Statins as Anticancer Agents in the Era of Precision Medicine
Longo, Joseph, van Leeuwen, Jenna E, Elbaz, Mohamad, Branchard, Emily, Penn, Linda Z
Published in Clinical cancer research (15.11.2020)
Published in Clinical cancer research (15.11.2020)
Get full text
Journal Article
MYC protein interactors in gene transcription and cancer
Lourenco, Corey, Resetca, Diana, Redel, Cornelia, Lin, Peter, MacDonald, Alannah S., Ciaccio, Roberto, Kenney, Tristan M. G., Wei, Yong, Andrews, David W., Sunnerhagen, Maria, Arrowsmith, Cheryl H., Raught, Brian, Penn, Linda Z.
Published in Nature reviews. Cancer (01.09.2021)
Published in Nature reviews. Cancer (01.09.2021)
Get full text
Journal Article
Dysregulation of the mevalonate pathway promotes transformation
Clendening, James W., Pandyra, Aleks, Boutros, Paul C., Ghamrasni, Samah El, Khosravi, Fereshteh, Trentin, Grace A., Martirosyan, Anna, Hakem, Anne, Hakem, Razqallah, Jurisica, Igor, Penn, Linda Z., Mak, Tak Wah
Published in Proceedings of the National Academy of Sciences - PNAS (24.08.2010)
Published in Proceedings of the National Academy of Sciences - PNAS (24.08.2010)
Get full text
Journal Article
The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase
Wei, Yong, Redel, Cornelia, Ahlner, Alexandra, Lemak, Alexander, Johansson-Åkhe, Isak, Houliston, Scott, Kenney, Tristan M G, Tamachi, Aaliya, Morad, Vivian, Duan, Shili, Andrews, David W, Wallner, Björn, Sunnerhagen, Maria, Arrowsmith, Cheryl H, Penn, Linda Z
Published in Nucleic acids research (08.04.2022)
Published in Nucleic acids research (08.04.2022)
Get full text
Journal Article
MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability
Dingar, Dharmendra, Tu, William B., Resetca, Diana, Lourenco, Corey, Tamachi, Aaliya, De Melo, Jason, Houlahan, Kathleen E., Kalkat, Manpreet, Chan, Pak-Kei, Boutros, Paul C., Raught, Brian, Penn, Linda Z.
Published in Nature communications (29.08.2018)
Published in Nature communications (29.08.2018)
Get full text
Journal Article
Rapid 3D phenotypic analysis of neurons and organoids using data-driven cell segmentation-free machine learning
Mergenthaler, Philipp, Hariharan, Santosh, Pemberton, James M, Lourenco, Corey, Penn, Linda Z, Andrews, David W
Published in PLoS computational biology (01.02.2021)
Published in PLoS computational biology (01.02.2021)
Get full text
Journal Article
Computational pharmacogenomic screen identifies drugs that potentiate the anti-breast cancer activity of statins
van Leeuwen, Jenna E., Ba-Alawi, Wail, Branchard, Emily, Cruickshank, Jennifer, Schormann, Wiebke, Longo, Joseph, Silvester, Jennifer, Gross, Peter L., Andrews, David W., Cescon, David W., Haibe-Kains, Benjamin, Penn, Linda Z., Gendoo, Deena M. A.
Published in Nature communications (24.10.2022)
Published in Nature communications (24.10.2022)
Get full text
Journal Article
The c-Myc oncogene directly induces the H19 noncoding RNA by allele-specific binding to potentiate tumorigenesis
BARSYTE-LOVEJOY, Dalia, LAU, Suzanne K, BOUTROS, Paul C, KHOSRAVI, Fereshteh, JURISICA, Igor, ANDRULIS, Irene L, TSAO, Ming S, PENN, Linda Z
Published in Cancer research (Chicago, Ill.) (15.05.2006)
Published in Cancer research (Chicago, Ill.) (15.05.2006)
Get full text
Journal Article
An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer
Longo, Joseph, Mullen, Peter J., Yu, Rosemary, van Leeuwen, Jenna E., Masoomian, Mehdi, Woon, Dixon T.S., Wang, Yuzhuo, Chen, Eric X., Hamilton, Robert J., Sweet, Joan M., van der Kwast, Theodorus H., Fleshner, Neil E., Penn, Linda Z.
Published in Molecular metabolism (Germany) (01.07.2019)
Published in Molecular metabolism (Germany) (01.07.2019)
Get full text
Journal Article
Transient structure and dynamics in the disordered c-Myc transactivation domain affect Bin1 binding
Andresen, Cecilia, Helander, Sara, Lemak, Alexander, Farès, Christophe, Csizmok, Veronika, Carlsson, Jonas, Penn, Linda Z, Forman-Kay, Julie D, Arrowsmith, Cheryl H, Lundström, Patrik, Sunnerhagen, Maria
Published in Nucleic acids research (01.07.2012)
Published in Nucleic acids research (01.07.2012)
Get full text
Journal Article
Sterol-like drugs potentiate statin-triggered prostate cancer cell death by inhibiting SREBP2 nuclear translocation
dos Santos, Diandra Zipinotti, Elbaz, Mohamad, Branchard, Emily, Schormann, Wiebke, Brown, Carla E., Meek, Autumn R., Njar, Vincent C.O., Hamilton, Robert J., Reed, Mark A., Andrews, David W., Penn, Linda Z.
Published in Biomedicine & pharmacotherapy (01.08.2024)
Published in Biomedicine & pharmacotherapy (01.08.2024)
Get full text
Journal Article
Prognostic gene signatures for non-small-cell lung cancer
Boutros, Paul C, Lau, Suzanne K, Pintilie, Melania, Liu, Ni, Shepherd, Frances A, Der, Sandy D, Tsao, Ming-Sound, Penn, Linda Z, Jurisica, Igor
Published in Proceedings of the National Academy of Sciences - PNAS (24.02.2009)
Published in Proceedings of the National Academy of Sciences - PNAS (24.02.2009)
Get full text
Journal Article
Three-Gene Prognostic Classifier for Early-Stage Non–Small-Cell Lung Cancer
LAU, Suzanne K, BOUTROS, Paul C, NI LIU, LAU, Davina, PENN, Linda Z, SHEPHERD, Frances A, JURISICA, Igor, DER, Sandy D, TSAO, Ming-Sound, PINTILIE, Melania, BLACKHALL, Fiona H, ZHU, Chang-Qi, STRUMPF, Dan, JOHNSTON, Michael R, DARLING, Gail, KESHAVJEE, Shaf, WADDELL, Thomas K
Published in Journal of clinical oncology (10.12.2007)
Published in Journal of clinical oncology (10.12.2007)
Get full text
Journal Article
Exploiting the mevalonate pathway to distinguish statin-sensitive multiple myeloma
Clendening, James W., Pandyra, Aleksandra, Li, Zhihua, Boutros, Paul C., Martirosyan, Anna, Lehner, Richard, Jurisica, Igor, Trudel, Suzanne, Penn, Linda Z.
Published in Blood (10.06.2010)
Published in Blood (10.06.2010)
Get full text
Journal Article
Modelling the MYC-driven normal-to-tumour switch in breast cancer
Lourenco, Corey, Kalkat, Manpreet, Houlahan, Kathleen E, De Melo, Jason, Longo, Joseph, Done, Susan J, Boutros, Paul C, Penn, Linda Z
Published in Disease models & mechanisms (01.07.2019)
Published in Disease models & mechanisms (01.07.2019)
Get full text
Journal Article
Cancer therapeutics: Targeting the dark side of Myc
Ponzielli, Romina, Katz, Sigal, Barsyte-Lovejoy, Dalia, Penn, Linda Z.
Published in European journal of cancer (1990) (01.11.2005)
Published in European journal of cancer (1990) (01.11.2005)
Get full text
Journal Article