The mechanisms of pharmacokinetic food-drug interactions – A perspective from the UNGAP group
Koziolek, Mirko, Alcaro, Stefano, Augustijns, Patrick, Basit, Abdul W., Grimm, Michael, Hens, Bart, Hoad, Caroline L., Jedamzik, Philipp, Madla, Christine M., Maliepaard, Marc, Marciani, Luca, Maruca, Annalisa, Parrott, Neil, Pávek, Petr, Porter, Christopher J.H., Reppas, Christos, van Riet-Nales, Diana, Rubbens, Jari, Statelova, Marina, Trevaskis, Natalie L., Valentová, Kateřina, Vertzoni, Maria, Čepo, Dubravka Vitali, Corsetti, Maura
Published in European journal of pharmaceutical sciences (15.06.2019)
Published in European journal of pharmaceutical sciences (15.06.2019)
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Novel Stably Transfected Gene Reporter Human Hepatoma Cell Line for Assessment of Aryl Hydrocarbon Receptor Transcriptional Activity: Construction and Characterization
Novotna, Aneta, Pavek, Petr, Dvorak, Zdenek
Published in Environmental science & technology (01.12.2011)
Published in Environmental science & technology (01.12.2011)
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Discovery of Novel Human Constitutive Androstane Receptor Agonists with the Imidazo[1,2‑a]pyridine Structure
Mejdrová, Ivana, Dušek, Jan, Škach, Kryštof, Stefela, Alžbeta, Skoda, Josef, Chalupský, Karel, Dohnalová, Klára, Pavkova, Ivona, Kronenberger, Thales, Rashidian, Azam, Smutná, Lucie, Duchoslav, Vojtěch, Smutny, Tomas, Pávek, Petr, Nencka, Radim
Published in Journal of medicinal chemistry (23.02.2023)
Published in Journal of medicinal chemistry (23.02.2023)
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Development of 3,5-Dinitrobenzylsulfanyl-1,3,4-oxadiazoles and Thiadiazoles as Selective Antitubercular Agents Active Against Replicating and Nonreplicating Mycobacterium tuberculosis
Karabanovich, Galina, Zemanová, Júlia, Smutný, Tomáš, Székely, Rita, Šarkan, Michal, Centárová, Ivana, Vocat, Anthony, Pávková, Ivona, Čonka, Patrik, Němeček, Jan, Stolaříková, Jiřina, Vejsová, Marcela, Vávrová, Kateřina, Klimešová, Věra, Hrabálek, Alexandr, Pávek, Petr, Cole, Stewart T, Mikušová, Katarína, Roh, Jaroslav
Published in Journal of medicinal chemistry (24.03.2016)
Published in Journal of medicinal chemistry (24.03.2016)
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Rifabutin but not rifampicin can partly out-balance P-glycoprotein induction by concurrent P-glycoprotein inhibition through high affinity binding to the inhibitory site
Phondeth, Lottida, Kamaraj, Rajamanikkam, Nilles, Julie, Weiss, Johanna, Haefeli, Walter E., Pávek, Petr, Theile, Dirk
Published in Archives of toxicology (01.01.2024)
Published in Archives of toxicology (01.01.2024)
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Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β‑d‑ribofuranose 2′-Oxidase
Karabanovich, Galina, Dušek, Jan, Savková, Karin, Pavliš, Oto, Pávková, Ivona, Korábečný, Jan, Kučera, Tomáš, Kočová Vlčková, Hana, Huszár, Stanislav, Konyariková, Zuzana, Konečná, Klára, Jand’ourek, Ondřej, Stolaříková, Jiřina, Korduláková, Jana, Vávrová, Kateřina, Pávek, Petr, Klimešová, Věra, Hrabálek, Alexandr, Mikušová, Katarína, Roh, Jaroslav
Published in Journal of medicinal chemistry (12.09.2019)
Published in Journal of medicinal chemistry (12.09.2019)
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Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway
Karabanovich, Galina, Fabiánová, Viktória, Vocat, Anthony, Dušek, Jan, Valášková, Lenka, Stolaříková, Jiřina, Kitson, Russell R. A., Pávek, Petr, Vávrová, Kateřina, Djaout, Kamel, Mikušová, Katarína, Baulard, Alain R., Cole, Stewart T., Korduláková, Jana, Roh, Jaroslav
Published in Journal of medicinal chemistry (11.01.2024)
Published in Journal of medicinal chemistry (11.01.2024)
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Journal Article
Transcriptional and post-transcriptional regulation of the pregnane X receptor: a rationale for interindividual variability in drug metabolism
Smutny, Tomas, Hyrsova, Lucie, Braeuning, Albert, Ingelman-Sundberg, Magnus, Pavek, Petr
Published in Archives of toxicology (01.01.2021)
Published in Archives of toxicology (01.01.2021)
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P-glycoprotein in the placenta: Expression, localization, regulation and function
Ceckova-Novotna, Martina, Pavek, Petr, Staud, Frantisek
Published in Reproductive toxicology (Elmsford, N.Y.) (01.10.2006)
Published in Reproductive toxicology (Elmsford, N.Y.) (01.10.2006)
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The pregnane X receptor down‐regulates organic cation transporter 1 (SLC22A1) in human hepatocytes by competing for (“squelching”) SRC‐1 coactivator
Hyrsova, Lucie, Smutny, Tomas, Carazo, Alejandro, Moravcik, Stefan, Mandikova, Jana, Trejtnar, Frantisek, Gerbal‐Chaloin, Sabine, Pavek, Petr
Published in British journal of pharmacology (01.05.2016)
Published in British journal of pharmacology (01.05.2016)
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