A potent class of GPR40 full agonists engages the enteroinsular axis to promote glucose control in rodents
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Published in PloS one (09.10.2012)
Published in PloS one (09.10.2012)
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Identification and pharmacological characterization of multiple allosteric binding sites on the free fatty acid 1 receptor
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Published in Molecular pharmacology (01.11.2012)
Published in Molecular pharmacology (01.11.2012)
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Activation of FFA1 mediates GLP-1 secretion in mice. Evidence for allosterism at FFA1
Xiong, Yumei, Swaminath, Gayathri, Cao, Qiong, Yang, Li, Guo, Qi, Salomonis, Heather, Lu, Jenny, Houze, Jonathan B., Dransfield, Paul J., Wang, Yingcai, Liu, Jiwen (Jim), Wong, Simon, Schwandner, Ralf, Steger, Franziska, Baribault, Helene, Liu, Lily, Coberly, Suzanne, Miao, Lynn, Zhang, Jane, Lin, Daniel C.-H., Schwarz, Margrit
Published in Molecular and cellular endocrinology (30.04.2013)
Published in Molecular and cellular endocrinology (30.04.2013)
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Discovery and Optimization of Potent GPR40 Full Agonists Containing Tricyclic Spirocycles
Wang, Yingcai, Liu, Jiwen (Jim), Dransfield, Paul J, Zhu, Liusheng, Wang, Zhongyu, Du, Xiaohui, Jiao, Xianyun, Su, Yongli, Li, An-rong, Brown, Sean P, Kasparian, Annie, Vimolratana, Marc, Yu, Ming, Pattaropong, Vatee, Houze, Jonathan B, Swaminath, Gayathri, Tran, Thanhvien, Nguyen, Khanh, Guo, Qi, Zhang, Jane, Zhuang, Run, Li, Frank, Miao, Lynn, Bartberger, Michael D, Correll, Tiffany L, Chow, David, Wong, Simon, Luo, Jian, Lin, Daniel C.-H, Medina, Julio C
Published in ACS medicinal chemistry letters (13.06.2013)
Published in ACS medicinal chemistry letters (13.06.2013)
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Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist
Brown, Sean P, Dransfield, Paul J, Vimolratana, Marc, Jiao, XianYun, Zhu, Liusheng, Pattaropong, Vatee, Sun, Ying, Liu, Jinqian, Luo, Jian, Zhang, Jane, Wong, Simon, Zhuang, Run, Guo, Qi, Li, Frank, Medina, Julio C, Swaminath, Gayathri, Lin, Daniel C.-H, Houze, Jonathan B
Published in ACS medicinal chemistry letters (13.09.2012)
Published in ACS medicinal chemistry letters (13.09.2012)
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Optimization of GPR40 Agonists for Type 2 Diabetes
Liu, Jiwen (Jim), Wang, Yingcai, Ma, Zhihua, Schmitt, Mike, Zhu, Liusheng, Brown, Sean P, Dransfield, Paul J, Sun, Ying, Sharma, Rajiv, Guo, Qi, Zhuang, Run, Zhang, Jane, Luo, Jian, Tonn, George R, Wong, Simon, Swaminath, Gayathri, Medina, Julio C, Lin, Daniel C.-H, Houze, Jonathan B
Published in ACS medicinal chemistry letters (08.05.2014)
Published in ACS medicinal chemistry letters (08.05.2014)
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Novel Series of Potent Glucokinase Activators Leading to the Discovery of AM-2394
Dransfield, Paul J, Pattaropong, Vatee, Lai, Sujen, Fu, Zice, Kohn, Todd J, Du, Xiaohui, Cheng, Alan, Xiong, Yumei, Komorowski, Renee, Jin, Lixia, Conn, Marion, Tien, Eric, DeWolf, Walter E, Hinklin, Ronald J, Aicher, Thomas D, Kraser, Christopher F, Boyd, Steven A, Voegtli, Walter C, Condroski, Kevin R, Veniant-Ellison, Murielle, Medina, Julio C, Houze, Jonathan, Coward, Peter
Published in ACS medicinal chemistry letters (14.07.2016)
Published in ACS medicinal chemistry letters (14.07.2016)
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Improving the Pharmacokinetics of GPR40/FFA1 Full Agonists
Du, Xiaohui, Dransfield, Paul J, Lin, Daniel C.-H, Wong, Simon, Wang, Yingcai, Wang, Zhongyu, Kohn, Todd, Yu, Ming, Brown, Sean P, Vimolratana, Marc, Zhu, Liusheng, Li, An-Rong, Su, Yongli, Jiao, Xianyun, Liu, Jiwen (Jim), Swaminath, Gayathri, Tran, Thanhvien, Luo, Jian, Zhuang, Run, Zhang, Jane, Guo, Qi, Li, Frank, Connors, Richard, Medina, Julio C, Houze, Jonathan B
Published in ACS medicinal chemistry letters (10.04.2014)
Published in ACS medicinal chemistry letters (10.04.2014)
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A unified synthetic strategy toward oroidin-derived alkaloids premised on a biosynthetic proposal
Dransfield, Paul J., Dilley, Anja S., Wang, Shaohui, Romo, Daniel
Published in Tetrahedron (29.05.2006)
Published in Tetrahedron (29.05.2006)
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Preparation and reactivity of imino glycals: stereocontrolled, divergent approach to imino sugars
Dransfield, PJ, Gore, PM, Prokes, Shipman, M, Slawin, AMZ
Published in Organic & biomolecular chemistry (07.08.2003)
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Identification of 2‑Sulfonyl/Sulfonamide Pyrimidines as Covalent Inhibitors of WRN Using a Multiplexed High-Throughput Screening Assay
Parker, Mackenzie J., Lee, Hyelee, Yao, Shihua, Irwin, Sean, Hwang, Sunil, Belanger, Kylie, de Mare, Sofia Woo, Surgenor, Richard, Yan, Lu, Gee, Patricia, Morla, Shravan, Puyang, Xiaoling, Hsiao, Peng, Zeng, Hao, Zhu, Ping, Korpal, Manav, Dransfield, Paul, Bolduc, David M., Larsen, Nicholas A.
Published in Biochemistry (Easton) (18.07.2023)
Published in Biochemistry (Easton) (18.07.2023)
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Stereocontrolled synthesis of polyhydroxylated hexahydro-1H-cyclopent[c]isoxazoles by intramolecular oxime olefin cycloadditions: an approach to aminocyclopentitols
Dransfield, PJ, Moutel, S, Shipman, M, Sik
Published in Journal of the Chemical Society, Perkin Transactions 1 (1999)
Published in Journal of the Chemical Society, Perkin Transactions 1 (1999)
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Cardiovascular response to small-molecule APJ activation
Ason, Brandon, Chen, Yinhong, Guo, Qi, Hoagland, Kimberly M, Chui, Ray W, Fielden, Mark, Sutherland, Weston, Chen, Rhonda, Zhang, Ying, Mihardja, Shirley, Ma, Xiaochuan, Li, Xun, Sun, Yaping, Liu, Dongming, Nguyen, Khanh, Wang, Jinghong, Li, Ning, Rajamani, Sridharan, Qu, Yusheng, Gao, BaoXi, Boden, Andrea, Chintalgattu, Vishnu, Turk, Jim R, Chan, Joyce, Hu, Liaoyuan A, Dransfield, Paul, Houze, Jonathan, Wong, Jingman, Ma, Ji, Pattaropong, Vatee, Véniant, Murielle M, Vargas, Hugo M, Swaminath, Gayathri, Khakoo, Aarif Y
Published in JCI insight (23.04.2020)
Published in JCI insight (23.04.2020)
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Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates
Brown, Sean P., Dransfield, Paul, Vimolratana, Marc, Zhu, Liusheng, Luo, Jian, Zhang, Jane, Jiao, XianYun, Pattaropong, Vatee, Wong, Simon, Zhuang, Run, Swaminath, Gayathri, Houze, Jonathan B., Lin, Daniel C.-H.
Published in ACS medicinal chemistry letters (12.07.2018)
Published in ACS medicinal chemistry letters (12.07.2018)
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5‑Alkyl-2-urea-Substituted Pyridines: Identification of Efficacious Glucokinase Activators with Improved Properties
Kohn, Todd J, Du, Xiaohui, Lai, SuJen, Xiong, YuMei, Komorowski, Renee, Veniant, Murielle, Fu, Zice, Jiao, Xianyun, Pattaropong, Vatee, Chow, David, Cardozo, Mario, Jin, Lixia, Conn, Marion, DeWolf, Walter E, Kraser, Christopher F, Hinklin, Ronald J, Boys, Mark L, Medina, Julio C, Houze, Jonathan, Dransfield, Paul, Coward, Peter
Published in ACS medicinal chemistry letters (14.07.2016)
Published in ACS medicinal chemistry letters (14.07.2016)
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C5-Alkyl-2-methylurea-Substituted Pyridines as a New Class of Glucokinase Activators
Du, Xiaohui, Hinklin, Ronald J, Xiong, Yumei, Dransfield, Paul, Park, Jaehyeon, Kohn, Todd J, Pattaropong, Vatee, Lai, SuJen, Fu, Zice, Jiao, Xianyun, Chow, David, Jin, Lixia, Davda, Jasmine, Veniant, Murielle M, Anderson, Deborah A, Baer, Brian R, Bencsik, Josef R, Boyd, Steven A, Chicarelli, Mark Joseph, Mohr, Peter J, Wang, Bin, Condroski, Kevin R, DeWolf, Walter E, Conn, Marion, Tran, Thanhvien, Yang, Jerry, Aicher, Thomas D, Medina, Julio C, Coward, Peter, Houze, Jonathan B
Published in ACS medicinal chemistry letters (11.12.2014)
Published in ACS medicinal chemistry letters (11.12.2014)
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ΡΡΑRγ MODULATORS AND METHODS OF USE
ROLFE, Alan, LEE, Hyelee, CARTY, Megan, COOK, Andrew, PRAJAPATI, Sudeep, OMOTO, Kiyoyuki, LIU, Xiang, IOANNIDIS, Stephanos, DRANSFIELD, Paul
Year of Publication 10.10.2024
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Year of Publication 10.10.2024
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