Total Synthesis of 6‑Deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 Cancer Cell Line
Arai, Kenzo, Buonamici, Silvia, Chan, Betty, Corson, Laura, Endo, Atsushi, Gerard, Baudouin, Hao, Ming-Hong, Karr, Craig, Kira, Kazunobu, Lee, Linda, Liu, Xiang, Lowe, Jason T, Luo, Tuoping, Marcaurelle, Lisa A, Mizui, Yoshiharu, Nevalainen, Marta, O’Shea, Morgan Welzel, Park, Eun Sun, Perino, Samantha A, Prajapati, Sudeep, Shan, Mingde, Smith, Peter G, Tivitmahaisoon, Parcharee, Wang, John Yuan, Warmuth, Markus, Wu, Kuo-Ming, Yu, Lihua, Zhang, Huiming, Zheng, Guo-Zhu, Keaney, Gregg F
Published in Organic letters (07.11.2014)
Published in Organic letters (07.11.2014)
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Journal Article
CFT7455, a Novel IKZF1/3 Degrader, Demonstrates Potent Anti-Tumor Activity in Models of Non-Hodgkin's Lymphoma As a Single Agent or in Combination with Clinically Approved Agents
Perino, Samantha, Kirby, R. Jason, Agafonov, Roman, Chaturvedi, Prasoon, Eron, Scott, Good, Andrew, Hart, Ashley, He, Minsheng, Lobbardi, Riadh, Phillips, Andrew J, Proia, David, Henderson, James, Thomeius, Michael, Nasveschuk, Christopher, Fisher, Stewart L, Pollock, Roy Macfarlane
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Journal Article
Targeting the Somatostatin Receptor 2 with the Miniaturized Drug Conjugate, PEN-221: A Potent and Novel Therapeutic for the Treatment of Small Cell Lung Cancer
Whalen, Kerry A, White, Brian H, Quinn, James M, Kriksciukaite, Kristina, Alargova, Rossitza, Au Yeung, Tsun P, Bazinet, Patrick, Brockman, Adam, DuPont, Michelle M, Oller, Haley, Gifford, James, Lemelin, Charles-Andre, Lim Soo, Patrick, Perino, Samantha, Moreau, Benoît, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Bilodeau, Mark T, Wooster, Richard
Published in Molecular cancer therapeutics (01.11.2019)
Published in Molecular cancer therapeutics (01.11.2019)
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Journal Article
Discovery of an SSTR2-Targeting Maytansinoid Conjugate (PEN-221) with Potent Activity in Vitro and in Vivo
White, Brian H, Whalen, Kerry, Kriksciukaite, Kristina, Alargova, Rossitza, Au Yeung, Tsun, Bazinet, Patrick, Brockman, Adam, DuPont, Michelle, Oller, Haley, Lemelin, Charles-Andre, Lim Soo, Patrick, Moreau, Benoît, Perino, Samantha, Quinn, James M, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Wooster, Richard, Bilodeau, Mark T
Published in Journal of medicinal chemistry (14.03.2019)
Published in Journal of medicinal chemistry (14.03.2019)
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Journal Article
Abstract 5806: Combination of the miniature drug conjugate PEN-866 with PARP inhibitors as a rational approach to overcoming limitations of PARP inhibitor monotherapy
Perino, Samantha, Quinn, James M., Callahan, Marrissa, Sharma, Gitanjali, White, Brian, Bilodeau, Mark, Alland, Leila, Whalen, Kerry, Wooster, Richard
Published in Cancer research (Chicago, Ill.) (01.07.2018)
Published in Cancer research (Chicago, Ill.) (01.07.2018)
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Journal Article
Abstract 4328: Epigenetic modulation of SSTR2 expression provides the potential to broaden PEN-221 treatment population
Perino, Samantha, Quinn, James, Freda, Jessica, White, Brian, Bailey, Scott, Bhatia, Viren, Sweryda-Krawiec, Beata, Bilodeau, Mark, Bloss, Jeffrey D., Whalen, Kerry, Wooster, Richard
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract P39: CFT7455, a novel IKZF1/3 degrader enhances the anti-myeloma activity of monoclonal and bispecific antibodies by augmenting immune responses
Totman, Jennifer A, Bret-Mounet, Vanessa, Perino, Samantha, Henderson, James A, Pollock, Roy M, Fisher, Stewart L, Thomenius, Michael J
Published in Blood cancer discovery (04.03.2024)
Published in Blood cancer discovery (04.03.2024)
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Journal Article
Abstract LB007: CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models
Henderson, James A., Kirby, R. Jason, Perino, Samantha, Agafonov, Roman V., Chaturvedi, Prasoon, Class, Bradley, Cocozziello, David, Eron, Scott J., Good, Andrew, Hart, Ashley A., Henderson, Christina, Isasa, Marta, Ladd, Brendon, Schnaderbeck, Matt, Mahler, Michelle, Pollock, Roy M., Crystal, Adam S., Nasveschuk, Christopher G., Phillips, Andrew J., Fisher, Stewart L., Proia, David A.
Published in Cancer research (Chicago, Ill.) (01.07.2021)
Published in Cancer research (Chicago, Ill.) (01.07.2021)
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Journal Article
Novel Miniaturized Drug Conjugate Leverages HSP90-driven Tumor Accumulation to Overcome PI3K Inhibitor Delivery Challenges to Solid Tumors
Perino, Samantha, Moreau, Benoit, Freda, Jessica, Cirello, Amanda, White, Brian H., Quinn, James M., Kriksciukaite, Kristina, Someshwar, Ashwajith, Romagnoli, Janel, Robinson, Megan, Movassaghian, Sara, Cipriani, Tyler, Wooster, Richard, Bilodeau, Mark T., Whalen, Kerry A.
Published in Molecular cancer therapeutics (01.08.2020)
Published in Molecular cancer therapeutics (01.08.2020)
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Journal Article
Abstract 1658: CFT1946, a potent, selective BRAF V600X mutant-specific degrader demonstrates superior activity as a single agent to clinically approved BRAF inhibitors and standard of care combinations in preclinical models of BRAF V600X melanoma, CRC, NSCLC, and brain metastasis
Kreger, Bridget, Stephenson, Jacob R., Sowa, Mathew E., Perino, Samantha A., Poling, Laura L., Hurh, Eunju, Thomenius, Michael J., Liang, Yanke, Fisher, Stewart L., Pollock, Roy M.
Published in Cancer research (Chicago, Ill.) (22.03.2024)
Published in Cancer research (Chicago, Ill.) (22.03.2024)
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Journal Article
23814, an Inhibitory Antibody of Ligand-Mediated Notch1 Activation, Modulates Angiogenesis and Inhibits Tumor Growth without Gastrointestinal Toxicity
Proia, Theresa, Jiang, Feng, Bell, Alisa, Nicoletti, Richard, Kong, Lingxin, Kreuter, Kelly, Poling, Laura, Winston, William M, Flaherty, Meghan, Weiler, Solly, Perino, Samantha, O'Hagan, Ronan, Lin, Jie, Gyuris, Jeno, Okamura, Heidi
Published in Molecular cancer therapeutics (01.08.2015)
Published in Molecular cancer therapeutics (01.08.2015)
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Journal Article
Abstract 39: Discovery of PEN-221, an SSTR2-targeting maytansinoid conjugate with potent activity in vitro and in vivo
White, Brian H., Bazinet, Patrick, Whalen, Kerry, DuPont, Michelle, Quinn, James M., Alargova, Rossitza, Yeung, Tsun Au, Brockman, Adam, Gifford, James, Oller, Haley, Kriksciukaite, Kristina, Lemelin, Charles-Andre, Soo, Patrick Lim, Moreau, Benoit, Perino, Samantha, Sharma, Gitanjali, Shinde, Rajesh, Sweryda-Krawiec, Beata, Simcox, Mary, Wooster, Richard, Bilodeau, Mark T.
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
표적 치료제를 포함하는 병용 요법
BILODEAU MARK T, KADIYALA SUDHAKAR, ALLAND LEILA, PERINO SAMANTHA, WOOSTER RICHARD, SIMCOX MARY, WHALEN KERRY
Year of Publication 17.02.2020
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Year of Publication 17.02.2020
Patent
Abstract 2040: Mutations in SF3B1 lead to aberrant splicing through cryptic 3′ splice site selection and impair hematopoietic cell differentiation
Buonamici, Silvia, Perino, Samantha, Lim, Kian Huat, Feala, Jacob, Darman, Rachel, Obeng, Esther, Furman, Richard R., Bailey, Suzanna, Keaney, Gregg, Kumar, Pavan, Mizui, Yoshiharu, Park, Eunice, Wang, John, Warmuth, Markus, Yu, Lihua, Zhu, Ping, Ebert, Benjamin L., Smith, Peter
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Abstract CT186: Pharmacokinetic (PK) profile of a novel IKZF1/3 degrader, CFT7455, enables significant potency advantage over other IKZF1/3 degraders in models of multiple myeloma (MM) and the results of the initial treatment cohort from a first-in-human (FIH) phase 1/2 study of CFT7455 in MM
Lonial, Sagar, Richard, Shambavi, Matous, Jeffrey V, Yee, Andrew J., Shah, Urvi, Mehta-Shah, Neha, Martin, Thomas, Muchtar, Eli, Ailawadhi, Sikander, Richardson, Paul G., Bhutani, Manisha, Perino, Samantha, Kirby, Jason, Agafonov, Roman V., Chaturvedi, Prasoon, Class, Bradley, Schnaderbeck, Matthew, Palmer, Michael R., Gorman, Cathleen, Schoenborn-Kellenberger, Oliver, Hoerres, Amanda, Fisher, Stewart L., Pollock, Roy M., Crystal, Adam, Mahler, Michelle, Bardeja, Jesus
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract ND13: The discovery and characterization of CFT7455: A potent and selective degrader of IKZF1/3 for the treatment of relapsed/refractory multiple myeloma
Henderson, James A., Eron, Scott J., Good, Andrew, Kirby, R Jason, Perino, Samantha, Agafonov, Roman V., Chaturvedi, Prasoon, Class, Bradley, Cocozziello, David, Hart, Ashley A., Henderson, Christina S., Isasa, Marta, Ladd, Brendon, Schnaderbeck, Matt, Mahler, Michelle, Crystal, Adam S., Pollock, Roy M., Nasveschuk, Christopher G., Phillips, Andrew J., Fisher, Stewart L., Proia, David A.
Published in Cancer research (Chicago, Ill.) (15.06.2022)
Published in Cancer research (Chicago, Ill.) (15.06.2022)
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Journal Article
Abstract B125: Mutant SF3B1 downregulates proteins involved in differentiation, including ABCB7
Darman, Rachel B., Perino, Samantha A., Seiler, Michael, Peng, Shouyong, Feala, Jacob, Fekkes, Peter, Keaney, Gregg F., Kunii, Kaiko, Lee, Linda, Lim, Kian Huat, Oda, Yoshiya, Myint, Khin, Obeng, Esther A., Pazolli, Ermira, Park, Eun Sun, Wang, John Yuan, Warmuth, Markus, Yu, Lihua, Zhu, Ping, Mizui, Yoshiharu, Ebert, Benjamin L., Smith, Peter G., Buonamici, Silvia
Published in Molecular cancer therapeutics (01.12.2015)
Published in Molecular cancer therapeutics (01.12.2015)
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Journal Article
Heterozygous Hotspot SF3B1 Mutations Found in Myelodysplastic Syndromes Downregulate Genes Involved in Differentiation of Erythroid Cells
Buonamici, Silvia, Darman, Rachel, Perino, Samantha, Agrawal, Anant, Peng, Shouyong, Seiler, Michael, Lim, Kian Huat, Bhavsar, Erica B., Feala, Jacob, Obeng, Esther A., Bailey, Suzanna, Chan, Betty, Fekkes, Peter, Keaney, Gregg F., Kumar, Pavan, Kunii, Kaiko, Lee, Linda, Mackenzie, Crystal, Matijevic, Mark, Mizui, Yoshiharu, Myint, Khin, Park, Eunice, Pazolli, Ermira, Thomas, Michael, Wang, John, Warmuth, Markus, Yu, Lihua, Zhu, Ping, Furman, Richard R., Ebert, Benjamin L, Smith, Peter G
Published in Blood (03.12.2015)
Published in Blood (03.12.2015)
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Journal Article
Abstract 5564: Total synthesis of 6-deoxypladienolide D and assessment of splicing inhibitory activity in a mutant SF3B1 cancer cell line
Arai, Kenzo, Buonamici, Silvia, Chan, Betty, Corson, Laura, Endo, Atsushi, Gerard, Baudouin, Hao, Ming-Hong, Karr, Craig, Kira, Kazunobu, Lee, Linda, Liu, Xiang, Lowe, Jason T., Luo, Tuoping, Marcaurelle, Lisa A., Mizui, Yoshiharu, Nevalainen, Marta, Welzel O'Shea, Morgan, Park, Eun Sun, Perino, Samantha A., Prajapati, Sudeep, Shan, Mingde, Smith, Peter G., Tivitmahaisoon, Parcharee, Wang, John Yuan, Warmuth, Markus, Wu, Kuo-Ming, Yu, Lihua, Zhang, Huiming, Zheng, Guo Zhu, Keaney, Gregg F.
Published in Cancer research (Chicago, Ill.) (01.08.2015)
Published in Cancer research (Chicago, Ill.) (01.08.2015)
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Journal Article
Cancer-Associated Mutations in SF3B1 Exhibit Neomorphic Splicing Activity and Block Erythroid Differentiation
Buonamici, Silvia, Perino, Samantha, Lim, Kian Huat, Feala, Jacob, Obeng, Esther A., Aicher, Michelle, Aird, Daniel, Bailey, Suzanna, Berkenblit, Anna, Chan, Betty, Erik, Corcoran, Corson, Laura, Darman, Rachel, Fekkes, Peter, Furman, Richard R., Keaney, Gregg F, Kumar, Pavan, Kunii, Kaiko, Lee, Linda, Mackenzie, Crystal, Park, Eunice, Puyang, Xiaoling, Selvaraj, Anand, Thomas, Michael, Wang, John, Warmuth, Markus, Yu, Lihua, Zhu, Ping, Mizui, Yoshiharu, Ebert, Benjamin L., Smith, Peter G
Published in Blood (06.12.2014)
Published in Blood (06.12.2014)
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Journal Article