Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death
Magnaghi, Paola, D'Alessio, Roberto, Valsasina, Barbara, Avanzi, Nilla, Rizzi, Simona, Asa, Daniela, Gasparri, Fabio, Cozzi, Liviana, Cucchi, Ulisse, Orrenius, Christian, Polucci, Paolo, Ballinari, Dario, Perrera, Claudia, Leone, Antonella, Cervi, Giovanni, Casale, Elena, Xiao, Yang, Wong, Chihunt, Anderson, Daniel J, Galvani, Arturo, Donati, Daniele, O'Brien, Tom, Jackson, Peter K, Isacchi, Antonella
Published in Nature chemical biology (01.09.2013)
Published in Nature chemical biology (01.09.2013)
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Poly(ADP-ribose) polymerase inhibition in cancer therapy: are we close to maturity?
Papeo, Gianluca, Forte, Barbara, Orsini, Paolo, Perrera, Claudia, Posteri, Helena, Scolaro, Alessandra, Montagnoli, Alessia
Published in Expert opinion on therapeutic patents (01.10.2009)
Published in Expert opinion on therapeutic patents (01.10.2009)
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The mismatch DNA repair heterodimer, hMSH2 6, regulates BLM helicase
QIN YANG, RAN ZHANG, MODRICH, Paul, HARRIS, Curtis C, XIN W. WANG, LINKE, Steven P, SENGUPTA, Sagar, HICKSON, Ian D, PEDRAZZI, Graziella, PERRERA, Claudia, STAGLJAR, Igor, LITTMAN, Susan J
Published in Oncogene (06.05.2004)
Published in Oncogene (06.05.2004)
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Targeting the mitotic checkpoint for cancer therapy with NMS-P715, an inhibitor of MPS1 kinase
Colombo, Riccardo, Caldarelli, Marina, Mennecozzi, Milena, Giorgini, Maria Laura, Sola, Francesco, Cappella, Paolo, Perrera, Claudia, Depaolini, Stefania Re, Rusconi, Luisa, Cucchi, Ulisse, Avanzi, Nilla, Bertrand, Jay Aaron, Bossi, Roberto Tiberio, Pesenti, Enrico, Galvani, Arturo, Isacchi, Antonella, Colotta, Francesco, Donati, Daniele, Moll, Jürgen
Published in Cancer research (Chicago, Ill.) (15.12.2010)
Published in Cancer research (Chicago, Ill.) (15.12.2010)
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Identification of unprecedented ATP-competitive choline kinase inhibitors
Quartieri, Francesca, Nesi, Marcella, Avanzi, Nilla R., Borghi, Daniela, Casale, Elena, Corti, Emiliana, Cucchi, Ulisse, Donati, Daniele, Fasolini, Marina, Felder, Eduard R., Galvani, Arturo, Giorgini, Maria L., Lomolino, Antonio, Menichincheri, Maria, Orrenius, Christian, Perrera, Claudia, Re Depaolini, Stefania, Riccardi-Sirtori, Federico, Salsi, Enea, Isacchi, Antonella, Gnocchi, Paola
Published in Bioorganic & medicinal chemistry letters (01.11.2021)
Published in Bioorganic & medicinal chemistry letters (01.11.2021)
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Abstract 509: The MPS1/TTK inhibitor, NMS-01940153, synergizes with tisotumab vedotin in colorectal cancer
Texido, Gemma, Gasparri, Fabio, Ciavolella, Antonella, Gianellini, Laura, Pedersen, Anders E., Ocaña, Alberto, Colombo, Riccardo, Roberti, Domenico, Mahnke, Lisa, Perrera, Claudia
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Structural Insight into Maternal Embryonic Leucine Zipper Kinase (MELK) Conformation and Inhibition toward Structure-Based Drug Design
Canevari, Giulia, Re Depaolini, Stefania, Cucchi, Ulisse, Bertrand, Jay A, Casale, Elena, Perrera, Claudia, Forte, Barbara, Carpinelli, Patrizia, Felder, Eduard R
Published in Biochemistry (Easton) (17.09.2013)
Published in Biochemistry (Easton) (17.09.2013)
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Functional analysis of MLH1 mutations linked to hereditary nonpolyposis colon cancer
Nyström-Lahti, Minna, Perrera, Claudia, Räschle, Markus, Panyushkina-Seiler, Elena, Marra, Giancarlo, Curci, Anna, Quaresima, Barbara, Costanzo, Francesco, D'Urso, Michele, Venuta, Salvatore, Jiricny, Josef
Published in Genes chromosomes & cancer (01.02.2002)
Published in Genes chromosomes & cancer (01.02.2002)
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Abstract 1615: NMS-812, a novel potent PERK inhibitor that also inhibits GCN2, exhibits strong anti-tumor activity as single agent and in combination in preclinical models
Perrera, Claudia, Pulici, Maurizio, Banfi, Patrizia, Avanzi, Nilla, Carenzi, Davide, Casero, Daniele, Ciavolella, Antonella, Gianellini, Laura, Gasparri, Fabio, Saturno, Grazia, Valsasina, Barbara, Ardini, Elena, Montagnoli, Alessia, Galvani, Arturo P., Isacchi, Antonella
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
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Abstract 5163: Characterization of NMS-E194, a selective and potent PERK inhibitor with efficacy in the KMS-11 multiple myeloma
Perrera, Claudia, Pulici, Maurizio, Carenzi, Davide, Motto, Ilaria, Fasolini, Marina, Casale, Elena, Depaolini, Stefania Re, Rizzi, Simona, Asa, Daniela, Roletto, Fulvia, Bindi, Simona, Casero, Daniele, Banfi, Patrizia, Ardini, Elena, Amboldi, Nadia, Ballinari, Dario, Gasparri, Fabio, Cribioli, Sabrina, Mancini, Laura, Ciomei, Marina, Donati, Daniele, Felder, Eduard, Galvani, Arturo, Isacchi, Antonella, Valsasina, Barbara
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Identification of Myb-binding Protein 1A (MYBBP1A) as a Novel Substrate for Aurora B Kinase
Perrera, Claudia, Colombo, Riccardo, Valsasina, Barbara, Carpinelli, Patrizia, Troiani, Sonia, Modugno, Michele, Gianellini, Laura, Cappella, Paolo, Isacchi, Antonella, Moll, Jurgen, Rusconi, Luisa
Published in The Journal of biological chemistry (16.04.2010)
Published in The Journal of biological chemistry (16.04.2010)
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Conversion of diploidy to haploidy
Vogelstein, Bert, Yan, Hai, Papadopoulos, Nickolas, Marra, Giancarlo, Perrera, Claudia, Jiricny, Josef, Boland, C. Richard, Lynch, Henry T, Chadwick, Robert B, de la Chapelle, Albert, Berg, Karin, Eshleman, James R, Yuan, Weishi, Markowitz, Sanford, Laken, Steven J, Lengauer, Christoph, Kinzler, Kenneth W
Published in Nature (London) (17.02.2000)
Published in Nature (London) (17.02.2000)
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Abstract B241: Targeting the mitotic checkpoint with NMS-P153, a novel MPS1 kinase inhibitor
Colombo, Riccardo, Caldarelli, Marina, Giorgini, Maria Laura, Sola, Francesco, Cappella, Paolo, Perrera, Claudia, Avanzi, Nilla, Berthrand, Jay A., Pesenti, Enrico, Isacchi, Antonella, Donati, Daniele, Moll, Jurgen, Galvani, Arturo
Published in Molecular cancer therapeutics (12.11.2011)
Published in Molecular cancer therapeutics (12.11.2011)
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Abstract 2940: Identification of potent VCP/p97/CDC48 inhibitors with distinct biochemical mechanisms including a reversible, allosteric inhibitor that activates the unfolded protein response, induce autophagy and cancer cell death
Magnaghi, Paola, D'Alessio, Roberto, Valsasina, Barbara, Avanzi, Nilla R., Rizzi, Simona, Asa, Daniela, Gasparri, Fabio, Cozzi, Liviana, Cucchi, Ulisse, Orrenius, Cristian, Polucci, Paolo, Ballinari, Dario, Perrera, Claudia, Leone, Antonella, Cervi, Giovanni, Galvani, Arturo, Donati, Daniele, O'Brien, Tom, Jackson, Peter K., Isacchi, Antonella
Published in Cancer research (Chicago, Ill.) (15.04.2012)
Published in Cancer research (Chicago, Ill.) (15.04.2012)
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Direct association of Bloom's syndrome gene product with the human mismatch repair protein MLH1
Pedrazzi, G, Perrera, C, Blaser, H, Kuster, P, Marra, G, Davies, S L, Ryu, G H, Freire, R, Hickson, I D, Jiricny, J, Stagljar, I
Published in Nucleic acids research (01.11.2001)
Published in Nucleic acids research (01.11.2001)
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Abstract C202: Targeting the mitotic checkpoint for cancer therapy with NMS-P715, a novel MPS1 kinase inhibitor
Colombo, Riccardo, Caldarelli, Marina, Mennecozzi, Milena, Giorgini, Maria L., Sola, Francesco, Cappella, Paolo, Ballinari, Dario, Perrera, Claudia, Re Depaolini, Stefania, Rusconi, Luisa, Avanzi, Nilla, Volpi, Daniele, Bossi, Roberto, Bertrand, Jay A., Pesenti, Enrico, Isacchi, Antonella, Donati, Daniele, Moll, Jurgen
Published in Molecular cancer therapeutics (10.12.2009)
Published in Molecular cancer therapeutics (10.12.2009)
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High-Frequency Microsatellite Instability is Associated with Defective DNA Mismatch Repair in Human Melanoma
Alvino, Ester, Marra, Giancarlo, Pagani, Elena, Falcinelli, Sabrina, Pepponi, Rita, Perrera, Claudia, Haider, Ritva, Castiglia, Daniele, Ferranti, Giulio, Bonmassar, Enzo, Jiricny, Josef, Zambruno, Giovanna, D'Atri, Stefania
Published in Journal of investigative dermatology (01.01.2002)
Published in Journal of investigative dermatology (01.01.2002)
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Phenotypic analysis of hMSH2 mutations in mouse cells carrying human chromosomes
MARRA, Giancarlo, D'ATRI, Stefania, HAI YAN, PERRERA, Claudia, CANNAVO, Elda, VOGELSTEIN, Bert, JIRICNY, Josef
Published in Cancer research (Chicago, Ill.) (01.11.2001)
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Published in Cancer research (Chicago, Ill.) (01.11.2001)
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Design of Selective Eglin Inhibitors of HCV NS3 Proteinase
Martin, Franck, Dimasi, Nazzareno, Volpari, Cinzia, Perrera, Claudia, Di Marco, Stefania, Brunetti, Mirko, Steinkühler, Christian, De Francesco, Raffaele, Sollazzo, Maurizio
Published in Biochemistry (Easton) (18.08.1998)
Published in Biochemistry (Easton) (18.08.1998)
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