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4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2

by Talley, John J, Brown, David L, Carter, Jeffery S, Graneto, Matthew J, Koboldt, Carol M, Masferrer, Jaime L, Perkins, William E, Rogers, Roland S, Shaffer, Alexander F, Zhang, Yan Y, Zweifel, Ben S, Seibert, Karen
Published in Journal of medicinal chemistry (09.03.2000)

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1,2-DIARYLCYCLOPENTENES AS SELECTIVE CYCLOOXYGENASE-2 INHIBITORS AND ORALLY-ACTIVE ANTIINFLAMMATORY AGENTS

1,2-DIARYLCYCLOPENTENES AS SELECTIVE CYCLOOXYGENASE-2 INHIBITORS AND ORALLY-ACTIVE ANTIINFLAMMATORY AGENTS

by LI, JJ, ANDERSON, GD, BURTON, EG, COGBURN, JN, COLLINS, JT, GARLAND, DJ, GREGORY, SA, HUANG, HC, ISAKSON, PC, KOBOLDT, CM, LOGUSCH, EW, NORTON, MB, PERKINS, WE, REINHARD, EJ, SEIBERT, K, VEENHUIZEN, AW, ZHANG, Y, REITZ, DB
Published in Journal of medicinal chemistry (27.10.1995)

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Novel Terphenyls as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents

Novel Terphenyls as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents

by Li, James J, Norton, Monica B, Reinhard, Emily J, Anderson, Gary D, Gregory, Susan A, Isakson, Peter C, Koboldt, Carol M, Masferrer, Jaime L, Perkins, William E, Seibert, Karen, Zhang, Yan, Zweifel, Ben S, Reitz, David B
Published in Journal of medicinal chemistry (26.04.1996)

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Selective Cyclooxygenase Inhibitors: Novel 1,2-Diarylcyclopentenes Are Potent and Orally Active COX-2 Inhibitors

Selective Cyclooxygenase Inhibitors: Novel 1,2-Diarylcyclopentenes Are Potent and Orally Active COX-2 Inhibitors

by Reitz, David B., Li, James J., Norton, Monica B., Reinhard, Emily J., Collins, Joe T., Anderson, Gary D., Gregory, Susan A., Koboldt, Carol M., Perkins, William E.
Published in Journal of medicinal chemistry (01.11.1994)

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3,4-diarylthiophenes are selective COX-2 inhibitors

3,4-diarylthiophenes are selective COX-2 inhibitors

by Bertenshaw, Stephen R., Talley, John J., Rogier, D.J., Graneto, Matthew J., Rogers, Roland S., Kramer, Steven W., Penning, Thomas D., Koboldt, Carol M., Veenhuizen, Amy W., Zhang, Yan, Perkins, William E.
Published in Bioorganic & medicinal chemistry letters (07.12.1995)

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Selective cyclooxygenase inhibitors: Novel 4-spiro 1,2-diarylcyclopentenes are potent and orally active cox-2 inhibitors

Selective cyclooxygenase inhibitors: Novel 4-spiro 1,2-diarylcyclopentenes are potent and orally active cox-2 inhibitors

by Reitz, David B., Huang, Horng-Chih, Li, James J., Garland, Danny J., Manning, Robert E., Anderson, Gary D., Gregory, Susan A., Koboldt, Carol M., Perkins, William E., Seibert, Karen, Isakson, Peter C.
Published in Bioorganic & medicinal chemistry letters (20.04.1995)

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Mechanical interaction between longitudinal and circular axes of the small intestine

Mechanical interaction between longitudinal and circular axes of the small intestine

by Wood, J D, Perkins, W E
Published in The American journal of physiology (01.03.1970)

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Chronic effects of misoprostol in combination with the NSAID, diclofenac, on gastrointestinal tract of pigs. Relation to diarrheagenic activity, leukocyte infiltration, and mucosal leukotrienes

Chronic effects of misoprostol in combination with the NSAID, diclofenac, on gastrointestinal tract of pigs. Relation to diarrheagenic activity, leukocyte infiltration, and mucosal leukotrienes

by Rainsford, K D, Perkins, W E, Stetsko, P I
Published in Digestive diseases and sciences (01.07.1995)

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Supercritical fluid extraction-liquid chromatography method development for a polymeric controlled-release drug formulation

Supercritical fluid extraction-liquid chromatography method development for a polymeric controlled-release drug formulation

by Roston, Daryl A., Sun, Jeffrey J., Collins, Paul W., Perkins, William E., Tremont, Samuel J.
Published in Journal of pharmaceutical and biomedical analysis (01.11.1995)

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Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib)

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib)

by Penning, T D, Talley, J J, Bertenshaw, S R, Carter, J S, Collins, P W, Docter, S, Graneto, M J, Lee, L F, Malecha, J W, Miyashiro, J M, Rogers, R S, Rogier, D J, Yu, S S, AndersonGD, Burton, E G, Cogburn, J N, Gregory, S A, Koboldt, C M, Perkins, W E, Seibert, K, Veenhuizen, A W, Zhang, Y Y, Isakson, P C
Published in Journal of medicinal chemistry (25.04.1997)

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Catalytic functionalization of polymers: a novel approach to site-specific delivery of misoprostol to the stomach

Catalytic functionalization of polymers: a novel approach to site-specific delivery of misoprostol to the stomach

by Tremont, Samuel J, Collins, Paul W, Perkins, William E, Fenton, Rick L, Forster, Denis, McGrath, Martin P, Wagner, Grace M, Gasiecki, Alan F, Bianchi, Robert G
Published in Journal of medicinal chemistry (15.10.1993)

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Polymeric delivery of the active isomer of misoprostol reduces systemic availability and uterotonic activity

Polymeric delivery of the active isomer of misoprostol reduces systemic availability and uterotonic activity

by Gullikson, G W, Loeffler, R F, Mehrotra, D V, Casler, J J, Bianchi, R G, Schmidt, R E, Khoshaba, N, Perkins, W E
Published in The Journal of pharmacology and experimental therapeutics (01.06.1995)

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Preferential binding of the novel prostaglandin SC-46275 to canine gastric versus intestinal receptors

Preferential binding of the novel prostaglandin SC-46275 to canine gastric versus intestinal receptors

by Tsai, B S, Keith, R H, Perkins, W E, Walsh, R E, Anglin, C P, Collins, P W, Gasiecki, A W, Bauer, R F, Jones, P H, Gaginella, T S
Published in The Journal of pharmacology and experimental therapeutics (01.10.1995)

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Polymer delivery of the active isomer of misoprostol: a solution to the intestinal side effect problem

Polymer delivery of the active isomer of misoprostol: a solution to the intestinal side effect problem

by PERKINS, W. E, BIANCHI, R. G, GASIECKI, A. F, FORSTER, D, JONES, P. H, TREMONT, S. J, COLLINS, P. W, CASLER, J. J, FENTON, R. L, WAGNER, G. M, MCGRATH, M. P, STOLZENBACH, J. C, KOWALSKI, D. L
Published in The Journal of pharmacology and experimental therapeutics (01.04.1994)

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Use of magnetic resonance procedures for measurement of oil in French-style dressings

Use of magnetic resonance procedures for measurement of oil in French-style dressings

by Heil, J.R. (Univ. of California, Davis, CA), Perkins, W.E, McCarthy, M.J
Published in Journal of food science (01.05.1990)

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Stabilization of a prostaglandin tertiary allylic alcohol system by fluorine: synthesis, acid stability studies and pharmacology of a 16-fluoromethyl analog of SC-46275

Stabilization of a prostaglandin tertiary allylic alcohol system by fluorine: synthesis, acid stability studies and pharmacology of a 16-fluoromethyl analog of SC-46275

by Collins, P.W., Shone, R.L., Gasiecki, A.F., Kramer, S.W., Perkins, W.E., Bianchi, R.G.
Published in Bioorganic & medicinal chemistry letters (01.12.1992)

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Somatostatin modulation of peptide-induced acetylcholine release in guinea pig ileum

Somatostatin modulation of peptide-induced acetylcholine release in guinea pig ileum

by Teitelbaum, D H, O'Dorisio, T M, Perkins, W E, Gaginella, T S
Published in The American journal of physiology (01.05.1984)

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SC-46275: a potent, long-acting gastric antisecretory prostaglandin with low oral bioavailability in the dog

SC-46275: a potent, long-acting gastric antisecretory prostaglandin with low oral bioavailability in the dog

by PERKINS, W. E, BURTON, E. G, TSAI, B. S, COLLINS, P. W, CASLER, J. J, GASIECKI, A. F, BAUER, R. F, JONES, P. H, GAGINELLA, T. S
Published in The Journal of pharmacology and experimental therapeutics (01.12.1991)

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Synthesis and structure-activity relationships of acyclic .omega. chain conjugated diene analogs of enisoprost

Synthesis and structure-activity relationships of acyclic .omega. chain conjugated diene analogs of enisoprost

by Collins, P. W, Shone, R. L, Perkins, W. E, Gasiecki, A. F, Kalish, V. J, Kramer, S. W, Bianchi, R. G
Published in Journal of medicinal chemistry (01.02.1992)

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Chemistry and structure-activity relationships of C-17 unsaturated 18-cycloalkyl and cycloalkenyl analogs of enisoprost. Identification of a promising new antiulcer prostaglandin

Chemistry and structure-activity relationships of C-17 unsaturated 18-cycloalkyl and cycloalkenyl analogs of enisoprost. Identification of a promising new antiulcer prostaglandin

by Collins, P. W, Gasiecki, A. F, Perkins, W. E, Gullikson, G. W, Bianchi, R. G, Kramer, S. W, Ng, J. S, Yonan, E. E, Swenton, L
Published in Journal of medicinal chemistry (01.10.1990)

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