A Survey of the Role of Noncovalent Sulfur Interactions in Drug Design
Beno, Brett R, Yeung, Kap-Sun, Bartberger, Michael D, Pennington, Lewis D, Meanwell, Nicholas A
Published in Journal of medicinal chemistry (11.06.2015)
Published in Journal of medicinal chemistry (11.06.2015)
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Journal Article
Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors
Lloyd, David J, St Jean, Jr, David J, Kurzeja, Robert J M, Wahl, Robert C, Michelsen, Klaus, Cupples, Rod, Chen, Michelle, Wu, John, Sivits, Glenn, Helmering, Joan, Komorowski, Renée, Ashton, Kate S, Pennington, Lewis D, Fotsch, Christopher, Vazir, Mukta, Chen, Kui, Chmait, Samer, Zhang, Jiandong, Liu, Longbin, Norman, Mark H, Andrews, Kristin L, Bartberger, Michael D, Van, Gwyneth, Galbreath, Elizabeth J, Vonderfecht, Steven L, Wang, Minghan, Jordan, Steven R, Véniant, Murielle M, Hale, Clarence
Published in Nature (London) (01.12.2013)
Published in Nature (London) (01.12.2013)
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Holistic drug design for multiparameter optimization in modern small molecule drug discovery
Pennington, Lewis D., Muegge, Ingo
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
Published in Bioorganic & medicinal chemistry letters (01.06.2021)
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Journal Article
Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 1. Discovery of a Novel Tool Compound for in Vivo Proof-of-Concept
Ashton, Kate S., Andrews, Kristin L., Bryan, Marion C., Chen, Jie, Chen, Kui, Chen, Michelle, Chmait, Samer, Croghan, Michael, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Jordan, Steve R., Kurzeja, Robert J. M., Michelsen, Klaus, Pennington, Lewis D., Poon, Steve F., Sivits, Glenn, Van, Gwyneth, Vonderfecht, Steve L., Wahl, Robert C., Zhang, Jiandong, Lloyd, David J., Hale, Clarence, St. Jean, David J.
Published in Journal of medicinal chemistry (23.01.2014)
Published in Journal of medicinal chemistry (23.01.2014)
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Journal Article
A Unified Strategy for Enantioselective Total Synthesis of Cladiellin and Briarellin Diterpenes: Total Synthesis of Briarellins E and F and the Putative Structure of Alcyonin and Revision of Its Structure Assignment
Corminboeuf, Olivier, Overman, Larry E, Pennington, Lewis D
Published in Journal of organic chemistry (07.08.2009)
Published in Journal of organic chemistry (07.08.2009)
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Journal Article
Harnessing the necessary nitrogen atom in chemical biology and drug discovery
Pennington, Lewis D., Collier, Philip N., Comer, Eamon
Published in Medicinal chemistry research (01.07.2023)
Published in Medicinal chemistry research (01.07.2023)
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Journal Article
Quinolinone-based agonists of S1P1: Use of a N-scan SAR strategy to optimize in vitro and in vivo activity
Pennington, Lewis D., Croghan, Michael D., Sham, Kelvin K.C., Pickrell, Alexander J., Harrington, Paul E., Frohn, Michael J., Lanman, Brian A., Reed, Anthony B., Lee, Matthew R., Xu, Han, McElvain, Michele, Xu, Yang, Zhang, Xuxia, Fiorino, Michael, Horner, Michelle, Morrison, Henry G., Arnett, Heather A., Fotsch, Christopher, Tasker, Andrew S., Wong, Min, Cee, Victor J.
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
Published in Bioorganic & medicinal chemistry letters (01.01.2012)
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Journal Article
Property-Based Drug Design Merits a Nobel Prize
Pennington, Lewis D., Hesse, Matthew J., Koester, Dennis C., McAtee, Rory C., Qunies, Alshaima’a M., Hu, Dennis X.
Published in Journal of medicinal chemistry (25.07.2024)
Published in Journal of medicinal chemistry (25.07.2024)
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Journal Article
A General Strategy for the Synthesis of Cladiellin Diterpenes: Enantioselective Total Syntheses of 6-Acetoxycladiell-7(16),11-dien-3-ol (Deacetoxyalcyonin Acetate), Cladiell-11-ene-3,6,7-triol, Sclerophytin A, and the Initially Purported Structure of Sclerophytin A
MacMillan, David W. C, Overman, Larry E, Pennington, Lewis D
Published in Journal of the American Chemical Society (19.09.2001)
Published in Journal of the American Chemical Society (19.09.2001)
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Journal Article
Total Synthesis of the Reputed Structure of Alcyonin and Reassignment of Its Structure
Corminboeuf, Olivier, Overman, Larry E, Pennington, Lewis D
Published in Organic letters (01.05.2003)
Published in Organic letters (01.05.2003)
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Journal Article
Structure−Activity Relationships of Selective Estrogen Receptor Modulators: Modifications to the 2-Arylbenzothiophene Core of Raloxifene
Grese, Timothy A, Cho, Stephen, Finley, Don R, Godfrey, Alexander G, Jones, Charles D, Lugar, Charles W, Martin, Michael J, Matsumoto, Ken, Pennington, Lewis D, Winter, Mark A, Adrian, M. Dee, Cole, Harlan W, Magee, David E, Phillips, D. Lynn, Rowley, Ellen R, Short, Lorri L, Glasebrook, Andrew L, Bryant, Henry U
Published in Journal of medicinal chemistry (17.01.1997)
Published in Journal of medicinal chemistry (17.01.1997)
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Journal Article
Small Molecule Disruptors of the Glucokinase–Glucokinase Regulatory Protein Interaction: 3. Structure–Activity Relationships within the Aryl Carbinol Region of the N‑Arylsulfonamido‑N′‑arylpiperazine Series
Nishimura, Nobuko, Norman, Mark H, Liu, Longbin, Yang, Kevin C, Ashton, Kate S, Bartberger, Michael D, Chmait, Samer, Chen, Jie, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Jordan, Steven R, Kunz, Roxanne K, Pennington, Lewis D, Poon, Steve F, Siegmund, Aaron, Sivits, Glenn, Lloyd, David J, Hale, Clarence, St. Jean, David J
Published in Journal of medicinal chemistry (10.04.2014)
Published in Journal of medicinal chemistry (10.04.2014)
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Journal Article
Discovery and Structure-Guided Optimization of Diarylmethanesulfonamide Disrupters of Glucokinase–Glucokinase Regulatory Protein (GK–GKRP) Binding: Strategic Use of a N → S (nN → σS–X) Interaction for Conformational Constraint
Pennington, Lewis D, Bartberger, Michael D, Croghan, Michael D, Andrews, Kristin L, Ashton, Kate S, Bourbeau, Matthew P, Chen, Jie, Chmait, Samer, Cupples, Rod, Fotsch, Christopher, Helmering, Joan, Hong, Fang-Tsao, Hungate, Randall W, Jordan, Steven R, Kong, Ke, Liu, Longbin, Michelsen, Klaus, Moyer, Carolyn, Nishimura, Nobuko, Norman, Mark H, Reichelt, Andreas, Siegmund, Aaron C, Sivits, Glenn, Tadesse, Seifu, Tegley, Christopher M, Van, Gwyneth, Yang, Kevin C, Yao, Guomin, Zhang, Jiandong, Lloyd, David J, Hale, Clarence, St. Jean, David J
Published in Journal of medicinal chemistry (24.12.2015)
Published in Journal of medicinal chemistry (24.12.2015)
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