Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction
Simonetta, Kyle R., Taygerly, Joshua, Boyle, Kathleen, Basham, Stephen E., Padovani, Chris, Lou, Yan, Cummins, Thomas J., Yung, Stephanie L., von Soly, Szerenke Kiss, Kayser, Frank, Kuriyan, John, Rape, Michael, Cardozo, Mario, Gallop, Mark A., Bence, Neil F., Barsanti, Paul A., Saha, Anjanabha
Published in Nature communications (29.03.2019)
Published in Nature communications (29.03.2019)
Get full text
Journal Article
Structure-Based Drug Design of Novel Potent and Selective Tetrahydropyrazolo[1,5‑a]pyrazines as ATR Inhibitors
Barsanti, Paul A, Aversa, Robert J, Jin, Xianming, Pan, Yue, Lu, Yipin, Elling, Robert, Jain, Rama, Knapp, Mark, Lan, Jiong, Lin, Xiaodong, Rudewicz, Patrick, Sim, Janet, Taricani, Lorena, Thomas, George, Xiao, Linda, Yue, Qin
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
Get full text
Journal Article
Design and Discovery of N‑(3-(2-(2-Hydroxyethoxy)-6-morpholinopyridin-4-yl)-4-methylphenyl)-2-(trifluoromethyl)isonicotinamide, a Selective, Efficacious, and Well-Tolerated RAF Inhibitor Targeting RAS Mutant Cancers: The Path to the Clinic
Ramurthy, Savithri, Taft, Benjamin R, Aversa, Robert J, Barsanti, Paul A, Burger, Matthew T, Lou, Yan, Nishiguchi, Gisele A, Rico, Alice, Setti, Lina, Smith, Aaron, Subramanian, Sharadha, Tamez, Victoriano, Tanner, Huw, Wan, Lifeng, Hu, Cheng, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Tellew, John E, Huang, Shenlin, Yue, Qin, Chaudhary, Apurva, Tian, Hung, Iyer, Raman, Hassan, A. Quamrul, Mathews Griner, Lesley A, La Bonte, Laura R, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Mishina, Yuji, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Sellers, William R, Lees, Emma, Shao, Wenlin, Dillon, Michael P, Stuart, Darrin D
Published in Journal of medicinal chemistry (12.03.2020)
Published in Journal of medicinal chemistry (12.03.2020)
Get full text
Journal Article
Structure-Based Drug Design of Novel, Potent, and Selective Azabenzimidazoles (ABI) as ATR Inhibitors
Barsanti, Paul A, Pan, Yue, Lu, Yipin, Jain, Rama, Cox, Matthew, Aversa, Robert J, Dillon, Michael P, Elling, Robert, Hu, Cheng, Jin, Xianming, Knapp, Mark, Lan, Jiong, Ramurthy, Savithri, Rudewicz, Patrick, Setti, Lina, Subramanian, Sharadha, Mathur, Michelle, Taricani, Lorena, Thomas, George, Xiao, Linda, Yue, Qin
Published in ACS medicinal chemistry letters (08.01.2015)
Published in ACS medicinal chemistry letters (08.01.2015)
Get full text
Journal Article
Total Synthesis of (+)-Zaragozic Acid C
Armstrong, Alan, Barsanti, Paul A, Jones, Lyn H, Ahmed, Ghafoor
Published in Journal of organic chemistry (20.10.2000)
Published in Journal of organic chemistry (20.10.2000)
Get full text
Journal Article
Synthesis of the C1-side chain of zaragozic acid D and progress towards a total synthesis
Armstrong, Alan, Barsanti, Paul A, Blench, Toby J, Ogilvie, Ron
Published in Tetrahedron (13.01.2003)
Published in Tetrahedron (13.01.2003)
Get full text
Journal Article
BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS
HU CHENG, BENJAMIN TAFT, PAUL A BARSANTI, AARON SMITH, NAEEM YUSUFF, ROBERT AVERSA, MICHAEL PATRICK DILLON, VALERY POLYAKOV, WAN LIFENG, PAN YUE, SAVITHRI RAMURTHY, LU YANG, SHARADHA SUBRAMANIAN, LINA SETTI, MATTHEW BURGER, HUW TANNER, ALAN DIPESA, GISELE NISHIGUCHI, ALICE RICO
Year of Publication 10.09.2020
Get full text
Year of Publication 10.09.2020
Patent
Preparation of Chlorosilyl Enolates
Denmark, Scott E, Stavenger, Robert A, Winter, Stephen B. D, Wong, Ken-Tsung, Barsanti, Paul A
Published in Journal of organic chemistry (11.12.1998)
Published in Journal of organic chemistry (11.12.1998)
Get full text
Journal Article
BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS
HU CHENG, BENJAMIN TAFT, PAUL A BARSANTI, AARON SMITH, NAEEM YUSUFF, ROBERT AVERSA, MICHAEL PATRICK DILLON, VALERY POLYAKOV, WAN LIFENG, PAN YUE, SAVITHRI RAMURTHY, LU YANG, SHARADHA SUBRAMANIAN, LINA SETTI, MATTHEW BURGER, HUW TANNER, ALAN DIPESA, GISELE NISHIGUCHI, ALICE RICO
Year of Publication 27.09.2018
Get full text
Year of Publication 27.09.2018
Patent
PYRIDINE AND PYRAZINE DERIVATIVES AS PROTEIN KINASE MODULATORS
HU CHENG, LIN XIAODONG, MARTIN SENDZIK, PAUL A BARSANTI, JIN JEFF, WAN LIFENG, PAN YUE, ROBERT KEYES, ROBERT KUCEJKO, KEITH B PFISTER, JAMES SUTTON
Year of Publication 19.03.2015
Get full text
Year of Publication 19.03.2015
Patent
Design and Discovery of N‑(2-Methyl-5′-morpholino-6′-((tetrahydro‑2H‑pyran-4-yl)oxy)-[3,3′-bipyridin]-5-yl)-3-(trifluoromethyl)benzamide (RAF709): A Potent, Selective, and Efficacious RAF Inhibitor Targeting RAS Mutant Cancers
Nishiguchi, Gisele A, Rico, Alice, Tanner, Huw, Aversa, Robert J, Taft, Benjamin R, Subramanian, Sharadha, Setti, Lina, Burger, Matthew T, Wan, Lifeng, Tamez, Victoriano, Smith, Aaron, Lou, Yan, Barsanti, Paul A, Appleton, Brent A, Mamo, Mulugeta, Tandeske, Laura, Dix, Ina, Tellew, John E, Huang, Shenlin, Mathews Griner, Lesley A, Cooke, Vesselina G, Van Abbema, Anne, Merritt, Hanne, Ma, Sylvia, Gampa, Kalyani, Feng, Fei, Yuan, Jing, Wang, Yingyun, Haling, Jacob R, Vaziri, Sepideh, Hekmat-Nejad, Mohammad, Jansen, Johanna M, Polyakov, Valery, Zang, Richard, Sethuraman, Vijay, Amiri, Payman, Singh, Mallika, Lees, Emma, Shao, Wenlin, Stuart, Darrin D, Dillon, Michael P, Ramurthy, Savithri
Published in Journal of medicinal chemistry (22.06.2017)
Published in Journal of medicinal chemistry (22.06.2017)
Get full text
Journal Article
Abstract 2696: Genetic and pharmacologic evaluation of the ubiquitin ligase CBL-B as a small-molecule, tumor immunotherapy target
Gosling, Jennifa, Rountree, Ryan, Taherbhoy, Asad, Wang, Chenbo, Cummins, Thomas, Cohen, Frederick, Tanaka, Hiroko, Weiss, Dahlia, Cardozo, Mario, Karim, Christopher, Tan, May, Juan, Joseph, Tenn-McClellan, Austin, Soly, Szerenke Kiss von, Sheung, Julie, Boyle, Kathleen, Dhamnaskar, Ketki, Kurylo, Katherine, Bruffey, Jilliane, McKinnell, Jennifer, Karr, Dane, Christianson, Andria, Vries, Anne-Renee Van Der Vuurst de, Sivakumar, Pallavur, Gallop, Mark, Barsanti, Paul A., Saha, Anjanabha, Bence, Neil F., Zapf, Christoph W.
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Published in Cancer research (Chicago, Ill.) (01.07.2019)
Get full text
Journal Article
Abstract 1628: A small-molecule inhibitor of WRN selectively kills MSI-H cancer cells and phenocopies WRN genetic defects
Rao, Yanhua, Srivatsan, Anjana, Liimatta, Marya, Munoz, Diana, Quirit, Jeanne, Shi, Jianxia, Nguyen, An, Linghu, Xin, Federowicz, Federowicz, Jones, Brian, Fleury, Melissa, Newby, Zach, Dillon, Michael P., Barsanti, Paul A., Lackner, Mark R., White, Michael A., Lee, Yang, Landis, Phil, Peng, Yang, Cicchini, Michelle, Cottom, Josh, Nickels, Leng, Brnardic, Ed, DeMartino, Michael, Taygerly, Josh
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Published in Cancer research (Chicago, Ill.) (04.04.2023)
Get full text
Journal Article
The intramolecular 1,3-dipolar cyclisation of mesoionic species generated by the thermolysis of the mixed anhydrides of acetic and N-alkynoyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acids
Sainsbury, Malcolm, Strange, Rosalind H., Woodward, Peter R., Barsanti, Paul A.
Published in Tetrahedron (01.03.1993)
Published in Tetrahedron (01.03.1993)
Get full text
Journal Article
Ketone-directed peracid epoxidation of cyclic alkenes
Armstrong, A, Barsanti, PA, Clarke, PA, Wood, A
Published in Journal of the Chemical Society, Perkin Transactions 1 (21.06.1996)
Published in Journal of the Chemical Society, Perkin Transactions 1 (21.06.1996)
Get full text
Journal Article