Targeting the p300/CBP Axis in Lethal Prostate Cancer
Welti, Jonathan, Sharp, Adam, Brooks, Nigel, Yuan, Wei, McNair, Christopher, Chand, Saswati N, Pal, Abhijit, Figueiredo, Ines, Riisnaes, Ruth, Gurel, Bora, Rekowski, Jan, Bogdan, Denisa, West, William, Young, Barbara, Raja, Meera, Prosser, Amy, Lane, Jordan, Thomson, Stuart, Worthington, Jenny, Onions, Stuart, Shannon, Jonathan, Paoletta, Silvia, Brown, Richard, Smyth, Don, Harbottle, Gareth W, Gil, Veronica S, Miranda, Susana, Crespo, Mateus, Ferreira, Ana, Pereira, Rita, Tunariu, Nina, Carreira, Suzanne, Neeb, Antje J, Ning, Jian, Swain, Amanda, Taddei, David, Schiewer, Matthew J, Knudsen, Karen E, Pegg, Neil, de Bono, Johann S
Published in Cancer discovery (01.05.2021)
Published in Cancer discovery (01.05.2021)
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Journal Article
P863: AN OPEN‐LABEL PHASE I/IIA STUDY TO EVALUATE THE SAFETY AND EFFICACY OF CCS1477 AS MONOTHERAPY AND IN COMBINATION WITH POMALIDOMIDE/DEXAMETHASONE IN RELAPSED/REFRACTORY MULTIPLE MYELOMA
Searle, Emma, Cavet, Jim, Knapper, Steven, Bygrave, Ceri, Campbell, Victoria, El‐Sharkawi, Dima, Pawlyn, Charlotte, Creignou, Maria, Walter, Harriet S., Valcarcel, David, Hidalgo, Marta, Knurowski, Tomasz, Clegg, Karen, Pegg, Neil, West, Will, Haynes, Debbie, Frese, Kris, Somervaille, Tim C. P.
Published in HemaSphere (08.08.2023)
Published in HemaSphere (08.08.2023)
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Identification of [4-[4-(methylsulfonyl)phenyl]-6-(trifluoromethyl)-2-pyrimidinyl] amines and ethers as potent and selective cyclooxygenase-2 inhibitors
Swarbrick, Martin E., Beswick, Paul J., Gleave, Robert J., Green, Richard H., Bingham, Sharon, Bountra, Chas, Carter, Malcolm C., Chambers, Laura J., Chessell, Iain P., Clayton, Nick M., Collins, Sue D., Corfield, John A., Hartley, C. David, Kleanthous, Savvas, Lambeth, Paul F., Lucas, Fiona S., Mathews, Neil, Naylor, Alan, Page, Lee W., Payne, Jeremy J., Pegg, Neil A., Price, Helen S., Skidmore, John, Stevens, Alexander J., Stocker, Richard, Stratton, Sharon C., Stuart, Alastair J., Wiseman, Joanne O.
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
Published in Bioorganic & medicinal chemistry letters (01.08.2009)
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Journal Article
Preclinical and Early Clinical Results Indicate a Role for the Oral p300/CBP Inhibitor Inobrodib (CCS1477) in T-Cell Lymphoma
Campbell, Victoria, Walter, Harriet, Gibb, Adam, Davies, Andrew S., Elmusharaf, Nagah, Pegg, Neil, West, Will Henry, Knurowski, Tomasz, Frese, Kris, Haynes, Debbie, Clegg, Karen, Somervaille, Tim
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Potent Pre-Clinical and Early Phase Clinical Activity of EP300/CBP Bromodomain Inhibitor CCS1477 in Multiple Myeloma
Nicosia, Luciano, Brooks, Nigel, Amaral, Fabio, Sinclair, Oliver, Pegg, Neil A, West, William, Knurowski, Tomasz, Frese, Kris, Clegg, Karen, Cavet, James, Searle, Emma, Somervaille, Tim C.P
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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Abstract 1019: P300/CBP inhibitor CCS1477 targets 22Rv1 prostate tumor AR and c-myc gene expression in vivo
Elvin, Paul, Pegg, Neil, Daminelli, Simone, Eden, Izabela, Young, Barbara, Prosser, Amy, Worthington, Jenny, Brooks, Nigel
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Abstract 3826: CCS1477, a potent and selective p300/CBP bromodomain inhibitor, is targeted & differentiated from BET inhibitors in prostate cancer cell lines in vitro
Brooks, Nigel, Prosser, Amy, Young, Barbara, Gaughan, Luke, Elvin, Paul, Pegg, Neil
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Preclinical investigation of a small molecule inhibitor of p300/CBP reveals efficacy in patient-derived prostate tumor explants
Butler, Lisa, Irani, Swati, Centenera, Margaret, Ryan, Natalie, Pegg, Neil, Brooks, Anthony Nigel
Published in Journal of clinical oncology (20.05.2019)
Published in Journal of clinical oncology (20.05.2019)
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Journal Article
CCS1477, a Novel p300/CBP Bromodomain Inhibitor, Enhances Efficacy of Azacitidine and Venetoclax in Pre-Clinical Models of Acute Myeloid Leukaemia and Lymphoma
Brooks, Nigel, Knurowski, Tomasz, Hughes, Andrew, Clegg, Karen, West, William, Pegg, Neil A, Spencer, Gary J, Chadwick, John, Somervaille, Tim C.P
Published in Blood (23.11.2021)
Published in Blood (23.11.2021)
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Journal Article
Therapeutic targeting of EP300/CBP by bromodomain inhibition in hematologic malignancies
Nicosia, Luciano, Spencer, Gary J, Brooks, Nigel, Amaral, Fabio M R, Basma, Naseer J, Chadwick, John A, Revell, Bradley, Wingelhofer, Bettina, Maiques-Diaz, Alba, Sinclair, Oliver, Camera, Francesco, Ciceri, Filippo, Wiseman, Daniel H, Pegg, Neil, West, Will, Knurowski, Tomasz, Frese, Kris, Clegg, Karen, Campbell, Victoria L, Cavet, James, Copland, Mhairi, Searle, Emma, Somervaille, Tim C P
Published in Cancer cell (11.12.2023)
Published in Cancer cell (11.12.2023)
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Journal Article
Tolerability and Clinical Activity of Novel First in Class Oral Agent, Inobrodib (CCS1477), in Combination with Pomalidomide and Dexamethasone in Relapsed/Refractory Multiple Myeloma
Searle, Emma, Cavet, James, Campbell, Victoria, Knapper, Steve, Bygrave, Ceri, El-Sharkawi, Dima, Pawlyn, Charlotte, Creignou, Maria, Walter, Harriet, Valcárcel, David, Hidalgo Soto, Marta, O'Nions, Jenny, Sridhar, Amrutha, Knurowski, Tomasz, Clegg, Karen, Pegg, Neil, West, Will Henry, Haynes, Debbie, Frese, Kris, Somervaille, Tim
Published in Blood (02.11.2023)
Published in Blood (02.11.2023)
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Journal Article
Effect of welding-induced residual stress and distortion on ship hull girder ultimate strength
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Conference Proceeding
P-190 Potent pre-clinical activity of EP300/CBP bromodomain inhibitor CCS1477 in multiple myeloma
Frese, Kris, Nicosia, Luciano, Amaral, Fabio, Sinclair, Oliver, Pegg, Neil, West, Will, Knurowski, Tomasz, Clegg, Karen, Haynes, Debbie, Searle, Emma, Cavet, James, Somervaille, Tim
Published in Clinical lymphoma, myeloma and leukemia (01.09.2023)
Published in Clinical lymphoma, myeloma and leukemia (01.09.2023)
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Journal Article
AR coactivators, CBP/p300, are critical mediators of DNA repair in prostate cancer
Sardar, Sumaira, McNair, Christopher M., Ravindranath, Lakshmi, Chand, Saswati N., Yuan, Wei, Bogdan, Denisa, Welti, Jon, Sharp, Adam, Ryan, Natalie K., Knudsen, Liam A., Schiewer, Matthew J., DeArment, Elise G., Janas, Thomas, Su, Xiaofeng A., Butler, Lisa M., de Bono, Johann S., Frese, Kris, Brooks, Nigel, Pegg, Neil, Knudsen, Karen E., Shafi, Ayesha A.
Published in Oncogene (21.10.2024)
Published in Oncogene (21.10.2024)
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Journal Article
Therapeutic Targeting of EP300/CBP By Bromodomain Inhibition in Acute Myeloid Leukemia
Nicosia, Luciano, Spencer, Gary J, Brooks, Nigel, Amaral, Fabio, Basma, Naseer, Chadwick, John, Revell, Bradley, Wingelhofer, Bettina, Maiques-Diaz, Alba, Ciceri, Filippo, Wiseman, Daniel H, Pegg, Neil A, West, William, Knurowski, Tomasz, Frese, Kris, Clegg, Karen, Campbell, Victoria Louise, Copland, Mhairi, Searle, Emma, Somervaille, Tim C.P
Published in Blood (15.11.2022)
Published in Blood (15.11.2022)
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