia, MIMS, Alice, KLISOVIC, Rebecca, WALKER, Alison R, CHAN, Kenneth K
Published in Clinical cancer research (01.05.2013)
Published in Clinical cancer research (01.05.2013)
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Somatic variants in epigenetic modifiers can predict failure of response to imatinib but not to second-generation tyrosine kinase inhibitors
Nteliopoulos, Georgios, Bazeos, Alexandra, Claudiani, Simone, Gerrard, Gareth, Curry, Edward, Szydlo, Richard, Alikian, Mary, Foong, Hui En, Nikolakopoulou, Zacharoula, Loaiza, Sandra, Khorashad, Jamshid S, Milojkovic, Dragana, Perrotti, Danilo, Gale, Robert Peter, Foroni, Letizia, Apperley, Jane F
Published in Haematologica (Roma) (01.12.2019)
Published in Haematologica (Roma) (01.12.2019)
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Journal Article
miR-328 Functions as an RNA Decoy to Modulate hnRNP E2 Regulation of mRNA Translation in Leukemic Blasts
Eiring, Anna M., Harb, Jason G., Neviani, Paolo, Garton, Christopher, Oaks, Joshua J., Spizzo, Riccardo, Liu, Shujun, Schwind, Sebastian, Santhanam, Ramasamy, Hickey, Christopher J., Becker, Heiko, Chandler, Jason C., Andino, Raul, Cortes, Jorge, Hokland, Peter, Huettner, Claudia S., Bhatia, Ravi, Roy, Denis C., Liebhaber, Stephen A., Caligiuri, Michael A., Marcucci, Guido, Garzon, Ramiro, Croce, Carlo M., Calin, George A., Perrotti, Danilo
Published in Cell (05.03.2010)
Published in Cell (05.03.2010)
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Journal Article
Role of altered growth factor receptor-mediated JAK2 signaling in growth and maintenance of human acute myeloid leukemia stem cells
Cook, Amy M., Li, Liang, Ho, Yinwei, Lin, Allen, Li, Ling, Stein, Anthony, Forman, Stephen, Perrotti, Danilo, Jove, Richard, Bhatia, Ravi
Published in Blood (01.05.2014)
Published in Blood (01.05.2014)
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Journal Article
BCR-ABL1 mediated miR-150 downregulation through MYC contributed to myeloid differentiation block and drug resistance in chronic myeloid leukemia
Srutova, Klara, Curik, Nikola, Burda, Pavel, Savvulidi, Filipp, Silvestri, Giovannino, Trotta, Rossana, Klamova, Hana, Pecherkova, Pavla, Sovova, Zofie, Koblihova, Jitka, Stopka, Tomas, Perrotti, Danilo, Machova Polakova, Katerina
Published in Haematologica (Roma) (01.12.2018)
Published in Haematologica (Roma) (01.12.2018)
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Journal Article
Concurrent Inhibition of Pim and FLT3 Kinases Enhances Apoptosis of FLT3-ITD Acute Myeloid Leukemia Cells through Increased Mcl-1 Proteasomal Degradation
Kapoor, Shivani, Natarajan, Karthika, Baldwin, Patrick R, Doshi, Kshama A, Lapidus, Rena G, Mathias, Trevor J, Scarpa, Mario, Trotta, Rossana, Davila, Eduardo, Kraus, Manfred, Huszar, Dennis, Tron, Adriana E, Perrotti, Danilo, Baer, Maria R
Published in Clinical cancer research (01.01.2018)
Published in Clinical cancer research (01.01.2018)
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Estrogen mediated-activation of miR-191/425 cluster modulates tumorigenicity of breast cancer cells depending on estrogen receptor status
Di Leva, Gianpiero, Piovan, Claudia, Gasparini, Pierluigi, Ngankeu, Apollinaire, Taccioli, Cristian, Briskin, Daniel, Cheung, Douglas G, Bolon, Brad, Anderlucci, Laura, Alder, Hansjuerg, Nuovo, Gerard, Li, Meng, Iorio, Marilena V, Galasso, Marco, Santhanam, Ramasamy, Ramasamy, Santhanam, Marcucci, Guido, Perrotti, Danilo, Powell, Kimerly A, Bratasz, Anna, Garofalo, Michela, Nephew, Kenneth P, Croce, Carlo M
Published in PLoS genetics (01.03.2013)
Published in PLoS genetics (01.03.2013)
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Journal Article
Preclinical and clinical efficacy of XPO1/CRM1 inhibition by the karyopherin inhibitor KPT-330 in Ph+ leukemias
Walker, Christopher J., Oaks, Joshua J., Santhanam, Ramasamy, Neviani, Paolo, Harb, Jason G., Ferenchak, Gregory, Ellis, Justin J., Landesman, Yosef, Eisfeld, Ann-Kathrin, Gabrail, Nash Y., Smith, Carrie L., Caligiuri, Michael A., Hokland, Peter, Roy, Denis Claude, Reid, Alistair, Milojkovic, Dragana, Goldman, John M., Apperley, Jane, Garzon, Ramiro, Marcucci, Guido, Shacham, Sharon, Kauffman, Michael G., Perrotti, Danilo
Published in Blood (24.10.2013)
Published in Blood (24.10.2013)
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Journal Article
Adverse Prognostic Significance of KIT Mutations in Adult Acute Myeloid Leukemia With inv(16) and t(8;21): A Cancer and Leukemia Group B Study
Paschka, Peter, Marcucci, Guido, Ruppert, Amy S., Mrózek, Krzysztof, Chen, Hankui, Kittles, Rick A., Vukosavljevic, Tamara, Perrotti, Danilo, Vardiman, James W., Carroll, Andrew J., Kolitz, Jonathan E., Larson, Richard A., Bloomfield, Clara D.
Published in Journal of clinical oncology (20.08.2006)
Published in Journal of clinical oncology (20.08.2006)
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Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis
Saddoughi, Sahar A., Gencer, Salih, Peterson, Yuri K., Ward, Katherine E., Mukhopadhyay, Archana, Oaks, Joshua, Bielawski, Jacek, Szulc, Zdzislaw M., Thomas, Raquela J., Selvam, Shanmugam P., Senkal, Can E., Garrett‐Mayer, Elizabeth, De Palma, Ryan M., Fedarovich, Dzmitry, Liu, Angen, Habib, Amyn A., Stahelin, Robert V., Perrotti, Danilo, Ogretmen, Besim
Published in EMBO molecular medicine (01.01.2013)
Published in EMBO molecular medicine (01.01.2013)
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Journal Article
c-MYC Generates Repair Errors via Increased Transcription of Alternative-NHEJ Factors, LIG3 and PARP1, in Tyrosine Kinase-Activated Leukemias
Muvarak, Nidal, Kelley, Shannon, Robert, Carine, Baer, Maria R, Perrotti, Danilo, Gambacorti-Passerini, Carlo, Civin, Curt, Scheibner, Kara, Rassool, Feyruz V
Published in Molecular cancer research (01.04.2015)
Published in Molecular cancer research (01.04.2015)
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Journal Article
Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis
Zhang, Bin, Zhao, Dandan, Chen, Fang, Frankhouser, David, Wang, Huafeng, Pathak, Khyatiben V., Dong, Lei, Torres, Anakaren, Garcia-Mansfield, Krystine, Zhang, Yi, Hoang, Dinh Hoa, Chen, Min-Hsuan, Tao, Shu, Cho, Hyejin, Liang, Yong, Perrotti, Danilo, Branciamore, Sergio, Rockne, Russell, Wu, Xiwei, Ghoda, Lucy, Li, Ling, Jin, Jie, Chen, Jianjun, Yu, Jianhua, Caligiuri, Michael A., Kuo, Ya-Huei, Boldin, Mark, Su, Rui, Swiderski, Piotr, Kortylewski, Marcin, Pirrotte, Patrick, Nguyen, Le Xuan Truong, Marcucci, Guido
Published in Nature communications (01.09.2023)
Published in Nature communications (01.09.2023)
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