The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec) : Implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients
BREEDVELD, Pauline, PLUIM, Dick, CIPRIANI, Greta, WIELINGA, Peter, VAN TELLINGEN, Olaf, SCHINKEL, Alfred H, SCHELLENS, Jan H. M
Published in Cancer research (Chicago, Ill.) (01.04.2005)
Published in Cancer research (Chicago, Ill.) (01.04.2005)
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Journal Article
Salvia Miltiorrhiza Root Water-Extract (Danshen) Has No Beneficial Effect on Cardiovascular Risk Factors. A Randomized Double-Blind Cross-Over Trial
van Poppel, Pleun C M, Breedveld, Pauline, Abbink, Evertine J, Roelofs, Hennie, van Heerde, Waander, Smits, Paul, Lin, Wenzhi, Tan, Aaitje H, Russel, Frans G, Donders, Rogier, Tack, Cees J, Rongen, Gerard A
Published in PloS one (20.07.2015)
Published in PloS one (20.07.2015)
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Evidence for Two Interacting Ligand Binding Sites in Human Multidrug Resistance Protein 2 (ATP Binding Cassette C2)
Zelcer, Noam, Huisman, Maarten T, Reid, Glen, Wielinga, Peter, Breedveld, Pauline, Kuil, Annemieke, Knipscheer, Puck, Schellens, Jan H M, Schinkel, Alfred H, Borst, Piet
Published in The Journal of biological chemistry (27.06.2003)
Published in The Journal of biological chemistry (27.06.2003)
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Journal Article
The Effect of Low pH on Breast Cancer Resistance Protein (ABCG2)-Mediated Transport of Methotrexate, 7-Hydroxymethotrexate, Methotrexate Diglutamate, Folic Acid, Mitoxantrone, Topotecan, and Resveratrol in In Vitro Drug Transport Models
Breedveld, Pauline, Pluim, Dick, Cipriani, Greta, Dahlhaus, Femke, van Eijndhoven, Maria A J, de Wolf, Cornelia J F, Kuil, Annemieke, Beijnen, Jos H, Scheffer, George L, Jansen, Gerrit, Borst, Piet, Schellens, Jan H M
Published in Molecular pharmacology (01.01.2007)
Published in Molecular pharmacology (01.01.2007)
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Breast Cancer Resistance Protein (Bcrp1/Abcg2) Limits Net Intestinal Uptake of Quercetin in Rats by Facilitating Apical Efflux of Glucuronides
Sesink, Aloys L A, Arts, Ilja C W, de Boer, Vincent C J, Breedveld, Pauline, Schellens, Jan H M, Hollman, Peter C H, Russel, Frans G M
Published in Molecular pharmacology (01.06.2005)
Published in Molecular pharmacology (01.06.2005)
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Journal Article
Mechanism of the Pharmacokinetic Interaction between Methotrexate and Benzimidazoles
Breedveld, Pauline, Zelcer, Noam, Pluim, Dick, Sönmezer, Özgür, Tibben, Matthijs M., Beijnen, Jos H., Schinkel, Alfred H., van Tellingen, Olaf, Borst, Piet, Schellens, Jan H. M.
Published in Cancer research (Chicago, Ill.) (15.08.2004)
Published in Cancer research (Chicago, Ill.) (15.08.2004)
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Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: Potential role for breast cancer resistance protein in clinical drug-drug interactions
BREEDVELD, Pauline, ZELCER, Noam, PLUIM, Dick, SÖNMEZER, Özgür, TIBBEN, Matthijs M, BEIJNEN, Jos H, SCHINKEL, Alfred H, VAN TELLINGEN, Olaf, BORST, Piet, SCHELLENS, Jan H. M
Published in Cancer research (Chicago, Ill.) (15.08.2004)
Published in Cancer research (Chicago, Ill.) (15.08.2004)
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Journal Article
Salvia Miltiorrhiza Root Water-Extract (Danshen) Has No Beneficial Effect on Cardiovascular Risk Factors. A Randomized Double-Blind Cross-Over Trial: e0128695
Poppel, C Mvan, Breedveld, Pauline, Abbink, Evertine J, Roelofs, Hennie, Heerde, Waander van, Smits, Paul, Lin, Wenzhi, Tan, Aaitje H, Russel, Frans G, Donders, Rogier
Published in PloS one (01.07.2015)
Published in PloS one (01.07.2015)
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Journal Article
Adjuvant testing for vaccine preparations
BREEDVELD, PAULINE, DE GRUIJL, TANJA, SCHEPER, RIEKELD J, VAN DE VEN, RIENEKE
Year of Publication 14.07.2010
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Year of Publication 14.07.2010
Patent
Combination Comprising a Bcrp Inhibitor and 4- (4-Methylpiperazin-1-Ylmethyl)-N-[4-Methyl-3- (4-Pyridin-3-Yl) Pyrimidin-2-Ylamino) Phenyl] -Benzamide
CIPRIANI GRETA, BREEDVELD PAULINE, VAN TELLINGEN OLAF, PLUIM DICK, SCHELLENS JOHANNES HENRICUS MATTHIAS, WIELINGA PIETER ROELAND
Year of Publication 18.12.2008
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Year of Publication 18.12.2008
Patent
COMBINATION COMPRISING A BCRP INHIBITOR AND 4-(4-METHYLPIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL)PYRIDIMIN-2-YLAMINO)PHENYL]-BENZAMIDE
CIPRIANI GRETA, BREEDVELD PAULINE, VAN TELLINGEN OLAF, PLUIM DICK, SCHELLENS JOHANNES HENRICUS MATTHIAS, WIELINGA PIETER ROELAND
Year of Publication 30.05.2007
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Year of Publication 30.05.2007
Patent
COMBINATION COMPRISING A BCRP INHIBITOR AND 4-(4-METHYLPIPERAZIN-1-YLMETHYL)-N-Ý4-METHYL-3-(4-PYRIDIN-3-YL)PYRIMIDIN-2-YLAMINO)PHENYL¨-BENZAMIDE
CIPRIANI, GRETA, BREEDVELD, PAULINE, VAN TELLINGEN, OLAF, SCHELLENS, JOHANNES, HENRICUS, MATTHIAS, WIELINGA, PIETER, ROELAND, PLUIM, DICK
Year of Publication 04.04.2007
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Year of Publication 04.04.2007
Patent
COMBINATION COMPRISING A BCRP INHIBITOR AND 4-(4-METHYLPIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL)PYRIMIDIN-2-YLAMINO)PHENYL]-BENZAMIDE
CIPRIANI, GRETA, BREEDVELD, PAULINE, VAN TELLINGEN, OLAF, SCHELLENS, JOHANNES, HENRICUS, MATTHIAS, WIELINGA, PIETER, ROELAND, PLUIM, DICK
Year of Publication 28.09.2006
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Year of Publication 28.09.2006
Patent
COMBINATION COMPRISING A BCRP INHIBITOR AND 4-(4-METHYLPIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL)PYRIMIDIN-2-YLAMINO)PHENYL]-BENZAMIDE
CIPRIANI, GRETA, BREEDVELD, PAULINE, VAN TELLINGEN, OLAF, SCHELLENS, JOHANNES HENRICUS MATTHIAS, WIELINGA, PIETER ROELAND, PLUIM, DICK
Year of Publication 09.02.2006
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Year of Publication 09.02.2006
Patent