Jak2 inhibition deactivates Lyn kinase through the SET-PP2A-SHP1 pathway, causing apoptosis in drug-resistant cells from chronic myelogenous leukemia patients
Samanta, A K, Chakraborty, S N, Wang, Y, Kantarjian, H, Sun, X, Hood, J, Perrotti, D, Arlinghaus, R B
Published in Oncogene (09.04.2009)
Published in Oncogene (09.04.2009)
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Pharmacological targeting of miR-155 via the NEDD8-activating enzyme inhibitor MLN4924 (Pevonedistat) in FLT3-ITD acute myeloid leukemia
Khalife, J, Radomska, H S, Santhanam, R, Huang, X, Neviani, P, Saultz, J, Wang, H, Wu, Y-Z, Alachkar, H, Anghelina, M, Dorrance, A, Curfman, J, Bloomfield, C D, Medeiros, B C, Perrotti, D, Lee, L J, Lee, R J, Caligiuri, M A, Pichiorri, F, Croce, C M, Garzon, R, Guzman, M L, Mendler, J H, Marcucci, G
Published in Leukemia (01.10.2015)
Published in Leukemia (01.10.2015)
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Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia
Mims, A, Walker, A R, Huang, X, Sun, J, Wang, H, Santhanam, R, Dorrance, A M, Walker, C, Hoellerbauer, P, Tarighat, S S, Chan, K K, Klisovic, R B, Perrotti, D, Caligiuri, M A, Byrd, J C, Chen, C-S, James Lee, L, Jacob, S, Mrózek, K, Bloomfield, C D, Blum, W, Garzon, R, Schwind, S, Marcucci, G
Published in Leukemia (01.04.2013)
Published in Leukemia (01.04.2013)
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Bcl-xL anti-apoptotic network is dispensable for development and maintenance of CML but is required for disease progression where it represents a new therapeutic target
Harb, J G, Neviani, P, Chyla, B J, Ellis, J J, Ferenchak, G J, Oaks, J J, Walker, C J, Hokland, P, Roy, D C, Caligiuri, M A, Marcucci, G, Huettner, C S, Perrotti, D
Published in Leukemia (01.10.2013)
Published in Leukemia (01.10.2013)
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Chronic myeloproliferative diseases with and without the Ph chromosome: some unresolved issues
Goldman, J M, Green, A R, Holyoake, T, Jamieson, C, Mesa, R, Mughal, T, Pellicano, F, Perrotti, D, Skoda, R, Vannucchi, A M
Published in Leukemia (01.10.2009)
Published in Leukemia (01.10.2009)
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TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis
Perrotti, Danilo, Bonatti, Silvia, Trotta, Rossana, Martinez, Robert, Skorski, Tomasz, Salomoni, Paolo, Grassilli, Emanuela, Iozzo, Renato V., Cooper, Denise R., Calabretta, Bruno
Published in The EMBO journal (03.08.1998)
Published in The EMBO journal (03.08.1998)
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The Ph-positive and Ph-negative myeloproliferative neoplasms: some topical pre-clinical and clinical issues
VAN ETTEN, Richard A, KOSCHMIEDER, Steffen, GALE, Robert Peter, GOLDMAN, John, DELHOMMEAU, Francois, PERROTTI, Danilo, HOLYOAKE, Tessa, PARDANANI, Animesh, MESA, Ruben, GREEN, Tony, IBRAHIM, Amr R, MUGHAL, Tariq
Published in Haematologica (Roma) (01.04.2011)
Published in Haematologica (Roma) (01.04.2011)
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BCR-ABL1-positive CML and BCR-ABL1-negative chronic myeloproliferative disorders: some common and contrasting features
Cross, N C P, Daley, G Q, Green, A R, Hughes, T P, Jamieson, C, Manley, P, Mughal, T, Perrotti, D, Radich, J, Skoda, R, Soverini, S, Vainchenker, W, Verstovsek, S, Villeval, J-L, Goldman, J M
Published in Leukemia (01.11.2008)
Published in Leukemia (01.11.2008)
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BCR-ABL Prevents c-Jun-Mediated and Proteasome-Dependent FUS (TLS) Proteolysis through a Protein Kinase CβII-Dependent Pathway
Perrotti, Danilo, Iervolino, Angela, Cesi, Vincenzo, Cirinná, Maria, Lombardini, Silvia, Grassilli, Emanuela, Bonatti, Silvia, Claudio, Pier Paolo, Calabretta, Bruno
Published in Molecular and Cellular Biology (01.08.2000)
Published in Molecular and Cellular Biology (01.08.2000)
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Overexpression of the zinc finger protein MZF1 inhibits hematopoietic development from embryonic stem cells: correlation with negative regulation of CD34 and c-myb promoter activity
Perrotti, Danilo, Melotti, Paola, Skorski, Tomasz, Casella, Ida, Peschle, Cesare, Calabretta, Bruno
Published in Molecular and Cellular Biology (01.11.1995)
Published in Molecular and Cellular Biology (01.11.1995)
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Bcl-2 expression restores the leukemogenic potential of a BCR/ABL mutant defective in transformation
Cirinnà, Maria, Trotta, Rossana, Salomoni, Paolo, Kossev, Plamen, Wasik, Mariusz, Perrotti, Danilo, Calabretta, Bruno
Published in Blood (01.12.2000)
Published in Blood (01.12.2000)
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Inhibition of Leukemia Cell Proliferation by Receptor-Mediated Uptake of c-myb Antisense Oligodeoxynucleotides
Citro, Gennaro, Perrotti, Danilo, Cucco, Carla, D'Agnano, Igea, Sacchi, Ada, Zupi, Gabriella, Calabretta, Bruno
Published in Proceedings of the National Academy of Sciences - PNAS (01.08.1992)
Published in Proceedings of the National Academy of Sciences - PNAS (01.08.1992)
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