Peptide therapeutics from venom: Current status and potential
Pennington, Michael W., Czerwinski, Andrzej, Norton, Raymond S.
Published in Bioorganic & medicinal chemistry (01.06.2018)
Published in Bioorganic & medicinal chemistry (01.06.2018)
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Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease
Rangaraju, Srikant, Dammer, Eric B, Raza, Syed Ali, Rathakrishnan, Priyadharshini, Xiao, Hailian, Gao, Tianwen, Duong, Duc M, Pennington, Michael W, Lah, James J, Seyfried, Nicholas T, Levey, Allan I
Published in Molecular neurodegeneration (21.05.2018)
Published in Molecular neurodegeneration (21.05.2018)
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Journal Article
Adeno-Associated virus 8 delivers an immunomodulatory peptide to mouse liver more efficiently than to rat liver
Wang, Yuqing, Hurley, Ayrea, De Giorgi, Marco, Tanner, Mark R, Hu, Rong-Chi, Pennington, Michael W, Lagor, William R, Beeton, Christine
Published in PloS one (11.04.2023)
Published in PloS one (11.04.2023)
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Development of highly selective Kv1.3-blocking peptides based on the sea anemone peptide ShK
Pennington, Michael W, Chang, Shih Chieh, Chauhan, Satendra, Huq, Redwan, Tajhya, Rajeev B, Chhabra, Sandeep, Norton, Raymond S, Beeton, Christine
Published in Marine drugs (16.01.2015)
Published in Marine drugs (16.01.2015)
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Biophysical basis for Kv1.3 regulation of membrane potential changes induced by P2X4‐mediated calcium entry in microglia
Nguyen, Hai M., Lucente, Jacopo, Chen, Yi‐Je, Cui, Yanjun, Ibrahim, Rania H., Pennington, Michael W., Jin, Lee‐Way, Maezawa, Izumi, Wulff, Heike
Published in Glia (01.11.2020)
Published in Glia (01.11.2020)
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Journal Article
Blocking KCa3.1 channels increases tumor cell killing by a subpopulation of human natural killer lymphocytes
Koshy, Shyny, Wu, Danli, Hu, Xueyou, Tajhya, Rajeev B, Huq, Redwan, Khan, Fatima S, Pennington, Michael W, Wulff, Heike, Yotnda, Patricia, Beeton, Christine
Published in PloS one (11.10.2013)
Published in PloS one (11.10.2013)
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Journal Article
A bioengineered probiotic for the oral delivery of a peptide Kv1.3 channel blocker to treat rheumatoid arthritis
Wang, Yuqing, Zhu, Duolong, Ortiz-Velez, Laura C, Perry, Jacob L, Pennington, Michael W, Hyser, Joseph M, Britton, Robert A, Beeton, Christine
Published in Proceedings of the National Academy of Sciences - PNAS (10.01.2023)
Published in Proceedings of the National Academy of Sciences - PNAS (10.01.2023)
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A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation
Rashid, M Harunur, Heinzelmann, Germano, Huq, Redwan, Tajhya, Rajeev B, Chang, Shih Chieh, Chhabra, Sandeep, Pennington, Michael W, Beeton, Christine, Norton, Raymond S, Kuyucak, Serdar
Published in PloS one (07.11.2013)
Published in PloS one (07.11.2013)
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Journal Article
Development of a sea anemone toxin as an immunomodulator for therapy of autoimmune diseases
Chi, Victor, Pennington, Michael W., Norton, Raymond S., Tarcha, Eric J., Londono, Luz M., Sims-Fahey, Brian, Upadhyay, Sanjeev K., Lakey, Jonathan T., Iadonato, Shawn, Wulff, Heike, Beeton, Christine, Chandy, K. George
Published in Toxicon (Oxford) (15.03.2012)
Published in Toxicon (Oxford) (15.03.2012)
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Journal Article
The molecular evolution of feathers with direct evidence from fossils
Pan, Yanhong, Zheng, Wenxia, Sawyer, Roger H., Pennington, Michael W., Zheng, Xiaoting, Wang, Xiaoli, Wang, Min, Hu, Liang, O’Connor, Jingmai, Zhao, Tao, Li, Zhiheng, Schroeter, Elena R., Wu, Feixiang, Xu, Xing, Zhou, Zhonghe, Schweitzer, Mary H.
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2019)
Published in Proceedings of the National Academy of Sciences - PNAS (19.02.2019)
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Journal Article
Total Synthesis of Human Hepcidin through Regioselective Disulfide-Bond Formation by using the Safety-Catch Cysteine Protecting Group 4,4′-Dimethylsulfinylbenzhydryl
Dekan, Zoltan, Mobli, Mehdi, Pennington, Michael W., Fung, Eileen, Nemeth, Elizabeta, Alewood, Paul F.
Published in Angewandte Chemie International Edition (10.03.2014)
Published in Angewandte Chemie International Edition (10.03.2014)
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Journal Article
A systems pharmacology-based approach to identify novel Kv1.3 channel-dependent mechanisms in microglial activation
Rangaraju, Srikant, Raza, Syed Ali, Pennati, Andrea, Deng, Qiudong, Dammer, Eric B, Duong, Duc, Pennington, Michael W, Tansey, Malu G, Lah, James J, Betarbet, Ranjita, Seyfried, Nicholas T, Levey, Allan I
Published in Journal of neuroinflammation (26.06.2017)
Published in Journal of neuroinflammation (26.06.2017)
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Journal Article
Preclinical Efficacy of a Lipooligosaccharide Peptide Mimic Candidate Gonococcal Vaccine
Gulati, Sunita, Pennington, Michael W, Czerwinski, Andrzej, Carter, Darrick, Zheng, Bo, Nowak, Nancy A, DeOliveira, Rosane B, Shaughnessy, Jutamas, Reed, George W, Ram, Sanjay, Rice, Peter A
Published in mBio (05.11.2019)
Published in mBio (05.11.2019)
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Journal Article
Kv1.3 Channels Are a Therapeutic Target for T Cell-Mediated Autoimmune Diseases
Beeton, Christine, Wulff, Heike, Standifer, Nathan E., Azam, Philippe, Mullen, Katherine M., Pennington, Michael W., Kolski-Andreaco, Aaron, Wei, Eric, Grino, Alexandra, Counts, Debra R., Wang, Ping H., LeeHealey, Christine J., Andrews, Brian S., Sankaranarayanan, Ananthakrishnan, Homerick, Daniel, Roeck, Werner W., Tehranzadeh, Jamshid, Stanhope, Kimber L., Zimin, Pavel, Havel, Peter J., Griffey, Stephen, Knaus, Hans-Guenther, Nepom, Gerald T., Gutman, George A., Calabresi, Peter A., Chandy, K. George
Published in Proceedings of the National Academy of Sciences - PNAS (14.11.2006)
Published in Proceedings of the National Academy of Sciences - PNAS (14.11.2006)
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Journal Article
KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis
Tanner, Mark R, Pennington, Michael W, Chauhan, Satendra S, Laragione, Teresina, Gulko, Pércio S, Beeton, Christine
Published in Arthritis research & therapy (07.01.2019)
Published in Arthritis research & therapy (07.01.2019)
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Journal Article
Prolonged immunomodulation in inflammatory arthritis using the selective Kv1.3 channel blocker HsTX1[R14A] and its PEGylated analog
Tanner, Mark R, Tajhya, Rajeev B, Huq, Redwan, Gehrmann, Elizabeth J, Rodarte, Kathia E, Atik, Mustafa A, Norton, Raymond S, Pennington, Michael W, Beeton, Christine
Published in Clinical immunology (Orlando, Fla.) (01.07.2017)
Published in Clinical immunology (Orlando, Fla.) (01.07.2017)
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Journal Article
Targeting KCa1.1 Channels with a Scorpion Venom Peptide for the Therapy of Rat Models of Rheumatoid Arthritis
Tanner, Mark R, Pennington, Michael W, Chamberlain, Brayden H, Huq, Redwan, Gehrmann, Elizabeth J, Laragione, Teresina, Gulko, Pércio S, Beeton, Christine
Published in The Journal of pharmacology and experimental therapeutics (01.05.2018)
Published in The Journal of pharmacology and experimental therapeutics (01.05.2018)
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Journal Article
Blocking KV1.3 Channels Inhibits Th2 Lymphocyte Function and Treats a Rat Model of Asthma
Koshy, Shyny, Huq, Redwan, Tanner, Mark R., Atik, Mustafa A., Porter, Paul C., Khan, Fatima S., Pennington, Michael W., Hanania, Nicola A., Corry, David B., Beeton, Christine
Published in The Journal of biological chemistry (02.05.2014)
Published in The Journal of biological chemistry (02.05.2014)
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