Inhibition of influenza virus replication via small molecules that induce the formation of higher-order nucleoprotein oligomers
Gerritz, Samuel W, Cianci, Christopher, Kim, Sean, Pearce, Bradley C, Deminie, Carol, Discotto, Linda, McAuliffe, Brian, Minassian, Beatrice F, Shi, Shuhao, Zhu, Shirong, Zhai, Weixu, Pendri, Annapurna, Li, Guo, Poss, Michael A, Edavettal, Suzanne, McDonnell, Patricia A, Lewis, Hal A, Maskos, Klaus, Mörtl, Mario, Kiefersauer, Reiner, Steinbacher, Stefan, Baldwin, Eric T, Metzler, William, Bryson, James, Healy, Matthew D, Philip, Thomas, Zoeckler, Mary, Schartman, Richard, Sinz, Michael, Leyva-Grado, Victor H, Hoffmann, Hans-Heinrich, Langley, David R, Meanwell, Nicholas A, Krystal, Mark
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2011)
Published in Proceedings of the National Academy of Sciences - PNAS (13.09.2011)
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Inhibitors of HIV-1 attachment. Part 2: An initial survey of indole substitution patterns
MEANWELL, Nicholas A, WALLACE, Owen B, YEUNG, Kap-Sun, ZHILEI QIU, WRIGHT, J. J. Kim, ZHENG YANG, ZADJURA, Lisa, TWEEDIE, Donald L, YEOLA, Suresh, FANG ZHAO, RANADIVE, Sunanda, ROBINSON, Brett A, HAIQUAN FANG, GONG, Yi-Fei, WANG, Hwei-Gene Heidi, BLAIR, Wade S, SHI, Pei-Yong, COLONNO, Richard J, LIN, Pin-Fang, WANG, Henry, DESHPANDE, Milind, TAO WANG, ZHIWEI YIN, ZHONGXING ZHANG, PEARCE, Bradley C, JAMES, Jennifer
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
Published in Bioorganic & medicinal chemistry letters (01.04.2009)
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Inhibitors of HIV-1 attachment. Part 3: A preliminary survey of the effect of structural variation of the benzamide moiety on antiviral activity
Meanwell, Nicholas A., Wallace, Owen B., Wang, Henry, Deshpande, Milind, Pearce, Bradley C., Trehan, Ashok, Yeung, Kap-Sun, Qiu, Zhilei, Wright, J.J. Kim, Robinson, Brett A., Gong, Yi-Fei, Wang, Hwei-Gene Heidi, Blair, Wade S., Shi, Pei-Yong, Lin, Pin-fang
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
Published in Bioorganic & medicinal chemistry letters (01.09.2009)
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Discovery of the Human Immunodeficiency Virus Type 1 (HIV-1) Attachment Inhibitor Temsavir and Its Phosphonooxymethyl Prodrug Fostemsavir
Wang, Tao, Ueda, Yasu, Zhang, Zhongxing, Yin, Zhiwei, Matiskella, John, Pearce, Bradley C, Yang, Zheng, Zheng, Ming, Parker, Dawn D, Yamanaka, Gregory A, Gong, Yi-Fei, Ho, Hsu-Tso, Colonno, Richard J, Langley, David R, Lin, Pin-Fang, Meanwell, Nicholas A, Kadow, John F
Published in Journal of medicinal chemistry (26.07.2018)
Published in Journal of medicinal chemistry (26.07.2018)
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Discovery of Orally Active Isofuranones as Potent, Selective Inhibitors of Hematopoetic Progenitor Kinase 1
Degnan, Andrew P, Kumi, Godwin K, Allard, Christopher W, Araujo, Erika V, Johnson, Walter L, Zimmermann, Kurt, Pearce, Bradley C, Sheriff, Steven, Futran, Alan, Li, Xin, Locke, Gregory A, You, Dan, Morrison, John, Parrish, Karen E, Stromko, Caitlyn, Murtaza, Anwar, Liu, Jinqi, Johnson, Benjamin M, Vite, Gregory D, Wittman, Mark D
Published in ACS medicinal chemistry letters (11.03.2021)
Published in ACS medicinal chemistry letters (11.03.2021)
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E-Novo: An Automated Workflow for Efficient Structure-Based Lead Optimization
Pearce, Bradley C, Langley, David R, Kang, Jia, Huang, Hongwei, Kulkarni, Amit
Published in Journal of Chemical Information and Modeling (27.07.2009)
Published in Journal of Chemical Information and Modeling (27.07.2009)
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Journal Article
BMS-986163, a Negative Allosteric Modulator of GluN2B with Potential Utility in Major Depressive Disorder
Marcin, Lawrence R, Warrier, Jayakumar, Thangathirupathy, Srinivasan, Shi, Jianliang, Karageorge, George N, Pearce, Bradley C, Ng, Alicia, Park, Hyunsoo, Kempson, James, Li, Jianqing, Zhang, Huiping, Mathur, Arvind, Reddy, Aliphedi B, Nagaraju, G, Tonukunuru, Gopikishan, Gupta, Grandhi V. R. K. M, Kamble, Manjunatha, Mannoori, Raju, Cheruku, Srinivas, Jogi, Srinivas, Gulia, Jyoti, Bastia, Tanmaya, Sanmathi, Charulatha, Aher, Jayant, Kallem, Rajareddy, Srikumar, Bettadapura N, Vijaya, Kumar Kuchibhotla, Naidu, Pattipati S, Paschapur, Mahesh, Kalidindi, Narasimharaju, Vikramadithyan, Reeba, Ramarao, Manjunath, Denton, Rex, Molski, Thaddeus, Shields, Eric, Subramanian, Murali, Zhuo, Xiaoliang, Nophsker, Michelle, Simmermacher, Jean, Sinz, Michael, Albright, Charlie, Bristow, Linda J, Islam, Imadul, Bronson, Joanne J, Olson, Richard E, King, Dalton, Thompson, Lorin A, Macor, John E
Published in ACS medicinal chemistry letters (10.05.2018)
Published in ACS medicinal chemistry letters (10.05.2018)
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Journal Article
Inhibitors of Cholesterol Biosynthesis. 2. Hypocholesterolemic and Antioxidant Activities of Benzopyran and Tetrahydronaphthalene Analogs of the Tocotrienols
Pearce, Bradley C, Parker, Rex A, Deason, Michael E, Dischino, Douglas D, Gillespie, Elizabeth, Qureshi, Asaf A, Wright, J. J. Kim, Volk, Kevin
Published in Journal of medicinal chemistry (01.02.1994)
Published in Journal of medicinal chemistry (01.02.1994)
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Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia
Higgins, Mendi A., Marcin, Lawrence R., Christopher Zusi, F., Gentles, Robert, Ding, Min, Pearce, Bradley C., Easton, Amy, Kostich, Walter A., Seager, Matthew A., Bourin, Clotilde, Bristow, Linda J., Johnson, Kim A., Miller, Regina, Hogan, John, Whiterock, Valerie, Gulianello, Michael, Ferrante, Meredith, Huang, Yanling, Hendricson, Adam, Alt, Andrew, Macor, John E., Bronson, Joanne J.
Published in Bioorganic & medicinal chemistry (15.01.2017)
Published in Bioorganic & medicinal chemistry (15.01.2017)
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Molecular characterization and identification of surrogate substrates for diacylglycerol lipase α
Pedicord, Donna L., Flynn, Michael J., Fanslau, Caroline, Miranda, Maricar, Hunihan, Lisa, Robertson, Barbara J., Pearce, Bradley C., Yu, Xuan-Chuan, Westphal, Ryan S., Blat, Yuval
Published in Biochemical and biophysical research communications (12.08.2011)
Published in Biochemical and biophysical research communications (12.08.2011)
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Journal Article
Identification of small molecules that selectively inhibit diacylglycerol lipase-α activity
Appiah, Kingsley K, Blat, Yuval, Robertson, Barbara J, Pearce, Bradley C, Pedicord, Donna L, Gentles, Robert G, Yu, Xuan-Chuan, Mseeh, Faika, Nguyen, Nghi, Swaffield, Jonathan C, Harden, David G, Westphal, Ryan S, Banks, Martyn N, O'Connell, Jonathan C
Published in Journal of biomolecular screening (01.04.2014)
Published in Journal of biomolecular screening (01.04.2014)
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Journal Article
HCV NS5A Replication Complex Inhibitors. Part 4. Optimization for Genotype 1a Replicon Inhibitory Activity
St. Laurent, Denis R., Serrano-Wu, Michael H., Belema, Makonen, Ding, Min, Fang, Hua, Gao, Min, Goodrich, Jason T., Krause, Rudolph G., Lemm, Julie A., Liu, Mengping, Lopez, Omar D., Nguyen, Van N., Nower, Peter T., O’Boyle, Donald R., Pearce, Bradley C., Romine, Jeffrey L., Valera, Lourdes, Sun, Jin-Hua, Wang, Ying-Kai, Yang, Fukang, Yang, Xuejie, Meanwell, Nicholas A., Snyder, Lawrence B.
Published in Journal of medicinal chemistry (13.03.2014)
Published in Journal of medicinal chemistry (13.03.2014)
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Respiratory syncytial virus fusion inhibitors. Part 6: An examination of the effect of structural variation of the benzimidazol-2-one heterocycle moiety
Combrink, Keith D., Gulgeze, H. Belgin, Thuring, Jan W., Yu, Kuo-Long, Civiello, Rita L., Zhang, Yi, Pearce, Bradley C., Yin, Zhiwei, Langley, David R., Kadow, Kathleen F., Cianci, Christopher W., Li, Zhufang, Clarke, Junius, Genovesi, Eugene V., Medina, Ivette, Lamb, Lucinda, Yang, Zheng, Zadjura, Lisa, Krystal, Mark, Meanwell, Nicholas A.
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
Published in Bioorganic & medicinal chemistry letters (01.09.2007)
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Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo
Yu, Kuo-Long, Wang, Xiangdong Alan, Civiello, Rita L., Trehan, Ashok K., Pearce, Bradley C., Yin, Zhiwei, Combrink, Keith D., Gulgeze, H. Belgin, Zhang, Yi, Kadow, Kathleen F., Cianci, Christopher W., Clarke, Junius, Genovesi, Eugene V., Medina, Ivette, Lamb, Lucinda, Wyde, Philip R., Krystal, Mark, Meanwell, Nicholas A.
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
Published in Bioorganic & medicinal chemistry letters (01.03.2006)
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Journal Article
Dietary α-Tocopherol Attenuates the Impact of γ-Tocotrienol on Hepatic 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Chickens
Qureshi, Asaf A., Pearce, Bradley C., Nor, Rosnah M., Gapor, A., Peterson, David M., Elson, Charles E.
Published in The Journal of nutrition (01.02.1996)
Published in The Journal of nutrition (01.02.1996)
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Journal Article
Respiratory syncytial virus inhibitors. Part 2: Benzimidazol-2-one derivatives
YU, Kuo-Long, YI ZHANG, CIANCI, Christopher W, KRYSTAL, Mark, MEANWELL, Nicholas A, CIVIELLO, Rita L, TREHAN, A. Ashok K, PEARCE, Bradley C, ZHIWEI YIN, COMBRINK, Keith D, GULGEZE, H. Belgin, WANG, Xiangdong Alan, KADOW, Kathleen F
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
Published in Bioorganic & medicinal chemistry letters (08.03.2004)
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HPK1 억제제로서 유용한 이소푸라논 화합물
DEGNAN ANDREW P, ZHANG GUIFEN, ARAUJO ERIKA M. V, DASGUPTA BIRESHWAR, CHEN YAN, HILL MATTHEW D, KUMI GODWIN KWAME, WITTMAN MARK D, PEARCE BRADLEY C, MASTALERZ HAROLD A
Year of Publication 14.07.2020
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Year of Publication 14.07.2020
Patent
Hypocholesterolemic activity of synthetic and natural tocotrienols
Pearce, Bradley C, Parker, Rex A, Deason, Michael E, Qureshi, Asaf A, Wright, J. J. Kim
Published in Journal of medicinal chemistry (01.10.1992)
Published in Journal of medicinal chemistry (01.10.1992)
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Journal Article
1,2-Benzisothiazol-3-one 1,1-Dioxide Inhibitors of Human Mast Cell Tryptase
Combrink, Keith D, Gülgeze, H. Belgin, Meanwell, Nicholas A, Pearce, Bradley C, Zulan, Pi, Bisacchi, Gregory S, Roberts, Daniel G. M, Stanley, Paul, Seiler, Steven M
Published in Journal of medicinal chemistry (19.11.1998)
Published in Journal of medicinal chemistry (19.11.1998)
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