H3B-8800, an orally available small-molecule splicing modulator, induces lethality in spliceosome-mutant cancers
Seiler, Michael, Yoshimi, Akihide, Darman, Rachel, Chan, Betty, Keaney, Gregg, Thomas, Michael, Agrawal, Anant A, Caleb, Benjamin, Csibi, Alfredo, Sean, Eckley, Fekkes, Peter, Karr, Craig, Klimek, Virginia, Lai, George, Lee, Linda, Kumar, Pavan, Lee, Stanley Chun-Wei, Liu, Xiang, Mackenzie, Crystal, Meeske, Carol, Mizui, Yoshiharu, Padron, Eric, Park, Eunice, Pazolli, Ermira, Peng, Shouyong, Prajapati, Sudeep, Taylor, Justin, Teng, Teng, Wang, John, Warmuth, Markus, Yao, Huilan, Yu, Lihua, Zhu, Ping, Abdel-Wahab, Omar, Smith, Peter G, Buonamici, Silvia
Published in Nature medicine (01.04.2018)
Published in Nature medicine (01.04.2018)
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Journal Article
Sensitivity to splicing modulation of BCL2 family genes defines cancer therapeutic strategies for splicing modulators
Aird, Daniel, Teng, Teng, Huang, Chia-Ling, Pazolli, Ermira, Banka, Deepti, Cheung-Ong, Kahlin, Eifert, Cheryl, Furman, Craig, Wu, Zhenhua Jeremy, Seiler, Michael, Buonamici, Silvia, Fekkes, Peter, Karr, Craig, Palacino, James, Park, Eunice, Smith, Peter G, Yu, Lihua, Mizui, Yoshiharu, Warmuth, Markus, Chicas, Agustin, Corson, Laura, Zhu, Ping
Published in Nature communications (11.01.2019)
Published in Nature communications (11.01.2019)
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Journal Article
p38MAPK plays a crucial role in stromal-mediated tumorigenesis
Alspach, Elise, Flanagan, Kevin C, Luo, Xianmin, Ruhland, Megan K, Huang, Hui, Pazolli, Ermira, Donlin, Maureen J, Marsh, Timothy, Piwnica-Worms, David, Monahan, Joseph, Novack, Deborah V, McAllister, Sandra S, Stewart, Sheila A
Published in Cancer discovery (01.06.2014)
Published in Cancer discovery (01.06.2014)
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Journal Article
Senescent Stromal-Derived Osteopontin Promotes Preneoplastic Cell Growth
PAZOLLI, Ermira, XIANMIN LUO, STEWART, Sheila A, BREHM, Sarah, CARBERY, Kelly, CHUNG, Jun-Jae, PRIOR, Julie L, DOHERTY, Jason, DEMEHRI, Shadmehr, SALAVAGGIONE, Lorena, PIWNICA-WORMS, David
Published in Cancer research (Chicago, Ill.) (01.02.2009)
Published in Cancer research (Chicago, Ill.) (01.02.2009)
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Journal Article
Osteopontin stimulates preneoplastic cellular proliferation through activation of the MAPK pathway
Luo, Xianmin, Ruhland, Megan K, Pazolli, Ermira, Lind, Anne C, Stewart, Sheila A
Published in Molecular cancer research (01.08.2011)
Published in Molecular cancer research (01.08.2011)
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Journal Article
Chromatin Remodeling Underlies the Senescence-Associated Secretory Phenotype of Tumor Stromal Fibroblasts That Supports Cancer Progression
PAZOLLI, Ermira, ALSPACH, Elise, MILCZAREK, Agnieszka, PRIOR, Julie, PIWNICA-WORMS, David, STEWART, Sheila A
Published in Cancer research (Chicago, Ill.) (01.05.2012)
Published in Cancer research (Chicago, Ill.) (01.05.2012)
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Journal Article
AZD9496: An Oral Estrogen Receptor Inhibitor That Blocks the Growth of ER-Positive and ESR1-Mutant Breast Tumors in Preclinical Models
Weir, Hazel M, Bradbury, Robert H, Lawson, Mandy, Rabow, Alfred A, Buttar, David, Callis, Rowena J, Curwen, Jon O, de Almeida, Camila, Ballard, Peter, Hulse, Michael, Donald, Craig S, Feron, Lyman J L, Karoutchi, Galith, MacFaul, Philip, Moss, Thomas, Norman, Richard A, Pearson, Stuart E, Tonge, Michael, Davies, Gareth, Walker, Graeme E, Wilson, Zena, Rowlinson, Rachel, Powell, Steve, Sadler, Claire, Richmond, Graham, Ladd, Brendon, Pazolli, Ermira, Mazzola, Anne Marie, D'Cruz, Celina, De Savi, Chris
Published in Cancer research (Chicago, Ill.) (01.06.2016)
Published in Cancer research (Chicago, Ill.) (01.06.2016)
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Journal Article
Allosteric PI3Kα Inhibition Overcomes On-target Resistance to Orthosteric Inhibitors Mediated by Secondary PIK3CA Mutations
Varkaris, Andreas, Fece de la Cruz, Ferran, Martin, Elizabeth E, Norden, Bryanna L, Chevalier, Nicholas, Kehlmann, Allison M, Leshchiner, Ignaty, Barnes, Haley, Ehnstrom, Sara, Stavridi, Anastasia-Maria, Yuan, Xin, Kim, Janice S, Ellis, Haley, Papatheodoridi, Alkistis, Gunaydin, Hakan, Danysh, Brian P, Parida, Laxmi, Sanidas, Ioannis, Ji, Yongli, Lau, Kayao, Wulf, Gerburg M, Bardia, Aditya, Spring, Laura M, Isakoff, Steven J, Lennerz, Jochen K, Del Vecchio, Kathryn, Pierce, Levi, Pazolli, Ermira, Getz, Gad, Corcoran, Ryan B, Juric, Dejan
Published in Cancer discovery (08.02.2024)
Published in Cancer discovery (08.02.2024)
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Journal Article
Abstract P5-16-10: RLY-2608: The first allosteric mutant- and isoform-selective inhibitor of PI3Kα, is efficacious as a single agent and drives regressions in combination with standard of care therapies in PIK3CA mutant breast cancer models
Pazolli, Ermira, Kipp, Randy, Boezio, Alessandro, Gunaydin, Hakan, Iskandar, Amanda, Zubrowski, Matthew, Williams, Bret, Shortsleeves, Kelley, Larivee, Alexandre, McLean, Tom, Michelsen, Klaus, Zeng, Hongtao, LaRochelle, Jonathan, Manna, Joe, DiPietro, Lucian, Lescarbeau, Andre, Mader, Mary, Bennet, Bindu, Wilbur, Jeremy, Wang, Qi, Pierce, Levi, Martin, Iain, Watters, James, Fortin, Pascal, Bergstrom, Donald
Published in Cancer research (Chicago, Ill.) (15.02.2022)
Published in Cancer research (Chicago, Ill.) (15.02.2022)
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Journal Article
Discovery and Clinical Proof-of-Concept of RLY-2608, a First-in-Class Mutant-Selective Allosteric PI3Kα Inhibitor That Decouples Antitumor Activity from Hyperinsulinemia
Varkaris, Andreas, Pazolli, Ermira, Gunaydin, Hakan, Wang, Qi, Pierce, Levi, Boezio, Alessandro A, Bulku, Artemisa, DiPietro, Lucian, Fridrich, Cary, Frost, Adam, Giordanetto, Fabrizio, Hamilton, Erika P, Harris, Katherine, Holliday, Michael, Hunter, Tamieka L, Iskandar, Amanda, Ji, Yongli, Larivée, Alexandre, LaRochelle, Jonathan R, Lescarbeau, André, Llambi, Fabien, Lormil, Brenda, Mader, Mary M, Mar, Brenton G, Martin, Iain, McLean, Thomas H, Michelsen, Klaus, Pechersky, Yakov, Puente-Poushnejad, Erika, Raynor, Kevin, Rogala, Dipali, Samadani, Ramin, Schram, Alison M, Shortsleeves, Kelley, Swaminathan, Sweta, Tajmir, Shahein, Tan, Gege, Tang, Yong, Valverde, Roberto, Wehrenberg, Bryan, Wilbur, Jeremy, Williams, Bret R, Zeng, Hongtao, Zhang, Hanmo, Walters, W Patrick, Wolf, Beni B, Shaw, David E, Bergstrom, Donald A, Watters, James, Fraser, James S, Fortin, Pascal D, Kipp, D Randal
Published in Cancer discovery (08.02.2024)
Published in Cancer discovery (08.02.2024)
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Journal Article
Abstract P251: Discovery and characterization of RLY-2608: The first allosteric, mutant, and isoform-selective inhibitor of PI3Kα
Pazolli, Ermira, Kipp, Randy, Boezio, Alessandro, Gunaydin, Hakan, Iskandar, Amanda, Zubrowski, Matthew, Williams, Bret, Shortsleeves, Kelley, Larivee, Alexandre, McLean, Tom, Michelsen, Klaus, Zeng, Hongtao, LaRochelle, Jonathan, Manna, Joe, DiPietro, Lucian, Mader, Mary, Bennet, Bindu, Wilbur, Jeremy, Wang, Qi, Pierce, Levi, Martin, Iain, Watters, James, Fortin, Pascal, Bergstrom, Donald
Published in Molecular cancer therapeutics (01.12.2021)
Published in Molecular cancer therapeutics (01.12.2021)
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Journal Article
c-Myb and C/EBPβ regulate OPN and other senescence-associated secretory phenotype factors
Flanagan, Kevin C, Alspach, Elise, Pazolli, Ermira, Parajuli, Shankar, Ren, Qihao, Arthur, Laura L, Tapia, Roberto, Stewart, Sheila A
Published in Oncotarget (02.01.2018)
Published in Oncotarget (02.01.2018)
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Journal Article
항-BCMA 항체-약물 컨쥬게이트 및 이용 방법
PAZOLLI ERMIRA, ALMAGRO JUAN C, HENRY RYAN, ZHU PING, PALACINO JAMES, SAMARAKOON THIWANKA, FISHKIN NATHAN
Year of Publication 10.02.2023
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Year of Publication 10.02.2023
Patent
Senescence: the good the bad and the dysfunctional
Pazolli, Ermira, Stewart, Sheila A
Published in Current opinion in genetics & development (01.02.2008)
Published in Current opinion in genetics & development (01.02.2008)
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Journal Article
Abstract 281: Sensitivity to splicing modulation of BCL2 family genes reveals cancer therapeutic strategies for splicing modulators
Aird, Daniel, Teng, Teng, Huang, Chia-Ling, Pazolli, Ermira, Banka, Deepti, Cheung-Ong, Kahlin, Eifert, Cheryl, Furman, Craig, Wu, Jeremy, Seiler, Michael, Buonamici, Silvia, Fekkes, Peter, Karr, Craig, Palacino, James, Park, Eunice, Smith, Peter, Yu, Lihua, Mizui, Yoshiharu, Warmuth, Markus, Chicas, Agustin, Corson, Laura, Zhu, Ping
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
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Journal Article
Abstract GS03-10: Allosteric PI3K-alpha inhibition overcomes on-target resistance to orthosteric inhibitors mediated by secondary PIK3CA mutations
Varkaris, Andreas, Cruz, Ferran Fece de la, Martin, Elizabeth, Nordern, Bryanna, Chevalier, Nicholas, Leshchiner, Ignaty, Stavridi, Anastasia, Kim, Janice, Papatheodoridi, Alkistis, Gunaydin, Hakan, Danysh, Brian, Parida, Laxmi, Sanidas, Ioannis, Ji, Yongli, Lau, Kayao, Wulf, Gerburg, Bardia, Aditya, Spring, Laura, Isakoff, Steven, Lennerz, Jochen, Pierce, Levi, Pazolli, Ermira, Getz, Gad, Corcoran, Ryan, Juric, Dejan
Published in Cancer research (Chicago, Ill.) (02.05.2024)
Published in Cancer research (Chicago, Ill.) (02.05.2024)
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Journal Article
스플라이싱 조정제를 사용하는 방법
PAZOLLI ERMIRA, SEILER MICHAEL, YU LIHUA, BARRY EVAN, PALACINO JAMES, ZHU PING, BUONAMICI SILVIA
Year of Publication 15.02.2021
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Year of Publication 15.02.2021
Patent
H3B-8800, an Orally Bioavailable Modulator of the SF3b Complex, Shows Efficacy in Spliceosome-Mutant Myeloid Malignancies
Buonamici, Silvia, Yoshimi, Akihide, Thomas, Michael, Seiler, Michael, Chan, Betty, Caleb, Benjamin, Darman, Rachel, Fekkes, Peter, Karr, Craig, Keaney, Gregg F., Klimek, Virginia M., Kunii, Kaiko, Lee, Linda, Lee, Stanley Chun-Wei, Liu, Xiang, Meeske, Carol, Mizui, Yoshiharu, Padron, Eric, Park, Eunice, Pazolli, Ermira, Prajapati, Sudeep, Taylor, Justin, Wang, John, Warmuth, Markus, Yu, Lihua, Zhu, Ping, Abdel-Wahab, Omar, Smith, Peter G
Published in Blood (02.12.2016)
Published in Blood (02.12.2016)
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Journal Article
Abstract 1185: H3B-8800, a novel orally available SF3b modulator, shows preclinical efficacy across spliceosome mutant cancers
Buonamici, Silvia, Yoshimi, Akihide, Thomas, Michael, Seiler, Michael, Chan, Betty, Caleb, Benjamin, Csibi, Fred, Darman, Rachel, Fekkes, Peter, Karr, Craig, Keaney, Gregg, Kim, Amy, Klimek, Virginia, Kumar, Pavan, Kunii, Kaiko, Lee, Stanley Chun-Wei, Liu, Xiang, MacKenzie, Crystal, Meeske, Carol, Mizui, Yoshiharu, Padron, Eric, Park, Eunice, Pazolli, Ermira, Prajapati, Sudeep, Rioux, Nathalie, Taylor, Justin, Wang, John, Warmuth, Markus, Yao, Huilan, Yu, Lihua, Zhu, Ping, Abdel-Wahab, Omar, Smith, Peter
Published in Cancer research (Chicago, Ill.) (01.07.2017)
Published in Cancer research (Chicago, Ill.) (01.07.2017)
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Journal Article
Abstract A146: Preclinical models relevant to the treatment of post-menopausal breast cancer
Pazolli, Ermira, Mazzola, Anne Marie, Curwen, Jon, Weir, Hazel, Kiessel, Casey, Grondine, Michael, D'Cruz, Celina, Zinda, Mike
Published in Molecular cancer therapeutics (01.11.2013)
Published in Molecular cancer therapeutics (01.11.2013)
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